ライフサイエンスコーパス: neuronally

1 Abeta1-42 peptide and human tau protein pan-neuronally.

2 cue experiments indicate that cmpy functions neuronally.

3 coexpression of brain slo1 channels with the neuronally abundant BK(Ca) channel beta(4) subunit.

4 on and camouflage via stratified networks of neuronally actuated yellow, red, and brown chromatophore

5 By contrast, naive virgins were neuronally and behaviourally sensitized to the most comm

6 MTG is expressed neuronally and detected in the synaptic cleft, and is re

7 at targeted protein synthesis inhibition pan-neuronally and in excitatory neurons in the lateral amyg

8 -27 is localized to synapse-rich regions pan-neuronally and is also expressed in intestinal cells.

9 e consider how these messages might manifest neuronally and simulate the inferences they perform.

10 The extensive presence of neuronally-associated Cx36 in brainstem auditory structu

11 Neuronally based symptoms depend on the organ in which t

12 Neuronally coexpressed ELAV/Hu proteins comprise a famil

13 Loss of Pbx1 expression in neuronally committed neuroblasts in the rostral migrator

14 lassical immune response, eukaryotes rely on neuronally controlled mechanisms to detect microbes and

15 Taking advantage of neuronally controlled whole-body ciliary arrests, we als

16 of cats and macaque monkeys toward the less neuronally dense areas of the cerebral cortex.

17 In the neuronally derived A1A1 cell line, which expresses both

18 in the brain that can respond to a number of neuronally derived and circulating transmitters and meta

19 gate the properties and function of TRPC4 in neuronally derived cells, we transiently expressed mouse

20 eceptor, but not store-operated, channels in neuronally derived cells.

21 re important for transcriptional activity in neuronally derived cells.

22 CX3CL1, the neuronally derived cognate ligand for CX3CR1, signals bo

23 active or inactive mutants was induction of neuronally derived components of the classic complement

24 The egress of alpha-synuclein in neuronally derived exosomes predates the clinical presen

25 d Ca(2+) entry via Ca(v)1A served to inhibit neuronally derived Hedgehog signals, as evidenced by dat

26 Activation of MuSK by agrin, a neuronally derived heparan-sulfate proteoglycan, and LRP

27 ll-length Abeta, including toxicity toward a neuronally derived human cell line, activation of caspas

28 er have been well described, but the role of neuronally derived IGF-1 remains largely unexplored.

29 Amyloid-beta (Abeta) is thought to be neuronally derived in Alzheimer's disease (AD).

30 on requires, among others proteins, Agrin, a neuronally derived ligand, and the following muscle prot

31 rescent-labeled PrP-res was used to infect a neuronally derived murine cell line (SN56) and adult ham

32 cted enzyme that catalyzes the hydrolysis of neuronally derived N-acetylaspartate (NAA) to acetate an

33 hysiologically S-nitrosylated by endogenous, neuronally derived nitric oxide (NO).

34 nuclear proteins that completely depends on neuronally derived nitric oxide.

35 Thus, neuronally derived NO and cardiac inhibitory G protein a

36 he aggressive behavior caused by the lack of neuronally derived NO is not known.

37 These results indicate that neuronally derived NO mediates, in part, MPTP-induced ne

38 These findings suggest that neuronally derived NPY accelerates the early response to

39 osome preparations also allowed detection of neuronally derived peptides (23 positively identified) w

40 at the latter method increased the number of neuronally derived peptides positively identified by app

41 which fixes tissue, allows identification of neuronally derived peptides whereas similar analysis of

42 A total of 39 novel neuronally derived peptides, including some originating

43 dependently evaluated mouse brain tissue and neuronally derived plasma extracellular vesicle proteins

44 ation in rats: a transient early increase in neuronally derived plasma NPY and increase in platelet N

45 of the unique coupling of Ca(2+) channels to neuronally derived polarity cues.

46 Other neuronally derived proteins, but not total protein, were

47 In addition, neuronally derived small extracellular vesicles (NDEs) w

48 amyloid plaques following acute exposure to neuronally derived soluble Abeta from Tg2576 transgenic

49 e to amyloid plaques but mediated in part by neuronally derived soluble Abeta, supporting a role for

50 To further define the role of neuronally derived TNF-alpha during early AD-like pathol

51 Neuronally derived XBP-1s was sufficient to rescue stres

52 that the observed effect is NO mediated and neuronally derived.

53 These effects are specific to neuronally-derived proteins, which suggests they are lik

54 By contrast, when TDP-43 was depleted in neuronally-derived, differentiated HD10.6 cells, HSV-1 i

55 t aurally presented names were processed and neuronally differentiated across the wake-sleep spectrum

56 calpastatin overexpressing (CST1) cells were neuronally differentiated and apoptosis-induced with sta

57 D-risk (G/-) and wild-type (A/G) clones were neuronally differentiated and then compared transcriptio

58 sociated with 14-3-3 zeta when the cells are neuronally differentiated by nerve growth factor.

59 s that acquire drug tolerance exhibit a more neuronally differentiated cell-state and expression of l

60 but were remarkably effective in doing so in neuronally differentiated cells.

61 In neuronally differentiated embryonic stem (ES) cells, pat

62 e study structural aspects of integration of neuronally differentiated human NSCs in the motor circui

63 The concept that a neuronally differentiated key sensory and regulatory cel

64 e nodular compartment comprises postmitotic, neuronally differentiated malignant cells.

65 in a WT background, leads to early onset of neuronally differentiated medulloblastomas (MBs) in a p5

66 2C interferes with expression of NR1 mRNA in neuronally differentiated P19 cells.

67 such findings with other retinal neurons or neuronally differentiated PC-12 cells.

68 of IAPs to stringently regulate apoptosis in neuronally differentiated PC12 and primary cells.

69 on site was altered upon C-CGB expression in neuronally differentiated PC12 and SHSY5Y cells.

70 1 (HSV-1) reactivation were identified using neuronally differentiated PC12 cells (ND-PC12 cells) in

71 serum from naive PC12 cells and of NGF from neuronally differentiated PC12 cells and sympathetic neu

72 the expression of the fragment in the ER of neuronally differentiated PC12 cells attenuated agonist-

73 ICP10 but not p139 protected neuronally differentiated PC12 cells from death due to n

74 d CPP32-like enzymatic activity in naive and neuronally differentiated PC12 cells that had been depri

75 retation of our FDAP data (from processes of neuronally differentiated PC12 cells) in light of the he

76 In neuronally differentiated PC12 cells, sPLA(2)-X was pref

77 ry, Western blotting, and calcium imaging in neuronally differentiated PC12 cells.

78 We found that exposure of neuronally differentiated SH-SY5Y cells to AM, OT and PT

79 d miRs, miR-146a was strongly upregulated in neuronally differentiated when compared with miR-146a ex

80 Neuronally differentiated wild-type and GD3S(-/-) ES cel

81 We examined the neuronally directed effects of the retinoid X receptor a

82 d lines of Caenorhabditis elegans expressing neuronally directed human LRRK2.

83 ined activity of two molecularly related but neuronally distinct hygrosensing systems.

84 scribe our first efforts at behaviorally and neuronally distinguishing hedonic from homeostatic hunge

85 b, and highlight that this structure is more neuronally diverse than previously thought.

86 However, neuronally driven expression of the mutant FMRP is unabl

87 Knockdown of Tob pan-neuronally, either constitutively or conditionally, adva

88 ld also benefit future generations; however, neuronally-encoded behavior isn't thought to be inherite

89 as DAL1, encodes the ubiquitously expressed, neuronally enriched 4.1B protein, part of the 4.1 superf

90 We show that two neuronally enriched and highly conserved microRNAs, miR-

91 Here, we demonstrate that mutations in a neuronally enriched arginine tRNA, n-Tr20, increased sei

92 hese and previous studies, we postulate that neuronally enriched Bace1 cleaves neuregulin-1 and that

93 esses a cohort of hundreds of genes that are neuronally enriched but are not specific to a single neu

94 TRIM9 and TRIM67 are neuronally enriched E3 ubiquitin ligases essential for a

95 2 was higher during neurodevelopment and was neuronally enriched in the adult human cortex.

96 DLK is a neuronally enriched kinase upstream in the MAPK-JNK casc

97 KIF5A encodes for a neuronally enriched kinesin involved in protein transpor

98 eased in a gene-targeted mouse mutant of the neuronally enriched KLC1 gene.

99 Protein 4.1N is a neuronally enriched member of the 4.1 family of cytoskel

100 new kinesin-like proteins, we identified two neuronally enriched mouse kinesins that provide insight

101 Here we demonstrate that PARP6, a neuronally enriched PARP that catalyzes MARylation, regu

102 -of-function variants to heterodimerise with neuronally enriched partner protein ARNT2 was then deter

103 The cytoskeletal regulator Phactr1 is a neuronally enriched PP1 cofactor that is controlled by G

104 tissue-specific F-actin binding protein), a neuronally enriched protein of 1,095 amino acids that co

105 ometry approach, we discovered that RUFY3, a neuronally enriched protein, is essential for caspase-me

106 Neuronally enriched RGS4 plays a critical role attenuati

107 Neuronally enriched RUFY3 thus provides an entry point f

108 Neuronally enriched transcriptional changes revealed dop

109 Calcineurin, a neuronally enriched, calcium-stimulated phosphatase, is

110 have focused on tomosyn, a highly conserved, neuronally enriched, syntaxin-binding protein that has b

111 One of these light chains is neuronally enriched, while another shows ubiquitous expr

112 Neuronally-enriched exosomal microRNAs were extracted fr

113 how that buffering astrocyte Ca(2+) inhibits neuronally evoked capillary dilation, that astrocyte [Ca

114 dly rectifying K(+) (Kir) channels can sense neuronally evoked increases in interstitial K(+) and ind

115 gulatory group between cell types, including neuronally excised introns repressed by polypyrimidine t

116 ensure that coalitions work effectively, and neuronally expensive cognitive skills of the kind known

117 ensure that coalitions work effectively, and neuronally expensive cognitive skills of the kind known

118 We have created transgenic mice that neuronally express the baculoviral caspase inhibitor p35

119 Vertebrate orthologs of Drosophila MICAL are neuronally expressed and also interact with vertebrate p

120 The pan-neuronally expressed and phylogenetically conserved CUT

121 Neuronally expressed auxilin and ubiquitously expressed

122 or the presence of DNA binding motifs of 136 neuronally expressed C. elegans transcription factors.

123 d that maintenance of this response requires neuronally expressed calcium activator for protein secre

124 1 loads, weak brain immune responses, lacked neuronally expressed changes in neocortex and exhibited

125 how that the sushi domain protein SRPX2 is a neuronally expressed complement inhibitor that regulates

126 study, we report the expression pattern for neuronally expressed connexin 35b (cx35b), the zebrafish

127 erminal domain that affects trafficking of a neuronally expressed DEG/ENaC.

128 Hyperactivation of neuronally expressed DEG/ENaCs that conduct both Na+ and

129 The neuronally expressed dmist gene is conserved across vert

130 nteracting proteins, we identified APLIP1, a neuronally expressed Drosophila homolog of JIP-1, a JNK

131 n mice in which the kinase activity of three neuronally expressed EphBs can be rapidly, reversibly an

132 Neuronally expressed family members include the C. elega

133 (shot) encodes an evolutionarily conserved, neuronally expressed family of rod-like proteins require

134 These phenotypes suggest that the neuronally expressed Fgf14 gene is essential for regulat

135 we replaced the goa-1 gene, encoding the pan-neuronally expressed G-protein subunit GOA-1, with a deg

136 In particular, some neuronally expressed genes appear refractory to dsRNA-me

137 s have been identified, de novo mutations in neuronally expressed genes are a common scenario.

138 enetic screen to assess the function of >400 neuronally expressed genes for a role in the homeostatic

139 n and assessed the function of more than 250 neuronally expressed genes for a role in the homeostatic

140 uronal phenotype, including the induction of neuronally expressed genes such as vgf.

141 tion of the alternative splicing of 17 other neuronally expressed genes were investigated, and no eff

142 in schizophrenia of rare coding variants in neuronally expressed genes, including activity-regulated

143 Pan-neuronally expressed genes, such as genes involved in th

144 ar cis-regulatory architecture of individual neuronally expressed genes, we have defined a conserved

145 esponse, regulates the transcription of many neuronally expressed genes.

146 licing determines the protein output of most neuronally expressed genes.

147 tions to address the function of neurons and neuronally expressed genes.

148 ed in brain-expressed genes, particularly in neuronally expressed genes; most of this elevation arose

149 its regrowth, we analyzed mRNAs bound to pan-neuronally expressed GFP::CAR-1 using a crosslinking and

150 NKAIN family members are neuronally expressed in multiple regions of the mouse br

151 Here we show that TMEM106B is neuronally expressed in postmortem human brain tissue, a

152 r 1 d in culture, CHO cells synthesizing the neuronally expressed isoform with an eight amino acid in

153 iochemical and biophysical properties of the neuronally expressed isoforms with that of the ubiquitou

154 TRAAK (also known as KCNK4) ion channels are neuronally expressed members of the two-pore domain K(+)

155 This neuronally expressed microRNA was not only suppressed by

156 Katanin is a neuronally expressed microtubule-severing complex regula

157 nsory organ lineage is controlled by the non-neuronally expressed mir-279/996 cluster, with a majorit

158 ted glial cells, which was then activated by neuronally expressed MMP14.

159 TIR) motif-containing protein 1 (SARM1) is a neuronally expressed NAD(+) glycohydrolase whose activit

160 Here, we administered soluble PD1 to engage neuronally expressed PDL1 and found that PD1 significant

161 PEP-19 is a 7.6 kDa neuronally expressed polypeptide that contains a single

162 Here, we identify R7BP, a novel neuronally expressed protein that binds R7-Gbeta5 comple

163 The diffusible signal molecule Slit and the neuronally expressed receptor Robo mediate growth cone c

164 Receptor 64 (Gr64) genes are a cluster of 6 neuronally expressed receptors involved in sweet taste s

165 suggests that this process is dependent upon neuronally expressed regulatory factors.

166 All four encode neuronally expressed RNA binding proteins conserved in D

167 Connector enhancer of KSR-2 (CNK2) is a neuronally expressed scaffold recently implicated in non

168 Mosaic genetic analysis shows that neuronally expressed Spock1 is cell non-autonomously req

169 activation 3, a homolog of human CD46, as a neuronally expressed synapse-associated complement inhib

170 ions, in neuronal-synaptobrevin (n-syb), the neuronally expressed synaptobrevin gene in Drosophila.

171 Neuronally expressed Syt I4C rescues the syt I null muta

172 A search for additional neuronally expressed T cell receptor components has reve

173 (A)Rs in response to TNFalpha is mediated by neuronally expressed TNF receptor 1 and requires activat

174 further demonstrate ultrasonic modulation of neuronally expressed TRAAK.

175 identified additional bacterial species and neuronally expressed transcripts that should be explored

176 A number of neuronally expressed tubulin genes are associated with a

177 Given that TUBB4 is a neuronally expressed tubulin, our results imply abnormal

178 ransgenic complementation of ax(J) mice with neuronally expressed ubiquitin prevents early postnatal

179 (15q11-q13/7qC) and GTL2(14q32.2/12qF1), are neuronally expressed, localized to imprinted loci and in

180 Here we survey the role of neuronally expressed, paralogous tumor necrosis factor r

181 The neuronally expressed, proton-gated acid-sensing ion chan

182 a small novel gene family which is primarily neuronally expressed.

183 In a Drosophila model neuronally expressing human TBC1D24, we demonstrated tha

184 e changes were attenuated in transgenic mice neuronally expressing the general caspase inhibitor prot

185 ed with 2DG, the majority of the slices were neuronally functional after activation by Glu.

186 Neuronally generated nitric oxide is a mediator of brain

187 We show that neuronally generated pathogenic species of alphaSyn accu

188 the cells against damage caused by glial and neuronally generated reactive oxygen species (ROS), but

189 e-dependent membrane currents similar to the neuronally guided BMSCs, although with smaller amplitude

190 rix genes were selectively down-regulated in neuronally guided BMSCs.

191 based and model-free reinforcement learning, neuronally implemented in frontostriatal circuits involv

192 AS is caused by deletion or mutation of the neuronally imprinted gene encoding the ubiquitin-protein

193 d Tau seeds rodent Tau that propagates trans-neuronally in a quantifiable manner in a microfluidic cu

194 ome correlations were explicitly represented neuronally in right midinsula with a learning prediction

195 g the gene encoding these channels prevented neuronally induced vasodilation and suppression of arter

196 art by brain lipid-binding protein (BLBP), a neuronally induced, radial glial molecule, previously sh

197 manner, heme-derived carbon monoxide affects neuronally mediated activities.

198 Moreover, our data suggest that neuronally mediated BOLD signal variance generally incre

199 alpha1, AMPK activity in BAT and muscle are neuronally mediated, as they are present in neuron- but

200 imental RIPC has two temporal components, is neuronally mediated, is induced by limb ischemia, and re

201 nd late (prolonged) phase, both of which are neuronally mediated.

202 to show that the poststimulus fMRI signal is neuronally modulated.

203 Mice expressing K(ATP)-GOF mutations pan-neuronally (nK(ATP)-GOF) demonstrated sensorimotor and c

204 g RNA used to reduce Luman expression either neuronally or just axonally significantly impaired the a

205 nonphosphorylatable UNC-18 S322A, either pan-neuronally or specifically in AFD thermosensory neurons,

206 stereotyped state of sickness that involves neuronally orchestrated behavioural and physiological ch

207 iational message passing offers a simple and neuronally plausible architecture, it falls short of the

208 These results implicate neuronally produced betaine as a neuromodulator in vivo

209 ytic interaction in the spinal cord by which neuronally produced CXCL13 activates astrocytes via CXCR

210 In particular, neuronally produced NO appears to play a role in rapid u

211 resents the first demonstration in vivo that neuronally produced NO is an important factor in the con

212 n, but the signaling pathways that program a neuronally protective or destructive phenotype in microg

213 isoforms specifically activates splicing of neuronally regulated exons.

214 In addition, baroreflex-mediated, ie, neuronally regulated, bradycardia after phenylephrine wa

215 conversely, there were frequent decreases in neuronally-related genes.

216 adder, indicating a second mode of action of neuronally released ATP.

217 ned to determine the role of the reuptake of neuronally released glutamate in lactate delivery to the

218 cells play an important role in sequestering neuronally released glutamate via Na+-dependent transpor

219 pic glutamate receptors on the astrocytes by neuronally released glutamate.

220 asked where different schema components are neuronally represented and converge during retrieval.

221 ored the biological importance of particular neuronally responsive regions within the promoter by cre

222 Neuronally restricted expression and male germline mosai

223 However, the neuronally restricted expression of CaBP and its inhibit

224 These results demonstrate that the neuronally restricted expression of the human beta2 adre

225 PTB, the only change was upregulation of the neuronally restricted nPTB, resulting from decreased ski

226 nal-like exocytotic tissues, consistent with neuronally restricted symptoms of REEP1 genetic disorder

227 ms, we here demonstrate that angiogenin is a neuronally secreted factor that is endocytosed by astrog

228 nds on a well-orchestrated dialogue in which neuronally secreted misfolded proteins activate microgli

229 Here, we show that the neuronally secreted protein Neuregulin-1 (NRG1) fulfills

230 These analyses support a model in which neuronally secreted Spock1 initiates BBB properties by a

231 Neuronally, seizures feature overall decreased but rhyth

232 ed by disease-linked mutations and suggest a neuronally selective mechanism through which TDP-43 muta

233 eta2 subunit combination, making it the most neuronally selective nicotinic antagonist characterized

234 iously identified ILP8 receptor, globally or neuronally showed similar ovulation/egg laying defects,

235 Connexin-36 is a neuronally specific protein associated with low-resistan

236 Relevant to PD, the degradation of neuronally synthesized glucosylceramides by glia require

237 MuSK becomes phosphorylated when exposed to neuronally synthesized isoforms of agrin.

238 s in the limb; invoking additional roles for neuronally synthesized RA in motor neuron maintenance an

239 To test this hypothesis in vivo, we employed neuronally targeted expression of three human FMR1 trans

240 Ubiquitous or neuronally targeted mtg RNA interference (RNAi) similarl

241 GCLm) subunit of this enzyme, in a global or neuronally targeted pattern.

242 Similar to what was observed neuronally, the optokinetic reflex occurred more reliabl

243 Two are expressed pan-neuronally, while the others are restricted in their exp