ライフサイエンスコーパス: neuronal cell

1 to protein localization (with enrichment in neuronal cells).

2 g significant acute damage to endothelial or neuronal cells.

3 own-regulated microRNA (miR-204-3p) in human neuronal cells.

4 able to induce neurite outgrowth in the PC12 neuronal cells.

5 ntributor towards transcriptome diversity in neuronal cells.

6 in endoplasmic reticulum (ER) homeostasis in neuronal cells.

7 es on the surface of TBEV derived from human neuronal cells.

8 ocesses reminiscent of neurites in these non-neuronal cells.

9 brillar alpha-synuclein pathologies in human neuronal cells.

10 iral replication in epithelial cells but not neuronal cells.

11 rophin receptors TrkB and p75 on transfected neuronal cells.

12 may be due in part to its expression in non-neuronal cells.

13 is, genotoxicity, and ultimately necrosis of neuronal cells.

14 studying factors that regulate infection of neuronal cells.

15 here was no increase in the number of normal neuronal cells.

16 hich was confirmed in iPSC-derived forebrain neuronal cells.

17 AF-32 present in embryonic cells and CTCF in neuronal cells.

18 n of differentiated and undifferentiated rat neuronal cells.

19 is retained in intracellular compartments in neuronal cells.

20 cancer, stem, epithelial, immune, glial, and neuronal cells.

21 responses through populations of immune and neuronal cells.

22 am and directs a more faithful conversion to neuronal cells.

23 , decreased BACE1 protein levels in cultured neuronal cells.

24 itro and on ectopic expression of tau in non-neuronal cells.

25 enes and enhancers, in clear contrast to non-neuronal cells.

26 [Formula: see text]-synuclein expression in neuronal cells.

27 tion and accumulation of protein deposits in neuronal cells.

28 ansmission of ORF7-deficient virus among the neuronal cells.

29 eatment of SINV-infected differentiated AP-7 neuronal cells.

30 herapeutic efficacy of autophagy inducers in neuronal cells.

31 d nonhomologous end joining is important for neuronal cells.

32 platelets, vascular smooth muscle cells, and neuronal cells.

33 the differentiation of two types of cultured neuronal cells.

34 PCs), assembled rosettes, and differentiated neuronal cells.

35 (HSV-1) establishes a lifelong infection in neuronal cells.

36 efficiency in keratinocytes, hepatocytes and neuronal cells.

37 bipolar, amacrine, retinal ganglion and non-neuronal cells.

38 ntracellular Ca(2+) concentration in sensory neuronal cells.

39 What is the reason for Tau toxicity in neuronal cells?

40 pG methylation (CG-DMRs and CH-DMRs) only in neuronal cells across brain regions.

41 However, imaging of neuronal cell activity under stable physiological condit

42 well as GSK3B and L1CAM that are involved in neuronal cell adhesion and migration.

43 yte-neuron junctions in vivo, which includes neuronal cell adhesion molecule (NRCAM).

44 ma2 GABAA receptors in both neuronal and non-neuronal cells and characterized their effects on recept

45 is a secretory vertebrate RNase that enters neuronal cells and cleaves a subset of tRNAs, leading to

46 OTUB1 formed inclusions in neuronal cells and co-localized with thioflavin S and wi

47 to the E protein of TBEV when grown in human neuronal cells and compare it to the profile of virus gr

48 ated, the number of cortical and hippocampal neuronal cells and dendritic arborization, when evaluate

49 ons, is active in late mitotic phases in non-neuronal cells and directly phosphorylates PP4R3beta, th

50 es can establish spontaneous latency only in neuronal cells and emphasize the stochastic nature of ly

51 creased the levels of extracellular Abeta in neuronal cells and impaired the clearance of extracellul

52 monstrated reduced neurotoxicity in-vitro in neuronal cells and prevented development of peripheral n

53 2-mediated TC-NER activity in differentiated neuronal cells and protection of neurons from cisplatin-

54 replication of these neurotropic viruses in neuronal cells and rabies virus infection in mouse brain

55 ubcellular compartments of mouse hippocampal neuronal cells and rat brain tissue.

56 activity had slower replication in mammalian neuronal cells and reduced virulence in 2-day-old mice.

57 AD-related tau hyperphosphorylation in human neuronal cells and reverses memory impairment in transge

58 ugh an intercellular interaction between non-neuronal cells and sensory neurons.

59 due to the GAA.TTC repeat expansion in FRDA neuronal cells and the effect of HDACi on these changes,

60 creases parkin protein levels using cultured neuronal cells and the PD-relevant stressor, L-DOPA.

61 R-1), a thrombin receptor expressed by vECs, neuronal cells, and glial cells.

62 ton damage, rapid internalization inside the neuronal cells, and mitochondrial damage, all of which c

63 cell death in fibroblasts, cardiomyoblasts, neuronal cells, and primary cardiomyocytes.

64 racteristic of other hematopoietic lineages, neuronal cells, and the CNS, lung, pancreas, and other c

65 asts, pericytes, adipocytes, endothelial and neuronal cells, and the extracellular matrix proteins.

66 HSV-1 forms an organized assembly factory in neuronal cells, and we identify some of the viral and ho

67 differentiated and differentiated AP7 (dAP7) neuronal cells, antibody treatment decreased levels of v

68 c activities, leading to reduced spinal cord neuronal cell apoptosis and smaller lesion area than in

69 during long-term culturing in BrainPhys, non-neuronal cells appeared and eventually took over the cul

70 These non-neuronal cells are crucial in determining the functional

71 TAD borders that are specific to neuronal cells are enriched in enhancers controlled by n

72 Immune and neuronal cells are often colocalized at defined anatomic

73 Using immortalized mouse hippocampal neuronal cells as an in vitro model, 4-hydroxyestrone, a

74 has great potential for in vitro analysis of neuronal cells as well as early diagnosis of different n

75 luated the absolute number and morphology of neuronal cells, as well as the expression of growth, pro

76 es elevated extramitochondrial Ca(2+) in non-neuronal cells, axonal mitochondria readily take up Ca(2

77 In neuronal cell-based models of mTOR hyperactivity, 7 corr

78 st high-resolution contact map of Drosophila neuronal cells (BG3) and identify different classes of T

79 cell autonomously for these early changes in neuronal cell biology in bystander neurons, as were the

80 s by using two independent sets of olfactory neuronal cells biopsied from patients and healthy contro

81 ized high-quality population data, olfactory neuronal cells biopsied from patients with SZ or BP, and

82 ic reduction in nascent protein synthesis in neuronal cell bodies and dendrites.

83 i-hnRNP A1 antibodies were found to surround neuronal cell bodies and interact with CD68(+) immune ce

84 e, we identified an interaction site between neuronal cell bodies and microglial processes in mouse a

85 ionally balances microglial association with neuronal cell bodies and myelin phagocytosis in the opti

86 We found a reduction of NeuN(+) neuronal cell bodies in areas of the ventral gray matter

87 us monitoring of calcium transients in ~1000 neuronal cell bodies in the ganglia during tracheal perf

88 , anti-hnRNP A1 antibodies were found within neuronal cell bodies including those of the ventral spin

89 nveys retrograde pro-degenerative signals to neuronal cell bodies via its downstream target c-Jun N-t

90 lia (which associate almost exclusively with neuronal cell bodies) to understand glia-soma interactio

91 elin outfolds surrounded unmyelinated axons, neuronal cell bodies, and other myelin profiles.

92 In neuronal cell bodies, CAR-1 fully colocalizes with CGH-1

93 s: to track activity in large populations of neuronal cell bodies, or to follow dynamics in subcellul

94 spread by retrograde axonal transport to the neuronal cell bodies.

95 ssion, extruding the dendrites away from the neuronal cell bodies.

96 Moreover, while GnRH was expressed in both neuronal cell body and axons in the hypothalamus of 4.1N

97 l day 30 Snord116p-/m+ mice the reduction in neuronal cell body size was associated with decreased ne

98 apse of type I neurites, followed by type II neuronal cell-body degeneration.

99 We propose that H1N1 virus replication in neuronal cells can induce seeds of aggregated alpha-synu

100 ddition, even when located at distant sites, neuronal cells can receive signals from and provide sign

101 al microenvironment, such as endothelial and neuronal cells, can influence epithelial development.

102 ent dose levels induced vascular, as well as neuronal cell changes and glial cell remodeling.

103 pression of RNA-modifying enzymes in a given neuronal cell cluster can be characterized and simultane

104 ned anatomical locations in which immune and neuronal cells colocalize and functionally interact to s

105 + ET1 rats showed extensive degeneration of neuronal cells compared with ET1 rats alone starting fro

106 Galactosylceramide also increased neuronal cell counts significantly in male and female mi

107 on on longevity, neurobehavioral parameters, neuronal cell counts, astrogliosis, and diminution in br

108 gevity, subunit C storage, astrogliosis, and neuronal cell counts.

109 ed in blocking Abeta-induced cytotoxicity in neuronal cell cultures.

110 ty and reactive oxygen species production in neuronal cell cultures.

111 thetics leads to neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition

112 urodegenerative diseases, often resulting in neuronal cell death and functional impairment.

113 st that birth may be an important trigger of neuronal cell death and identify transient cell groups t

114 vates inflammation that leads to progressive neuronal cell death and impairments in cognition (Alzhei

115 ion of spatial memory characterized by early neuronal cell death and subsequent microglia-dependent p

116 ke and intracerebral haemorrhage, results in neuronal cell death and the release of factors such as d

117 morphous structures and a 3-fold increase in neuronal cell death as compared to Abeta and hIAPP alone

118 propagation of the inflammatory response and neuronal cell death by extracellular dysfunctional mitoc

119 root ganglion sensory neurons and prevented neuronal cell death following cisplatin treatment.

120 s by which mutant huntingtin (mHTT) leads to neuronal cell death in Huntington's disease (HD) are not

121 immunohistochemistry was used to investigate neuronal cell death in the nucleus ambiguus.

122 These findings identify a neuronal cell death mechanism that can be initiated by t

123 ovide greater protection from DNRAb-mediated neuronal cell death than GluN2B antagonists.

124 rIAPP exhibited reductions in Abeta induced neuronal cell death that was independent of its ability

125 gnificant differences in swallow function or neuronal cell death were found between the two groups.

126 CDK5 contributes to neuronal cell death while beta-catenin enters the neuron

127 We focus on the hippocampus neuronal cell death, as well as the potential link betwe

128 ns associated with disease state and induces neuronal cell death, establishing this miRNA as a regula

129 m (Ca(2+) ) dysregulation has been linked to neuronal cell death, including in hereditary retinal deg

130 lphaS) is widely regarded as a key factor in neuronal cell death, leading to a wide range of synuclei

131 sible for unchecked inflammation that causes neuronal cell death, systemic stress, and lethal immunod

132 Multiple insults to the brain lead to neuronal cell death, thus raising the question to what e

133 enerative disorder with accelerated suicidal neuronal cell death, which could be reversed by lithium.

134 uch as PSP by promoting tau accumulation and neuronal cell death.

135 t or exacerbate neuroinflammation and hasten neuronal cell death.

136 a pathogenic process ultimately resulting in neuronal cell death.

137 ylin (rIAPP) reduced oligomer Abeta-mediated neuronal cell death.

138 , oxidative stress, and by directly inducing neuronal cell death.

139 rease in NAPE and FAE levels, which precedes neuronal cell death.

140 aumatic brain injury (TBI) causes widespread neuronal cell death.

141 owth, branching, neurite self-avoidance, and neuronal cell death.

142 This volume loss was not the result of neuronal cell death.

143 iated sustained ERK MAPK phosphorylation and neuronal cell death.

144 roxide generation, metabolic dysfunction and neuronal cell death.

145 GDPGP1 in mouse neurons leads to widespread neuronal cell death.

146 The Mfsd7c-KO brain exhibited hypoxia and neuronal cell death.

147 on of protein aggregates, tau pathology, and neuronal cell death.

148 ey vary little in cell density compared with neuronal cell densities within the cerebral cortex, acro

149 nistration, coupled with increased glial and neuronal cell density.

150 olarized structure of axons and dendrites in neuronal cells depends in part on RNA localization.

151 Physiologic maturation of neuronal cells derived from isolated stem or progenitor

152 tify Parp-1 as a direct target of miR-124 in neuronal cells, establish miR-124 as a cocaine-regulated

153 endogenous PI3K was immunoprecipitated from neuronal cells exposed to ACM or control media, followed

154 Neuronal and non-neuronal cells express the huntingtin (HTT) protein, yet

155 Non-neuronal cells expressing both NgR1 and PlexinA2, but no

156 volutionarily conserved mechanism to specify neuronal cell fate by repressing non-neuronal genes.

157 Stochastic neuronal cell fate choice involving notch-independent me

158 inding protein LIN28 controls progenitor and neuronal cell fate during postnatal neurogenesis.

159 se stem cells and progenitors, immune cells, neuronal cells, fibroblasts, and endothelial cells.

160 ults suggest that clearance of senescent DRG neuronal cells following platinum-based cancer treatment

161 zes to the AIS and when overexpressed in non-neuronal cells forms microtubule arrays that closely res

162 fier of amyloidogenic processes that shields neuronal cells from amyloid toxicity.

163 The BTZ derivative 13 protected neuronal cells from oxidative stimuli and increased 2-AG

164 C25A4 interactome components was affected in neuronal cells from schizophrenia patients.

165 In the second set, olfactory neuronal cells from SZ and BP patients who were not pre-

166 e concept of insulin resistance in olfactory neuronal cells from SZ patients.

167 suggest that neuronal LXRs may regulate non-neuronal cell function via a Nrg1-dependent mechanism.

168 echanism underlying this complex activity in neuronal cells has remained unclear.

169 These data suggest that neuronal cells have a different type of transcriptome in

170 ILC3s and neuronal cells have been shown to interact at discrete m

171 in human skeletal muscle, cardiac muscle and neuronal cells having numerous properties that confers p

172 In this Review, we outline how distinct neuronal cell identities are established in response to

173 the specification of distinct progenitor and neuronal cell identities.

174 The role of non-neuronal cells in Alzheimer's disease progression has no

175 the complement protein C1q in beta-endorphin neuronal cells in both in vitro and in vivo systems.

176 ation of PARP-1 protein in dopaminergic-like neuronal cells in culture.

177 that microglial cells constitute ~7% of non-neuronal cells in different brain structures as well as

178 The accumulation of senescent-like neuronal cells in DRG is associated with cisplatin-induc

179 e show that cisplatin induces senescent-like neuronal cells in primary culture and in mouse dorsal ro

180 ntially regulate activity of neurons and non-neuronal cells in proximal and distal colon to promote d

181 ly distinct roles played by various types of neuronal cells in the cortical microcircuit.SIGNIFICANCE

182 e the pathways controlling the most abundant neuronal cells in the mammalian cerebellum, cerebellar g

183 ither treatment altered the number of normal neuronal cells in the model.

184 cords, suggesting a strong influence of non-neuronal cells in the outcome after injury and providing

185 Reprogramming non-neuronal cells in vivo into stem or progenitor cells is

186 A surge of interest in non-neuronal cells, including glia, blood vasculature, and i

187 eural activity, as well as activation of non-neuronal cells, induced by sympathetic nerve stimulation

188 ous N40D subject-specific induced inhibitory neuronal cells (iNs) from seven human-induced pluripoten

189 ectopic expression of Neurod1 converted non- neuronal cells into neurons.

190 Differentiation of neuronal cells is crucial for the development and functi

191 ort that DLK subcellular localization in non-neuronal cells is highly palmitoylation-dependent and ca

192 Interestingly, PRV infection of neuronal cells leads not only to a nonspecific depletion

193 e the context of the whole animal at a human neuronal cell level.

194 Co-culture of PA5 cells with a neuronal cell line (NG108-15) and with primary dorsal ro

195 HT22 neuronal cell line and adult male C57BL/6 mice.

196 owth, and synapse number in the LUHMES human neuronal cell line exposed to varying concentrations of:

197 us 1 (HSV-1) to infect the human DRG-derived neuronal cell line HD10.6 in order to study the establis

198 , we utilized a recently characterized human neuronal cell line model of HSV latency and reactivation

199 We utilized a human neuronal cell line model of HSV latency and reactivation

200 Live-cell imaging of cultured striatal neuronal cell line shows Rhes surrounds globular mitocho

201 hagy and cell death in the cultured striatal neuronal cell line.

202 -dependent action potentials, hallmarks of a neuronal cell lineage.

203 re comparable with those in neuronal and non-neuronal cell lines permitting persistent prion infectio

204 ndogenous alpha-synuclein pathology in human neuronal cell lines, including primary human neurons dif

205 When evaluating neuronal cell lines, we found that SARA accumulates in n

206 er-blocking insulator in both epithelial and neuronal cell lines.

207 ted transcript (LAT) to inhibit apoptosis in neuronal cell lines.

208 XR from sensory neurons altered genes in non-neuronal cells located in the sciatic nerve (potentially

209 erization and toxicity, induces dopaminergic neuronal cell loss in mice, and affects motor performanc

210 oral abnormalities, as well as age-dependent neuronal cell loss, microgliosis and DNA damage, probabl

211 nserved lncRNA functionally enhances induced neuronal cell maturation and directly occupies and regul

212 To determine if depletion of senescent-like neuronal cells may effectively mitigate CIPN, we used a

213 Mutations in TMTC3 have been linked to neuronal cell migration diseases including Cobblestone l

214 sion has been reported to enhance cancer and neuronal cell migration either by mediating actomyosin-b

215 Thus, we have a human neuronal cell model of HD that may recapitulate some of

216 We have developed a new human neuronal cell model of HD, using neural stem cells (ReNc

217 TET2 depletion in a neuronal cell model results in cytosine modification cha

218 ates Parp-1 3'UTR activity in a dopaminergic neuronal cell model.

219 Patient iPSC-derived neuronal cell models replicate disease-relevant phenotyp

220 rontotemporal dementia (FTD) patient-derived neuronal cell models, with minimal effect on tau from ne

221 Here, we knocked down NF-Y in two types of neuronal cells, neuro2a neuroblastoma cells and mouse br

222 We tested Scellector on single human neuronal cells, obtained in vitro and amplified by MDA.

223 ing is known about the function of hTim8a in neuronal cells or how mutation of this protein leads to

224 n differentiated but not in undifferentiated neuronal cells or mouse embryo fibroblasts.

225 erved regulator of lipid biosynthesis in non-neuronal cells; our studies reveal a surprising role for

226 ctional proteins expressed in peripheral and neuronal cells, playing critical roles in development, p

227 single cells revealed 20 neuronal and 18 non-neuronal cell populations, defined by suites of discrimi

228 y to verify TSPO protein in neuronal and non-neuronal cell populations.

229 ggest that the ontology of MCC arises from a neuronal cell precursor.

230 nsely packed microtubule (MT) array found in neuronal cell projections (neurites) serves two fundamen

231 system signaling, AChE can also modulate non-neuronal cell properties, although it remains controvers

232 The electrical properties of neuronal cells rely on gradients of ions across their me

233 reprogramming, which is not observed in non-neuronal cells, resolves over a similar time course as t

234 Overexpression of functional NMDAR in non-neuronal cells results in cell death by excitotoxicity,

235 demonstrated that clearance of DRG senescent neuronal cells reverses CIPN, suggesting that senescent-

236 c MPP(+) treatment of differentiated SH-SY5Y neuronal cells significantly decreases PINK1 expression

237 a-syn may affect lysosomal clustering in non-neuronal cells, similar to its role in presynaptic vesic

238 In cultured dopaminergic neuronal cells stably expressing wild-type human alphaSy

239 that in neocortex neuron-network coupling is neuronal cell-subtype specific.

240 its has highlighted an important role of non-neuronal cells such as glia in the genesis and spreading

241 The communication between neurons and non-neuronal cells such as SC could be a new biological path

242 ic transmitters can regulate activity in non-neuronal cells (such as enteric glia and innate immune c

243 nds also showed potent antiviral activity in neuronal cells, such as A172 and SH-SY5Y cells, suggesti

244 ty impairs timely differentiation of retinal neuronal cells, such that the densities of early-born re

245 rs labeling epidermal cell junctions and the neuronal cell surface.

246 enerate isolated primary trigeminal ganglion neuronal cells (TGNC).

247 center (cVAC) in both cancerous and primary neuronal cells that concentrates viral structural protei

248 Astrocytes are non-neuronal cells that govern the homeostatic regulation of

249 s exist but mostly comprise non-human or non-neuronal cells that may not recapitulate the correct bio

250 th further demonstration of such guidance to neuronal cells, these conductive scaffolds may see versa

251 We hypothesise that enhanced sensitivity of neuronal cells to apoptosis is the underlying mechanism

252 ubcellular transcriptomes of FMRP-null mouse neuronal cells to identify transcripts that depend on FM

253 ferential responses of gBS tumors and normal neuronal cells to sustained treatments with anti-cancer

254 anatomical context of neurons is crucial for neuronal cell type classification and circuitry mapping.

255 However, neuronal cell type diversity within the VPH is poorly un

256 nderstanding of the mechanisms through which neuronal cell type identities are programmed during deve

257 D-seq enables simultaneous reconstruction of neuronal cell type, cell lineage, and sequential neurona

258 ulate throughout development of the Atoh1(+) neuronal cell type, which is highly conserved in vertebr

259 It is not known at present whether neuronal cell-type diversity-defined by cell-type-specif

260 ntities reflects the evolutionary history of neuronal cell-type specification.

261 its, we must distil these broad classes into neuronal cell types and describe their network connectiv

262 These results suggest specific neuronal cell types and genes may be involved in intelli

263 n neocortex is characterized by a variety of neuronal cell types and precise arrangements of synaptic

264 future radiotracers that can identify other neuronal cell types and would allow visualization and in

265 Neuronal cell types are the nodes of neural circuits tha

266 ord comprises multiple functionally distinct neuronal cell types arranged in characteristic positions

267 i were heavily brain-enriched, with specific neuronal cell types being implicated from single cell da

268 rse haematopoietic, stromal, parenchymal and neuronal cell types can store inflammatory memory.

269 diated by gene transcriptomic changes within neuronal cell types forming cortical microcircuits, name

270 Transcriptionally distinct neuronal cell types identified within the MHb and LHb, w

271 umans, it is possible to identify particular neuronal cell types in the peripheral nervous system (PN

272 Understanding the function of different neuronal cell types is key to understanding brain functi

273 f this study was to morphologically identify neuronal cell types of the CX in the honeybee Apis melli

274 Individual neuronal cell types predominantly express a single FXG t

275 The predominant gene signatures defining neuronal cell types reflect shared developmental histori

276 crine responses is made possible by the many neuronal cell types that coexist in intercalated hypotha

277 al FMRP-dependent regulation of mRNAs across neuronal cell types that may contribute to phenotypes su

278 After EDU/SES conditioning, neuronal cell types were identified for risky behaviour

279 g (PRDD-seq), which combines RNA analysis of neuronal cell types with analysis of nested spontaneous

280 To better constrain the definition of neuronal cell types, we characterized the transcriptomes

281 vesicular function in serotonergic and other neuronal cell types, which might help explain its associ

282 resource for further investigation of mouse neuronal cell types.

283 g rise to a wide variety of neuronal and non-neuronal cell types.

284 the soma and dendrites of various mammalian neuronal cell types.

285 cells contained a diverse array of glial and neuronal cell types.

286 s into cardiomyocyte-like, hepatic-like, and neuronal cell types.

287 rted to be safe for stem cells and other non-neuronal cell types.

288 ith GWAS data, we identified 26, exclusively neuronal, cell types from the hypothalamus, subthalamus,

289 rcuits consist of dynamically interconnected neuronal cell-types, thus elucidating how neuron types s

290 ic memory, benefits from a rich diversity of neuronal cell-types.

291 lts thus add novel functional granularity to neuronal cell-typing, and provided insights critical to

292 g to these motifs in vivo, we analysed human neuronal cells using ChIP-seq and ATAC-seq technologies.

293 ligands to target the construct to specific neuronal cells utilizing only native components of the n

294 SK-N-SH neuronal cells were exposed to active recombinant histid

295 The nAChR-expressing neuronal cells were treated with nanomolar Abeta(1-42) t

296 evidence pointed to their expression in non-neuronal cells where they play a role in exocytosis and

297 leads to a reduction of pathological tau in neuronal cells, whereas genetic silencing of VPS35 resul

298 sults in markedly reduced viral infection of neuronal cells, which is restored upon complementation w

299 iated human neuroblastoma (SK-N-SH) cells to neuronal cells with all-trans retinoic acid (ATRA).

300 Here, we show that a subset of neuronal cells within the parasympathetic submandibular