ライフサイエンスコーパス: neuroticism

1 s identified nine novel loci associated with neuroticism.

2 IL-1ra was identified in females with lower neuroticism.

3 enge increased IL-1beta in females with high neuroticism.

4 This study identifies a novel locus for neuroticism.

5 etic variants explain 15% of the variance in neuroticism.

6 ders that are phenotypically correlated with neuroticism.

7 sm but there is no established connection to neuroticism.

8 nancial risk taking through its influence on neuroticism.

9 eft BA44 reflected individual differences in neuroticism.

10 grees of optimism and extraversion, and less neuroticism.

11 Personality Questionnaire was used to assess neuroticism.

12 lotype or diplotype-predicted expression and neuroticism.

13 in amygdala or subgenual AC activation with neuroticism.

14 appeared when we controlled for the level of neuroticism.

15 tic vulnerability to MD are not reflected in neuroticism.

16 version-extroversion and emotional stability-neuroticism.

17 that contribute to an individual's level of neuroticism.

18 nxiety disorder and the personality trait of neuroticism.

19 ed with depression, alcohol consumption, and neuroticism.

20 hip of panic attacks, cigarette smoking, and neuroticism.

21 o longer evident after analyses adjusted for neuroticism.

22 related traits, including harm avoidance and neuroticism.

23 on and that this association is moderated by neuroticism.

24 ked to an anxiety-related personality trait, Neuroticism.

25 y-and how they contrast with that of general neuroticism.

26 ing that emotional variability is central to neuroticism.

27 riability are thought to reflect the core of neuroticism.

28 associated with these protective aspects of neuroticism.

29 genetic effects on SBP, mood instability and neuroticism.

30 epressive disorder, depressive symptoms, and neuroticism.

31 ce of pleiotropy with cognitive function and neuroticism.

32 D, P < .001), they reported little change on neuroticism (-0.18 SD, P = .08) or extraversion (0.08 SD

33 ticism in 27 cohorts significantly predicted neuroticism (1.09 x 10-12 < P < .05) and MDD (4.02 x 10-

34 childhood sexual abuse, cluster C features, neuroticism, a history of anxiety and eating disorders,

35 Genetic factors shared with neuroticism accounted for between one-third and one-half

36 aits of the five-factor model (extraversion, neuroticism, agreeableness, conscientiousness, and openn

37 oxetine reported 6.8 times as much change on neuroticism and 3.5 times as much change on extraversion

38 t hypotheses in examples of a human GWAS for neuroticism and a joint human-pathogen GWAS for hepatiti

39 An interaction was seen between neuroticism and adversity such that individuals with hig

40 Neuroticism and affective instability manifested varied

41 The findings suggest that neuroticism and affective instability--which are conside

42 constructs related to affective experience: neuroticism and affective instability.

43 s combined with major depression, increasing neuroticism and age, less education, and an interaction

44 ial phobia and agoraphobia, and that between neuroticism and animal phobia was moderate.

45 vided a neural correlate of the link between neuroticism and anxiety and mood disorders.

46 correlations were high and positive between neuroticism and both social phobia and agoraphobia, and

47 ssociation between individual differences in neuroticism and brain activity in response to threat of

48 , and helping to elucidate the links between neuroticism and complex diseases from a genetic perspect

49 s were lower on agreeableness, extraversion, neuroticism and conscientiousness but higher on openness

50 tial genetic correlations were found between neuroticism and depressive symptoms (r g = 0.82, standar

51 tial genetic correlations were found between neuroticism and depressive symptoms (r g = 0.82, standar

52 the models, the genetic correlations between neuroticism and each disorder were high, while individua

53 n, this may account for the relation between neuroticism and emotional variability.

54 Neuroticism and extraversion are personality traits asso

55 The correlation between sensitivity, neuroticism and extraversion was largely explained by sh

56 pleted a self-report questionnaire assessing neuroticism and extroversion in 1972 and 1973 and were p

57 udies suggest that the personality traits of neuroticism and extroversion may be related to the liabi

58 ould confirm the role of the MAGI1 locus for neuroticism and further investigate the association of M

59 Studies examining links between neuroticism and health typically operationalize neurotic

60 eries significantly advance understanding of neuroticism and its association with MDD.

61 Regarding personality factors, high neuroticism and low conscientiousness are most widely as

62 individuals, males, and AAs scored higher on Neuroticism and lower on other personality factors.

63 elative to the depressive characteristics of neuroticism and may constitute vulnerability markers for

64 eling indicated that the association between neuroticism and MD resulted largely from shared genetic

65 ntified a strong genetic correlation between neuroticism and MDD and a less strong but significant ge

66 in phobic twins, was found between levels of neuroticism and mode of acquisition.

67 ), we tested whether the association between neuroticism and negative emotional variability was cloud

68 a medium-sized positive association between neuroticism and negative emotional variability, but, whe

69 Lower neuroticism and neuropsychiatric features, along with hi

70 raits and psychiatric disorders, except that neuroticism and openness to experience were clustered wi

71 s been associated with several dimensions of neuroticism and psychopathology, especially anxiety trai

72 f E effects, we also examined the effects of neuroticism and psychoticism (P) scores.

73 e forward future work on the neurobiology of neuroticism and related phenotypes.

74 loci and identified two loci shared between neuroticism and schizophrenia and six loci shared betwee

75 Controlling for neuroticism and self efficacy, affective disorder histor

76 onal Assessment of Fatigue and indicators of neuroticism and self efficacy.

77 ntal factors shared by the personality trait neuroticism and seven internalizing disorders may help e

78 Stage of cancer, trait extroversion/neuroticism and spiritual support were significantly dif

79 ctors that influence individual variation in neuroticism and those that increase liability across the

80 ctors that influence individual variation in neuroticism and those that increase liability for genera

81 Because women have higher levels of neuroticism and twice the risk of lifetime generalized a

82 m scale described one broad trait of general neuroticism and two special factors, one characterizing

83 Psychosocial adversity interacts both with neuroticism and with sex in the etiology of major depres

84 ment, has examined dimensional traits (e.g., neuroticism) and anxious temperament (e.g., behavioral i

85 aseline depressive symptom score, and higher neuroticism) and during internship (increased work hours

86 ) = 0.36 with bipolar disorder and 0.34 with neuroticism) and negative genetic correlations with meta

87 e 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor g

88 ong genetic correlations between loneliness, neuroticism, and a scale of 'depressive symptoms.' We al

89 ion are female sex, the personality trait of neuroticism, and adversity resulting from exposure to st

90 thods to life satisfaction, positive affect, neuroticism, and depressive symptoms, collectively refer

91 compose the correlations among extraversion, neuroticism, and each phobia.

92 an anxious cluster personality disorder, low neuroticism, and high agreeableness.

93 me harbours significant variants influencing neuroticism, and might prove important for other quantit

94 was at chance level for depression, anxiety, neuroticism, and polygenic scores across traits.

95 lerosis, depression, insomnia, intelligence, neuroticism, and schizophrenia).

96 rsonality dispositions such as extraversion, neuroticism, and self-esteem can markedly influence leve

97 ores for depressive symptoms, schizophrenia, neuroticism, and subjective well-being to address potent

98 rment, and help seeking; (3) lower levels of neuroticism; and (4) an increased risk of MD in cotwins-

99 the genetically related emotional domains of neuroticism, anxiety and depression.

100 contributions to the two special factors of neuroticism-anxiety/tension and worry/vulnerability-and

101 rvation that some responses to threat (i.e., neuroticism/anxiety) are associated with a more left-win

102 nce individual variation in extraversion and neuroticism appear to account entirely for the genetic l

103 The personality domains of extraversion and neuroticism are regarded as being stable individual psyc

104 Two personality traits, extraversion and neuroticism, are strongly associated with emotional expe

105 s facets, each contributing to the effect of neuroticism as a whole.

106 support for a role of either extraversion or neuroticism as determinants of long-term mortality risk.

107 the nervous system (p = 4.29 x 10(-11) with neuroticism), as well as SARM1, which has been previousl

108 gistry, we assessed the personality trait of neuroticism--as an index of phobia-proneness--and the li

109 The identification of nine novel neuroticism-associated loci will drive forward future wo

110 positively with measures of cyclothymia and neuroticism at baseline, but not with measures of depres

111 signatures for developmental trajectories of neuroticism based on a voxel-wise whole-brain structural

112 manifested varied concurrent relations, with neuroticism being strongly related to an anxious, avoida

113 howed that individuals with a higher risk of neuroticism (beta = 1.01; 95% CI, 0.50-1.52) or depressi

114 uals who developed dementia scored higher on neuroticism (beta = 2.83; 95% CI, 1.44 to 4.22; P < .001

115 paired and the Alzheimer disease groups (eg, neuroticism: beta = 0.00; 95% CI, -0.08 to 0.08; P = .91

116 who developed mild cognitive impairment (eg, neuroticism: beta = 0.00; 95% CI, -0.12 to 0.12; P = .98

117 o 0.05; P = .18) and all-cause dementia (eg, neuroticism: beta = 0.02; 95% CI, -0.06 to 0.10; P = .49

118 aist-hip ratio, childhood cognitive ability, neuroticism, bipolar disorder, major depressive disorder

119 three emerging endophenotypes of depression: neuroticism, blunted reward learning, and cognitive cont

120 rences in the common allelic architecture of neuroticism by sex.

121 roticism and health typically operationalize neuroticism by summing the items from a neuroticism scal

122 ing on this and other (eg, personality trait neuroticism) core phenotypes to identify risk loci.

123 Neuroticism correlated positively with amygdala and subg

124 The results revealed that neuroticism correlated positively with the ratings of fe

125 n, emotional stability (i.e., the inverse of neuroticism) correlated with increased activation in the

126 ects of the envirome on lifetime depression: neuroticism, current depressive symptoms, parental depre

127 To determine whether increases in neuroticism, declines in conscientiousness, and changes

128 howed higher levels of the personality trait neuroticism, despite not differing from others with resp

129 Although neuroticism did not positively correlate with any whole-

130 ble personality dimensions, extroversion and neuroticism, differentially influence emotional reactivi

131 a greater impact in women: parental warmth, neuroticism, divorce, social support, and marital satisf

132 ing closely tied to the personality trait of neuroticism, does not fit with the established personali

133 itive correlation between brain activity and neuroticism during anticipation was found in regions ass

134 e regions showed a negative correlation with neuroticism during pain (P < .001).

135 between anorexia nervosa and schizophrenia, neuroticism, educational attainment, and high-density li

136 esources (e.g., a good marriage, a low level neuroticism, enjoyment of vacations, and a capacity for

137 ng of pain in subjects with higher levels of neuroticism, especially the anxiety component of this tr

138 mportant contributors to the model including neuroticism, extraversion, and conscientiousness.

139 g descriptors of personality (agreeableness, neuroticism, extraversion, conscientiousness, and openne

140 of the "Big Five" personality factors (i.e., neuroticism, extraversion, openness to experience, agree

141 the personality factors termed the "big 5" (neuroticism, extraversion, openness to experience, agree

142 The Big Five personality traits neuroticism, extraversion, openness, agreeableness and c

143 acets, 6 for each of the 5 major dimensions: neuroticism, extraversion, openness, agreeableness, and

144 st), and personality traits (measured by the Neuroticism-Extraversion-Openness Personality Inventory)

145 st), and personality traits (measured by the Neuroticism-Extraversion-Openness Personality Inventory)

146 inistered the Beck Depression Inventory, the Neuroticism-Extraversion-Openness Personality Inventory,

147 was administered consisting of the NEO-FFI (Neuroticism-Extroversion-Openness-Five Factor Inventory)

148 x model for prediction of depressive onsets, neuroticism, female sex, and greater adversity all stron

149 le in those vulnerable for depression due to neuroticism, genetic risk, or previous depressive illnes

150 who were divided into High (HN) and Low (LN) Neuroticism groups.

151 Neuroticism h(2) significantly increased by 20.23% after

152 Genome-wide association studies (GWAS) of neuroticism have identified up to 11 associated genetic

153 (hypothesis-driven scales) of perfectionism, neuroticism, highly sensitive person, ego resiliency, ne

154 contagion is related to trait differences in neuroticism (i.e., the tendency to experience negative e

155 Sex and neuroticism impacted IL-1 family cytokines; higher basel

156 lygenic scores based on the meta-analysis of neuroticism in 27 cohorts significantly predicted neurot

157 significant independent loci from a GWAS of neuroticism in 329,821 UK Biobank participants; 15 of th

158 ion, using the personality phenotype of high neuroticism in a double-blind, between-groups design.

159 rkers were tested for their association with neuroticism in a genomewide association study (GWAS).

160 gdala and subgenual AC associated with trait neuroticism in a nonclinical sample of 36 volunteers dur

161 have successfully been associated with trait neuroticism in genome-wide analysis of adequately powere

162 stimuli are correlated with extraversion and neuroticism in healthy women.

163 At the same time, the role of neuroticism in later-life depression warrants further st

164 of both introversion (low extraversion) and neuroticism in some psychiatric disorders.

165 captured approximately 1% of the variance in neuroticism in the GS:SFHS and QIMR samples, although mo

166 d with those that influence extraversion and neuroticism; in contrast, only a small proportion of the

167 ve symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms.

168 In addition, the authors could identify a neuroticism-independent genetic factor that significantl

169 Neuroticism independently predicted the co-occurrence of

170 jor personality dimensions (extraversion and neuroticism) index the genetic and environmental risk fo

171 This association arises largely because neuroticism indexes the genetic risk for depressive illn

172 nutritional status) decreases with a woman's neuroticism, indicating a reproductive trade-off between

173 mplitude was greater in patients with higher neuroticism, indicating that error processing is moderat

174 ll participants were assessed using the same neuroticism instrument, the Eysenck Personality Question

175 ons between generalized anxiety disorder and neuroticism into genetic and environmental components, i

176 of certain personality traits, particularly neuroticism, introversion, and interpersonal dependency.

177 Neuroticism involves a tendency for enhanced emotional a

178 High neuroticism is a personality risk factor that reflects m

179 Neuroticism is a personality trait of fundamental import

180 Neuroticism is a pervasive risk factor for psychiatric c

181 Neuroticism is a relatively stable personality trait cha

182 anxiety and mood disorders, for which trait neuroticism is a risk factor.

183 Neuroticism is a trait that reflects a tendency toward n

184 study provides novel data suggesting higher neuroticism is associated with engagement of brain regio

185 Increased neuroticism is associated with poorer mental and physica

186 we show that, whereas the polygenic load for neuroticism is associated with the genetic risk of coron

187 Although neuroticism is heritable, attempts to identify the allel

188 In addition, the study shows that neuroticism is influenced by many genetic variants of sm

189 However, neuroticism is made up of multiple heterogeneous facets,

190 Neuroticism is one of the major traits describing human

191 As neuroticism is positively associated with mean levels of

192 expression is correlated with trait anxiety (neuroticism) is not replicated in a data set consisting

193 ness is achieved by women at an intermediate neuroticism level.

194 nts have been associated with depression and neuroticism, likely because of limitations on sample siz

195 hough individuals who were higher on general neuroticism lived shorter lives, individuals whose neuro

196 lored depressive symptoms, bipolar disorder, neuroticism, loneliness, and mental health-related socio

197 w perceived social support, followed by high neuroticism, low treatment expectancy, and low perceptio

198 l relation between emotional variability and neuroticism may be partially the result of a measurement

199 arette smoking but provide new evidence that neuroticism may play an essential role in this relations

200 preliminary but, if replicated, suggest that neuroticism may reflect a shared vulnerability for the c

201 The coheritability between loneliness and neuroticism may reflect the role of negative affectivity

202 Neuroticism measured about 3 decades before the diagnost

203 Anxiety and neuroticism measures were completed by 385 monozygotic a

204 eralised anxiety disorder, bipolar disorder, neuroticism, mood instability and risk-taking behaviour.

205 gnificantly (p < 1 x 10(-5)) associated with neuroticism, mood instability and risk-taking respective

206 420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911).

207 A PRS based on a GWAS of neuroticism (n = 390,278) was positively associated with

208 dimensions: Extraversion (E), Openness (O), Neuroticism (N), and Agreeableness (A).

209 uroticism that reflected the anxious form of neuroticism (N1) explained a greater proportion of varia

210 ticism that reflected the depressive form of neuroticism (N3).

211 In PREVENT-AD, lower neuroticism, neuropsychiatric burden, and higher educati

212 Moreover, neither neuroticism nor extraversion was shown to have a moderat

213 polymorphism-based heritability estimate for neuroticism of approximately 15% (s.e.=0.7%).

214 known to influence the experience of pain is neuroticism, of which little is known about in visceral

215 The impact of neuroticism on illness risk is greater at high than at l

216 ism scores (range, 0-22) but no influence of neuroticism on skin conductance level and pain tolerance

217 Significant association was found with neuroticism on the X chromosome for 204 markers found wi

218 o moderate its correlation with openness and neuroticism (OR = 1.39, 95%CI = 1.18-1.63, p = 7.64e-04

219 9), somatization (OR, 4.1; 95% CI, 2.7-6.0), neuroticism (OR, 3.3; 95% CI, 1.6-6.5), and clinical ind

220 life stress, social status, social support, neuroticism, or sleep disturbance.

221 itary gland was associated with the slope of neuroticism over time.

222 I data at age 14 years, predicting change in neuroticism over time.

223 significant after controlling for change in neuroticism (P = .46) or extraversion (P = .14).

224 .04]), personality (extroversion [P = .03], neuroticism [P = .01]), pruritus characteristics (severi

225 fter controlling for depression improvement (neuroticism, P < .001; extraversion, P = .002).

226 logical pathways are linked to each of these neuroticism phenotypes.

227 ed to consolidation of fear associations and neuroticism points to underlying mechanisms of the enhan

228 In women, neuroticism positively predicts the number of children,

229 Prospectively, neuroticism predicted later symptoms, occupational impai

230 300) did not predict significant variance in neuroticism, psychological distress, or depressive disor

231 ur aim was to study the relationship between neuroticism, psychophysiologic response, and brain proce

232 cant common variant overlaps between RLS and neuroticism (r(g) = 0.40, se = 0.08, p value = 5.4 x 10(

233 ety (r(g)=0.75), depression (r(g)=0.81), and neuroticism (r(g)=0.75).

234 blood pressure, cholesterol, hostility, and neuroticism (rate ratio=0.76, p=0.002).

235 Neuroticism reduction during treatment predicted lower r

236 Neuroticism reflects emotional instability, and is relat

237 Most of the lead neuroticism-related X chromosome variants were located i

238 majority of genetic variants associated with neuroticism remain unclear.

239 result of a measurement artifact reflecting neuroticism's relation with higher mean levels-rather th

240 A recent study showed that a 12-item neuroticism scale described one broad trait of general n

241 Questionnaire-Revised (EPQ-R-S) Short Form's Neuroticism scale.

242 lize neuroticism by summing the items from a neuroticism scale.

243 bipolar disorder, major depressive disorder, neuroticism, schizophrenia and verbal-numerical reasonin

244 There was a wide spread of neuroticism scores (range, 0-22) but no influence of neu

245 Neuroticism scores harmonized across all 29 discovery co

246 was compared in volunteers with high vs low neuroticism scores on the Eysenck Personality Questionna

247 diagnoses had effects on harm avoidance and neuroticism scores, there was no main effect of genotype

248 group, and genotype with harm avoidance and neuroticism scores.

249 th most of these participants also reporting neuroticism scores.

250 trait level, G carriers reported higher NEO-Neuroticism scores; a personality trait previously assoc

251 ldhood parental loss), 2) early adolescence (neuroticism, self-esteem, and early-onset anxiety and co

252 terviews on the basis of previously assessed neuroticism, sex, and adversity during the past year; ad

253 e addition of terms for depressive symptoms, neuroticism, social network size, and number of chronic

254 Levels of neuroticism strongly predicted the risks for both lifeti

255 genetic analyses support the hypothesis that neuroticism strongly reflects the liability to MD.

256 s of genome-wide association study (GWAS) of neuroticism that includes 91 370 participants from the U

257 a maladaptive mechanism in those with higher neuroticism that promotes overarousal during anticipatio

258 The subscale of neuroticism that reflected the anxious form of neurotici

259 n the observed clusters than the subscale of neuroticism that reflected the depressive form of neurot

260 For both anxiety and neuroticism, the models provide support for significant

261 Higher scores on the personality trait of neuroticism, the tendency to experience negative emotion

262 uding addictive behavior, schizophrenia, and neuroticism, thus suggesting a mechanistic link between

263 ess, and openness to more engagement coping; neuroticism to more disengagement coping; and optimism,

264 measures assessing anxiety proneness (e.g., neuroticism, trait anxiety, and anxiety sensitivity) wer

265 ores for related phenotypes and 13 different neuroticism traits and schizophrenia.

266 likely to be female, and had lower levels of neuroticism, treatment-seeking, and guilt and higher lev

267 nsional measures of depression, anxiety, and neuroticism using functional magnetic resonance imaging-

268 performed on G and the personality scale of neuroticism using the regression-based linkage program M

269 le nucleotide polymorphisms (SNPs) and trait neuroticism using UK Biobank samples (N = 405,274).

270 s perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecu

271 d cigarette smoking and to determine whether neuroticism was an independent predictor of the co-occur

272 The effect of neuroticism was assessed using correlation analysis.

273 for depressive symptoms, schizophrenia, and neuroticism was associated with 6%, 5%, and 6% increase

274 This indicated that neuroticism was associated with experiencing more intens

275 Neuroticism was associated with increased resting gamma

276 Prospectively assessed neuroticism was associated with the subsequent developme

277 icism lived shorter lives, individuals whose neuroticism was characterized by worry and vulnerability

278 tive stimuli in localized brain regions, and neuroticism was correlated with brain reactivity to nega

279 ion between generalized anxiety disorder and neuroticism was estimated at 0.20 for both genders.

280 X-variant heritability of neuroticism was estimated at 0.22% (SE = 0.05) from a fu

281 rsonality Questionnaire in all subjects, and neuroticism was measured by the NEO Five-Factor Inventor

282 an placebo (P </= .01); but its advantage on neuroticism was no longer significant after controlling

283 atios for the 75th versus 25th percentile of neuroticism were 1.38 (95% CI: 1.10, 1.73) and 0.63 (95%

284 Lifetime generalized anxiety disorder and neuroticism were assessed in more than 8,000 twins from

285 obia, animal phobia, situational phobia, and neuroticism were assessed in over 9,000 twins from male-

286 on (CS+/- differentiation), higher levels of neuroticism were associated with a stronger interaction

287 nd adversity such that individuals with high neuroticism were at greater overall risk for major depre

288 s for plasma cortisol, major depression, and neuroticism were calculated using data from large genome

289 ons between generalized anxiety disorder and neuroticism were estimated at 0.80 (95% confidence inter

290 ons between generalized anxiety disorder and neuroticism were high and differed (nonsignificantly) be

291 Medical burden and neuroticism were independently associated with major dep

292 identified within a UK Biobank-only GWAS of neuroticism were not independently replicated within the

293 uring which their levels of extraversion and neuroticism were quantified.

294 In Study 2, volunteers with high neuroticism were randomized in a double-blind design to

295 More income and less neuroticism were related to reduced manifestation of gen

296 Stressful early family environments and neuroticism were significantly associated with shorter p

297 dependent associations of medical burden and neuroticism with depression in a group of 196 subjects,

298 d with extraversion-introversion and grouped neuroticism with internalizing psychopathology (e.g., de

299 Especially neuroticism with its link to the development of psychopa

300 with variants in WSCD2 and near PCDH15, and neuroticism with variants on chromosome 8p23.1 and in L3