ライフサイエンスコーパス: neuropathology

1 d cognitive performance for a given level of neuropathology.

2 progressive behavioral deficits and FTD-like neuropathology.

3 tudied link between DA neurotransmission and neuropathology.

4 e development of behavioral deficits and tau neuropathology.

5 at link pathological aggregate structure and neuropathology.

6 logy has been proposed based on genetics and neuropathology.

7 adrenergic signaling in neurodevelopment and neuropathology.

8 anistic role of RNA editing in schizophrenia neuropathology.

9 impaired (m)Ca(2+) efflux capacity precedes neuropathology.

10 about neuroanatomy and improves detection of neuropathology.

11 neurodevelopmental disorders that share this neuropathology.

12 A that also targets BACE1, contributes to AD neuropathology.

13 nvolved in the development of the associated neuropathology.

14 tion, longitudinal cognitive decline, and AD neuropathology.

15 disease symptoms and some of the responsible neuropathology.

16 ates and reversed well-established secondary neuropathology.

17 liferation as a significant component of the neuropathology.

18 to translate findings into new therapies for neuropathology.

19 ith defined incubation times and patterns of neuropathology.

20 ropagation of aggregation, and transmissible neuropathology.

21 ular development, neurovascular coupling and neuropathology.

22 on, in the absence of detectable progressive neuropathology.

23 vivo (18) F-flortaucipir and postmortem tau neuropathology.

24 are points at which intervention may reduce neuropathology.

25 ve effects against THC-induced developmental neuropathology.

26 63 (30%) with high-level Alzheimer's disease neuropathology.

27 tein to the polyQ protein-mediated selective neuropathology.

28 ssociated with a characteristic 4-repeat tau neuropathology.

29 get(s) of FTP in cases of suspected FTLD-TDP neuropathology.

30 hich endogenous single-strand breaks trigger neuropathology.

31 tratify them by level of Alzheimer's disease neuropathology.

32 tent with the zebrafish findings and patient neuropathology.

33 estigating the development of stress-induced neuropathology.

34 rupt synaptic endosomal signaling and induce neuropathology.

35 ch correlates with lupus disease and limited neuropathology.

36 ttent hypoxia, are ineffective in preventing neuropathology.

37 ectivity in sea lion brains, with or without neuropathology.

38 otential therapeutic target for galactosemia neuropathology.

39 to AIDS-related central nervous system (CNS) neuropathology.

40 nction is a key component in methamphetamine neuropathology.

41 olism, and/or inflammation contribute to ASD neuropathology.

42 in the CNS, which can lead to HIV-associated neuropathology.

43 in patients with primary Alzheimer's disease neuropathology.

44 umference) produces particularly devastating neuropathology.

45 e Delta-9-tetrahydrocannabinol (THC)-induced neuropathology.

46 ates and reversed well-established secondary neuropathology.

47 presence and absence of Alzheimer's disease neuropathology.

48 to that associated with Alzheimer's disease neuropathology.

49 loidosis inside the brain and contributes to neuropathology.

50 Postmortem data documented AD neuropathology.

51 ut triggering leukocyte recruitment or overt neuropathology.

52 beta-amyloid-mediated memory impairment and neuropathology.

53 tively unimpaired in the face of substantial neuropathology.

54 nown about how ZIKV infection produces fetal neuropathology.

55 ion of spinal cord microglia without causing neuropathology.

56 ers of this MMP family were implicated in AD neuropathology.

57 most had TAR DNA-binding protein 43 (TDP-43) neuropathology.

58 sporter MCT1/SLC16A1 as a novel facet of the neuropathology.

59 lity regardless of the burden of traditional neuropathologies.

60 ia attributable to pathologic AD and 8 other neuropathologies.

61 lved spatiotemporal mechanisms of underlying neuropathologies.

62 ing drugs for treatment of AD and/or similar neuropathologies.

63 n-amyloid-plaque, non-neurofibrillary-tangle neuropathologies.

64 rapeutic strategies to manage PD and related neuropathologies.

65 chaperone downregulation mediates different neuropathologies.

66 inked to a wide range of olfactory tasks and neuropathologies.

67 (18)F-FET PET findings were verified by neuropathology (40 patients) or clinicoradiologic follow

68 56 (26%) with low-level Alzheimer's disease neuropathology, 45 (21%) with intermediate-level Alzheim

69 9 (23%) patients with no Alzheimer's disease neuropathology, 56 (26%) with low-level Alzheimer's dise

70 er TBI, post-mortem studies on the long-term neuropathology after injury have identified complex pers

71 encing recovery of neurological function and neuropathology after SCI.

72 nflammatory response, known to contribute to neuropathology after TBI, appears to differ depending up

73 based on studies demonstrating prevention of neuropathology after trauma-induced nerve injury.

74 sed on biomarkers that reflect underlying AD neuropathology allow better assessment of the strength o

75 zheimer's dementia cases, but multiple other neuropathologies also contribute.

76 derable progress in the understanding of its neuropathology, Alzheimer's disease (AD) remains a compl

77 p learning pipeline that identifies specific neuropathologies-amyloid plaques and cerebral amyloid an

78 ly the 38 proteins that act independently of neuropathologies and are also hub proteins of protein co

79 ent mutations can have an additive effect on neuropathologies and associated co-morbidities, possibly

80 ogether, our data highlights the synergistic neuropathologies and associated cognitive and synaptic a

81 assessed for the effect of the treatment on neuropathologies and behavioral impairments.

82 emistry, we performed tau phenotyping of CTE neuropathologies and compared this to a range of tau pat

83 grating insights from comparable findings in neuropathologies and primary CNS tumors.

84 ation to protect against poly (I:C) imparted neuropathology and altered behavior in offspring.

85 ties: they may be cascade effects of earlier neuropathology and behavioral abnormalities.

86 ral nervous system on the development of the neuropathology and behavioral deficits of the triple tra

87 er, whether targeting this pathway after the neuropathology and behavioral impairments have been esta

88 ther, we show specific short-term changes in neuropathology and behaviour induced by (56)Fe irradiati

89 after injury, attenuates the development of neuropathology and brain dysfunction during acute and ch

90 lites and metabolic pathways associated with neuropathology and cognitive performance and to identify

91 This study measured nerve agent-related neuropathology and determined whether quantitative T(2)

92 Pcmt1 knock-out mice exhibit a profound neuropathology and die 30-60 days postnatal from an epil

93 20 days and assessed for cognitive behavior, neuropathology and disruptions in the gut microbiota at

94 However, the genetic frequency, neuropathology and downstream consequences of riboflavin

95 ng by dysregulating genes associated with AD neuropathology and inflammation and reveal a possible re

96 n, reduced Cav-1 levels induce AD-associated neuropathology and learning and memory deficits.

97 other growth factors, is associated with AD neuropathology and lower cognitive function.

98 lleviating Machado-Joseph disease-associated neuropathology and motor impairments.

99 eserving synapses and cognition, attenuating neuropathology and neuroinflammation, and enhancing resi

100 obilization and has therefore been linked to neuropathology and organismal individuality.

101 ucture of ApoE and how this might impact the neuropathology and pathogenesis of AD.

102 Concordant patterns of neuropathology and prion deposition in susceptible mice

103 clearance of proteolipid aggregates, reduces neuropathology and prolongs survival of diseased mice.

104 deficiency compounded the severity of MuPyV neuropathology and resulted in dramatically elevated vir

105 strains, which produce distinct patterns of neuropathology and spread through the nervous system.

106 peralgesia may provide new insights into the neuropathology and treatments of these nociceptive, inte

107 acteristic pattern of infection that mirrors neuropathology and ultimately results in gross morpholog

108 protective mechanisms, they may also promote neuropathology and, in some cases, induce persistent alt

109 with intermediate-level Alzheimer's disease neuropathology, and 63 (30%) with high-level Alzheimer's

110 novel critical player in tau metabolism and neuropathology, and a new therapeutic target for human t

111 ional outcomes, postmortem analyses assessed neuropathology, and brain atrophy was detected by ex viv

112 anges in neuroinflammation, virus clearance, neuropathology, and development of brain atrophy via T2-

113 ect prion transmission, disease progression, neuropathology, and emergence of new prion strains, but

114 post-traumatic neuroinflammatory responses, neuropathology, and long-term functional recovery.

115 g c-Abl reduced alpha-synuclein aggregation, neuropathology, and neurobehavioral deficits.

116 ice accelerated alpha-synuclein aggregation, neuropathology, and neurobehavioral deficits.

117 appraisal of the epidemiology, pathobiology, neuropathology, and neuroimaging of vascular cognitive i

118 ecific genes and pathways associated with AD neuropathology, and pinpoint a specific functional gene

119 reduces cognitive impairments, the degree of neuropathology, and seizure susceptibility, after pediat

120 proved their wellness scores, grip strength, neuropathology, and survival.

121 ly associated with beta-amyloid, tau-related neuropathology, and the rate of cognitive decline.

122 ebral vasculature in other models of chronic neuropathology, and we observed that acute Adora2a antag

123 wildtype mice and in a mouse model of Abeta neuropathology (APPSWE /PS1dE9 ) from 6 months of age.

124 These results suggest that age-related neuropathologies are differentially related to late life

125 in motility, and consequently their links to neuropathology, are not understood.

126 -brain barrier breakdown and T-cell-mediated neuropathology as potential underpinnings of ZIKV-associ

127 ogical and neuroimaging evidence implicating neuropathology associated with psychosis is consistent w

128 nally assessing the timing of the structural neuropathology associated with schizophrenia.

129 tiple sclerosis, characterising the cellular neuropathology associated with TSPO expression is of cle

130 Following neuropathology, astrocytes become reactive and many of t

131 ts typically present with multiple co-morbid neuropathologies at autopsy, but the impact of these pat

132 ong-term functional recovery or decrease TBI neuropathology at 28 d post-injury.

133 YMAD), i.e., individuals with significant AD neuropathology at death but without evidence for cogniti

134 pared with ataxin-3-23Q and develop ataxin-3 neuropathology, ataxin-3 cleavage fragments and motor im

135 xers and American football players described neuropathology attributed to CTE that was broad and dive

136 e led to striking findings that recapitulate neuropathology-based staging of tau.

137 ells via beta2 m deficiency does not reverse neuropathology, but exacerbates disease both in the brai

138 evidence implicates amyloid oligomers in AD neuropathology, but the precise mechanisms are uncertain

139 ndrome (DS) develop Alzheimer's disease (AD) neuropathology by age 40.

140 he protein MECP2 is thought to contribute to neuropathology by causing dysregulation of plasticity.

141 The mitigation of TDP-43 neuropathology by IkappaBalpha-SR, which is likely due t

142 So that the core underlying neuropathologies can be further elucidated, we emphasize

143 beneficial effects of female sex on PD-like neuropathology can be reinstated by elevating estrogen i

144 Although underlying neuropathology cannot be ruled out, treatable conditions

145 t alpha7 nAChR may play an important role in neuropathology caused by gp120, METH and NT, which are t

146 DS) develop Alzheimer's disease (AD)-related neuropathology, characterized by amyloid plaques with am

147 ee cross-sectional cohorts: an Arizona-based neuropathology cohort (cohort 1), including 34 participa

148 P beginning at any time up to early signs of neuropathology confers benefit similar to constitutive h

149 The degree to which Alzheimer's versus other neuropathologies contribute to the risk of Alzheimer's d

150 We analyzed the neuropathology data from the hippocampus to identify tho

151 Leveraging neuropathology data from the same participants, we also

152 Genetic, cognitive, and neuropathology data were acquired from the Religious Ord

153 has been steadily emerging evidence that the neuropathology described as unique to CTE may not be uni

154 Standard neuropathology diagnostic methods including histology an

155 Surprisingly, neuropathology differs depending on viral strain with a

156 Neuropathology disclosed a high percentage of macrophage

157 hile considerable interanimal variability in neuropathology, disease onset, and tau prion formation i

158 Additionally, three distinct patterns of neuropathology emerged when investigating white matter f

159 Recent advances in neuroimaging, neuropathology, epidemiology, and genetics have led to a

160 able of inducing LID behavior and associated neuropathology, even in resistant subjects.

161 Neuropathology follow-up of patients in therapeutic tria

162 velopment and hypoconnectivity, which mirror neuropathologies found in schizophrenia patients.

163 mpus postmortem in four groups of drug-free, neuropathology-free subjects (N = 52 total): psychologic

164 , the immunohistochemical distinction of CTE neuropathology from other mixed 3R/4R tauopathies of Alz

165 th, and the full impact of these more subtle neuropathologies has yet to be determined.

166 lved in the coordination of movements, in HD neuropathology has been controversial.

167 motor coordination and associated cerebellar neuropathology have been described.

168 Autopsy measures of Alzheimer's disease neuropathology have been leveraged as endophenotypes in

169 and local delivery at the location of active neuropathology highlight the potential to use endogenous

170 d demyelination are not factors in long-term neuropathology.-Huseby Kelcher, A.

171 Brain MRI, neuropathology, immunohistochemistry for astrocyte and m

172 investigated for trait and state progressive neuropathologies in MDD using both unbiased approaches a

173 specific locomotor impairments onto distinct neuropathologies in mice.

174 es that investigating PC-specific cerebellar neuropathologies in zebrafish allows for interconnecting

175 o compare antemortem 18F-flortaucipir PET to neuropathology in a consecutive series of patients with

176 eractivity levels on epilepsy and associated neuropathology in a mouse model of TSC and FCD.

177 with the severity of epilepsy and associated neuropathology in a mouse model of TSC and FCD.

178 herefore develop the spectrum of Alzheimer's neuropathology in a uniform manner, they constitute an i

179 ting tau hyperphosphorylation and subsequent neuropathology in AD and related tauopathies.

180 lays an important role in the development of neuropathology in AD.

181 ind no evidence for alpha-synuclein-positive neuropathology in aged VPS35 KI mice, a hallmark of Lewy

182 expression of microRNA-338-5p contributes to neuropathology in Alzheimer's disease.

183 al role in the dissociation of cognition and neuropathology in an aging population, and we expanded o

184 lia to neurotoxic phenotypes and ameliorated neuropathology in an animal model of MS.

185 P-tau181 (AUC = 0.94-0.98), and detected AD neuropathology in an autopsy-confirmed cohort.

186 nal structural stability as a major cellular neuropathology in ASD.

187 ence the severity of epilepsy and associated neuropathology in experimental TSC and FCD.

188 ween the regional densities of microglia and neuropathology in FTLD-TDP (A), FTLD-TDP (C), and FTLD-P

189 alleviate the deficient exosome release and neuropathology in HD mice.

190 perone function contributes to the selective neuropathology in HD, and highlight the therapeutic pote

191 inclusions, recapitulating the diversity of neuropathology in human tauopathies.

192 tion of brain SCD activity prevented PD-like neuropathology in multiple PD models.

193 Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barre syn

194 emerged as a pandemic associated with severe neuropathology in newborns and adults.

195 rent types and cellular distributions of tau neuropathology in our model that recapitulate the hetero

196 uggested to contribute to the progression of neuropathology in Parkinson's disease (PD).

197 alovirus (HCMV) infection is associated with neuropathology in patients with impaired immunity and/or

198 ally help to improve antemortem diagnosis of neuropathology in PPA.

199 r our understanding of regional and cellular neuropathology in schizophrenia.

200 reliable biomarkers for Alzheimer's disease neuropathology in synucleinopathies should help to ident

201 icient (Ppt1(-/-) ) mice before the onset of neuropathology in the brain.

202 lls ameliorated clinical disease and reduced neuropathology in the classic CD4+ T cell-mediated autoi

203 detail how ZIKV infection produces extensive neuropathology in the developing mouse brain and spinal

204 efore age 5 weeks, and significant (P < .05) neuropathology in the hindbrain of 24-week-old mice was

205 , synaptic dysfunction, amyloid-beta and tau neuropathology in the offspring by transcriptional regul

206 ociated TREM2 variant (R47H) on tau-mediated neuropathology in the PS19 mouse model of tauopathy.

207 nd a role for estrogen in mitigating PD-like neuropathology in vivo Brain-selective estrogen therapy

208 HCMV infection may be a treatable source of neuropathology in vulnerable MDD patients.

209 may help stratify clinical cohorts with pure neuropathology in which low CSF phosphorylated-tau level

210 As levels of Alzheimer's disease neuropathology increased, cerebral alpha-synuclein score

211 amyloid beta levels and deposition, less tau neuropathology, increased synaptic integrity, and autoph

212 it directly modulates the development of tau neuropathology independently of amyloid beta in vivo is

213 s without the pain disorder do not show this neuropathology, indicating a pathogenic contribution of

214 ll subjects with available (18)F-FDG PET and neuropathology information (n = 38), PES of (18)F-FDG-AD

215 tress and an activated immune system have in neuropathology, innate immune training has important imp

216 o not support its use for neuroprotection in neuropathologies involving oxygen deprivation.

217 A good correlation with the human neuropathology is also reported.

218 INTERPRETATION: Alzheimer's disease neuropathology is common in synucleinopathies and confer

219 and strain rate are greatest in sulci, where neuropathology is prominently seen in chronic traumatic

220 ctioning of white matter, but the underlying neuropathology is unclear.

221 he extent of proteinopathy in tissue with AD neuropathology, it was strongly associated with the rate

222 agnosis usually was associated with comorbid neuropathologies; less than one-quarter of MCI cases sho

223 h neurofibrillary tau staging established in neuropathology literature.

224 gCRND8 mice that exhibit moderately advanced neuropathology markedly diminished the sizes of enlarged

225 Therefore, a critical aspect of ZIKV-induced neuropathology may be defined by death of uninfected cel

226 arly prodromal stage of synucleinopathy when neuropathology may be more responsive to treatment.

227 However, their molecular neuropathology mechanisms remain mostly unexplored.

228 gressive, and there is now evidence that CTE neuropathology might not be progressive in some individu

229 cerbated leukocyte and humoral infiltration, neuropathology, motor disability, and mortality.

230 (n = 266), and controls with no significant neuropathology (n = 368).

231 e emergence of "nondemented with Alzheimer's neuropathology" (NDAN) individuals, cognitively intact d

232 t, p = 1.5 x 10-10), and was associated with neuropathology (NIA ADC, Braak stage of neurofibrillary

233 Conclusion: Asymmetry of fibrillar plaque neuropathology occurs frequently in Abeta mouse models a

234 s needed to identify differences between the neuropathology of aging in humans and felines.

235 liminary consensus criteria for defining the neuropathology of CTE were forged in 2015 and published

236 The neuropathology of different neurodegenerative diseases b

237 tance in the further characterization of the neuropathology of DMD.

238 Postmortem neuropathology of five TIA1 mutations carriers showed a

239 ng of the genetic architecture and molecular neuropathology of human cocaine addiction and provides a

240 Furthermore, neuropathology of jam2 KO mouse showed prominent vacuola

241 and behavioral symptoms attributed to major neuropathology of mainly the basal ganglia and cerebral

242 eview, we aim to describe recent advances in neuropathology of MSA from a review of the literature an

243 ration of leukocytes into the CNS drives the neuropathology of multiple sclerosis (MS).

244 prefrontal cortex (PFC) and striatum in the neuropathology of obsessive compulsive disorder (OCD).

245 gate whether RGMa might model aspects of the neuropathology of Parkinson's disease in mouse, we targe

246 The neuropathology of post-traumatic dementias is increasing

247 in multiple brain systems implicated in the neuropathology of psychiatric disorders.

248 meostasis, defects in which may underlie the neuropathology of SCAR20.

249 ranscript (GAD67) has been implicated in the neuropathology of schizophrenia, the transcript structur

250 ained the CNS infectivity, cell tropism, and neuropathology of the parental virus.

251 In contrast, the neuropathology of this disease remains understudied desp

252 Neuropathology of vitamin B(12) deficiency in the Cd320(

253 entia, which is usually accompanied by other neuropathology, often cerebrovascular disease such as br

254 o examine whether the effects of age-related neuropathologies on cognition change over time.

255 the effects of TDP-43 and other age-related neuropathologies on cross-sectional grey matter volume i

256 Brain neuropathology on 14 CLIPPERS cases demonstrated marked

257 on framework to estimate the effects of each neuropathology on cognitive decline as assessed by the m

258 e, not easily generalizable across different neuropathologies or inflammatory conditions.

259 ciation with tau pathology (determined using neuropathology or positron emission tomography [PET]).

260 own concerning their direct contributions to neuropathology or the cellular mechanisms regulating the

261 e pace of cellular aging, disease onset, and neuropathology, particularly in older, stressed populati

262 ns in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59

263 sing CWD in Norway induced incubation times, neuropathology, regional deposition of misfolded prion p

264 ms by which microglia alter the course of AD neuropathology remain poorly understood.

265 ynuclein (alphaS) homeostasis and related PD neuropathology remain unknown.

266 gh the exact role of the immunoproteasome in neuropathology remains poorly defined.

267 In neuropathology research, induced pluripotent stem cell (

268 synuclein pff can lead to selective regional neuropathology resembling the premotor stage of idiopath

269 involved in the development of Abeta and tau neuropathology, respectively.

270 We suggest that the neuropathology resulted from two separate factors: the i

271 In the infective endocarditis group, neuropathology revealed brain infarctions (n = 12/23, 52

272 acteremia group, MRI studies were normal and neuropathology revealed only hemorrhages (n = 2/11, 18%)

273 At termination, neuropathology showed more IgG deposited in the brains o

274 e network-based degeneration framework where neuropathology spreads across connectivity networks.

275 e treatment for the systemic manifestations, neuropathology still remains untreatable.

276 Genetics and neuropathology strongly link alpha-synuclein aggregation

277 temortem diagnostic tests are not available, neuropathology studies suggest a pathogenic role for mic

278 tical to brain function, and dysregulated in neuropathologies such as brain tumors.

279 gh microcephaly is the most obvious outcome, neuropathologies, such as intracranial calcifications an

280 cases are attributable to common age-related neuropathologies, suggesting that other disease and resi

281 tify common pathways that influence multiple neuropathologies that coexist with NFT and found suggest

282 ch passage, a combination of clinical signs, neuropathology (transmissible spongiform encephalopathy

283 We aimed to describe the neuropathology underlying dementia in PD.

284 The neuropathology underlying HIV-associated neurocognitive

285 ntia is commonly associated with more than 1 neuropathology, usually Alzheimer disease with cerebrova

286 of HD cases, including those with low-level neuropathology (Vonsattel grade 0/1).

287 His neuropathology was extensive and involved the medial tem

288 Neuropathology was measured by determining the percentag

289 clinical evaluations, and Alzheimer disease neuropathology was quantified after death among a subset

290 some dementia cases are not driven by common neuropathologies, we re-estimated the attributable risks

291 s that altered Ca(2+) dynamics contribute to neuropathology, we tested if disease mutations in NPC1 a

292 microinfarcts and arteriolar sclerosis, all neuropathologies were associated with the cognitive traj

293 cubation periods, western blot profiles, and neuropathology were maintained.

294 associations of brain insulin signaling with neuropathology were observed.

295 Neuroimaging and neuropathology were reviewed by experienced neuroradiolo

296 eased to age 6 months, paralleled by PD-like neuropathology, whereas 3K females showed a significant

297 277, 44.5%) were also analysed using formal neuropathology, which showed neuroprotection by HT throu

298 rotection from the cognitive consequences of neuropathology, while also providing evidence for a nove

299 e cerebellar, basal ganglia, and neocortical neuropathology with the variability of motor/mood sympto

300 oring high viral loads and displaying marked neuropathology, with motor impairment a frequent manifes