ライフサイエンスコーパス: neurotrophin 3

1 lls still begin to develop in the absence of neurotrophin 3.

2 eurotrophic factor, nerve growth factor, and neurotrophin 3.

3 M1 activates TrkC by inducing the release of neurotrophin-3.

4 252a did not prevent GM1-mediated release of neurotrophin-3.

5 rs for brain-derived neurotrophic factor and neurotrophin-3.

6 utants, but were less severe in mice lacking neurotrophin-3.

7 factor, brain-derived neurotrophic factor or neurotrophin-3.

8 trations correlated with higher retention of neurotrophin-3.

9 phosphorylated ERK5 with MEF2 in response to neurotrophin-3.

10 Taken together, these results suggest that neurotrophin 3 activation of TrkC induces Schwann cell m

11 Previously, we demonstrated that neurotrophin 3 activation of TrkC inhibits Schwann cell

12 Eliminating one or both neurotrophin-3 alleles in mice that lack nerve growth fa

13 Neurotrophin-3 also enhanced locomotor recovery.

14 ligands, brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4, are survival factors

15 mbination of basic fibroblast growth factor, neurotrophin-3 and brain derived growth factor delivered

16 ession of GDNF by glia and overexpression of neurotrophin-3 and neurotrophin-4 in muscle did not caus

17 ition to modulate intracellular responses to neurotrophin-3 and/or nerve growth factor.

18 rain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4 (NT3 and NT4).

19 (NGF, brain-derived neurotrophic factor, and neurotrophin 3) and secrete NGF.

20 or (NGF), brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4.

21 FGF-2/Adts), nerve growth factor (NGF/Adts), neurotrophin-3, and the cell adhesion molecules N-cadher

22 enteric nervous system suggest that trkC and neurotrophin-3 are a major neurotrophin system in the ga

23 t that brain-derived neurotrophic factor and neurotrophin-3 are anterogradely transported from midbra

24 Our findings pave the way for Neurotrophin-3 as a therapy that treats the underlying c

25 tor receptors, namely, the trkC receptor for neurotrophin 3, as well as receptors for neurturin and g

26 nd brain-derived neurotrophic factor but not neurotrophin-3, as measured by ELISA.

27 associated viral vector (AAV) encoding human Neurotrophin-3 at a clinically-feasible time-point after

28 embryonic spinal cord tissue and delivery of neurotrophin-3 at the injury site further increased spin

29 In vitro, neurotrophin 3 binding to p75NTR increases neurite lengt

30 inding of NGF equivalent to TrkA, maintained neurotrophin-3 binding equivalent to TrkC, and also boun

31 GM1 failed to displace neurotrophin-3 binding, suggesting that this ganglioside

32 r survival were unaffected by the absence of neurotrophin-3 but neuronal survival was compromised so

33 GM1 induced neurotrophin-3 (but not brain-derived neurotrophic facto

34 sciatic nerves, is significantly enhanced by neurotrophin 3, but not by nerve growth factor or brain-

35 Furthermore, expression of neurotrophin-3, but not nerve growth factor, brain-deriv

36 id and significant increase in the amount of neurotrophin-3, but not other neurotrophins.

37 Application of neurotrophin-3, but not related neurotrophins, prevented

38 ial treatment with embryonic transplants and neurotrophin-3 can potentiate the effects of enriched ho

39 this possibility, we compared neuron loss in neurotrophin-3-deficient mice with that in nerve growth

40 us, closely relating this mouse model to the neurotrophin-3-deficient one.

41 abilized chABC in combination with sustained neurotrophin-3 delivery showed significant improvement i

42 Excess brain-derived neurotrophic factor or neurotrophin-3 did not inhibit neurite outgrowth.

43 ise in brain-derived neurotrophic factor and neurotrophin 3 during exercise, the increased growth pot

44 ic nerves of p75NTR-/- mice, indicating that neurotrophin 3 enhances cell migration through TrkC.

45 ons in brain-derived neurotrophic factor and neurotrophin 3 expression in muscle without appreciably

46 At the time of neuron loss, neurotrophin-3 expression, assayed with a lacZ reporter,

47 imulation with either nerve growth factor or neurotrophin-3 failed to evoke any changes in Kv1.3 func

48 C-expressing neurons and their dependence on neurotrophin-3 for survival.

49 The time constant for clearance of neurotrophin-3 from cochlear tissues was 38 h but neurot

50 We verified the sustained release of neurotrophin-3 from peptide-conjugated PEG hydrogels res

51 nglion in vivo, and found that expression of neurotrophin-3 from the vector protected peripheral sens

52 Based on the results, we overexpressed the neurotrophin-3 gene, NTF3, in the dorsal amygdala using

53 rneal expressions of nerve growth factor and neurotrophin-3 genes were unchanged; receptor gene expre

54 Neurotrophin-3 growth factor can improve cochlear neuron

55 e with a targeted disruption of the gene for neurotrophin-3 have 50% fewer neurons than those of wild

56 GF) and those in TrkC involved in binding to neurotrophin-3 have been mapped in this domain, the Trk

57 nervous system cells, fibroblasts expressing neurotrophin-3, hybridoma cells expressing inhibitory pr

58 thelial growth factor A, angiopoietin 1, and neurotrophin 3 in the ischemic muscle.

59 ired availability of nerve growth factor and neurotrophin 3 in the sciatic nerve and significant prev

60 y system that can allow localized release of neurotrophin-3 in a controlled and sustained manner.

61 Here, we demonstrate a novel role of neurotrophin-3 in synaptic assembly and function as a po

62 th factor (NGF), or antibody inactivation of neurotrophin-3 in the presence of NGF.

63 neurotrophic factor, nerve growth factor and neurotrophin-3 in the supernatant and increased intracel

64 on of neurotrophins (nerve growth factor and neurotrophin-3) in FAP nerves.

65 The trkC locus encodes several receptors for neurotrophin-3, including the well studied full-length t

66 In culture, neurotrophin-3 increases the survival of proliferating s

67 n, and brain-derived neurotrophic factor and neurotrophin-3 induced cellular maturation.

68 RK5 activator, MEK5, significantly inhibited neurotrophin-3-induced cell death.

69 Additionally, the neurotrophin-3-induced cell migration depended on Rho GT

70 tide exchange factor (RhoGEF) that regulates neurotrophin-3-induced cell migration in Schwann cells.

71 The neurotrophin-3-induced cell migration was also observed

72 , whereas TrkC receptors are responsible for neurotrophin-3 inhibition.

73 nfusion also increased hippocampal levels of neurotrophin 3, insulin-like growth factor 1, and nerve

74 y expressed on all the follicle cells, while neurotrophin 3 is transiently expressed only in the cell

75 Taken together these results suggest that neurotrophin-3 is required for survival of some sympathe

76 In transgenic neurotrophin-3 lacZ-neo (NT-3(lacZneo)) mice, in which t

77 richia coli lacZ gene is integrated into the neurotrophin-3 locus (NT-3(lacZneo)).

78 Neurotrophin-3 mRNA levels decrease in the hippocampus f

79 hippocampal neurons inversely correlate with neurotrophin-3 mRNA levels.

80 ts in an increase in miR21 and a decrease in neurotrophin-3 mRNA.

81 ed brain-derived neurotrophic factor (BDNF), neurotrophin-3, neurotrophin-4, ciliary neurotrophic fac

82 eurons by brain-derived neurotrophic factor, neurotrophin-3, neurotrophin-4, or glial-cell-line-deriv

83 Neurotrophin-3 normalized the short latency Hoffmann ref

84 Neurotrophin-3 not only enhanced ERK5 phosphorylation bu

85 e percentage of hSK1-positive cells, whereas neurotrophin 3 (NT-3) and glial cell line-derived neurot

86 mice that overexpress neurotrophins NGF and neurotrophin 3 (NT-3) at high levels in skin have shown

87 suggested qualitatively different effects of neurotrophin 3 (NT-3) in cochlear innervation patterning

88 Essential functions of neurotrophin 3 (NT-3) in regulating afferent and efferen

89 Tie2 also exhibit a chemotactic response to neurotrophin 3 (NT-3), a specific ligand for TrkC.

90 ADNF causes secretion of neurotrophin 3 (NT-3), and both proteins regulate NMDA r

91 nd neonatal mice with mutations in the BDNF, neurotrophin 3 (NT-3), and TrkC genes.

92 tional and structural synaptic regulation by neurotrophin 3 (NT-3), using the neuromuscular synapse a

93 mpounds have been identified that potentiate neurotrophin 3 (NT-3)-mediated activation of trk A.

94 also be activated by high concentrations of neurotrophin 3 (NT-3).

95 r activity is composed of two neurotrophins, neurotrophin-3 (NT-3) and Brain-Derived Neurotrophic Fac

96 esence of fibroblast growth factor (FGF) and neurotrophin-3 (NT-3) and differentiate in the presence

97 Administration of neurotrophin-3 (NT-3) and insulin-like growth factor-I (

98 Neurotrophin-3 (NT-3) and its high-affinity receptor Trk

99 have evaluated changes in the expression of neurotrophin-3 (NT-3) and its tyrosine kinase C (TrkC) r

100 The binding sites of neurotrophin-3 (NT-3) and nerve growth factor (NGF) to t

101 The effects of neurotrophin-3 (NT-3) and NT-4/5 on the function of axot

102 metics 1 were designed to mimic hot spots of neurotrophin-3 (NT-3) and others.

103 d to p75NTR and the 2:2 symmetric complex of neurotrophin-3 (NT-3) and p75NTR.

104 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) and their receptors trkB and trkC,

105 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) and their respective high-affinity

106 Animals lacking neurotrophin-3 (NT-3) are born with deficits in almost a

107 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are hypothesized to play an import

108 neurotrophins nerve growth factor (NGF) and neurotrophin-3 (NT-3) are potent chemotactic agents for

109 Nerve growth factor (NGF) and neurotrophin-3 (NT-3) are target-derived proteins that r

110 Similar effects were observed with neurotrophin-3 (NT-3) but not nerve growth factor.

111 to synaptic plasticity, we examined whether neurotrophin-3 (NT-3) changed the number, size, vesicle

112 rain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) contribute to those trophic effect

113 he present investigation, we studied whether neurotrophin-3 (NT-3) contributes to the rescue of axoto

114 brain-derived neurotrophin factor (BDNF) and neurotrophin-3 (NT-3) did not induce cell death.

115 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) differ among rat strains exhibitin

116 se and transfer of anterogradely transported neurotrophin-3 (NT-3) from a presynaptic to a postsynapt

117 Removal of the TrkC ligand neurotrophin-3 (NT-3) from cerebellar granule cells, whi

118 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) have been localized to the sensory

119 een identified, the biological functions for neurotrophin-3 (NT-3) in early retinal development remai

120 ld-type and transgenic mice that overexpress neurotrophin-3 (NT-3) in muscle (myo/NT-3 mice).

121 To clarify the role of muscle-derived neurotrophin-3 (NT-3) in the development of sensory neur

122 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in the development of synaptic tra

123 Here, we report that overexpression of neurotrophin-3 (NT-3) in the eye accelerates RGC laminar

124 We show that genetic ablation of neurotrophin-3 (NT-3) in the mouse neocortex results in

125 To obtain insights into the expression of neurotrophin-3 (NT-3) in the mouse, we have utilized mic

126 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) into C7 lesion sites, we found bot

127 roinjection of nerve growth factor (NGF) and neurotrophin-3 (NT-3) into the rostral pontine tegmentum

128 Neurotrophin-3 (NT-3) is a cystine knot growth factor th

129 Neurotrophin-3 (NT-3) is a member of the neurotrophin fa

130 Neurotrophin-3 (NT-3) is expressed specifically in cells

131 Since neurotrophin-3 (NT-3) is highly expressed in non-neural

132 Neurotrophin-3 (NT-3) is known to promote enteric neuron

133 Interestingly, neurotrophin-3 (NT-3) is upregulated in the brains of wi

134 edicted to target (and thus inhibit) NGF and neurotrophin-3 (NT-3) mRNA.

135 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) mRNAs were revealed in OLGs in viv

136 (STZ)-diabetic rats and examined effects of neurotrophin-3 (NT-3) on diabetes-induced events.

137 e effects of transgenic cellular delivery of neurotrophin-3 (NT-3) on morphological and functional di

138 To investigate the effects of neurotrophin-3 (NT-3) on postnatal proprioceptive neuron

139 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) on the dendritic complexity of lay

140 rain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) on the intraspinal regeneration of

141 neurotrophins nerve growth factor (NGF) and neurotrophin-3 (NT-3) on trigeminal axon growth patterns

142 Addition of either neurotrophin-3 (NT-3) or BDNF increases axon growth and

143 tral tegmental area (VTA) microinjections of neurotrophin-3 (NT-3) or brain-derived neurotrophic fact

144 Concurrently, lentiviral vectors expressing neurotrophin-3 (NT-3) or green fluorescent protein (GFP)

145 Mice lacking neurotrophin-3 (NT-3) or its receptor, TrkC, lose many s

146 th was prevented by co-treatment with either neurotrophin-3 (NT-3) or nerve growth factor (NGF).

147 ecause neither nerve growth factor (NGF) nor neurotrophin-3 (NT-3) prevented NO-induced growth cone c

148 ent receptor potential channel M5 (TrpM5) or neurotrophin-3 (NT-3) project to defined clusters of glo

149 Neurotrophin-3 (NT-3) promotes enteric neuronal developm

150 Endogenous neurotrophin-3 (NT-3) protein is present in the ganglion

151 Elevated expression of the neurotrophin-3 (NT-3) receptor TrkC by childhood medullo

152 rlier work in our laboratory showed that the neurotrophin-3 (NT-3) receptor TrkC is activated by T. c

153 Here, we investigate how neurotrophin-3 (NT-3) regulates DA cell density in the m

154 n the perirhinal cortex, although endogenous neurotrophin-3 (NT-3) regulates the expression of VGF in

155 on site if axons are guided by a gradient of neurotrophin-3 (NT-3) rostral to the lesion.

156 Neurotrophin-3 (NT-3) signaling has been shown to be req

157 Neurotrophin-3 (NT-3) supported striking terminal arbori

158 Neurotrophin-3 (NT-3) supports the survival and differen

159 ophins brain-derived neurotrophin (BDNF) and neurotrophin-3 (NT-3) synergistically enhance survival o

160 ously reported that retrogradely transported neurotrophin-3 (NT-3) to lumbar MNs attenuated SCI-induc

161 The ability of neurotrophin-3 (NT-3) to prevent abnormalities in neurof

162 were treated with either saline or exogenous neurotrophin-3 (NT-3) to promote the survival of proprio

163 he present study, we evaluate the ability of neurotrophin-3 (NT-3) to protect neurons against the tox

164 Addition of neurotrophin-3 (NT-3) to the culture medium rescued some

165 in noise-exposed mice that local delivery of neurotrophin-3 (NT-3) to the round window niche, 24 hour

166 al perfusion technique for local delivery of neurotrophin-3 (NT-3) to various regions of developing X

167 y of NGF leads to axonal elongation, whereas neurotrophin-3 (NT-3) treatment leads to short branching

168 and neurotrophin-4/5 (NT-4/5) via TrkB, and neurotrophin-3 (NT-3) via TrkC.

169 Finally, potentiation by neurotrophin-3 (NT-3) was also target specific.

170 ascular endothelial growth factor (VEGF) and neurotrophin-3 (NT-3) were significantly elevated in fem

171 Lentiviral vectors expressing neurotrophin-3 (NT-3) were then injected into an appropr

172 e injured axon was administered by injecting neurotrophin-3 (NT-3) within and beyond a cervical spina

173 sustained release of the neurotrophic factor neurotrophin-3 (NT-3) would support axonal plasticity in

174 erent neurons retrogradely transported [125I]neurotrophin-3 (NT-3), [125I]nerve growth factor (NGF),

175 neurons and thereby induces transcription of neurotrophin-3 (NT-3), a novel gene target of MEF2.

176 effect of this s-ODN on subsequent Fos, NGF, neurotrophin-3 (NT-3), and actin expression.

177 or brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and glial cell line-derived neuro

178 ), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and glial cell line-derived neuro

179 Brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) activat

180 ns brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5) upo

181 ly brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5), co

182 retion of brain-derived neurotrophic factor, neurotrophin-3 (NT-3), and neurotrophin-4/5.

183 IYIY-I2-BODIPY binds TrkC similar to neurotrophin-3 (NT-3), and NT-3 has been reported to mod

184 ng brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and NT-4.

185 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are believed to be genuine molecu

186 rain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3), are critical for the maintenance

187 phins, such as nerve growth factor (NGF) and neurotrophin-3 (NT-3), are essential for development, fu

188 that the endogenous neurotrophins, BDNF and neurotrophin-3 (NT-3), are transported anterogradely by

189 ntitative PCR (qPCR) to assay NTF expression-neurotrophin-3 (NT-3), BDNF, GDNF, neurturin, artemin, a

190 In this study, fibroblasts producing neurotrophin-3 (NT-3), brain-derived neurotrophic factor

191 brain-derived neurotrophic factor (BDNF) or neurotrophin-3 (NT-3), but not nerve growth factor (NGF)

192 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), but not proinflammatory molecules

193 We have shown previously that BDNF, neurotrophin-3 (NT-3), chlorphenylthio-cAMP (cpt-cAMP) (

194 We report that neurotrophin-3 (NT-3), delivered chronically via fibrobl

195 ic factor (BDNF), nerve-growth factor (NGF), neurotrophin-3 (NT-3), fibroblast growth factor-2 (FGF-2

196 Brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), glial cell line-derived neurotrop

197 from the brain metastatic protein signature, neurotrophin-3 (NT-3), has a dual function of regulating

198 Neurotrophic factors, particularly neurotrophin-3 (NT-3), may increase the regenerative cap

199 tors expressing nerve growth factor (NGF) or neurotrophin-3 (NT-3), neurons in the DRG were transduce

200 ), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), and glial

201 ell line-derived neurotrophic factor (GDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), and their

202 1: brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), ciliary ne

203 F, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), tyrosine k

204 ic neurotrophins [nerve growth factor (NGF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4)].

205 ophins, including nerve growth factor (NGF), neurotrophin-3 (NT-3), NT-4/5 and brain-derived neurotro

206 ), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or neurotrophin-4 (NT-4) results

207 to platelet-derived growth factor (PDGF) and neurotrophin-3 (NT-3), primary cultures of cortical olig

208 nar release of nerve growth factor (NGF) and neurotrophin-3 (NT-3), respectively.

209 ure to brain-derived neurotrophic factor and neurotrophin-3 (NT-3), suggesting that the electrophysio

210 rain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3), the cognate ligands for TrkA, Trk

211 se expression of the analogous neurotrophin, neurotrophin-3 (NT-3), was unaltered in the same irises.

212 by evidence that neurotrophins, particularly neurotrophin-3 (NT-3), which has been shown to promote s

213 signals in response to two ligands, NGF and neurotrophin-3 (NT-3), with very different functional co

214 , many of which are muscle afferents and are neurotrophin-3 (NT-3)-responsive, were severely decrease

215 es of podocytes treated with the TrkC ligand neurotrophin-3 (Nt-3).

216 cones of forebrain neurons is stimulated by neurotrophin-3 (NT-3).

217 gradient of collapsin-1/semaphorin III/D or neurotrophin-3 (NT-3).

218 ons in p75NTR, nerve growth factor (NGF) and neurotrophin-3 (NT-3).

219 lcholine, but not for the turning induced by neurotrophin-3 (NT-3).

220 in resting membrane potential (RMP) or added neurotrophin-3 (NT-3).

221 ophins such as nerve growth factor (NGF) and neurotrophin-3 (NT-3).

222 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3).

223 ions as an active protein tyrosine kinase by neurotrophin-3 (NT-3).

224 t not acute, forms of synaptic modulation by neurotrophin-3 (NT-3): endocytosis of NT-3-receptor comp

225 coadministration of the neurotrophic factor neurotrophin-3 (NT-3; 5-20 mg . kg-1 . d-1, s.c.) during

226 Neurotrophin 3 (NT3) ablation in mice causes a more seve

227 roliferation and survival in the presence of neurotrophin 3 (NT3) and brain-derived neurotrophin fact

228 ides 1315-1412 show ligand responsiveness to neurotrophin 3 (NT3) and myelin-associated glycoprotein

229 The selective elimination of neurotrophin 3 (NT3) from muscle spindles had no effect

230 on neurotrophins, however, has revealed that neurotrophin 3 (NT3) is critically involved in several a

231 Recent studies indicate that neurotrophin 3 (NT3) may be important for the maintenanc

232 ), platelet-derived growth factor (PDGF), or neurotrophin 3 (NT3) to clonal density cultures of corti

233 ), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), is impli

234 ), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4).

235 ), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4/5 (NT4/5).

236 ey also express neurotrophins NGF, BDNF, and neurotrophin 3 (NT3).

237 Neurotrophin-3 (NT3) acting through the TrkC receptor ty

238 We previously demonstrated that endogenous neurotrophin-3 (NT3) acting through the TrkC tyrosine ki

239 s, treatment with nerve growth factor (NGF), neurotrophin-3 (NT3) and glial-cell-line-derived neurotr

240 fication to probe cDNA arrays, we found that neurotrophin-3 (NT3) and trkB mRNA expression were reduc

241 , we report that embryonic overexpression of neurotrophin-3 (NT3) in muscles disrupts the development

242 s a specific downregulation in expression of neurotrophin-3 (NT3) in the transgenic cochleas before t

243 In the chick embryo, exogenous neurotrophin-3 (NT3) is sufficient to promote the differ

244 Neurotrophin-3 (NT3) plays a key role in the development

245 We show that the neurotrophin-3 (NT3) TrkCT1-truncated receptor binds to

246 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) were identified in Schwann cell/dor

247 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3), act to enhance cell growth and bra

248 or (NGF), brain-derived neurotrophin (BDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4)-and their

249 We expressed neurotrophin-3 (NT3), deoxyribonuclease (DNase), or vasc

250 RT-PCR analyses, that TrkC, the receptor for neurotrophin-3 (NT3), is expressed by mouse perisynaptic

251 rophic factors nerve growth factor (NGF) and neurotrophin-3 (NT3), the actions of which must be execu

252 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3), to the tyrosine-kinase (Trk) recep

253 the neuromuscular junction (NMJ) induced by neurotrophin-3 (NT3), using Xenopus nerve-muscle co-cult

254 Here we show that neurotrophin-3 (NT3)-induced potentiation of synaptic tr

255 One necessary factor for these neurons is neurotrophin-3 (NT3).

256 We show here that intramuscular delivery of neurotrophin-3 (NT3, encoded by NTF3) can induce sensori

257 Neurotrophin-3 (Ntf3) and brain derived neurotrophic fac

258 Together, these data implicate neurotrophin-3/NTRK3 signaling in the dorsal amygdala in

259 ts of enriched environment, transplants, and neurotrophin-3 on the plasticity of synaptic structures

260 th BDNF during activity blockade, but not by neurotrophin 3 or nerve growth factor.

261 sponse to brain-derived neurotrophic factor, neurotrophin 3, or neurotrophin 4/5.

262 ed neurotrophic factor, nerve growth factor, neurotrophin-3, or ciliary neurotrophic factor could pro

263 eric neurons along with recent evidence that neurotrophin-3 plays a role in the development of the en

264 hydrogels with affinity peptides specific to neurotrophin-3 proteins.

265 GFbetaR), TEL/Janus kinase 2 (JAK2), and TEL/neurotrophin-3 receptor (TRKC).

266 PTK (protein-tyrosine kinase) domain of the neurotrophin-3 receptor NTRK3.

267 cers, we identified in ACC expression of the neurotrophin-3 receptor TrkC/NTRK3, neural crest marker

268 y nerve growth factor receptor, or TrkC, the neurotrophin-3 receptor, and immunoreactive mPTPRO and T

269 mas, mouse tumors with reduced levels of the neurotrophin-3 receptor, trkC/Ntrk3, display decreased a

270 Expression of the neurotrophin-3 receptor, tyrosine kinase C (TrkC), is as

271 in growth factor-1, nerve growth factor, and neurotrophin 3 receptors in dorsal root ganglion cells.

272 ctor, brain-derived neurotrophic factor, and neurotrophin-3) regulate axonal mRNA levels and use dist

273 Finally, neurotrophin 3 released from muscle spindles regulates t

274 trophin-3 from cochlear tissues was 38 h but neurotrophin-3 remained detectable for at least 2 weeks.

275 demonstrate that axonal growth triggered by neurotrophin-3 remotely inhibits neurite outgrowth throu

276 ically significant increase in cell death of neurotrophin-3-responsive and nonresponsive medulloblast

277 e a radioactive tracer was used to determine neurotrophin-3 retention, distribution and clearance aft

278 Brain-derived neurotrophic factor, but not neurotrophin-3, selectively regulated immunoglobulin dom

279 Nerve growth factor (NGF) and neurotrophin-3 serve as attractive cues for chick embryo

280 MiR21 is a candidate for regulating neurotrophin-3 signaling in the hippocampus following st

281 tin filaments, nerve growth factor (NGF) and neurotrophin-3 still induced growth cone protrusion and

282 Additionally, human NGF and neurotrophin-3 stimulated c-Yes in brain-metastatic 70W

283 ed higher brain-derived neurotrophic factor, neurotrophin 3, synapsin I, and GAP43 mRNA levels than t

284 ified a miR21 binding site, in the 3' UTR of neurotrophin-3 that inhibits translation.

285 hat the binding is specifically inhibited by neurotrophin-3, the natural TrkC ligand.

286 ed vector containing the coding sequence for neurotrophin-3 to transduce sensory neurons of the rat d

287 had no effect on TrkB or TrkC activation in neurotrophin 3 treatment.

288 phic factor and neurotrophin-4/5 (trkB), and neurotrophin-3 (trkC).

289 NA encoding the receptor tyrosine kinase for neurotrophin-3, TrkC, were unchanged.

290 Our investigation of the mechanism of neurotrophin-3/TrkC-induced apoptosis has identified a n

291 Neurotrophin-3/TrkC-induced apoptosis is inhibited by th

292 s target myocyte enhancer factor 2 (MEF2) to neurotrophin-3/TrkC-induced medulloblastoma cell death.

293 Neurotrophin-3 was evident in the semi-circular canals w

294 (125)I-neurotrophin-3 was injected into guinea pig cochleae usi

295 rograde transport of nerve growth factor and neurotrophin-3 was not evident.

296 microm), and large-(> 40 microm), neurones, neurotrophin-3 was seen in medium and small neurones, wh

297 Distribution of neurotrophin-3 was widespread throughout the cochlear ti

298 -derived neurotrophic factor (BDNF), but not neurotrophin 3, was prevented by blockers of adenosine 3

299 nnel, brain-derived neurotrophic factor, and neurotrophin 3) were also abnormal, in parallel with the

300 ons of brain-derived neurotrophic factor and neurotrophin 3, which stimulated neurite outgrowth from

301 drogel formulation for localized delivery of neurotrophin-3, which provides affinity-controlled relea