ライフサイエンスコーパス: neurotrophin

1 -term enhancement of presynaptic function by neurotrophin.

2 ear factor-kappaB (NF-kappaB) pathway by the neurotrophins.

3 DCVs for future release of neuropeptides and neurotrophins.

4 ithelia are the key endogenous source of the neurotrophins.

5 s to release anti-inflammatory cytokines and neurotrophins.

6 a orthologue of BDNF is the highly conserved Neurotrophin 1 (DNT1).

7 ), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), is impli

8 ), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4).

9 ey also express neurotrophins NGF, BDNF, and neurotrophin 3 (NT3).

10 (NGF, brain-derived neurotrophic factor, and neurotrophin 3) and secrete NGF.

11 ons of brain-derived neurotrophic factor and neurotrophin 3, which stimulated neurite outgrowth from

12 Neurotrophin-3 (NT-3) and its high-affinity receptor Trk

13 ent receptor potential channel M5 (TrpM5) or neurotrophin-3 (NT-3) project to defined clusters of glo

14 ously reported that retrogradely transported neurotrophin-3 (NT-3) to lumbar MNs attenuated SCI-induc

15 in noise-exposed mice that local delivery of neurotrophin-3 (NT-3) to the round window niche, 24 hour

16 ), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and glial cell line-derived neuro

17 IYIY-I2-BODIPY binds TrkC similar to neurotrophin-3 (NT-3), and NT-3 has been reported to mod

18 ntitative PCR (qPCR) to assay NTF expression-neurotrophin-3 (NT-3), BDNF, GDNF, neurturin, artemin, a

19 nar release of nerve growth factor (NGF) and neurotrophin-3 (NT-3), respectively.

20 signals in response to two ligands, NGF and neurotrophin-3 (NT-3), with very different functional co

21 in resting membrane potential (RMP) or added neurotrophin-3 (NT-3).

22 es of podocytes treated with the TrkC ligand neurotrophin-3 (Nt-3).

23 Neurotrophin-3 (NT3) plays a key role in the development

24 We show here that intramuscular delivery of neurotrophin-3 (NT3, encoded by NTF3) can induce sensori

25 Neurotrophin-3 (Ntf3) and brain derived neurotrophic fac

26 Neurotrophin-3 also enhanced locomotor recovery.

27 Our findings pave the way for Neurotrophin-3 as a therapy that treats the underlying c

28 associated viral vector (AAV) encoding human Neurotrophin-3 at a clinically-feasible time-point after

29 The time constant for clearance of neurotrophin-3 from cochlear tissues was 38 h but neurot

30 We verified the sustained release of neurotrophin-3 from peptide-conjugated PEG hydrogels res

31 Based on the results, we overexpressed the neurotrophin-3 gene, NTF3, in the dorsal amygdala using

32 Neurotrophin-3 growth factor can improve cochlear neuron

33 y system that can allow localized release of neurotrophin-3 in a controlled and sustained manner.

34 Here, we demonstrate a novel role of neurotrophin-3 in synaptic assembly and function as a po

35 Neurotrophin-3 normalized the short latency Hoffmann ref

36 hydrogels with affinity peptides specific to neurotrophin-3 proteins.

37 trophin-3 from cochlear tissues was 38 h but neurotrophin-3 remained detectable for at least 2 weeks.

38 demonstrate that axonal growth triggered by neurotrophin-3 remotely inhibits neurite outgrowth throu

39 e a radioactive tracer was used to determine neurotrophin-3 retention, distribution and clearance aft

40 Neurotrophin-3 was evident in the semi-circular canals w

41 (125)I-neurotrophin-3 was injected into guinea pig cochleae usi

42 Distribution of neurotrophin-3 was widespread throughout the cochlear ti

43 drogel formulation for localized delivery of neurotrophin-3, which provides affinity-controlled relea

44 trations correlated with higher retention of neurotrophin-3.

45 Together, these data implicate neurotrophin-3/NTRK3 signaling in the dorsal amygdala in

46 Here, we discover that neurotrophin 4 (NT4) plays an essential role in mucus ov

47 hic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), is implicated in the physiology of

48 hic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4).

49 roblast growth factor-4, CX3CL1/fractalkine, neurotrophin 4 oncostatin-M, pulmonary and activation-re

50 brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) have different developmental roles

51 ived neurotrophic factor (BDNF) is an active neurotrophin abundantly expressed throughout the nervous

52 ndocytosis are potential mechanisms by which neurotrophins achieve diverse neuronal functions.

53 Huh7 human hepatocyte cells showed that the neurotrophins activate the sterol regulatory element-bin

54 development of small molecule modulators of neurotrophin activity.

55 roteasome activator IU1, suggesting that the neurotrophin acts by decreasing proteasome activity.

56 roles, how BDNF, or more generally speaking, neurotrophins affect synapses, particularly nerve termin

57 , long-term potentiation and depression, and neurotrophin and retrograde endocannabinoid signaling.

58 Neurotrophins and glucocorticoids are robust synaptic mo

59 technology can be utilized to deliver other neurotrophins and growth factors to the CNS, opening a n

60 hese findings reveal a non-neuronal role for neurotrophins and identify a new regulatory pathway in i

61 the central and peripheral levels, including neurotrophins and myokines that could contribute to impr

62 serum markers of inflammation, and levels of neurotrophins and neurotransmitters, but the BL group ha

63 Newly identified drug targets, including neurotrophins and the granulocyte-macrophage colony-stim

64 aracteristics of heparan fragments that bind neurotrophins and the presence of these fragments in the

65 ittermates, notably in the downregulation of neurotrophins and their cognate neurotrophin receptors a

66 Neurotrophins and their receptors are directly responsib

67 Neurotrophins and their receptors are frequently express

68 This study investigates the role of neurotrophins and Tropomyosin receptor kinases (Trk) in

69 f HNE were not associated with production of neurotrophins and were unaffected by pretreatment with a

70 t in Drosophila melanogaster pro- and mature neurotrophins are capable of inducing death and survival

71 Neurotrophins are growth factors that have a multitude o

72 Neurotrophins are promising therapeutic agents for neura

73 Nervous system growth factors, that is, neurotrophins, are a potential solution to these disorde

74 e kinase on mouse neuroblastoma cells by the neurotrophin artemin (ART) is quantitatively coupled to

75 g expression of nerve growth factor (NGF), a neurotrophin associated with airway remodeling and airwa

76 Both neurotrophin-based therapy and neural stem cell (NSC)-ba

77 or a given reward and that expression of the neurotrophin BDNF in the mOFC is both necessary and suff

78 The neurotrophin BDNF plays a prominent role in cognitive fu

79 Intriguingly, plasma levels of the neurotrophin BDNF were increased in patients treated wit

80 target are mediated transsynaptically by the neurotrophin BDNF.

81 -Pep5) and in mice lacking the extracellular neurotrophin binding site of p75 neurotrophin receptor.

82 The neurotrophin brain-derived neurotrophic factor (BDNF) is

83 The neurotrophin brain-derived neurotrophic factor (BDNF) me

84 Here, we show that deletion of the neurotrophin brain-derived neurotrophic factor (BDNF)-de

85 , we silenced the neuroplasticity-associated neurotrophin brain-derived neurotrophic factor (BDNF).

86 A major player in this process is the neurotrophin brain-derived neurotrophic factor (BDNF).

87 ell survival, and signaling responses to the neurotrophin brain-derived neurotrophic factor.

88 ent with a key protective role played by the neurotrophin brain-derived neurotrophic factor.

89 s ideal for examining this issue because the neurotrophins brain-derived neurotrophic factor (BDNF) a

90 ic ligands (i.e., proneurotrophins or mature neurotrophins), but several of the intracellular adaptor

91 Neurons release neuropeptides, enzymes, and neurotrophins by exocytosis of dense-core vesicles (DCVs

92 anglion sensory neurons and thereby promotes neurotrophin-dependent axonal viability.

93 ologic inhibition of Trk signaling decreases neurotrophin-dependent ERK activation and BTIC growth.

94 tial burst of fission, a new steady state of neurotrophin-dependent mitochondria length is establishe

95 Synaptic release of neuropeptides and neurotrophins depends on presynaptic accumulation of den

96 ivating insults ranging from nerve injury to neurotrophin deprivation result in both c-Jun N-terminal

97 enhanced early axon growth independently of neurotrophins, disruption of a CD40L/CD40 autocrine loop

98 ious neurological conditions associated with neurotrophin dysfunction.

99 ion efficacy was improved when combined with neurotrophins, elevation of cyclic AMP levels, olfactory

100 Then, we asked whether or not these two neurotrophins exert their unique roles on the gustatory

101 oreceptor apoptosis, gliosis, and changes in neurotrophin expression, and it preserved the photorespo

102 nstroke mice did not alter motor behavior or neurotrophin expression, suggesting that the prorecovery

103 A for neurotrophins, including brain-derived neurotrophin factor (BNDF), was decreased following ION

104 ived neurotrophic factor) is a member of the neurotrophin family and it is implicated in regulating b

105 The neurotrophin family of growth factors, comprised of nerv

106 ession of BDNF, but not other members of the neurotrophin family, is perturbed in muscle from patient

107 neurotrophic factor (BDNF), a member of the neurotrophin family, regulates both survival and differe

108 TrkB, TrkC) are activated by hormones of the neurotrophin family: nerve growth factor (NGF), brain de

109 silence those signals has long perplexed the neurotrophin field.

110 rived neurotrophic factor (BDNF), a critical neurotrophin for brain repair and plasticity.

111 fects of adeno-associated virus vectors with neurotrophin gene inserts, AAV.BDNF and AAV.Ntf3, on gui

112 Likely, a combination of neurotrophins, guidance molecules, and exosomes work in

113 t, in addition to their role in development, neurotrophins have critical roles in adult brain plastic

114 omal cells of the bone marrow indicates that neurotrophins have the potential to regulate hematopoiet

115 dosomal-lysosomal pathway and autophagy, and neurotrophins, highlighting the importance of proper cho

116 th in healthy immature brains by unbalancing neurotrophin homeostasis via p75 neurotrophin receptor s

117 Neurotrophin hypothesis of schizophrenia (SCZ) postulate

118 d provide evidence for a global role of this neurotrophin in the homeostasis of the organism by signa

119 Cochlear delivery of neurotrophins in humans is likely achievable as an offic

120 TR) is an important receptor for the role of neurotrophins in modulating brain plasticity and apoptos

121 vailability make exogenous administration of neurotrophins in vivo problematic; therefore, alternativ

122 Several studies have shown that neurotrophins including brain-derived neurotrophic facto

123 It has been well documented that neurotrophins, including brain-derived neurotrophic fact

124 The production of mRNA for neurotrophins, including brain-derived neurotrophin fact

125 Neurotrophins, including nerve growth factor (NGF), incr

126 a feedforward loop, whereby upregulation of neurotrophins increases sympathetic innervation and loca

127 We report that neurotrophins induce the fission of mitochondria along e

128 etary salt can affect blood pressure through neurotrophin-induced plasticity in a central homeostatic

129 for limiting neurotrophic support, and local neurotrophin insufficiency triggers caspase-dependent ax

130 Another very abundant neurotrophin is BDNF.

131 However, pharmacological modulation of this neurotrophin is challenging because BDNF is generated by

132 el a new role for BDNF, suggesting that this neurotrophin is necessary and sufficient to maintain the

133 epends on a functional nerve, application of neurotrophins is being investigated.

134 euregulin 1 (NRG1), a critical developmental neurotrophin, is associated with schizophrenia.

135 ts demonstrate that a transient elevation in neurotrophin levels can sustain the cochlear neural subs

136 kers of inflammation, neurotransmitters, and neurotrophin levels.

137 At that time, neurotrophins levels were not significantly elevated in

138 Delivery of neurotrophins may potentially revive degenerating motor

139 Overall our results identify a neurotrophin-mediated mechanism by which tau induces neu

140 accharides exhibited increased activation of neurotrophin-mediated signaling pathways and enhanced ax

141 The neurotrophin nerve growth factor (NGF) has been implicat

142 to promote axonal growth in response to the neurotrophin, nerve growth factor (NGF).

143 kB and TrkC, not TrkA, and they also express neurotrophins NGF, BDNF, and neurotrophin 3 (NT3).

144 nsulin, insulin-like growth factor-1, or the neurotrophins (NGF and BDNF).

145 In mammals, this is achieved by neurotrophin (NT) ligands, which promote cell survival v

146 The p75 neurotrophin (NT) receptor (p75(NTR)) plays a crucial ro

147 ound that postnatal ASM innervation required neurotrophin (NT)-4 signaling through the TrkB receptor

148 It is well known that neurotrophins (NTs) are major regulators of such changes

149 mental insight into the effects of exogenous neurotrophins on a degenerating neural system, and for t

150 Here, we report that in response to neurotrophin or cAMP stimulation the RING ligase praja2

151 s amyloid-beta (Abeta) and the precursors of neurotrophins, outbalance neurotrophic signals, causing

152 at supporting cells influence the outcome of neurotrophin over-expression aimed at enhancing the coch

153 Neurotrophins particularly brain-derived neurotrophic fa

154 ecent studies have demonstrated an effect of neurotrophins, particularly brain-derived neurotrophic f

155 eneral repression of gene sets annotated for neurotrophin pathways and axonal guidance functions.

156 Data indicate that precuneus neurotrophin pathways are resilient to amyloid toxicity

157 These results indicate that glial-derived neurotrophins play critical roles in inner ear synapse d

158 ntial loss of cochlear hair cells, exogenous neurotrophins prevent degeneration of the auditory nerve

159 thening the clinical evidence of an abnormal neurotrophin profile in the patients with SCZ.

160 r regions that include genes associated with neurotrophins, programmed cell death, synaptic function,

161 Neurotrophins promote neuronal survival and synaptic pla

162 f a CD40L/CD40 autocrine loop impaired early neurotrophin-promoted axon growth.

163 gulated intramembrane proteolysis of the p75 neurotrophin receptor (also known as p75 cleavage).

164 The neurotrophin receptor (CD271/NGFR/p75NTR) is a key regul

165 is and recent evidence suggests that the p75 neurotrophin receptor (NTR) contributes significantly to

166 nt on the proper subcellular localization of neurotrophin receptor (NTR) to plasmalemmal signaling mi

167 for choline acetyltransferase (ChAT) or p75-neurotrophin receptor (p75(NTR) ).

168 The p75 neurotrophin receptor (p75(NTR)) has been proposed to me

169 The role of the p75 neurotrophin receptor (p75(NTR)) in adult cholinergic ba

170 We show that cleaved p75 neurotrophin receptor (p75(NTR)) is a component of the n

171 The p75 neurotrophin receptor (p75(NTR)) is a multifunctional re

172 distinct structural determinants in the p75 neurotrophin receptor (p75(NTR)) is crucial for the iden

173 The p75 neurotrophin receptor (p75(NTR)) is highly expressed in

174 During development, the p75 neurotrophin receptor (p75(NTR)) is widely expressed in

175 The p75 neurotrophin receptor (p75(NTR)) mediates neuronal death

176 The p75 neurotrophin receptor (p75(NTR)) mediates the death of s

177 The p75 neurotrophin receptor (p75(NTR)) regulates a wide range

178 ular signaling networks regulated by the p75 neurotrophin receptor (p75(NTR)) substantially overlap w

179 Strikingly, mutant male mice lacking the p75 neurotrophin receptor (p75(NTR)) were resistant to the d

180 tingly, mutant male mice that lacked the p75 neurotrophin receptor (p75(NTR)) were seen to be resista

181 uctures of complexes formed by the DD of p75 neurotrophin receptor (p75(NTR)) with RhoGDI, for activa

182 binding to a receptor complex of the common neurotrophin receptor (p75NTR) and sortilin.

183 ur goal was to determine the role of the p75 neurotrophin receptor (p75NTR) in the loss of islet symp

184 Previously, we have shown that p75 neurotrophin receptor (p75NTR) is a novel mediator of in

185 The p75 neurotrophin receptor (p75NTR) is highly expressed in th

186 The p75 neurotrophin receptor (p75NTR) regulates numerous cellul

187 Plasticity was rescued by inhibiting p75 neurotrophin receptor (p75NTR) signaling or its downstre

188 drinking produces a mobilization of DLS p75 neurotrophin receptor (p75NTR), whose activities oppose

189 GF increased LDLR expression through the p75 neurotrophin receptor (p75NTR).

190 s in G1H mice that re-express the common p75 neurotrophin receptor (p75NTR).

191 ed a mouse model with a mutation in the TrkA neurotrophin receptor (P782S) that results in reduced ub

192 hibition of the cell death domain of the p75 neurotrophin receptor (TAT-Pep5) and in mice lacking the

193 udies provide a new reagent for altering p75 neurotrophin receptor actions after injury and suggest t

194 In adulthood, p75 neurotrophin receptor becomes down-regulated and propofo

195 Germline deletion of the p75 neurotrophin receptor causes dramatic axon guidance and

196 lus propofol applications at the peak of p75 neurotrophin receptor expression after experimental trau

197 ricted to the developing nervous system when neurotrophin receptor expression peaks, indicate that BI

198 Neurotrophin receptor expression was confirmed in a pane

199 developmental-like programs and increase p75 neurotrophin receptor expression, probably to foster rep

200 eres with oligomerization of full-length p75 neurotrophin receptor in a dose-dependent manner.

201 Ubiquitination of the TrkA neurotrophin receptor in response to NGF is critical in

202 p75 neurotrophin receptor is highly expressed during early n

203 The p75 neurotrophin receptor is important in multiple physiolog

204 aline residue at position 264 in the rat p75 neurotrophin receptor is necessary for the ability of p7

205 Previously, we have shown that p75 neurotrophin receptor is required for glioma invasion an

206 compound, EVT901, which interferes with p75 neurotrophin receptor oligomerization through direct int

207 unctionally blocking antibody toward the pan-neurotrophin receptor p75 (p75(NTR) ).

208 The neurotrophin receptor p75 (p75NTR) is a receptor of Abet

209 ceptors (tropomyosin-related kinase A [TrkA]/neurotrophin receptor p75 [p75(NTR)]).

210 The neurotrophin receptor p75(NTR) negatively regulates spin

211 kinase TrkA (also called NTRK1), the common neurotrophin receptor p75(NTR), and the proneurotrophin

212 ability of SorCS2 to form complexes with the neurotrophin receptor p75(NTR), required for pro-brain-d

213 n and induce their death via cleavage of the neurotrophin receptor p75.

214 We discovered that the expression of the neurotrophin receptor p75NTR in PV cells inhibits the ma

215 he pro-brain-derived neurotrophic factor-p75 neurotrophin receptor pathway.

216 same set of transcription factors from a p75 neurotrophin receptor peptide (p75NTRp)-tagged adenoviru

217 p75 neurotrophin receptor plays an important role in the ner

218 sults revealed new functions for proBDNF-p75 neurotrophin receptor signaling pathway in the control o

219 unbalancing neurotrophin homeostasis via p75 neurotrophin receptor signaling.

220 re, we demonstrate that EVT901 abrogates p75 neurotrophin receptor signalling by other ligands, such

221 a and other neurological disorders where p75 neurotrophin receptor signalling is affected.

222 Interestingly, APPL1-endosomes transport the neurotrophin receptor TrkB and mediate retrograde axonal

223 roitinase and fluoxetine are mediated by the neurotrophin receptor TRKB in parvalbumin-containing (PV

224 PNN removal requires intact signaling by the neurotrophin receptor TRKB in PV(+) neurons.

225 -ERK-CREB-BDNF pathway as pre-treatment with neurotrophin receptor TrkB inhibitor ANA-12 and MEK inhi

226 We show that the neurotrophin receptor tropomyosin-related kinase C (TrkC

227 Trk neurotrophin receptor ubiquitination in response to liga

228 e, nicotinic acetylcholine receptor, and p75 neurotrophin receptor), thus demonstrating that pseudoty

229 The p75 neurotrophin receptor, a member of the tumor necrosis fa

230 or induced apoptosis in cells expressing p75 neurotrophin receptor, and enhances neurite outgrowth in

231 es binding of pro-nerve growth factor to p75 neurotrophin receptor, blocks pro-nerve growth factor in

232 ceptor B (trkB) and a truncated form of this neurotrophin receptor, favoring the inactive form throug

233 cetyltransferase (ChAT) and the low-affinity neurotrophin receptor, p75(NTR) .

234 re, we demonstrate that mice lacking the p75 neurotrophin receptor, p75NTR, decrease their feeding an

235 rats by the recruitment of the low-affinity neurotrophin receptor, p75NTR, whose activities opposes

236 The neurotrophin receptor, TrkB receptor tyrosine kinase, is

237 ncoded by Csf1, Nt3, and the tyrosine kinase neurotrophin receptor, TrkB.

238 assays with cysteine-rich domains-fused p75 neurotrophin receptor, we confirmed that EVT901 interfer

239 Here we show that the p75 neurotrophin receptor, which is abundantly expressed in

240 library for genes affecting the dynamics of neurotrophin receptor-containing endosomes in motor neur

241 rotrophic factor ratio, which aggravates p75 neurotrophin receptor-mediated cell death.

242 tracellular neurotrophin binding site of p75 neurotrophin receptor.

243 similar gamma-secretase cleavage is the p75 neurotrophin receptor.

244 Pathway analyses implicated p75 neurotrophin receptor/nerve growth factor signaling and

245 osin-related kinase receptors (Trks) and p75 neurotrophin receptors (p75) compete to regulate surviva

246 ng cells (BTICs) and show that BTICs express neurotrophin receptors (p75NTR, TrkA, TrkB, and TrkC) an

247 egulation of neurotrophins and their cognate neurotrophin receptors among other classes of transcript

248 The expression of neurotrophin receptors and ligands by hematopoietic and

249 Neurotrophin receptors are emerging targets in oncology,

250 not fully understood how genes encoding Trk neurotrophin receptors are regulated.

251 dings indicate that intracellular sorting of neurotrophin receptors is critical for postnatal neuroge

252 chrome (DrBphP-PCM) to the kinase domains of neurotrophin receptors resulted in opto-RTKs controlled

253 ss sensory neuron-associated markers such as neurotrophin receptors TrkA, TrkB, TrkC, and RET and the

254 sion of extracellularly tagged transmembrane neurotrophin receptors TrkB and p75 on transfected neuro

255 n and is mediated by the opposing actions of neurotrophin receptors TrkB and p75(NTR) .

256 om fresh human malignant gliomas express the neurotrophin receptors TrkB and TrkC, not TrkA, and they

257 Neurotrophins regulate diverse aspects of neuronal devel

258 as essential molecules for neuropeptide and neurotrophin release from dense-core vesicles (DCVs) in

259 theless, the poor pharmacokinetic profile of neurotrophins severely restricts their clinical use.

260 s an essential scaffold protein coordinating neurotrophin signal pathways in neurites and is spatiall

261 Neurotrophins signal through the tropomyosin related kin

262 s provide new insight into synaptic roles of neurotrophin signaling and mechanisms controlling synapt

263 rneurons is disrupted due to a deficiency in neurotrophin signaling during early development in FXS.

264 Two divergent arms of neurotrophin signaling hold the balance between positive

265 Our results highlight a novel role for neurotrophin signaling in brain tumor and suggest that T

266 provides new insight into the involvement of neurotrophin signaling in synapse development and plasti

267 Whether and how concurrent GR and neurotrophin signaling integrate to modulate synaptic pl

268 by activation of neurotrophin signaling, and neurotrophin signaling is sufficient for long term BTIC

269 Neurotrophin signaling modulates the differentiation and

270 holipid metabolism (P=1.3x10(-10) ), and the neurotrophin signaling pathway (P=7.0x10(-6) ).

271 results demonstrate the existence of a novel neurotrophin signaling pathway that is required for syna

272 NF levels and amelioration of alterations in neurotrophin signaling pathways.

273 f neuronal IL-4 receptors, which potentiated neurotrophin signaling via the AKT and MAPK pathways.

274 tonergic synapse signaling and inhibition of neurotrophin signaling were identified as potential medi

275 neurotrophic factor (BDNF) levels, impaired neurotrophin signaling, and compromised mitochondrial fu

276 nhibitors could be overcome by activation of neurotrophin signaling, and neurotrophin signaling is su

277 al membrane protein that plays a key role in neurotrophin signaling.

278 ojections in vivo in the absence of upstream neurotrophin signaling.

279 ression peaks, indicate that BICD1 regulates neurotrophin signalling by modulating the endosomal sort

280 Robo-Slit midline repulsion system, and the neurotrophin signalling system; a high number of zinc fi

281 Interestingly, loss of the secreted neurotrophin Spatzle 3 (Spz3) phenocopied alphaSNAP phen

282 Genetic interactions also revealed that the neurotrophin Spatzle3 (Spz3) is a likely Tollo ligand.

283 Synaptic neuropeptide and neurotrophin stores are maintained by constitutive bidir

284 to elevate cAMP is pretreating neurons with neurotrophins, such as brain-derived neurotrophic factor

285 hese findings suggest a target organ-derived neurotrophin suppresses development of that organ's sens

286 Nerve growth factor (NGF) is a neurotrophin that activates nociceptive neurons to trans

287 Neuregulin 1 (NRG1) is a multifunctional neurotrophin that mediates neurodevelopment and schizoph

288 rain-derived neurotrophic factor (BDNF) is a neurotrophin that promotes neuronal proliferation, survi

289 rain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates synaptic function and plasti

290 genetically re-engineers neurons to produce neurotrophins that are neuroprotective to vulnerable dop

291 ations unveil a novel biological function of neurotrophins; the regulation of mitochondrial fission a

292 Neurotrophin therapy has potential to reverse some forms

293 m by which glucose recruits vascular-derived neurotrophins to control insulin secretion.

294 ink between calcineurin signalling, impaired neurotrophin trafficking and neurodevelopmental deficits

295 onclusion, clinically practicable short-term neurotrophin treatment is sufficient for long-term survi

296 NTRK3 genes (TRK fusions), which encode the neurotrophin tyrosine kinase receptors TRKA, TRKB, and T

297 In this study, the neurotrophin tyrosine receptor kinase TrkA (also called

298 Neuregulin 3 (NRG3), a brain-enriched neurotrophin, undergoes alternative splicing and is impl

299 experiments demonstrate robust elevation of neurotrophins with these viral vectors.

300 nase) family of RTKs, naturally activated by neurotrophins, with photosensory core module of DrBphP b