ライフサイエンスコーパス: neurosensory

1 eye dryness are linked with inflammation and neurosensory abnormalities and may occur with a differen

2 Dry eye disease (DED) includes neurosensory abnormalities as part of its multifactorial

3 pheral neuropathies, and visual and auditory neurosensory abnormalities.

4 ntional and unconventional, are critical for neurosensory activities.

5 Neurosensory and behavioural disruptions are some of the

6 These findings shed light on how the neurosensory and feeding systems coevolved during bird o

7 Neurosensory and neurologic dysfunctions were assessed a

8 ory epithelium (OE) to regenerate fully both neurosensory and nonneuronal cell types after severe epi

9 g the otic vesicle; the latter gives rise to neurosensory and nonsensory elements of the adult membra

10 pothyroidism, osteoporosis, cardiopulmonary, neurosensory, and neuromotor impairments.

11 ndocrine, gastrointestinal, musculoskeletal, neurosensory, and neuromotor impairments.

12 dverse events (TEAEs) were gastrointestinal, neurosensory, and resolvable ocular events.

13 : neuromotor (nonambulatory cerebral palsy), neurosensory (blindness, deafness, or need for visual/he

14 ialized integument, and acquisition of novel neurosensory capabilities.(5) Although pterosaurs and bi

15 ndings establish and characterize a distinct neurosensory cell signaling pathway that determines the

16 al hearing outcome and the long-term fate of neurosensory cells in the cochlea, i.e., hair cells and

17 human cell line 293 and also in vivo, within neurosensory cells of guinea pig eye.

18 c acoel, Symsagittifera roscoffensis, and in neurosensory cells of the jellyfish Clytia hemisphaerica

19 in neurons of the circumventricular organs, neurosensory cells responsive to systemic osmotic pressu

20 Pulmonary neuroendocrine (NE) cells are neurosensory cells sparsely distributed throughout the b

21 the activity of these Sox2 enhancers in otic neurosensory cells specifically depends on binding to Si

22 NEBs), innervated clusters of neuroendocrine/neurosensory cells within the bronchial epithelium, reve

23 ly expressed in differentiating nematocytes (neurosensory cells) and in statocytes (ciliated mechanos

24 The channel also occurs in other neurosensory cells, including inner-ear hair cells, sens

25 eveal in detail the spatial loss of cochlear neurosensory cells, providing new insights into the path

26 nia (22%), infection (13%), stomatitis (9%), neurosensory changes (7%), myalgia (7%), and diarrhea (7

27 Nonhematologic toxicity included neurosensory changes in 21% of patients (severe in 3%) a

28 low levels of Wnt activity repress Sox2 and neurosensory competence.

29 half of the otocyst, thereby positioning the neurosensory competent domains in the inner ear.

30 ssociated with BCVA gains, some IRC-mediated neurosensory damage remained permanent.

31 the type of autosomal recessive nonsyndromic neurosensory deafness known as "DFNB1." Studies indicate

32 tients consist of hypopigmentation, cochlear neurosensory deafness, and enteric aganglionosis.

33 system, or an overexpression of HGF, causes neurosensory deafness.

34 Recognition of these early neurosensory defects would enable a better understanding

35 val between the procedure that resulted in a neurosensory deficiency and the LC, qualifications of th

36 ng the surgical procedure that resulted in a neurosensory deficiency in 73 LCs (79.3%), and the DI wa

37 LCs for DIs that result in a neurosensory deficiency pose a legal risk to the practit

38 and analyzes a large series of patients with neurosensory deficiency related to the placement of dent

39 aling), and treatment after the diagnosis of neurosensory deficiency were recorded and analyzed.

40 (AS), a progressive disease characterized by neurosensory deficits and by metabolic defects including

41 Alms1-disrupted mice, which recapitulate the neurosensory deficits of human Alstrom Syndrome, cochlea

42 hyperinsulinemia, chronic hyperglycemia and neurosensory deficits.

43 lstrom syndrome, a disorder characterised by neurosensory degeneration, metabolic defects and cardiom

44 gence of new trade-offs with development and neurosensory demands.

45 l for inner ear neurosensory development and neurosensory-dependent morphogenesis.

46 nal pigment epithelium detachment (PED), and neurosensory detachment (NSD).

47 dditional unique features, including central neurosensory detachment and outer lamellar macular hole,

48 The assessment of neurosensory detachment as well as other ultrastructural

49 kness, subretinal fluid volume and height of neurosensory detachment before and after treatment with

50 Patients with alternative etiologies for neurosensory detachment or pigment epitheliopathy were e

51 al coherence tomography (OCT) showed macular neurosensory detachment with central highly reflective s

52 hages, cotton wool spots, macular edema, and neurosensory detachment.

53 to have developed at the margins of chronic neurosensory detachment.

54 nvascularized, serous PEDs with an overlying neurosensory detachment.

55 trates that miRNAs are crucial for inner ear neurosensory development and neurosensory-dependent morp

56 of Sox2, we explored the function of Sox2 in neurosensory development in a model with limited cell ty

57 The role of Sox2 in neurosensory development is not yet fully understood.

58 onstrated a critical role for this ligand in neurosensory development of the vertebrate inner ear, an

59 nd changes the current paradigm of inner ear neurosensory development.

60 primary outcomes for the child (death or any neurosensory disability) or for the woman (maternal seps

61 egies for managing children with physical or neurosensory disability.

62 es; for the children, they were death or any neurosensory disability; and for the women, maternal sep

63 r proteins, two of which have been linked to neurosensory disease phenotypes.

64 zard for any psychological developmental and neurosensory disorder was significantly higher for the t

65 on, clinically and genetically heterogeneous neurosensory disorder.

66 enes for hereditary and/or sporadic forms of neurosensory disorders in humans.

67 ous disease susceptibility, blood disorders, neurosensory disorders, drug addiction and toxicity.

68 seases, atherosclerosis, blood disorders and neurosensory disorders.

69 ers, tub and tulp1, have been shown to cause neurosensory disorders.

70 y sinus or nasal fossa, sinus lift sequelae, neurosensory disturbances, injuries to adjacent teeth, t

71 hatic duct outgrowth, and in the prospective neurosensory domain of the otic epithelium as morphogene

72 riginate from Sox2-positive and Notch-active neurosensory domains specified at early stages of otic d

73 luorescence imaging can reveal the extent of neurosensory dysfunction in gyrate atrophy patients.

74 These neurosensory elements are innervated by a sound-activate

75 teins at the basal and apical aspects of the neurosensory epithelia suggests the existence of regulat

76 he aminoglycoside gentamicin, the vestibular neurosensory epithelia undergo degeneration and then lim

77 We demonstrate Cdh23 expression in the neurosensory epithelium and show that during early hair-

78 In the vertebrate auditory organ, the neurosensory epithelium develops as a mosaic of sensory

79 tion task following surgical ablation of the neurosensory epithelium in one labyrinth.

80 ing neuroblasts, increased cell death in the neurosensory epithelium, and significantly reduced the C

81 SERPINB6A is present in the neurosensory epithelium, lateral wall, and spiral limbus

82 ntal canal morphogenesis and another set for neurosensory formation of the horizontal crista and asso

83 The neurosensory foundation for plasticity was ancestral wit

84 at not all domains of neurodevelopmental and neurosensory function may be equally affected.

85 ontribution of the channel in either cell to neurosensory function remains to be elucidated.

86 dent inner ear, Spata5l1 is expressed in the neurosensory hair cells and inner ear supporting cells.

87 Congenital hearing loss is the most common neurosensory handicap in neonates.

88 le long-term psychological developmental and neurosensory harms warrant careful consideration of risk

89 ch are critical for the survival of auditory neurosensory HCs.

90 liferate, and HC death leads to irreversible neurosensory hearing loss and balance impairment.

91 odel for the study of conductive rather than neurosensory hearing loss that has direct relevance to h

92 Neurosensory hearing loss, ataxia, spastic paraparesis,

93 by mice also suffer retinal degeneration and neurosensory hearing loss.

94 s as retinitis pigmentosa (RP) and bilateral neurosensory hearing loss.

95 sults in loss of Sox2 expression and lack of neurosensory identity, leading to abnormal apoptosis wit

96 ienced hypoglycemia were more likely to have neurosensory impairment (111 [23%] vs 125 [18%]; adjuste

97 The primary outcome was neurosensory impairment (any of the following: blindness

98 (280 [58.7%]) did not have increased risk of neurosensory impairment (risk difference [RD], 0.01; 95%

99 an increased risk of the primary outcomes of neurosensory impairment (risk ratio, 0.95; 95% confidenc

100 Serious respiratory morbidity, neurosensory impairment at 18 to 21 months of age, and a

101 in no significant difference in the risk of neurosensory impairment at 2 years' corrected age.

102 primary outcome of this follow-up study was neurosensory impairment at 2 years' corrected age.

103 t associated with increased risk of combined neurosensory impairment at 4.5 years but was associated

104 onatal hypoglycemia were more likely to have neurosensory impairment at corrected age 2 years, with h

105 d family socioeconomic status) and childhood neurosensory impairment at step 2 (HR, 0.59; 95% CI 0.40

106 Neurosensory impairment was not significantly different

107 rious respiratory morbidity, 257 infants had neurosensory impairment, and 12 infants died after disch

108 to isolate cognitive outcomes from motor and neurosensory impairment, and the strategy for dealing wi

109 The primary outcome was neurosensory impairment, defined as poor performance in

110 tcome was survival without cerebral palsy or neurosensory impairment, or a Bayley III developmental s

111 For serious neurosensory impairment, the AOR and AUC at 40 weeks' PM

112 Seventeen percent of patients developed neurosensory impairment.

113 were restricted to the participants without neurosensory impairment.

114 They had higher rates of neurosensory impairments (10 percent vs. <1 percent, P<0

115 igher proportion of premature adults without neurosensory impairments identified themselves as nonhet

116 After exclusion of individuals with neurosensory impairments, differences in employment, soc

117 ts pliable, easily mobilized skin, preserves neurosensory innervation, and facilitates early hand mob

118 nt, schooling position, and variation in the neurosensory lateral line.

119 to the retinal pigment epithelium (RPE) and neurosensory layers, such as the ellipsoid zone (EZ), wh

120 aining clones, we found evidence of a shared neurosensory lineage in the middle ear.

121 Here, we provide the neurosensory lineage reconstruction of a complex sensory

122 alysis should be considered in patients with neurosensory macular detachment not attributable to know

123 Seven eyes of 4 patients demonstrated neurosensory macular detachment with treatment-resistant

124 see these patients to be well versed in the neurosensory manifestations so that appropriate diagnosi

125 n acid nociception, but its possible role in neurosensory mechanotransduction is disputed.

126 e techniques provide an opportunity to probe neurosensory mechanotransduction with a defined substrat

127 y uncover profound consequences of microbial neurosensory modulation and the ensuing scratch-induced

128 it also displayed a good ability to predict neurosensory morbidity at 18 to 21 months.

129 e, and a composite outcome of respiratory or neurosensory morbidity or death after discharge.

130 are major marine predators, with integrated neurosensory, muscular and organ systems.

131 partially restored in several children with neurosensory nonsyndromic autosomal recessive deafness 9

132 In response to hypoxic challenge neurosensory odontoblasts express hypoxia-inducible fact

133 mmune barrier function at the expense of the neurosensory organ in chronic inflammation.

134 controlled microcirculation of craniofacial neurosensory organs is an essential evolutionary adaptat

135 in hair cell- and supporting cell-containing neurosensory organs is conserved in the zebrafish, in wh

136 ld influence the development and function in neurosensory organs, and contribute to functional altera

137 in the development and function of ciliated neurosensory organs.

138 data about long-term neurodevelopmental and neurosensory outcomes among the treatment-exposed childr

139 se in the CSF, the tonotopic distribution of neurosensory pathologies in the cochlea, and the long-te

140 nces in the vulnerability of biochemical and neurosensory pathways of the visual signal transduction

141 The relationship between the neurosensory photoreceptors and the adjacent retinal pig

142 ing substitutions points toward selection on neurosensory, physiological, and reproductive genes.

143 ells became concentrated to generate a large neurosensory precursor population.

144 of hair cells, possibly derived from common neurosensory precursors.

145 achable part of the brain' for investigating neurosensory processes.

146 inal cord drives pathological alterations in neurosensory processing and shapes functional outcome ea

147 ATP is involved in neurosensory processing, including nociceptive transduct

148 nt cell types arise from a common sensory or neurosensory progenitor, although little is known about

149 neration of the two cell types from a common neurosensory progenitor.

150 Here, we identified a population of common neurosensory progenitors in the zebrafish inner ear and

151 ed neurotoxicity was low grade and primarily neurosensory rather than neuromotor.

152 The ability of neurosensory release of serotonin to control cellular st

153 link between eosinophil-mediated events and neurosensory responses following exposure to some contac

154 modal reorganization is less detrimental for neurosensory restoration than previously thought.

155 nical tool for an individualized approach to neurosensory restoration with cochlear implants.

156 l implants) has led to remarkable success in neurosensory restoration, particularly in the auditory s

157 loited for improving clinical outcomes after neurosensory restoration.

158 s (440 femtomoles/mg protein), lowest in the neurosensory retina (14 femtomoles/mg protein), and inte

159 ght damage-induced transcript changes within neurosensory retina (NSR) and isolated retinal pigment e

160 tinal peptide (VIP), adult rat RPE cells, or neurosensory retina (NSR) for 5 days.

161 re calculated for segmented features such as neurosensory retina (NSR), drusen, intraretinal fluid (I

162 rsus age-matched controls in RPE/choroid and neurosensory retina (NSR), which corresponded to hyperme

163 This study suggests that rat neurosensory retina (R28) cells are more sensitive than

164 edly upregulated (>20-fold, P < 0.01) in the neurosensory retina 30 minutes postoperatively and maint

165 eneralized recovery with preservation of the neurosensory retina 7 weeks after PDT.

166 etinal laser photocoagulation can damage the neurosensory retina and cause iatrogenic visual impairme

167 s and in mediating communication between the neurosensory retina and choroid.

168 The neurosensory retina and retinal pigment epithelium (RPE)

169 roborated ERalpha staining of a young female neurosensory retina and RPE.

170 tive material (HRM) were present between the neurosensory retina and the Bruch membrane on optical co

171 yer of pigmented cells that lies between the neurosensory retina and the underlying choroid, plays a

172 Destruction of neurosensory retina and visual pathways after accidental

173 ent epithelial (RPE) cells that underlie the neurosensory retina are essential for the maintenance of

174 ented epithelium-choriocapillaris, iris, and neurosensory retina are predominately of the alpha2A sub

175 rodegenerative diseases has emerged with the neurosensory retina as a unique window into deeper brain

176 s characterized by the schitic separation of neurosensory retina between outer plexiform and outer nu

177 ndary that separated persistent HRM from the neurosensory retina continuous with the adjacent retinal

178 gical level, a reduction in thickness of the neurosensory retina due to shortening of the rod outer a

179 g the proteome of the macular and peripheral neurosensory retina during four progressive stages of AM

180 in the macular and peripheral regions of the neurosensory retina from donors at different stages of A

181 occurred in 5 stages: (1) separation of the neurosensory retina from the retinal pigment epithelium

182 roducible stages: stage A, separation of the neurosensory retina from the retinal pigment epithelium

183 enter the subretinal space and separate the neurosensory retina from the RPE.

184 EAMs can transduce and rescue cells from the neurosensory retina in vivo.

185 For example, the architecture of the neurosensory retina is a highly organized structure with

186 isual cycle for cone photopigment within the neurosensory retina may contribute to their favorable co

187 schitic or cavitated lamellar separation of neurosensory retina on spectral-domain optical coherence

188 d in 100% (15/15); 3) initial contact of the neurosensory retina to the retinal pigment epithelium oc

189 redistribution of fluid and approach of the neurosensory retina toward the retinal pigment epitheliu

190 C3 (>5-fold) and CFB (>30-fold) genes in the neurosensory retina was also significantly upregulated (

191 The neurosensory retina was removed from one globe of the pa

192 mRNA and protein were present in the RPE and neurosensory retina whereas the Wilson mRNA and protein

193 ed progression of cystic degeneration of the neurosensory retina within the torpedo lesion.

194 epithelium (RPE) in the treated area, intact neurosensory retina, and reperfusion of the choriocapill

195 cataract, minute crystalline deposits in the neurosensory retina, and retinal detachment.

196 eal contour, separation of the layers of the neurosensory retina, and the absence of full-thickness m

197 Both IP-10 and eotaxin were expressed in the neurosensory retina, but there was no detectable differe

198 tent in retinal pigment epithelium (RPE) and neurosensory retina, including a 95% reduction in retiny

199 Thickness measurements for neurosensory retina, photoreceptor layer (PRL) outer seg

200 s thickness/volume measurements of ICS, ONL, neurosensory retina, pigment epithelial detachments (PED

201 racterized by an elevated lesion beneath the neurosensory retina, resembling an egg yolk.

202 c membranes on the epiretinal surface of the neurosensory retina, resulting in a traction retinal det

203 nd colobomatouslike excavation involving the neurosensory retina, retinal pigment epithelium, and cho

204 Thickness and volume were calculated for neurosensory retina, subretinal fluid (SRF), subretinal

205 delineated by these boundaries included the neurosensory retina, subretinal fluid, subretinal tissue

206 Retinal detachment (RD) occurs when the neurosensory retina, the neurovascular tissue responsibl

207 isease of the retinal pigment epithelium and neurosensory retina, we conducted a genomewide scan in 3

208 etween the posterior surface of the lens and neurosensory retina.

209 phy, with minimal pigment migration into the neurosensory retina.

210 ented epithelium-choriocapillaris, iris, and neurosensory retina.

211 ffect of type 1 CNV on the RPE and overlying neurosensory retina.

212 n techniques, which can damage the overlying neurosensory retina.

213 ween the posterior cortical vitreous and the neurosensory retina.

214 ar region of the retina and splitting of the neurosensory retina.

215 induced by secondary formation of IRC in the neurosensory retina.

216 retinal pigment epithelium and occasionally neurosensory retina.

217 l pigment epithelial cells (ARPE-19) and rat neurosensory retinal cells (R28) were grown in tissue cu

218 Diabetic macular edema (DME) with neurosensory retinal detachment (NSD) remains an importa

219 led clinical findings of bilateral subfoveal neurosensory retinal detachment associated with MEK inhi

220 s (AS) and peau d'orange, as well as a small neurosensory retinal detachment in the macula of OD.

221 mography of the macula illustrated bilateral neurosensory retinal detachment with a thick, highly ref

222 g visits we slowly saw an improvement of the neurosensory retinal detachment.

223 pt the ophthalmologist to consider subfoveal neurosensory retinal detachment.

224 MEK inhibitors developed bilateral subfoveal neurosensory retinal detachment.

225 We report on a series of bilateral subfoveal neurosensory retinal detachments in patients with metast

226 Although neurosensory retinal edema and SRF showed an early reduc

227 Overall neurosensory retinal thickening in eyes with AMD versus

228 The neurosensory sequelae can be difficult to diagnose with

229 city, cerebrovascular injury, neurologic and neurosensory sequelae, and subsequent neoplasms.

230 t risk for both early and late neurologic or neurosensory sequelae.

231 traumatic brain injury with attention to the neurosensory sequelae.

232 modeling approach for statistical control of neurosensory side effects of the electric stimulation.

233 omatin-remodeling complex interacts with the neurosensory-specific transcriptional regulators Eya1/Si

234 evidence for such a response in an elemental neurosensory structure, human dental pulp, following chr

235 igm for understanding angiogenic capacity of neurosensory structures and aberrations of this response

236 inner ear contains minute three-dimensional neurosensory structures that are deeply embedded within

237 Despite extreme plasticity of neurosensory structures, the capacity to reconcile barri

238 laterian orthologues, associate with diverse neurosensory structures.

239 This direct effect of the neurosensory system on keratinocyte nerve growth factor

240 Thus, evidence was found for the neurosensory system providing opportunities and constrai

241 ent development of the plastic trait and the neurosensory system was not achieved until the regular u

242 hared evolutionary homology of teeth and the neurosensory system, and the archival nature of dentine

243 Although, neurosensory systems might have evolved independently in

244 training reduces the impaired performance on neurosensory tests of tactile function that is commonly

245 ade 3/4 diarrhea (11.9% v 5.3%), and grade 3 neurosensory toxicity (18.2% v 0%), but this did not res

246 rrhea, vomiting, and mucositis), and grade 3 neurosensory toxicity 3.9%.

247 Because of the unusual neurosensory toxicity of oxaliplatin, detailed neurologi

248 3 stomatitis were less frequent, and severe neurosensory toxicity was more frequent in those who rec

249 Grade 3 neurosensory toxicity was noted in 8.2% of patients rece

250 with FOLFIRI, and grade 3/4 neutropenia and neurosensory toxicity were more frequent with FOLFOX6.

251 increased hematologic toxicity and decreased neurosensory toxicity.