ライフサイエンスコーパス: neuropathological

1 are increasingly recognized(1-5) as shown by neuropathological(6,7), neuroimaging(4,8-11), and cerebr

2 chosis, consistent with dysconnectivity as a neuropathological account of symptom expression.

3 strategies capable of preventing THC-induced neuropathological adaptations.

4 and brain tissue from 48 individuals with no neuropathological alterations and from 87 subjects diagn

5 ific stages of development leads to distinct neuropathological alterations that determine the severit

6 rformed behavioral, electrophysiological and neuropathological analyses of BACHD and BACHD/GFAP-CreER

7 Brain tissue HI was verified by neuropathological analysis and by Adenosine Triphosphate

8 a of mutation-positive individuals including neuropathological analysis in one instance.

9 In-depth neuropathological analysis of 27 patients with non-demen

10 One week after treatment, neuropathological analysis of hemispheric and hippocampa

11 Neuropathological analysis of post-mortem brain tissue d

12 Brain Bank archival collection and detailed neuropathological analysis of the selected cases.

13 Neuropathological analysis shows a reduction in inflamma

14 Our transgenic zebrafish mimicking both neuropathological and behavioral changes manifested in S

15 reased survival of C9-BAC versus NT mice and neuropathological and behavioral deficits similar to tho

16 active humoral and Treg) and analyzed using neuropathological and biochemical markers.

17 This study describes new neuropathological and biochemical observations in a seri

18 t primary age-related tauopathy has distinct neuropathological and clinical features compared to Alzh

19 oid-beta species accumulate and affect other neuropathological and clinical features in the disease.

20 To determine the neuropathological and clinical features of deceased foot

21 We observe improvements in neuropathological and electrophysiological phenotypes in

22 Neuropathological and in vivo studies have revealed a ti

23 The present findings unveil particular neuropathological and neuroinflammatory profiles in FFI

24 linical trials and also provide guidance for neuropathological and neuroradiological assessment.

25 ritical roles in CNS function and in various neuropathological and psychiatric conditions.

26 njury to the pediatric brain reproduces many neuropathological and seizure-like hallmarks characteris

27 nt to cause electrophysiological, molecular, neuropathological, and behavioral changes related to SZ.

28 Galactosylceramide improved behavioral, neuropathological, and biochemical parameters in Cln3 (D

29 ration in AD.SIGNIFICANCE STATEMENT Genetic, neuropathological, and functional studies implicate both

30 nsequently, disagreement continues about the neuropathological aspects that make CTE unique.

31 BLSA, 191 participants underwent autopsy and neuropathological assessment, and 75 non-demented indivi

32 gnitive assessments during life and detailed neuropathological assessments at death, such as the BLSA

33 Systematic neuropathological assessments documented the severity of

34 Neuropathological assessments for neuron and oligodendro

35 Comprehensive post-mortem neuropathological assessments were performed from 4 mont

36 Though the end-stage neuropathological attributes of AD and primary tauopathi

37 or progression and, second, to determine the neuropathological basis of the initial clinical and neur

38 of diverse clinical phenotypes of FTLD on a neuropathological basis.

39 hat have enabled visualization of a specific neuropathological biomarker.

40 In combination with neuropathological biomarkers, in vivo locus coeruleus im

41 he dissociation of cognitive performance and neuropathological burden are poorly understood, and ther

42 a (Abeta(42) ), tau, and ptau(181) , and the neuropathological burden of neuritic plaques, neurofibri

43 that the combination of Alzheimer's disease neuropathological change (ADNC) and LATE neuropathologic

44 minary consensus diagnostic criteria for CTE neuropathological change (CTE-NC) were identified (athle

45 LATE neuropathological change (LATE-NC) is defined by a stere

46 to frequent neuritic plaques (i.e. Alzheimer neuropathological change) at subsequent autopsy.

47 een of 22 (77%) participants had Alzheimer's neuropathological change, whereas 5 of 22 (23%) had alte

48 worse prognosis for each increasing level of neuropathological change.

49 NC may be co-morbid with Alzheimer's disease neuropathological changes (ADNC).

50 ase neuropathological change (ADNC) and LATE neuropathological changes (LATE-NC) is associated with g

51 ls of pre-apoptotic proteins, attenuated the neuropathological changes and apoptosis and decreased th

52 HI resulted in decreased ATP and PCr levels, neuropathological changes and increased levels of cytoch

53 ecular mechanisms of cellular transport, and neuropathological changes associated with disruptions of

54 PLX5622 treatment limited TBI-associated neuropathological changes at 3 months postinjury; these

55 Neuropathological changes corresponded with neuroimaging

56 the onset and progression of biochemical and neuropathological changes during the preclinical stages

57 eased ICAM1, which could contribute to other neuropathological changes found in this subgroup of peop

58 Prion strains induce specific neuropathological changes in selected brain areas.

59 ssler-Scheinker syndrome can be explained by neuropathological changes in the spinal cord.

60 all adults with Down syndrome (DS) show the neuropathological changes of Alzheimer disease (AD) by t

61 an excellent surrogate marker for assessing neuropathological changes that occur in Alzheimer's dise

62 Interestingly, the most significant neuropathological changes were observed in those brain r

63 557 autopsied cases with Alzheimer's disease neuropathological changes with 1638 ante-mortem volumetr

64 -43 encephalopathy (LATE) and the underlying neuropathological changes, LATE-NC.

65 12 patients with alpha-synucleinopathies for neuropathological changes.

66 ransport was observed, which correlated with neuropathological changes.

67 tic brain injury can also induce progressive neuropathological changes.

68 ibrils, the hallmarks of Alzheimer's disease neuropathological changes; this co-occurrence suggests t

69 ell patterning cue models the behavioral and neuropathological characteristics of PD in a remarkable

70 with unique biochemical, morphological, and neuropathological characteristics.

71 Full neuropathological characterization has not been reported

72 Herewith a neuropathological characterization is presented in AD an

73 ia have not been agreed upon and the current neuropathological characterization of CTE is acknowledge

74 ultiple sclerosis and highlight the need for neuropathological characterization of TSPO expression fo

75 This Review outlines the neuropathological, clinical, molecular imaging and cereb

76 Further, our findings provide a neuropathological clue as to how endothelial tight junct

77 nts in the Memory and Aging Project clinical neuropathological cohort study, 2004-2013.

78 We developed a neuropathological comorbidity (NPC) score and compared i

79 active astrogliosis is a critical process in neuropathological conditions and neurotrauma.

80 ctivation in psychiatry, and likely in other neuropathological conditions as well.

81 lutamate signaling is associated with severe neuropathological conditions, such as epilepsy, and glio

82 ation of neural cells, implicated in several neuropathological conditions.

83 een implicated in learning, development, and neuropathological conditions.

84 ntly for behavioral studies and as models of neuropathological conditions: C57BL/6 J mice and Sprague

85 er reports added to our understanding of the neuropathological consequences of a career in boxing, le

86 ation and the ensuing neurodevelopmental and neuropathological consequences.

87 However, the underlying neuropathological correlates and pathophysiological mech

88 o MRI, histopathology approach to assess the neuropathological correlates and vascular pathology unde

89 ng lesions with smouldering inflammation are neuropathological correlates of progressive multiple scl

90 tive impairments, uncontrolled drinking, and neuropathological cortical changes characterize alcohol

91 opographical distribution is one of the core neuropathological criteria for the diagnosis of Alzheime

92 l Institute on Aging-Alzheimer's Association neuropathological criteria, and used multivariate regres

93 TDP can be differentiated by applying simple neuropathological criteria.

94 Our structures provide a unifying neuropathological criterion for CTE, and support the hyp

95 , we examined symptom onset, and genetic and neuropathological data from a cohort of patients with Le

96 Comparing genetic, cellular, and neuropathological data from patients with TDP-43 protein

97 y utilizing gene expression, methylation and neuropathological data identified 199 genes putatively i

98 Neuropathological data indicate that tau tangles in the

99 pathogenic microglia, although quantitative neuropathological data to support this interpretation ha

100 nsive clinical, cognitive, neuroimaging, and neuropathological data were collected from 69 patients w

101 heimer's disease dementia, and with complete neuropathological data, are included in our analyses.

102 ith cerebrovascular disease (CVD) in a large neuropathological database maintained by the National Al

103 ed in brain, and their loss in mice leads to neuropathological deficits that are reminiscent of Hunti

104 This condition has a clear neuropathological definition but the relationship betwee

105 Among these participants, 50% had neuropathological diagnoses of Alzheimer disease (AD), a

106 Neuropathological diagnoses of neurodegenerative disease

107 Compared to neuropathological diagnoses, clinical diagnosis had high

108 adults and the mismatch between clinical and neuropathological diagnoses.

109 Our results confirm the high prevalence of neuropathological diagnosis in older adults and the mism

110 Accurately predicting the underlying neuropathological diagnosis in patients with behavioural

111 The neuropathological diagnosis is based on a specific patte

112 63% of individuals given the 'gold-standard' neuropathological diagnosis of Alzheimer's disease in fa

113 ticipants were followed to autopsy and had a neuropathological diagnosis of FTLD-Tau (n=24), transact

114 also described and compared the frequency of neuropathological diagnosis to clinical diagnosis of dem

115 uracy of plasma P-tau217 for AD (clinical or neuropathological diagnosis).

116 To date, 49 patients have a neuropathological diagnosis.

117 -four percent of the sample met criteria for neuropathological diagnosis.

118 In total, 223 of 266 participants met neuropathological diagnostic criteria for CTE.

119 flects underlying genetic, environmental and neuropathological differences.

120 in alpha-synuclein are a hallmark of several neuropathological diseases including Parkinson's disease

121 S) is used to modulate plasticity in various neuropathological diseases, including chronic pain.

122 dictate the outcome of future infections and neuropathological diseases.

123 singly becoming recognized as a biomarker of neuropathological diseases.

124 ture aiming to establish neuroanatomical and neuropathological (e.g. amyloid and tau deposition) dime

125 scientific commentary refers to 'Persistent neuropathological effects 14 years following amyloid-bet

126 NR1 ABs caused long-lasting neuropathological effects also in aged mice (10 months),

127 lly impact the development of behavioral and neuropathological endophenotypes of disease.

128 thy is increasingly recognized as a separate neuropathological entity different from Alzheimer's dise

129 Neuropathological evaluations and retrospective telephon

130 sis is not a feature of BD; neither is there neuropathological evidence for an inflammatory process.

131 in the NAc following stress and provide new neuropathological evidence for reduced levels of inhibit

132 r brains for research, a high proportion had neuropathological evidence of CTE, suggesting that CTE m

133 We provide neuropathological evidence on decreased neuronal LMTK2 i

134 Neuropathological evidence suggests that demyelination c

135 with AD as well as in subjects with a normal neuropathological examination but with a history of T2DM

136 Neuropathological examination confirmed the PSP diagnosi

137 ng and histamine flare and itch response and neuropathological examination in some of those who died.

138 We also provide the first detailed neuropathological examination of a child with extreme me

139 Brain and spinal cord neuropathological examination of two cases with SLC52A3

140 Neuropathological examination showed astrocytic and micr

141 Neuropathological examination showed that NPT100-18A dec

142 Detailed neuropathological examination using 70mum and traditiona

143 did not impair hearing performance and, upon neuropathological examination, did not produce the chara

144 FTLD tau inclusion was strongly supported by neuropathological examinations of brains derived from Pi

145 s in substantia nigra pars compacta is a key neuropathological feature in Parkinson disease.

146 Inflammation is a common neuropathological feature in several neurological disord

147 detects amyloid plaques in the brain, a core neuropathological feature of Alzheimer disease.

148 Defective axonal transport is an early neuropathological feature of amyotrophic lateral scleros

149 Diffuse axonal injury is a primary neuropathological feature of concussion and is thought t

150 Cytoplasmic aggregated proteins are a common neuropathological feature of neurodegenerative diseases.

151 ggests that reduction in myelin is a primary neuropathological feature of Wolfram syndrome.

152 Another proposed neuropathological feature related to TDP-43 proteinopath

153 efficacy of bezafibrate in ameliorating both neuropathological features and disease phenotype in BACH

154 The identified neuropathological features closely resembled those in br

155 ioral deficits correlated with mitigation of neuropathological features commonly observed in HD.

156 e onset or severity of abnormal movements or neuropathological features in DYT1 mouse models.

157 White matter abnormalities are prominent neuropathological features in Huntington's disease (HD);

158 actions and mild working-memory defects, the neuropathological features indicate potentially widespre

159 rt genetic, clinical, neuroradiological, and neuropathological features of 50 children from 30 famili

160 Because neuropathological features of AD can be present several

161 pproximately 30% of older adults exhibit the neuropathological features of Alzheimer's disease withou

162 ur findings expand the genetic, clinical and neuropathological features of Brown-Vialetto-Van Laere s

163 how the networks intersect with the standard neuropathological features of LOAD.

164 Both share the neuropathological features of tau aggregates and neurona

165 or disease-causing genes and provide the key neuropathological features that should prompt geneticist

166 CTE is known to share similar neuropathological features with Alzheimer's disease (AD)

167 Cerebral amyloid angiopathy is a common neuropathological finding in the ageing human brain, ass

168 The study was designed to compare neuropathological findings between FTLD-TDP and patholog

169 As such, no neuropathological findings can be considered to have bee

170 Most of the macroscopic and microscopic neuropathological findings described as characteristic o

171 We report neuropsychological and neuropathological findings for a patient (A.B.), who dev

172 d imaging are presented here, in addition to neuropathological findings from two cases with novel mut

173 Various neuropathological findings have been reported in bipolar

174 flammatory gene expression, which are common neuropathological findings in HIV+ cases on ART with neu

175 Here we show that Arsg KO mice share common neuropathological findings with other Sanfilippo syndrom

176 s, evident from neuroimaging, biomarker, and neuropathological findings, and a high incidence of cogn

177 In light of these new neuropathological findings, GCIs and neuronal cytoplasmi

178 LIPPERS aetiologies by neuroradiological and neuropathological findings.

179 We performed a 15-year post-mortem neuropathological follow-up of patients in the first tri

180 influencing residual cognition, we leveraged neuropathological, genetic, epigenetic, and transcriptio

181 Through a multistep analysis of cognitive, neuropathological, genomic, epigenomic, and transcriptom

182 e HD patients were compared with HD striatal neuropathological grade, and symptom scores of motor imp

183 tion between Purkinje cell loss and striatal neuropathological grade, postmortem delay, CAG repeat in

184 neration correlated with increasing striatal neuropathological grade.

185 on disease onset and with the progression of neuropathological grades.

186 ggregation and hyperphosphorylation is a key neuropathological hallmark of Alzheimer's disease (AD),

187 ing of deposited beta-amyloid (Abeta), are a neuropathological hallmark of Alzheimer's Disease (AD).

188 d from amyloid precursor protein (APP), is a neuropathological hallmark of Alzheimer's disease (AD).

189 The formation of Abeta amyloid fibrils is a neuropathological hallmark of Alzheimer's disease and ce

190 Amyloid plaques, a neuropathological hallmark of Alzheimer's disease, are l

191 The neuropathological hallmark of HD is the loss of neurons

192 tion of mutant Huntingtin (Htt) is a primary neuropathological hallmark of Huntington's disease (HD).

193 Although sCJD neuropathological hallmarks are well-known, associated m

194 One of the neuropathological hallmarks of AD is the accumulation of

195 ntly, FAD mutant effects occur in absence of neuropathological hallmarks of AD, supporting that such

196 gingivalis infiltration, along with various neuropathological hallmarks of AD.

197 rectional relationship between sleep and the neuropathological hallmarks of AD; in particular, the ac

198 id-beta protein (Abeta) and synapse loss are neuropathological hallmarks of Alzheimer disease (AD).

199 One of the neuropathological hallmarks of Alzheimer's disease (AD)

200 tor skills and motor coordination and reduce neuropathological hallmarks of Cln6-deficient mice up to

201 e are remarkably similar to the clinical and neuropathological hallmarks of Parkinson's disease.

202 620N mutation is sufficient to reproduce key neuropathological hallmarks of PD as indicated by the pr

203 improvement of select behavioural and modest neuropathological HD-like phenotypes in Hu128/21 mice, s

204 TATEMENT Tauopathies show great clinical and neuropathological heterogeneity, despite the fact that t

205 ltifunctional protein p62 is associated with neuropathological inclusions in several neurodegenerativ

206 , preserves BBB permeability, and attenuates neuropathological indices more effectively than non-targ

207 With the exception of microinfarcts, all neuropathological indices were independently associated

208 regression models examined associations of 8 neuropathological indices with Alzheimer's dementia and

209 Detailed neuropathological information on the structural brain le

210 c biomarker, but caution is indicated in the neuropathological interpretation of its binding.

211 Associations between neuropathological lesions and cognitive impairment were

212 nd tau, the two major proteins composing the neuropathological lesions detected in brain tissue of Al

213 cy of neurodegenerative and vascular-related neuropathological lesions in 1,092 Brazilian admixed old

214 Disorders were assessed for alpha-synuclein neuropathological load and tyrosine hydroxylase levels i

215 es mediated by IL-1beta and the clinical and neuropathological manifestations of EAE disappeared in m

216 In summary, CART treatment reduced multiple neuropathological measures and improved memory in APP/PS

217 However, the neuropathological mechanism is unclear.

218 These findings suggest a novel neuropathological mechanism of early AD, which is initia

219 To better understand the neuropathological mechanism of TBI-related disorders, we

220 lyR functionality and thus might explain the neuropathological mechanism underlying hyperekplexia in

221 ims to identify common and disorder-specific neuropathological mechanisms and treatment targets in MD

222 x, multifactorial disease in which different neuropathological mechanisms are likely involved, includ

223 We identified the underlying neuropathological mechanisms in male and female shaky mi

224 Our findings provide novel insight into the neuropathological mechanisms of ASPD.

225 s extremely useful tools for elucidating the neuropathological mechanisms that underlie different dis

226 ifest stage of HD, which are relevant to the neuropathological mechanisms underlying the development

227 Neuropathological methods also differ across laboratorie

228 Here, we generated a comprehensive neuropathological, molecular, and transcriptomic charact

229 neuroregeneration, and the dissemination of neuropathological molecules.

230 terns in target regions were consistent with neuropathological neurofibrillary tau staging.

231 lted in significant reversal of biochemical, neuropathological, neurophysiological, and behavioural d

232 Together our findings define divergent neuropathological outcomes arising from different classe

233 roviral DNA, will likely lead to detrimental neuropathological outcomes during HIV CNS infection.

234 To determine clinical and neuropathological outcomes following a clinical diagnosi

235 The neuropathological overlap with amyotrophic lateral scler

236 forms) and a skepticism for the brain-based neuropathological paradigm of psychiatric research then

237 Main Outcomes and Measures: Neuropathological parameters and changes in hippocampal

238 n subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmen

239 he retired players suggested the presence of neuropathological patterns consistent with models of con

240 may be important in shaping the clinical and neuropathological patterns of the diverse clinical syndr

241 of 117VV Tg30 mice, produced a molecular and neuropathological phenotype congruent with that seen aft

242 DA1 treatment reduces behavioral and neuropathological phenotypes in HD transgenic mice.

243 ors to the progression of the behavioral and neuropathological phenotypes observed in HD.

244 Treatment with HV-3 reduces behavioural and neuropathological phenotypes of HD in both fragment- and

245 across 364 donors with varying cognitive and neuropathological phenotypes.

246 alone are sufficient to account for diverse neuropathological presentations, similar to those that d

247 ction, collectively known as synaptopathy, a neuropathological process contributing to excitotoxic ne

248 This, and the fact that the neuropathological process underlying PD symptoms may beg

249 adapt to IF and how such adaptations impact neuropathological processes are unknown.

250 of normal brain ageing as well as of various neuropathological processes associated with brain diseas

251 phrenia involve dynamic interactions between neuropathological processes in a tract-specific manner.

252 pulation of cerebrospinal fluid drainage and neuropathological processes in the CNS.

253 nges in the cerebral vasculature in numerous neuropathological processes including subarachnoid hemor

254 Therefore, neuropathological processes other than beta-amyloidosis

255 to identify biomarkers reflecting underlying neuropathological processes that predict clinical/behavi

256 ed interest in their possible involvement in neuropathological processes, yet little is known about t

257 MDA receptors (NMDARs) contribute to several neuropathological processes.

258 potentially indicating different underlying neuropathological processes.

259 ntal approach that, instead of assessing the neuropathological profile after serial transmissions in

260 d most frequent cognitive, neuroimaging, and neuropathological profile.

261 in HdhQ150 mice at both time points, with no neuropathological progression across time and a selectiv

262 The biochemical and neuropathological properties of bovine spongiform enceph

263 Many of the strain-specified biochemical and neuropathological properties of BSE and vCJD prions, inc

264 or of second RNA-recognition motif (RRM2) of neuropathological protein TDP43 under the effect of oxid

265 ot chronic, mTBI, and elevations of most NDE neuropathological proteins in chronic and acute mTBI del

266 rexpression mouse models as well as human PD neuropathological results further confirm the role of Fy

267 tion, neurofibrillary tangles, and composite neuropathological scores, independent of apolipoprotein

268 Characterization of the neuropathological sequelae of developmental exposure to

269 E, based on defined diagnostic criteria; CTE neuropathological severity (stages I to IV or dichotomiz

270 Neuropathological severity of CTE was distributed across

271 AD diagnosis, clinical dementia severity and neuropathological severity.

272 that both diseases likely belong to the same neuropathological spectrum.

273 and the utility of this system to study the neuropathological spread of tau aggregates.SIGNIFICANCE

274 the ALS group that coincided with postmortem neuropathological stages.

275 atterns similar to those prescribed by Braak neuropathological staging of tau pathology.

276 Our data are consistent with neuropathological studies and further suggest that entor

277 r clinical, neuroradiological, biomarker and neuropathological studies are essential to determine the

278 Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of spo

279 Moreover, few neuropathological studies have addressed whether blast e

280 Neuropathological studies have demonstrated that cerebro

281 In multiple sclerosis, neuropathological studies have shown widespread changes

282 We conducted neuropathological studies on patients with mitochondrial

283 ighlights the potential of AT-STED for human neuropathological studies.

284 m deep brain areas, which is consistent with neuropathological studies.

285 in both the brain slice model and the human neuropathological study.

286 rol (n = 39) cases was selected for detailed neuropathological study.

287 fferential disruption of a common primordial neuropathological substrate causes these differences in

288 tion of auditory nerve fibers as predominant neuropathological substrates of hearing loss in BACE1(-/

289 ortical tubers are believed to represent the neuropathological substrates of these disabling manifest

290 y patterns on MRI can reliably predict three neuropathological subtypes of Alzheimer's disease (AD):

291 bodies that are characteristic of different neuropathological subtypes of the disease.

292 n the nervous system can result in different neuropathological symptoms such as mental retardation, s

293 of CD8(+) T lymphocytes, leading to a lethal neuropathological syndrome.

294 called strains, are associated with distinct neuropathological syndromes.

295 for elucidating changes in the deposition of neuropathological tau aggregates that are occurring duri

296 level profiles that mirrored key features of neuropathological tau progression including profiles con

297 The causes for neuropathological TDP-43 aggregation are unknown, but it

298 ertain loci may influence multiple different neuropathological traits, including tau, amyloid beta pl

299 s of olfactory perception and to clarify the neuropathological underpinnings of these deficits.

300 ss-sectional study, we describe clinical and neuropathological variables related to cognitive impairm