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1 5 member 46 (Slc25a46) and treated them with neurotrophic AAV-PHP.B vector carrying the mouse Slc25a4
3 N365 and N486/489 residues and abolishes its neurotrophic activity, decreasing p-APP Y687 and alterin
4 an anti-inflammatory agent (minocycline), a neurotrophic agent (LM11A-31), and physical therapy cons
7 d are also being engineered with angiogenic, neurotrophic and anti-inflammatory molecules to accelera
8 chical clustering according to expression of neurotrophic and axon guidance genes also separated canc
9 GF2 and other FGF family members, as well as neurotrophic and differentiation factors, on mouse embry
10 erived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associ
12 inflammatory, and trophic factors along with neurotrophic and neurogenesis factors were detected; the
14 oid precursor protein-alpha (sAPPalpha) is a neurotrophic and neuroprotective protein that can promot
17 a role for macrophage-derived IGF-1 as a key neurotrophic and sensitizing factor in endometriosis, an
18 t physiological barrier and produces CSF and neurotrophic, angiogenic, and inflammatory factors invol
19 es of the dopaminergic (COMT, ANKK1) and the neurotrophic (BDNF, NGFR) system, associations with the
21 We showed previously that the angiogenic and neurotrophic cytokine, vascular endothelial growth facto
22 the early stages of PD facilitates critical neurotrophic delivery that can curb the rapid progressio
23 Furthermore, risperidone treatment had a neurotrophic effect on the PFC and antioxidant effects o
25 n regulates energy balance and also exhibits neurotrophic effects during critical developmental perio
28 ymorphism in the gene encoding brain-derived neurotrophic factor (BDNF(Val66Met)) is associated with
29 L-10, and its receptor, CXCR3, brain-derived neurotrophic factor (BDNF) and a receptor tyrosine-prote
30 ivity-induced genes, including brain-derived neurotrophic factor (Bdnf) and activity-regulated cytosk
31 d in potentiated expression of brain-derived neurotrophic factor (BDNF) and memory following HDAC inh
32 Neurotrophins particularly brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF)
33 dent structural plasticity via brain-derived neurotrophic factor (BDNF) and protein neo-synthesis.
34 A parallel downregulation of brain-derived neurotrophic factor (BDNF) and somatostatin (SST), a mar
35 sma corticosterone, as well as brain-derived neurotrophic factor (BDNF) and total percent DNA methyla
36 the BNST (ovBNST), is rich in brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kina
37 in asthmatic airways driven by brain-derived neurotrophic factor (BDNF) and Tropomyosin receptor kina
38 5-hydroxytryptamine, 5-HT) and brain-derived neurotrophic factor (BDNF) are two signaling molecules t
39 nscriptome analysis identified brain-derived neurotrophic factor (Bdnf) as a STAT3 target gene with n
40 pendent effects on hippocampal brain-derived neurotrophic factor (BDNF) BDNF-IX, BDNF-IV and BDNF-I t
44 hese neurons, we observed that brain-derived neurotrophic factor (BDNF) enhances co-localization of d
45 myostatin (3-fold) and lowered brain-derived neurotrophic factor (BDNF) expression (0.6-fold) in the
46 ks, is necessary for enhancing brain-derived neurotrophic factor (BDNF) expression and improved memor
47 urthermore, while sustained PL brain-derived neurotrophic factor (BDNF) expression is required for me
48 revealed a correlation between brain-derived neurotrophic factor (BDNF) expression, nerve density, an
50 Circulating concentrations of brain-derived neurotrophic factor (BDNF) have been linked to cancer, n
51 hanced by IN + FUS delivery of brain-derived neurotrophic factor (BDNF) in a toxin-based PD mouse mod
52 g E2-dependent upregulation of brain-derived neurotrophic factor (BDNF) in astrocytes, and subsequent
53 trograde axonal trafficking of brain-derived neurotrophic factor (BDNF) in DIV7 cultures of E18 corti
54 he glutamate AMPA receptor and brain-derived neurotrophic factor (BDNF) in the antidepressant-like ef
55 Results Protein expressions of brain-derived neurotrophic factor (BDNF) in the BCCAO rats treated wit
56 vated microglia and less total brain-derived neurotrophic factor (BDNF) in the cortex and/or hippocam
57 was to investigate the role of brain-derived neurotrophic factor (BDNF) in the regenerative ability o
58 idepressant response including brain-derived neurotrophic factor (BDNF) induction and increased phosp
64 es suggest that dysfunction of brain-derived neurotrophic factor (BDNF) is a possible contributor to
68 olymorphism (SNP) in precursor brain-derived neurotrophic factor (BDNF) is one of the earliest SNPs t
71 atment significantly increased brain-derived neurotrophic factor (BDNF) level and subventricular zone
72 he following: (1) enhances the brain-derived neurotrophic factor (BDNF) level in the brain; (2) reduc
73 This study addressed whether brain-derived neurotrophic factor (BDNF) mediates a transsynaptic effe
74 ecent studies demonstrate that brain-derived neurotrophic factor (BDNF) might be associated with nico
75 for cognitive flexibility and brain-derived neurotrophic factor (BDNF) modulates glutamate plasticit
76 in normal mice and reduced in brain-derived neurotrophic factor (BDNF) mutants, which are severely o
77 nscriptional activation at the brain-derived neurotrophic factor (Bdnf) P4 promoter, which is require
80 annabinoid receptor type 1 and brain-derived neurotrophic factor (BDNF) protein levels were measured.
81 essant ketamine: activation of brain-derived neurotrophic factor (BDNF) receptor TrkB, facilitation o
82 caused by upregulation of the brain-derived neurotrophic factor (BDNF) receptor trkB.T1, a truncated
83 hanism involving activation of brain-derived neurotrophic factor (BDNF) signaling and induction of LT
84 is mediated by upregulation of brain-derived neurotrophic factor (BDNF) signaling and that NV-5138 tr
85 ess (CSDS) in mice showed that brain-derived neurotrophic factor (BDNF) signaling in the mesolimbic d
87 enetic evidence indicates that brain-derived neurotrophic factor (BDNF) signaling through the TrkB re
91 evealed that the gene encoding brain-derived neurotrophic factor (BDNF) was associated with ADHD at B
93 eptor (LepRb) colocalizes with brain-derived neurotrophic factor (BDNF), a key player in the pathophy
94 mammary gland is controlled by brain-derived neurotrophic factor (BDNF), and sexually dimorphic seque
95 in-1, postsynaptic density 95, brain derived neurotrophic factor (BDNF), and stromal cell-derived fac
96 that neurotrophins, including brain-derived neurotrophic factor (BDNF), are severely affected in Alz
97 hrough increasing the level of brain-derived neurotrophic factor (BDNF), but the underlying mechanism
98 ly: nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and ne
99 rs; nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and g
100 facilitated its activation by brain-derived neurotrophic factor (BDNF), observed as levels of phosph
101 of neurotrophins, particularly brain-derived neurotrophic factor (BDNF), on airway contractility [ vi
102 ed the axon guidance molecule, brain-derived neurotrophic factor (BDNF), selectively at the location
103 ted protein kinase 1 (MSK1), a brain-derived neurotrophic factor (BDNF)-activated enzyme downstream o
104 t deletion of the neurotrophin brain-derived neurotrophic factor (BDNF)-dependent GR-phosphorylation
105 component aggrecan attenuates brain-derived neurotrophic factor (BDNF)-induced pTRKB in cortical neu
110 TP) that requires postsynaptic brain-derived neurotrophic factor (BDNF)/TrkB and presynaptic cyclic A
111 c plasticity markers including brain derived neurotrophic factor (BNDF) and phosphorylated CREB, both
116 We previously demonstrated that ciliary neurotrophic factor (CNTF) promotes process outgrowth fr
117 to early postnatal treatment with a ciliary neurotrophic factor (CNTF) small-molecule peptide mimeti
118 s of hepatocyte growth factor (HGF), ciliary neurotrophic factor (CNTF), and Artemin through specific
119 , including oncostatin (OSM), IL-11, ciliary neurotrophic factor (CNTF), and leukemia inhibitor facto
120 tor, fibroblast growth factor-2, and ciliary neurotrophic factor (CNTF), and the implantation of eMSC
121 its OPC proliferation by stimulating ciliary neurotrophic factor (CNTF)-mediated signaling through re
122 sion and function of glial cell line-derived neurotrophic factor (GDNF) and its receptor tyrosine kin
125 roach for delivering glial cell line-derived neurotrophic factor (GDNF) directly to the hippocampus o
126 apeutic potential of glial cell line-derived neurotrophic factor (GDNF) has been studied extensively
127 reased expression of glial cell line-derived neurotrophic factor (GDNF) in injured muscle and increas
128 gated the effects of glial cell line-derived neurotrophic factor (GDNF) in Parkinson's disease, using
129 iphasic function for glial cell line-derived neurotrophic factor (GDNF) in the development and subseq
130 whether administration of glial cell derived neurotrophic factor (GDNF) induces enteric nervous syste
133 We had previously found that glial derived neurotrophic factor (GDNF) is reduced in SMA astrocytes.
134 The effects of neither glial cell-derived neurotrophic factor (GDNF) nor serotonin are additive wi
135 s have reported that glial cell line-derived neurotrophic factor (GDNF) promotes IEB function, the me
136 Delivery of ectopic glial cell line-derived neurotrophic factor (GDNF) promotes the function, plasti
137 d ex vivo to produce glial cell line-derived neurotrophic factor (GDNF) readily migrate to the mouse
138 binding neuropeptide glial-cell-line-derived neurotrophic factor (GDNF) to increase cocaine intake wa
139 raocular muscle with glial cell line-derived neurotrophic factor (GDNF) to produce a strabismus in in
140 rophin-3 (NT-3), and glial cell line-derived neurotrophic factor (GDNF) were analysed by specific enz
142 cs to CNS, including glial cell line-derived neurotrophic factor (GDNF), and produce potent effects i
143 raspinally expressed glial cell line-derived neurotrophic factor (GDNF), but not the removal of chond
144 covered that mesencephalic astrocyte-derived neurotrophic factor (MANF) can revert defective RyR2-ind
145 much of the mesencephalic astrocyte-derived neurotrophic factor (MANF) is retained in the endoplasmi
146 then induces mesencephalic astrocyte-derived neurotrophic factor (MANF), an ER-resident protein with
147 tions in L1, where VM engages neuron-derived neurotrophic factor (NDNF+) cells in L1a and MD drives v
148 eopontin, chemokine ligand 23, brain derived neurotrophic factor and C-reactive protein (CRP) were fu
149 e fragments directly sequester brain-derived neurotrophic factor and impair hippocampal long-term pot
150 RET ligand/coreceptor complex, glial-derived neurotrophic factor and its coreceptor, exhibit improved
151 al signaling proteins, such as brain-derived neurotrophic factor and its downstream targets vs. contr
152 reted higher concentrations of brain-derived neurotrophic factor and nerve growth factor than NCSC-SC
153 neurotrophic factor, and glial cell-derived neurotrophic factor and release axon-guidance molecules
156 ons that were maintained under subsaturating neurotrophic factor conditions operates under cholinergi
158 stressed rats, the decline in brain-derived neurotrophic factor expression in the hippocampus and sh
159 pisodic memory and reduced HPC brain-derived neurotrophic factor expression, but did not affect anxie
160 dent of a coreceptor glial cell line-derived neurotrophic factor family receptor alpha, which is requ
161 onse cytokine of the glial cell line-derived neurotrophic factor family within the TGF-beta superfami
162 nucleotide polymorphism of the brain-derived neurotrophic factor gene (BDNF Val66Met), in a way that
163 ctor, myelin protein zero, and brain derived neurotrophic factor in a 4AP dose dependent manner.
164 urogenesis; the measurement of brain derived neurotrophic factor in plasma is a distal proxy and furt
165 Hg increased the expression of brain-derived neurotrophic factor in the IC, suggesting that astrocyti
167 IC, suggesting that astrocytic brain-derived neurotrophic factor is a potent protectant in the IC.
168 s for cardiotrophin-like cytokine (CLCF1), a neurotrophic factor known to modulate B and myeloid cell
169 blot analysis revealed significantly altered neurotrophic factor levels in diabetic rat corneas, whic
171 scriptional targets downstream of long-range neurotrophic factor ligand/receptor signaling that promo
174 disruption of the prototypic target-derived neurotrophic factor NGF leads to aberrant subtype-restri
175 several key components of the brain derived neurotrophic factor pathway that were marked by m6A.
176 ophin-like cytokine factor 1 (CLCF1)-ciliary neurotrophic factor receptor (CNTFR) signaling axis in l
177 lso found that death receptor 6, but not p75 neurotrophic factor receptor, is required for transition
179 This calcium flux is accompanied by p75 neurotrophic factor receptor-Rho-actin-dependent expansi
180 axon in response to trophic withdrawal, p75 neurotrophic factor receptor-RhoA signaling governs the
181 hat ShcD binds to active Ret, TrkA, and TrkB neurotrophic factor receptors predominantly via its phos
182 a show that activity-dependent brain-derived neurotrophic factor release from molecularly distinct vH
185 transcription associated with brain-derived neurotrophic factor signaling within vHC-PrL projectors
186 mechanisms including increased brain-derived neurotrophic factor signaling, increased synthesis of sy
190 ing hypothalamic insulin signaling.MANF is a neurotrophic factor that is secreted but also mediates t
191 target because it is a relatively unexplored neurotrophic factor that modulates intracellular neuropl
192 nd survival.SIGNIFICANCE STATEMENT BDNF is a neurotrophic factor that regulates plastic changes in th
193 take and has recently been shown to act as a neurotrophic factor to control the development of area p
194 vel of antioxidant markers and brain-derived neurotrophic factor were altered in PINK1-KO-PBMCs and b
195 Rat models of brain metastasis and ciliary neurotrophic factor were used to induce astrocyte reacti
196 decarboxylase 67, Reelin, and brain-derived neurotrophic factor), leading to their hypermethylation,
197 protein analyses of glial cell-line-derived neurotrophic factor, a crucial factor in ureteric bud br
198 atural growth factor glial cell line-derived neurotrophic factor, and are selective for cells express
199 s such as nerve growth factor, brain-derived neurotrophic factor, and glial cell-derived neurotrophic
200 in-related kinase B, binds the brain-derived neurotrophic factor, and has been shown to play an impor
202 othelial growth factor (VEGF), brain-derived neurotrophic factor, fibroblast growth factor-2, and cil
203 ne1/PAI-1) and growth factors (brain-derived neurotrophic factor, fibroblast growth factors, platelet
204 ved in proneuropeptide processing, is also a neurotrophic factor, named neurotrophic factor-alpha1 (N
205 g, transcriptional regulation, brain-derived neurotrophic factor, nitric oxide, renin-angiotensin).
206 phosphorylated at Thr286, and brain-derived neurotrophic factor, suggesting a role for Abeta in syna
209 essing, is also a neurotrophic factor, named neurotrophic factor-alpha1 (NF-alpha1) and has important
210 ovel N-terminal-truncated carboxypeptidase E/neurotrophic factor-alphal variants in embryonic mouse b
211 ong-term potentiation (LTP), a brain-derived neurotrophic factor-mediated (BDNF-mediated) process res
212 , mutant mice display impaired brain-derived neurotrophic factor-tropomyosin receptor kinase B-depend
213 approaches to test the role of brain-derived neurotrophic factor-tropomyosin-related kinase B (BDNF-T
217 promising tools to investigate brain-derived neurotrophic factor/TrkB signaling with tight spatial an
218 ed regulation of AKT activity emanating from neurotrophic-factor stimulation and endogenous DNA damag
219 c factors, nor intravenous administration of neurotrophic factors (either through protein or gene del
220 on relationship studies on this new class of neurotrophic factors and also assist in evaluation of th
222 exert neuroprotection through the release of neurotrophic factors and clearance of neurotoxic glutama
223 separated signals initiated by extracellular neurotrophic factors and nuclear DNA damage are integrat
224 hysical exercise increases the expression of neurotrophic factors and stimulates neuronal growth, res
227 s than neurons or astrocytes and that CSPG4E neurotrophic factors are diminished early in AD, with no
228 ramework for the combined therapeutic use of neurotrophic factors in degenerative motor neuron diseas
229 sexual divergence involves higher secretion neurotrophic factors in tears, which in turn modulate ge
230 ving DPCs could increase the availability of neurotrophic factors in the lesion site, thereby promoti
232 at depended on muscle type, a combination of neurotrophic factors may optimally rescue neuromuscular
234 this, we here screened 66 combinations of 12 neurotrophic factors on pure, highly viable, and standar
235 This approach can be generalized to other neurotrophic factors or molecules that act in a paracrin
238 G4 cells export in exosomes higher levels of neurotrophic factors than neurons or astrocytes and that
239 critical in upregulating gene expression of neurotrophic factors that are important in regulating ce
240 ;C* brain also led to enhanced expression of neurotrophic factors that have roles in neuronal surviva
241 ervous system, they function proximal to the neurotrophic factors that regulate cell survival, differ
242 meostasis, whereas target cells also produce neurotrophic factors to promote sympathetic innervation(
245 ation, such as firing activity or release of neurotrophic factors were shown to be required for the g
246 s that dental pulp stem cells (DPSC) secrete neurotrophic factors which play an important role in neu
248 ytokines on monoaminergic neurotransmission, neurotrophic factors, and measures of synaptic plasticit
249 d their ability to produce astrocyte-derived neurotrophic factors, BDNF and IGF-1, and the glutamate
250 bust downregulation of the astrocyte-derived neurotrophic factors, BDNF and IGF-1, as well as the ast
251 permissive, all-in-one niche which provides neurotrophic factors, extracellular matrix molecules, ce
252 e striatum and the ventral midbrain, without neurotrophic factors, nor intravenous administration of
253 by producing antiinflammatory cytokines and neurotrophic factors, support myelin production, and rem
258 ected from 72 h serum-free DPSC cultures and neurotrophic factors; nerve growth factor (NGF), brain-d
260 strocytes less effective in supporting these neurotrophic functions than those with APOE epsilon3/eps
261 e of GM1 is the bioactive portion of GM1 for neurotrophic functions, we investigated its therapeutic
262 n biochemical factors, such as brain derived neurotrophic growth factor (BDNF), vascular endothelial
263 dditionally, PEA-OXA administration enhanced neurotrophic growth factor release and decreased the ast
265 ngs included vitreous amyloid (26/26, 100%), neurotrophic keratitis (2/26, 8%), glaucoma (5/26, 19%),
266 her rates of corneal healing than vehicle in neurotrophic keratopathy associated with nonhealing corn
267 The primary end point was healing of the neurotrophic lesion (persistent epithelial defect or cor
270 research has shown that cancer cells express neurotrophic markers such as nerve growth factor, brain-
271 nal performance, cognition, inflammatory and neurotrophic markers, blood pressure, and lipid concentr
272 de novo synthesized source of high levels of neurotrophic molecules from human clonal ARPE-19 cells e
276 Overall, our study shows that AAV-PHP.B's neurotrophic properties are plausible for treating condi
277 sely, the combination of FUS and intravenous neurotrophic (protein or gene) delivery attenuates the d
280 ing receptors for nerve growth factor (NGF): neurotrophic receptor tyrosine kinase 1 and nerve growth
281 PLD4 binds three proteins that interact with neurotrophic receptor tyrosine kinase 1, a receptor also
283 O-Debenzoyltashironin (1) is a member of the neurotrophic sesquiterpenes, trace plant metabolites tha
284 a gap in a comparison set of convulsive and neurotrophic sesquiterpenes, which we hypothesized to sh
285 ressing the potential interplay between GDNF neurotrophic signaling and transcriptional regulation in
286 es provide a platform for the integration of neurotrophic signaling from the plasma membrane to the n
288 neural stem cell (NSC) therapies to provide neurotrophic support and inhibit detrimental host immune
289 ndings provide novel evidence that providing neurotrophic support during early brain development can
290 eneration and promotes Schwann-cell-mediated neurotrophic support in models of peripheral neuropathie
291 taste cell renewal on gustatory innervation, neurotrophic support of taste buds likely involves a com
292 l microglia, can provide photoreceptors with neurotrophic support or exacerbate neuroinflammation and
293 related pathological mechanism linking local neurotrophic support, pyramidal cell structure, dendriti
295 nd molecular systems, suggest involvement of neurotrophic systems, which point to the importance of n
296 nset, such as astrogliosis, as regulators of neurotrophic therapy in AD.SIGNIFICANCE STATEMENT Recent
297 oping optogenetic platforms to control three neurotrophic tropomyosin receptor kinases, TrkA, TrkB, a
299 have uncovered novel gene fusions involving neurotrophic tyrosine receptor kinases (NTRKs) in glioma