ライフサイエンスコーパス: neuronal function

1 stabilizes ECs, and are important for proper neuronal function.

2 t require more complex phenotypes related to neuronal function.

3 ically regulates neurodevelopment and normal neuronal function.

4 (MT) nucleation and dynamics is critical for neuronal function.

5 system (elav) gene, which are important for neuronal function.

6 xonal projection morphology, and a switch in neuronal function.

7 use and human and known to play key roles in neuronal function.

8 a calcium pump that plays important roles in neuronal function.

9 processes involved in brain development and neuronal function.

10 s within axons and dendrites is critical for neuronal function.

11 Slo2 potassium channel, which is critical to neuronal function.

12 urn, are major determinants of type-specific neuronal function.

13 homeostasis and influence diverse aspects of neuronal function.

14 traffic critically regulates most aspects of neuronal function.

15 otassium channels perform essential roles in neuronal function.

16 date gene for LOAD with an important role in neuronal function.

17 astating effects on neuronal development and neuronal function.

18 tem, reaching high levels which could affect neuronal function.

19 and metabolic alterations, which impacts on neuronal function.

20 ts preferentially impact genes important for neuronal function.

21 e calcium signaling and its consequences for neuronal function.

22 al aspects of neuronal signal processing and neuronal function.

23 lopmental processes, cell proliferation, and neuronal function.

24 d metabolic adjustments essential for normal neuronal function.

25 n 5-HT1A receptor, a GPCR that is central to neuronal function.

26 sion of genes that play an important role in neuronal function.

27 tic arbor morphology is a key determinant of neuronal function.

28 therapeutic targets in ChAc that may restore neuronal function.

29 oglia regulate dependence-induced changes in neuronal function.

30 inase pathways to produce lasting changes in neuronal function.

31 genetic screen to identify genes involved in neuronal function.

32 and is overrepresented at genes involved in neuronal function.

33 ules from cell body to synapse is crucial to neuronal function.

34 ions that have broad implications for proper neuronal function.

35 tion in coordinating gene transcription with neuronal function.

36 versity allows KChs to play diverse roles in neuronal function.

37 ow their changes in pathology may compromise neuronal function.

38 al composition for synaptic transmission and neuronal function.

39 critical role for this splicing regulator in neuronal function.

40 2 as a critical intracellular ion channel in neuronal function.

41 also plays an unexpectedly important role in neuronal function.

42 ropagation, gliotransmission, and ultimately neuronal function.

43 R) heteromers are key modulators of striatal neuronal function.

44 lls represses hundreds of genes essential to neuronal function.

45 ble tau aggregates are sufficient to disrupt neuronal function.

46 rms may have differences in localization and neuronal function.

47 mediators of the impact of noradrenaline on neuronal function.

48 aling in neurons and plays critical roles in neuronal function.

49 ecessary for appropriate gene expression and neuronal function.

50 program regulating synaptic transmission and neuronal function.

51 n polarised microtubule arrays essential for neuronal function.

52 he neurotransmitter glutamate, essential for neuronal function.

53 that TREM2 may exert detrimental effects on neuronal function.

54 nal, and other membranes highly important in neuronal function.

55 in the brain and regulates genes involved in neuronal function.

56 ive dendritic trees can significantly impact neuronal function.

57 emory, suggesting a role in post development neuronal function.

58 (2+) signals that can play critical roles in neuronal function.

59 s in neuronal strain and progressive loss of neuronal function.

60 ubiquitin-proteasome system is critical for neuronal function.

61 tial role of METTL5 in brain development and neuronal function.

62 olyte homeostasis, and in cardiovascular and neuronal function.

63 ondrial stress signaling therefore regulates neuronal function.

64 ient events have a more lasting influence on neuronal function.

65 ria and synaptic proteins, thereby restoring neuronal function.

66 epigenetic control of enhancers that modify neuronal functions.

67 P sets with distinct molecular processes and neuronal functions.

68 is mellifera, has been suggested to have non-neuronal functions.

69 human brain can be associated with different neuronal functions.

70 ic tone and may be less disruptive to normal neuronal functions.

71 c immune responses [1, 2] but also regulates neuronal functions.

72 lular localization that is crucial for their neuronal functions.

73 gliotransmitters that regulate synaptic and neuronal functions.

74 ains various types of neurons with different neuronal functions.

75 ), which control development, fertility, and neuronal functions.

76 , although they have been linked to critical neuronal functions.

77 ferent transcriptional programs required for neuronal functions.

78 nisms by which neurotrophins achieve diverse neuronal functions.

79 where they are major regulators of essential neuronal functions.

80 ccur leading to a long-term dysregulation of neuronal functions.

81 It is particularly important for neuronal functions.

82 te arbor morphological diversity for complex neuronal functions.

83 and associated with lifespan regulation and neuronal functions.

84 d the affected genes include many with known neuronal functions.

85 ctions could potentially monitor and protect neuronal functions.

86 0 kb) genes, many of which are important for neuronal functions.

87 les for local translation for many different neuronal functions.

88 mitophagy is essential for cell survival and neuronal functions.

89 changing environments is critical for normal neuronal functioning.

90 studied for over 30 years for their role in neuronal functioning.

91 mTORC1 controls various neuronal functions(12), particularly through cap-depende

92 nscriptional activity of genes important for neuronal function and behaviour.

93 of processes integral to the development of neuronal function and behaviour.

94 the RalA pathway has an important impact on neuronal function and brain development.

95 vated levels of glucocorticoids which impair neuronal function and can ultimately result in a psychia

96 xons is often incomplete, leading to loss of neuronal function and clinical disability.

97 ion of transcript expression is critical for neuronal function and clinically relevant to ASD.

98 Experience powerfully influences neuronal function and cognitive performance, but the cel

99 dies of the amygdala have largely focused on neuronal function and connectivity.

100 ption factors (TFs) instruct key features of neuronal function and connectivity.

101 iological insights, particularly relating to neuronal function and corticogenesis, and establish that

102 ynucleinopathies that leads to disruption in neuronal function and eventually to cell death.

103 he permanence of the failure of synaptic and neuronal function and health in Alzheimer's and Parkinso

104 oid phagocytes; they can act as governors of neuronal function and homeostasis in the adult brain.

105 ion reduces blood flow, which can jeopardize neuronal function and in the prefrontal cortex (PFC) it

106 a (Abeta) peptide have been shown to disrupt neuronal function and induce hyperexcitability, but it i

107 We reveal that neuronal function and integrity decline rapidly with age

108 he expression of several genes implicated in neuronal function and ion transport.

109 ients with Rett syndrome arises from altered neuronal function and is not the result of neurodegenera

110 ses (NDDs) comprise conditions with impaired neuronal function and loss and may be associated with a

111 hila designed to identify genes required for neuronal function and maintenance, we identified multipl

112 lammation (immune system activation) affects neuronal function and may have consequences for the effi

113 lecular and cellular mechanisms that disrupt neuronal function and morphology, resulting in dysfuncti

114 htly regulated CAMK2 auto-phosphorylation in neuronal function and neurodevelopment.

115 induced neurons may be applied to studies of neuronal function and neurological disease.

116 Mitochondria are crucial to proper neuronal function and overall brain health.

117 s into transcriptional programs required for neuronal function and plasticity.

118 g of AMPA receptors (AMPARs) is critical for neuronal function and plasticity.

119 es played by these non-degradative chains in neuronal function and plasticity.

120 onally silenced genes with GO enrichment for neuronal function and protein kinase A pathways.

121 alpha are essential for memory and long-term neuronal function and regeneration and as Abeta1-40/42 a

122 de insight into the influence of steroids on neuronal function and stress their potential use in the

123 These data shed light on BIN1's neuronal function and suggest that it may contribute to

124 te an essential role for SCYL2 in regulating neuronal function and survival and suggest a role for SC

125 altered microtubule dynamics with impact on neuronal function and survival in the developing brain.

126 te its importance, the role of APP family in neuronal function and survival remains unclear because o

127 of rapamycin and as such plays a key role in neuronal function and survival.

128 f protein pseudokinases as key regulators of neuronal function and survival.

129 mediated by motor proteins, is essential for neuronal function and survival.

130 the auditory system, FMRP deficiency alters neuronal function and synaptic connectivity and results

131 l mechanism that promotes sexually dimorphic neuronal function and synaptic connectivity in the nervo

132 in tissue homeostasis and can also modulate neuronal function and synaptic connectivity.

133 Cl(-) plays a crucial role in neuronal function and synaptic inhibition.

134 high-throughput in vitro model for assessing neuronal function and synaptic transmission in primary r

135 gested that SULT4A1 has an important role in neuronal function and that SULT4A1 altered expression mi

136 Astrocytes can control many aspects of neuronal function and their long-term alterations over w

137 axonal trafficking plays a critical role in neuronal function and transport defects have been linked

138 tes secrete diverse substances that regulate neuronal function and viability.

139 work reveals that CSB is required for normal neuronal function and we have established an alternative

140 nase kinase-2 (CaMKK2) is a key regulator of neuronal function and whole-body energy metabolism.

141 into the brain that is essential for normal neuronal functioning and information processing.

142 They have oncogenic and neuronal functions and are reported in exosomes.

143 ors (mGluRs) play important roles in various neuronal functions and have also been implicated in mult

144 Epigenetic control of enhancers alters neuronal functions and may be involved in Alzheimer's di

145 nt data suggest that Nedd4-2 plays a role in neuronal functions and may be linked to epilepsy and dys

146 results suggest that E2F3 is a key player in neuronal functions and may represent a good target for p

147 ences during early development can influence neuronal functions and modulate adult behaviors [1, 2].

148 long genes as a population are enriched for neuronal functions and selectively expressed in the brai

149 monstrate important roles of this complex in neuronal functions and sex determination, and implicate

150 n metabolism, which is involved in immunity, neuronal function, and aging.

151 maintaining brain homeostasis by monitoring neuronal function, and clearing protein aggregates acros

152 lasmic microtubular network is essential for neuronal function, and cytoplasmic dynein-1 is an establ

153 ociated with reduced Purkinje cells, altered neuronal function, and defects in motor learning and soc

154 , physiological systems, brain circuitry and neuronal function, and genetic and epigenetic variation.

155 s are unclear, although long-term changes in neuronal function, and low grade inflammation of the bow

156 2 potassium channels play important roles in neuronal function, and their mutations in humans may cau

157 Studies include genes specific to neuronal function, and those associated with more system

158 evealing GNL3's roles in cell proliferation, neuronal functions, and brain phenotypes.

159 on, neurite growth, synaptic development and neuronal functions, and that these defects can be rescue

160 r mechanisms by which CB2 receptors regulate neuronal functions are unknown.

161 might depend on differences in synaptic and neuronal function arising from the strikingly different

162 its receptor CCR5 are known to contribute to neuronal function as well as to metabolic disorders such

163 onse to pain, has important roles in several neuronal functions, as cytoskeleton dynamics, injured ne

164 Understanding neuronal function at the local and circuit level require

165 ever, how these oligomers might first impair neuronal function at the onset of pathology is poorly un

166 ered viruses thus enable characterization of neuronal function at unprecedented resolution.

167 However, VRK1 was not known to have neuronal functions before its identification as a gene m

168 Manganese supports numerous neuronal functions but in excess is neurotoxic.

169 uch as 17beta-estradiol (estradiol) regulate neuronal function by binding to estrogen receptors (ERs)

170 Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides.

171 tion factor Myt1-like (Myt1l) exerts its pro-neuronal function by direct repression of many different

172 e adult rat and human, where it may regulate neuronal function by mechanisms identified here.SIGNIFIC

173 echanisms give rise to stable alterations in neuronal function by modifying synaptic structure and fu

174 key role in mediating the regulation of the neuronal functions by this lipid pathway.

175 of molecular targets or compounds that alter neuronal function can lead to therapeutic advances that

176 Due to their close link to neuronal function, changes in microglia morphology, summ

177 les corresponding to T1 and T2 inflammation, neuronal function, cilia, epithelial growth, and repair

178 How developmental changes in neuronal function culminate in network dysfunction that

179 unction causes reduced viability, defects in neuronal function, decreased redox potential, and reduce

180 decrease in GABAergic inhibition accompanies neuronal function degradation.

181 ation of the transient processes integral to neuronal function demands rapid and high-resolution imag

182 Neuronal function depends on the integrity of the membra

183 l activity and can be manipulated to enhance neuronal function, despite mitochondrial impairment.

184 r understanding how autophagy contributes to neuronal function, development, and disease.

185 ifically modifies BDNF signaling and affects neuronal function during early prodromal stages of tauop

186 ability as evidenced by the rapid decline in neuronal function during ischemic attacks and acute seve

187 s of microglia engagement and restoration of neuronal function during tissue remodeling and highlight

188 light beams, enable precise interrogation of neuronal function, even at the level of single synapses.

189 us homeostatic mechanisms can restore normal neuronal function following cocaine-induced neuroadaptat

190 In contrast, but consistent with a neuronal function for Abetao/PrP(C) signaling, plaque de

191 ng tissue to selectively enhance or suppress neuronal function for adaptive feedback-loop application

192 lular mechanism(s) by which IP(3)Rs modulate neuronal function for specific behaviours remain specula

193 se cochlea implicate metabolic, sensory, and neuronal functions for NID2, CLRN2, and ARHGEF28.

194 drug (GABA-reuptake inhibitor, tiagabine) on neuronal function (GABA-ergic dynamics), opening the way

195 multifactorial role of SynGAP in regulating neuronal function gathered over the last two decades.

196 The role of astrocytes in neuronal function has received increasing recognition, b

197 examination of ZNF804A distribution and its neuronal functions has yet to be performed.

198 thermore, the stage-dependent alterations in neuronal function highlight the ability of cortical circ

199 These mechanisms all converge toward altered neuronal function highlighting the susceptibility of neu

200 How such mutations impair neuronal function, however, remains unclear.

201 process is particularly important for proper neuronal function; however, little is known about how RN

202 es, and maintains mitochondrial dynamics and neuronal function in AD neurons.

203 es, and maintains mitochondrial dynamics and neuronal function in AD.

204 Loss of ADARs affects neuronal function in all animals studied to date.

205 e that static magnetic fields interfere with neuronal function in animals.

206 the effects of tau pathology on hippocampal neuronal function in area CA1 of 7- to 8-month-old mice,

207 dulating neuropeptide levels and presynaptic neuronal function in both C. elegans and mammals.

208 nitive impairments in dementia by disrupting neuronal function in brain regions, including the hippoc

209 However, as researchers explore neuronal function in greater detail, they are increasing

210 impact of primed microglia on physiological neuronal function in intact cortical tissue (in situ) is

211 Here, we studied Pyk2 neuronal function in mice lacking expression with and wi

212 , we review mechanisms of peripheral sensory neuronal function in response to immune challenges, the

213 conclusion, electrophysiological analysis of neuronal function in rodent retinal explants is useful f

214 retention is a critical feature for optimal neuronal function in SC and dLGN.

215 hat EAAT5 may well be a player in modulating neuronal function in the human brain and propose that it

216 Our finding that elevated IOP alters neuronal function in the inner retina before irreversibl

217 r, if and how microglia contribute to normal neuronal function in the mature uninjured CNS is not wel

218 s have reported age-dependent degradation of neuronal function in the visual cortex and have attribut

219 ) might be the major deleterious species for neuronal function in these diseases.

220 est that single- and dual-pass NRGs regulate neuronal functions in fundamentally different ways.

221 molecular mechanisms underlying the impaired neuronal functions in FXS.

222 molecular mechanisms underlying the impaired neuronal functions in FXS.

223 s are of utmost importance in regulating the neuronal functions in the adult organism and in the prog

224 thin its physiologic boundary and in shaping neuronal functions in the central nervous system.

225 However, the consequences of the mutation on neuronal function, in particular in the cerebral cortex,

226 of proteins that regulate several aspects of neuronal function including neuronal excitability and sy

227 These changes were mapped to genes encoding neuronal functions including postsynaptic gene ontology

228 tive disorder (HAND), leading to the loss of neuronal functions, including synaptic long-term potenti

229 membrane and is implicated in a multitude of neuronal functions, including the control of neuronal ac

230 Reciprocally, brain cancers influence neuronal function, increasing neuronal activity and modu

231 study uncovers that a lipid pathway promotes neuronal functions involved in foraging under both fed a

232 The importance of mitochondria for neuronal function is evident by the large number of neur

233 hanisms underlying the effects of insulin on neuronal function is incomplete.

234 ve infection and the effects of infection on neuronal function is largely unknown.

235 The resultant effect on neuronal function is likely to be important in the devel

236 but whether vascular tone influences resting neuronal function is not known.

237 storage capacity of the CNS is limited, and neuronal function is rapidly impaired if oxygen supply i

238 POMC) neurons; whether the reduction in POMC neuronal function is secondary to the microglial activat

239 ole of PD-L1 and PD-1 in regulating pain and neuronal function is unclear.

240 er, but how mutant Huntingtin (Htt) disrupts neuronal function is unclear.

241 erved gene encoding an important channel for neuronal function; it is widely expressed in the brain a

242 ow an overrepresentation of genes related to neuronal functions, learning and cognition in regions un

243 ity-regulated genes (ARGs) are important for neuronal functions like long-term memory and are well-ch

244 egarding the role of astroglia in regulating neuronal function, little is known about regional or fun

245 ethods therefore reveal simple regulators of neuronal function lurking in the complexity of combined

246 Although iron is crucial for neuronal functioning, many aspects of cerebral iron biol

247 te immune receptors, which in turn influence neuronal function not only through secretion of soluble

248 Its neuronal functions now extend to long-term depression (L

249 s required for normal development and proper neuronal function of animals.

250 These findings reveal a surprising non-neuronal function of Cdkl5, identify a pathogenic Cdkl5-

251 deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is incompletely understood.

252 Our studies thus establish the first neuronal function of MAP7 and demonstrate its role in br

253 efore, our study not only uncovers the first neuronal function of MAP7, but also demonstrates the imp

254 aphrodite-specific synaptic connectivity and neuronal function of phasmid sensory neurons.

255 To clarify the neuronal function of S1P, we generated brain-specific kn

256 Neuronal functions of GSK3 are typically attributed to o

257 Both neuronal and non-neuronal functions of the methyl-binding protein underli

258 To understand whether neuronal functions of these proteins rely on microtubule

259 Thus, the neuronal functions of tra-1 are not limited to hermaphro

260 her exocyst complex subunits are critical to neuronal function, our findings suggest that EXOC2 varia

261 n examines the extended role of autophagy in neuronal function, plasticity, and memory.

262 We found that cellular pathways related to neuronal function, regulation of transcription, extracel

263 ndings implicate Kctd13 in the regulation of neuronal function relevant to neuropsychiatric disorders

264 ed in the developing nervous system, yet its neuronal functions remain poorly elucidated.

265 wever, the mechanisms by which Abeta impairs neuronal functions remain to be fully elucidated.

266 nGAP at the synapse and its contributions to neuronal function remains to be achieved.

267 ption factors have conserved or differential neuronal function remains uncertain.

268 ese results suggest a role for BAF53b in NAc neuronal function required for cocaine-associated memori

269 Maintaining an optimal milieu for neuronal function rests with supportive cells termed gli

270 K1a is critical for dendritic patterning and neuronal function, revealing a previously unidentified m

271 ion of neurodegeneration while improving the neuronal function, seemingly opening new therapeutic ave

272 molecular machinery required for hippocampal neuronal function.SIGNIFICANCE STATEMENT Numerous molecu

273 uts from multiple sources to generate normal neuronal functions.SIGNIFICANCE STATEMENT Critical perio

274 oles of the various Nav subtypes in specific neuronal functions such as synaptic transmission are unc

275 ge-gated calcium channels regulate important neuronal functions such as synaptic transmission.

276 (MT)-associated protein, participates in key neuronal functions such as the regulation of MT dynamics

277 hich is characterized by progressive loss of neuronal function, such as Alzheimer's disease (AD) and

278 hat integrates diverse processes to underpin neuronal function, suggesting instead that its primary r

279 otein kinase A (PKA) plays critical roles in neuronal function that are mediated by different regulat

280 at new candidate loci involved in immune and neuronal functions that await further replication.

281 tical role of Snord116 in the control of NPY neuronal functions that might be dysregulated in PWS.

282 proves animal fitness by activating distinct neuronal functions that trigger adaptive changes in both

283 siological properties consistent with mature neuronal function, the N398 neuronal population responde

284 g effects of background genetic variation on neuronal function, the regulatory effects of MORs on syn

285 Alcohol is thought to modulate neuronal function through low-affinity interactions with

286 ss I (MHCI) proteins have been implicated in neuronal function through the modulation of neuritogenes

287 perturb microglial phenotypes and influence neuronal functions throughout adulthood, and reveals a p

288 ng a robust and reliable means of modulating neuronal function to manipulate long-term changes in beh

289 molecular mechanisms by which mTOR regulates neuronal function under physiological and pathological c

290 omeostasis plays a major role in maintaining neuronal function under physiological conditions.

291 ally invasive imaging of cardiac neurons and neuronal function using radiolabeled compounds were deve

292 The importance of endophilin-B1 in neuronal function was further underscored by the develop

293 important in transcriptional regulation and neuronal function, we addressed the importance of TSPYL2

294 s linked to epithelial growth and repair and neuronal function were markedly decreased in SA.

295 Indeed, survival, climbing ability and neuronal function were unchanged in tau KO flies.

296 in type II cells, while pathways related to neuronal function were up-regulated in type III cells.

297 enes involved in reproduction and genes with neuronal functions were differentially abundant dependin

298 Energy metabolism is critical for normal neuronal function, which mainly depends on glucose utili

299 d, in part, to altered hippocampal pyramidal neuronal function with normal aging.

300 Remarkably, knockdown of Sima restores neuronal function without affecting the primary mitochon