ライフサイエンスコーパス: neuropathologic

1 causative factor of AD and other associated neuropathologic abnormalities are of secondary consequen

2 ginal G93A mice, but they developed the same neuropathologic abnormalities seen in the original G93A

3 The resemblance of these functional and neuropathologic abnormalities to human neurodevelopmenta

4 urophysiology and the development of certain neuropathologic abnormalities, stressing the importance

5 older adults, especially those with amyloid neuropathologic abnormalities.

6 Studies were small, biomarker cut points and neuropathologic AD were inconsistently defined, and meth

7 F-FDG PET, and MRI were highly sensitive for neuropathologic AD.

8 In addition, quantitative neuropathologic analyses were performed.

9 NCE STATEMENT This study provides a detailed neuropathologic analysis of hippocampal Lewy pathology i

10 Neuropathologic analysis of the mice with end-stage dise

11 Neuropathologic analysis revealed abundant PrP amyloid p

12 Progress has been made in clinical, neuropathologic and biochemical characterization of the

13 disease and reconcile apparently conflicting neuropathologic and biomarker data.

14 trocyte responses and overall improvement in neuropathologic and functional outcomes.

15 Neuropathologic and genetics studies as well as transgen

16 was used to determine substantial changes in neuropathologic and MR spectroscopic markers.

17 yet there is a remarkable convergence in the neuropathologic and neurologic phenotype.

18 ere calculated between plasma viral load and neuropathologic and spectroscopic markers.

19 To date, MPS IIIB neuropathologic and therapeutic studies have focused pre

20 Biochemical, neuropathologic, and cell culture analyses were used to

21 om 1.5 to 22.1 years of age, with systematic neuropathologic assessment according to NIA-Alzheimer's

22 nstitute of Ageing - Alzheimer's Association neuropathologic assessment guidelines.

23 Neuropathologic assessment of the father, who shared the

24 demonstrate neuritic plaques, we performed a neuropathologic assessment of the frontal, occipital, an

25 hology, emphasizing its potential to enhance neuropathologic assessment, diagnosis, and research.

26 Gross and microscopic neuropathologic assessment, including diagnosis of CTE,

27 Neuropathologic assessments were performed with investig

28 We performed neuropathologic assessments, molecular analyses, immunoh

29 earning and memory features of PPA and their neuropathologic associations have not been characterized

30 This study identified neuropathologic associations of learning and memory in a

31 Evidence from neuropathologic, biomarker, genetic and cellular/mouse s

32 Residual decline not attributable to neuropathologic burden was confined to a subset for each

33 lobal cognitive decline after adjustment for neuropathologic burden was weakly related to age at deat

34 metabolism) BAG with cognitive performance, neuropathologic burden, and disease progression in cogni

35 oss-sectional study examined a single-center neuropathologic CAA cohort of eligible patients from the

36 This neuropathologic case-control study investigated whether

37 reased odds of more severe Alzheimer disease neuropathologic change (ADNC) (odds ratio, 1.19; 95% CI,

38 a, whereas severities of Alzheimer's disease neuropathologic change (ADNC) and small vessel pathology

39 cohort of 38 patients with Braak-matched AD neuropathologic change (ADNC) or primary age-related tau

40 ptake occurred with high Alzheimer's disease neuropathologic change (ADNC) scores, followed by low-in

41 ying none-to-low vs. intermediate-to-high AD neuropathologic change (ADNC) was assessed for all bioma

42 Different subsets of Alzheimer's disease neuropathologic change (ADNC), including the intriguing

43 ical variables including Alzheimer's disease neuropathologic change (ADNC), Lewy-related pathology (L

44 ution and progression of Alzheimer's disease neuropathologic change (ADNC), we analysed associations

45 , including chronic traumatic encephalopathy neuropathologic change (CTE-NC).

46 redominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) increases with age, but

47 redominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) with and without Alzhei

48 nd gliosis in the hippocampal formation-is a neuropathologic change (NC) that affects up to 20% of el

49 rker-determined probable Alzheimer's disease neuropathologic change (pADNC) patients (49 eyes), and 5

50 h associations with Alzheimer's disease (AD) neuropathologic change and clinical stage.

51 association is mediated by dementia-related neuropathologic change found at autopsy.

52 6 subjects with CTE and 25 subjects with AD neuropathologic change matched for age (+/-5 years) and

53 ved adverse symptom was depression; no major neuropathologic change was detected in the patients by d

54 igh and low levels of Alzheimer disease (AD) neuropathologic changes (ADNC).

55 roup that remained MCI until death, mixed AD neuropathologic changes (ADNC; >/=1 comorbid pathology)

56 atients with autopsy-confirmed AD without LB neuropathologic changes (LBNC) (pure-AD), 24 with AD and

57 entia with high-level Alzheimer disease (AD) neuropathologic changes (NCs) but without Lewy body dise

58 AD progression is closely correlated with neuropathologic changes and accumulation of the two main

59 Background: Alzheimer's disease (AD) neuropathologic changes are beta-amyloid (Abeta) deposit

60 Association guidelines define postmortem AD neuropathologic changes as a composite score based on 3

61 overy of the conduction defect and corrected neuropathologic changes characteristic of 4-mo diabetic

62 lyzed by mutant CuZnSOD enzymes initiate the neuropathologic changes in FALS.

63 1,3-dinitrobenzene (DNB) is associated with neuropathologic changes in specific brainstem nuclei, me

64 reduce cerebral Abeta burden and consequent neuropathologic changes in the brains of mice transgenic

65 ta-form of the peptide failed to develop any neuropathologic changes more than 600 days after the pep

66 gical aspects of AD requires looking for the neuropathologic changes not only as the cause but also a

67 The current understanding is that the neuropathologic changes of the AD continuum begin up to

68 ne (MPTP) produces clinical, biochemical and neuropathologic changes reminiscent of those which occur

69 Understanding the progressive neuropathologic changes that occur in AD-and how scintig

70 Neither PrP(Sc) nor neuropathologic changes were found.

71 These neuropathologic changes were reversed following portal v

72 andardized histopathologic assessments of AD neuropathologic changes were the primary measures of int

73 presenting normal laryngeal function despite neuropathologic changes within nerve and muscle confirme

74 on of spatial learning/memory and diminished neuropathologic changes.

75 f 19 elderly subjects with Alzheimer-related neuropathologic changes.

76 gnitively normal controls with negligible AD neuropathologic changes.

77 rsonnel and was usually reflected by minimal neuropathologic changes.

78 ementia highlights the need to determine the neuropathologic characteristics of individuals whose cog

79 lude neurodevelopmentally induced structural neuropathologic characteristics, sensitization of nigros

80 rdless of ante-mortem clinical diagnosis and neuropathologic co-morbidities, and all assigned Thal am

81 the severity of an underlying and developing neuropathologic condition that does not manifest itself

82 specific type of molecular Alzheimer disease neuropathologic condition with clinically significant ne

83 Four of six brains from non-MS neuropathologic conditions associated with inflammation

84 had complete autopsy data and were free from neuropathologic conditions other than Alzheimer's diseas

85 ath in many experimental paradigms and human neuropathologic conditions.

86 gnitive decline after controlling for common neuropathologic conditions.

87 ve decline even after controlling for common neuropathologic conditions.

88 ine above and beyond the influence of common neuropathologic conditions.

89 indings were confirmed in the subsample with neuropathologic confirmation (n = 20).

90 dy was designed to investigate, in rats, the neuropathologic consequences of heightened leukocyte tra

91 tion of the Ub-proteasome system, leading to neuropathologic consequences.

92 xicity of alpha-synuclein and its downstream neuropathologic consequences.

93 However, understanding the neuropathologic correlates of early cognitive decline, a

94 This study aims to clarify the neuropathologic correlates of longitudinal brain atrophy

95 e research to uncover them, the anatomic and neuropathologic correlates of memory impairment in demen

96 Examination of neuropathologic correlates of these plasma biomarker pro

97 ording to National Institute on Aging-Reagan neuropathologic criteria at autopsy.

98 (AD-LB), and 7 with LBNC without fulfilling neuropathologic criteria for AD (pure-LB) were studied.

99 neurofibrillary tangles remains the primary neuropathologic criteria for AD diagnosis.

100 troscopy metabolite measurements against the neuropathologic criteria for AD, and when combined with

101 , among 41 participants who did not meet the neuropathologic criteria for AD, brain infarcts were onl

102 Among 61 participants who met the neuropathologic criteria for AD, those with brain infarc

103 neocortex were classified as having met the neuropathologic criteria for AD.

104 VI ratings, and 15 of the others (75.0%) met neuropathologic criteria for other dementia-related dise

105 ) had Braak stages III to VI ratings and met neuropathologic criteria for other dementia-related dise

106 ICIPANTS: This cross-sectional analysis used neuropathologic data from 1689 participants from the Rel

107 Pooled clinical and neuropathologic data from 3 prospective cohort studies i

108 These findings support neuropathologic data in which early LC TAU accumulation

109 y, we analyzed the clinical, radiologic, and neuropathologic data of 174 patients (77 women and 97 me

110 th results that agree with known trends from neuropathologic data showing increased axon diameter and

111 and efficiency for better interpretation of neuropathologic data.

112 he Cognitive Function and Ageing Study) with neuropathologic data; mean (SD) age at death was 90 (6.4

113 uropathologist's ability suggests a route to neuropathologic deep phenotyping.

114 he NAWM of SPMS patients is in line with the neuropathologic demonstration that activated microglial

115 In the 87 cases lacking a neuropathologic diagnosis of AD or other dementing disor

116 from families with affected individuals with neuropathologic diagnosis of dementia with Lewy bodies (

117 that affect autonomic function, a coexisting neuropathologic diagnosis, or insufficient clinical info

118 borated by 26 additional cases processed for neuropathologic diagnosis.

119 V2A PET imaging to have broad utility across neuropathologic diseases.

120 on of sEH was observed previously in various neuropathologic disorders including vascular dementia an

121 sport athletes may be at risk for long-term neuropathologic disorders, including chronic traumatic e

122 eactivate CD8 TRMs enables us to isolate the neuropathologic effects induced by this cell type indepe

123 ptor CD11b/CD18 protects from all immune and neuropathologic effects.

124 aphasia (PPA) can be caused by 1 of several neuropathologic entities, including forms of frontotempo

125 The neuropathologic entity of frontotemporal lobar degenerat

126 e testing proximate to death, and a complete neuropathologic evaluation at the time of these analyses

127 A subset provided postmortem tissue for neuropathologic evaluation for common age-related diseas

128 Those who died underwent a uniform neuropathologic evaluation from which previously establi

129 eterogeneity that inform patient history and neuropathologic evaluation of AD; CLix score (lower, rel

130 Results: On the basis of the neuropathologic evaluation of tissue from 88 stereotacti

131 within the ensuing 24 months, and underwent neuropathologic evaluation on autopsy.

132 Neuropathologic evaluation revealed extensive limbic and

133 Neuropathologic evaluation reveals a striking spongiform

134 In the population who underwent postmortem neuropathologic evaluation, 68% of extracorporeal membra

135 n evaluations during old age, and postmortem neuropathologic evaluations of the participants' brains.

136 Neuropathologic evaluations, retrospective telephone cli

137 ebrovascular conditions were assessed during neuropathologic evaluations.

138 ta) assembly is hypothesized to be a seminal neuropathologic event in Alzheimer's disease (AD).

139 Rating Scale scores lacked correlation with neuropathologic evidence of dementing disorders.

140 tin-treated Drosophila tissue, demonstrating neuropathologic evidence of increased neurodegeneration,

141 Based on previous neuroimaging studies and neuropathologic evidence, a combination of regions hypot

142 Neuropathologic examination assessed beta-amyloid burden

143 er 30 years' disease duration, the proband's neuropathologic examination demonstrated abundant intran

144 Neuropathologic examination demonstrated uneven, focally

145 performed on three patients, with postmortem neuropathologic examination for one patient.

146 Neuropathologic examination identified the presence of m

147 We also report the human neuropathologic examination of SIK1-related developmenta

148 Upon the proband's death at age 63, neuropathologic examination revealed frontotemporal loba

149 dard deviation = 5.0), died, and underwent a neuropathologic examination to quantify 9 postmortem mar

150 A neuropathologic examination was performed on 100 consecu

151 e past few years, however, studies comparing neuropathologic examination with PET have established re

152 On neuropathologic examination, we collected semiquantitati

153 e diagnosed during life, only by post-mortem neuropathologic examination.

154 and consented to brain donation for detailed neuropathologic examination.

155 equently, 57 participants died and underwent neuropathologic examination.

156 Neuropathologic examinations provided quantitative measu

157 up to 21 years, died, and underwent detailed neuropathologic examinations to identify Alzheimer's dis

158 yloid peptide (Abeta) plaques are a cardinal neuropathologic feature of Alzheimer disease (AD), yet m

159 Although the major neuropathologic feature of PD is the degeneration of dop

160 es composed of hyperphosphorylated tau are a neuropathologic feature of these closely related disorde

161 nvasive detection of amyloid plaques, a core neuropathologic feature that defines the disease.

162 at these disorders share common clinical and neuropathologic features and that overlap between the tw

163 glycosylated PrP showed strikingly different neuropathologic features compared to those expressing di

164 r disease (AD) display well-recognized early neuropathologic features in the endolysosomal and autoph

165 actors not directly related to these classic neuropathologic features may contribute to PD dementia.

166 We report the clinical and neuropathologic features of a family carrying a 6.4 Mb d

167 een these AD risk genes and the cellular and neuropathologic features of AD.

168 amyloid fibrils is one of the most prominent neuropathologic features of Alzheimer's disease.

169 ism does not strongly impact the clinical or neuropathologic features of Alzheimer's disease.

170 ceruleus (LC) are two of the most ubiquitous neuropathologic features of Parkinson's disease (PD).

171 We report the clinical, neuroimaging, and neuropathologic features of progressive nonfluent aphasi

172 utopsy many AD patients not only exhibit the neuropathologic features of that disorder but also exhib

173 ata set by weighting results by clinical and neuropathologic features, sibship size, and APOE genotyp

174 The neuropathologic features, taxonomy, history, role of bio

175 ffuse Lewy-body dementia (DLBD) have diverse neuropathologic features.

176 severe and accelerated disease with atypical neuropathologic features.

177 hanges and alterations resulting from non-AD neuropathologic features.

178 europathological change (CTE-NC), a specific neuropathologic finding that can only be established at

179 Methods: (123)I-FP-CIT-SPECT and neuropathologic findings among patients with neurodegene

180 two cases with TDP-C were studied, including neuropathologic findings and longitudinal magnetic reson

181 tic analyses using the clinical follow-up or neuropathologic findings as a reference.

182 creation on a workstation-were compared with neuropathologic findings describing the presence or abse

183 We have also assessed the detailed neuropathologic findings in 18 autopsies from these fami

184 techniques, which is in dramatic contrast to neuropathologic findings in comparably hyperglycemic 6-m

185 ural abnormalities, which were comparable to neuropathologic findings in the blast-exposed mice.

186 ANTS: We describe the clinical, genetic, and neuropathologic findings of 5 unrelated cases of parkin

187 has occurred to validate the AD8 against the neuropathologic findings of Alzheimer's disease, we inve

188 re needed to help explain the variability in neuropathologic findings seen in individuals whose cogni

189 patient with progressive neurologic decline, neuropathologic findings, and final diagnosis are discus

190 rkers of synaptic plasticity and exaggerated neuropathologic findings, before such changes were found

191 Description and analysis of neuropathologic findings.

192 neurodegenerative syndromes as referenced to neuropathologic findings.

193 ynuclein aggregation, are the most prominent neuropathologic findings.

194 conversion-related patterns (ADCRPs) against neuropathologic findings.

195 This neuropathologic form of alpha-Syn plays a central role i

196 eta-Amyloid protein (betaAP) deposition is a neuropathologic hallmark of Alzheimer's disease (AD).

197 Amyloid Abeta deposition is a neuropathologic hallmark of Alzheimer's disease.

198 tep in amyloid-beta (Abeta) production and a neuropathologic hallmark of Alzheimer's disease; thus, p

199 ng distal axons and synapses, represents the neuropathologic hallmark of diabetic sympathetic autonom

200 ted microglia and brain macrophages, are the neuropathologic hallmark of HIV dementia.

201 gregation of alpha-synuclein (alphaSyn) is a neuropathologic hallmark of Parkinson's disease and othe

202 junction with neurofibrillary lesions is the neuropathologic hallmark of the dementia associated with

203 n, we present a general overview of the main neuropathologic hallmarks and features of AD and related

204 Neuropathologic hallmarks include nuclear and cytosolic

205 Neuropathologic hallmarks of AD include neurofibrillary

206 th DS will eventually show both clinical and neuropathologic hallmarks of Alzheimer's disease (AD).

207 variety of neurologic, neuropsychologic, and neuropathologic impairments.

208 ransduced mouse brains, leading to motor and neuropathologic improvements in an MJD mouse model.

209 whether the effects of demographics and each neuropathologic index on cognition changed over time.

210 At autopsy, several neuropathologic indicators of Alzheimer disease were det

211 ed to 11 typical PSP cases with quantitative neuropathologic indices and assessment of demographics,

212 of 67.5% of cases were attributable to all 8 neuropathologic indices combined.

213 vitro and in-vivo models supports a role for neuropathologic injury and neurobehavioral deficits at o

214 nstitutions; however, previous autopsy-based neuropathologic investigations have provided conflicting

215 al applications in experimental and clinical neuropathologic investigations.

216 Fewer neuropathologic lesions of AD appeared to result in deme

217 home residents who had either no significant neuropathologic lesions or lesions associated only with

218 by several reports associating the cardinal neuropathologic lesions with markers of free radical-ind

219 Abnormally phosphorylated tau, an early neuropathologic marker of Alzheimer's disease (AD), firs

220 atistically significant correlation with any neuropathologic marker.

221 rative processes associated with the classic neuropathologic markers of senile plaques and neurofibri

222 ltivariable model with 3-way interactions of neuropathologic markers with hospitalization rate and ti

223 p < 0.001), and after controlling for all 7 neuropathologic markers, the association was essentially

224 chiatric ratings and densities of any of the neuropathologic markers.

225 ctly related to higher burden for any of the neuropathologic markers.

226 Neuropathologic measures of amyloid-beta, paired helical

227 derived standardized uptake value ratios to neuropathologic measures of amyloid.

228 Ten dementia-associated neuropathologic measures representing Alzheimer disease,

229 the associations between PM2.5, CDR-SB, and neuropathologic measures, adjusting for demographic fact

230 autopsy, conscientiousness was unrelated to neuropathologic measures, but it modified the associatio

231 ter excluding 429 cases with missing data on neuropathologic measures, demographic factors, APOE geno

232 did not differ on several Alzheimer disease neuropathologic measures; however, high CLS men had less

233 at anti-DNA antibodies may promote important neuropathologic mechanisms in chronic inflammatory disor

234 as the reference group) was associated with neuropathologic outcomes after adjusting for age at deat

235 The variation in the neuropathologic outcomes in individuals with and without

236 Neuropathologic outcomes included neurofibrillary tangle

237 impacts that induces the neurobehavioral and neuropathologic outcomes seen in humans with a history o

238 r and that intrauterine infection results in neuropathologic outcomes similar to those observed in hu

239 (45% fat, 17% sugar), and both metabolic and neuropathologic outcomes were determined.

240 without LOC, is associated with age-related neuropathologic outcomes, both neurodegenerative and vas

241 Neuropathologic patterns observed in the nonbacterial th

242 ession in relation to clinical, imaging, and neuropathologic patterns.

243 gregation-induced apoptosis and improves the neuropathologic phenotype in an animal model of human ne

244 This study describes the neuropathologic phenotype of PrP(d) accumulation in shee

245 otype resembles Alzheimer's disease, and the neuropathologic phenotype resembles progressive supranuc

246 TTR gene accelerated the development of the neuropathologic phenotype.

247 bservations provide a model for how a single neuropathologic process such as CAA may result in hemorr

248 condary inflammation that contributes to the neuropathologic process.

249 t cognitive profile that differed from other neuropathologic processes (related to decline in episodi

250 ltimodal neuroimaging measures of underlying neuropathologic processes account for over a third of th

251 subgroups likely reflect multiple underlying neuropathologic processes and affect susceptibility to A

252 have a distinct clinical profile when other neuropathologic processes are coexistent with CTE pathol

253 ted with infection in vivo may delineate the neuropathologic processes underlying these deficits.

254 , indicating potentially distinct underlying neuropathologic processes, genetic drivers, and suscepti

255 All CTE participants had co-occurring neuropathologic processes, including AD and most had TAR

256 may be better able to capture these limited neuropathologic processes.

257 th the symptomatology of ADC, as well as the neuropathologic profile of post-mortem HIV brains sugges

258 with unusual clinical features and a unique neuropathologic profile was reported in the United Kingd

259 ction may be explained by early HTLV-related neuropathologic progression.

260 mechanism by which alpha-synuclein becomes a neuropathologic protein through Nox1-mediated oxidative

261 analyzed using Aperio software, which allows neuropathologic quantification in the posterior cingulat

262 the cingulate island sign ratio (CISr), and neuropathologic ratings of SNnl.

263 The few available detailed neuropathologic reports suggest that homozygous and comp

264 gic analysis was still available, additional neuropathologic review led to a more specific categoriza

265 A retrospective neuropathologic review of 30 SIV-infected pigtailed maca

266 Despite a comprehensive neuropathologic review with additional studies and infor

267 stic oligodendroglioma on subsequent central neuropathologic review.

268 ain regions and analyzed to compute a summed neuropathologic score.

269 ened lesions in both fentanyl groups' summed neuropathologic scores (P=0.002) in protocol 1 and speci

270 In addition to analysis of specific regions, neuropathologic scores were also summated over all brain

271 oglia could be contributing to the secondary neuropathologic sequelae after a diffuse TBI.

272 Bcl-2 protein may play a protective role in neuropathologic sequelae after TBI.

273 e data support the hypothesis that there are neuropathologic signatures of cellular degeneration with

274 Clinical and neuropathologic similarities suggest that the disease in

275 rtaucipir PET in vivo does not correspond to neuropathologic staging in PSP.

276 eatures, there is an unmet need to translate neuropathologic staging to a biologic clinical staging s

277 harmacologic, and, most recently, postmortem neuropathologic studies have confirmed.

278 Recent neuroimaging, clinical and molecular neuropathologic studies have provided new insights into

279 Neuropathologic studies indicate that these disorders ma

280 Neuropathologic studies of nine affected individuals sho

281 Neuropathologic studies provide consistent evidence of a

282 RECENT FINDINGS: Although neuropathologic studies show that limbic system tau dise

283 There is strong evidence from neuropathologic studies that the most widely used tau PE

284 We report the results of a comprehensive neuropathologic study performed to identify AD and other

285 disease (AD) and may even represent the main neuropathologic substrate in a subset of patients with a

286 Alzheimer type (AD/SDAT) is the most common neuropathologic substrate of dementia.

287 RG1 provides beneficial effects in candidate neuropathologic substrates of AD and, therefore, is a po

288 er's neurofibrillary pathology is one of the neuropathologic substrates of mild cognitive impairments

289 Heterogeneity was driven by neuropathologic subtype and DKI technique.

290 es of Alzheimer's Disease (AD) cognitive and neuropathologic traits.

291 d clarified their associations with multiple neuropathologic traits.

292 RP deficiency and provide insight into their neuropathologic underpinnings.