1 Human
neuronatin cDNA was isolated and sequenced.
2 body weight greatly diminished the effect of
neuronatin deficiency on energy expenditure.
3 arental allele.We report here that the human
neuronatin gene (NNAT) on chromosome 20q11.2 is imprinte
4 The
neuronatin gene is expressed as two mRNA species, alpha
5 The
neuronatin gene is imprinted and only the paternal allel
6 The human
neuronatin gene is located in single copy of chromosome
7 ed on screening a somatic cell hybrid panel,
neuronatin gene was assigned to chromosome-20.
8 information about the structure of the human
neuronatin gene will help in understanding the significa
9 The
neuronatin gene, 3973 bases long, contains in its 5'-fla
10 Furthermore, on sequencing the human
neuronatin gene, it was determined that the alpha-form w
11 Neuronatin has also been shown to be translated peripher
12 Ectopic expression of
neuronatin in cultured neuronal cells results in increas
13 rovide a basis for investigating the role of
neuronatin in neuronal growth and differentiation.
14 Therefore, we studied the expression of
neuronatin in PC12 cells, an established model of neuron
15 there is fairly direct evidence implicating
neuronatin in the causation of Lafora disease and diabet
16 These findings suggest that the
neuronatin-
induced aberrant Ca(2+) signaling and endopla
17 Neuronatin is a brain-specific human gene that we recent
18 In conclusion,
neuronatin is a novel human gene that is developmentally
19 genomic structure and organization of human
neuronatin is described.
20 frequently used codons, except threonine, of
neuronatin is either G or C, consistent with codon usage
21 Neuronatin is highly expressed in human fetal brain with
22 The level of
neuronatin is increased and accumulated as insoluble agg
23 However, in adult brain,
neuronatin is predominantly expressed in parvalbumin-pos
24 Here we demonstrate that the level of
neuronatin is significantly up-regulated in the skin bio
25 response, microRNA silencing, Wnt signaling,
neuronatin-
mediated endoplasmic reticulum stress, and th
26 gulated by these treatments, three of these,
neuronatin,
metallothionein 3 and cystatin E/M, were fre
27 Neuronatin mRNA expression was found to be abundant in u
28 ion, was associated with a downregulation of
neuronatin mRNA expression.
29 When studied in the rat,
neuronatin mRNA first appeared at mid-gestation in assoc
30 In conclusion, we report the presence of
neuronatin mRNA in PC12 cells, and that NGF downregulate
31 moval of NGF was associated with a return of
neuronatin mRNA levels towards baseline.
32 basic fibroblast growth factor also reduced
neuronatin mRNA levels, the effect was less pronounced t
33 The NGF-induced decreased in
neuronatin mRNA occurred even in the presence of protein
34 In subsequent studies, we noted
neuronatin mRNA was brain-specific and that there were t
35 Neuronatin mRNA was selectively expressed in human brain
36 An integrative analysis identified
neuronatin (
Nnat) as a potential glucose-regulated targe
37 tivation of the mRNA encoding the glycolipid
Neuronatin (
Nnat) as determined both in mRNA reporter as
38 Neuronatin (
Nnat) has previously been reported to be par
39 Neuronatin (
NNAT) is a ubiquitous and highly conserved m
40 Neuronatin (
Nnat) is an imprinted gene that is expressed
41 Neuronatin (
Nnat) was selected for further analysis.
42 intron of Blcap/BLCAP contains the distinct
Neuronatin (
Nnat/NNAT) gene.
43 thylation were also detected at the loci for
neuronatin on Chr 2 and for M-cadherin on Chr 8.
44 high glucose conditions simulating diabetes,
neuronatin protein also accumulates and destroys pancrea
45 Neuronatin protein has a strong predisposition to misfol
46 nscription factors, Hu RNA-binding proteins,
neuronatin,
Racgap1, collapsin response mediator protein
47 The current understanding of the function of
neuronatin raises the possibility that this gene may par
48 Ectopic expression of
neuronatin refractory to suppression by miR-708 rescued
49 m28 or of members of this network, including
neuronatin,
results in an unusual phenotype of a bimodal
50 08 targets the endoplasmic reticulum protein
neuronatin to decrease intracellular calcium level, resu
51 The definitive localization of
neuronatin to human chromosome 20q11.2-12 provides the b
52 ssion of SERCA uncouplers, sarcolipin and/or
neuronatin,
under chow-fed and HFD-fed conditions.
53 Recently,
neuronatin was identified as a novel substrate of malin
54 e-20 and fluorescence in situ hybridization,
neuronatin was localized to chromosome-20q11.2-12.
55 Neuronatin was recently cloned from neonatal rat brain.
56 lay and library screening, a novel rat cDNA,
neuronatin,
was identified and used to screen a human fe
57 Aggregation of
Neuronatin within cortical neurons and resulting cell de