ライフサイエンスコーパス: neurovascular coupling

1 cerebral blood flow to neuronal metabolism (neurovascular coupling).

2 associated with increased neuronal activity (neurovascular coupling).

3 aECs, but not in neighbouring SMCs, impaired neurovascular coupling.

4 e been proposed to play a role in functional neurovascular coupling.

5 V4 channels are engaged in and contribute to neurovascular coupling.

6 endfoot microdomain and assess their role in neurovascular coupling.

7 e synthase is involved in astrocyte-mediated neurovascular coupling.

8 erent conditions of neuronal stimulation and neurovascular coupling.

9 ells (aECs) have an active role in mediating neurovascular coupling.

10 ha, and ultimately lead to the impairment of neurovascular coupling.

11 rocytes, and arterioles-causing inversion of neurovascular coupling.

12 l and impose constraints on future models of neurovascular coupling.

13 one of the key players in coordinating this neurovascular coupling.

14 f this glial cell-K+ siphoning hypothesis of neurovascular coupling.

15 only indirectly, by way of hemodynamics and neurovascular coupling.

16 zed changes in blood flow, a response termed neurovascular coupling.

17 retina does not contribute significantly to neurovascular coupling.

18 vasoconstriction and a general disruption of neurovascular coupling.

19 nd may help to refine quantitative models of neurovascular coupling.

20 x in real time, revealing the hidden duet of neurovascular coupling.

21 ings shed light on the complex regulation of neurovascular coupling.

22 ebrovascular reactivity, autoregulation, and neurovascular coupling.

23 t differences in neural activity rather than neurovascular coupling.

24 imaging, suggesting potential disruptions in neurovascular coupling.

25 ation signals through the vasculature during neurovascular coupling.

26 tivity drive changes in local blood flow via neurovascular coupling.

27 blood oxygenation despite relatively intact neurovascular coupling.

28 ural activity and therefore not a product of neurovascular coupling.

29 ing molecule that plays an important role in neurovascular coupling.

30 sulin receptors in astrocytes participate in neurovascular coupling.

31 ed pathway in aECs is a major contributor to neurovascular coupling.

32 ng neural activity can modulate CSF flow via neurovascular coupling.

33 l role in regulating cerebral blood flow and neurovascular coupling.

34 sion, a response that disrupted light-evoked neurovascular coupling.

35 Isovolumic haemodilution did not alter neurovascular coupling.

36 a longer time span and is less dependent on neurovascular coupling.

37 derstand temporal correlations that describe neurovascular coupling.

38 t release Ca(2+) from stores does not affect neurovascular coupling.

39 y visual cortex to investigate the limits of neurovascular coupling.

40 hese networks, over and above the effects on neurovascular coupling.

41 ishing astrocytes as potential regulators of neurovascular coupling.

42 ulation, endothelial-mediated signaling, and neurovascular coupling.

43 nge in cerebral blood flow, a process termed neurovascular coupling.

44 ggesting that pericytes could have a role in neurovascular coupling.

45 gs, as well as a more principled modeling of neurovascular coupling.

46 tigators to probe the role of capillaries in neurovascular coupling.

47 rlying neuronal activity by a process termed neurovascular coupling.

48 Roy and Sherrington, 1890), a process termed neurovascular coupling.

49 can also disrupt astrocytes, which modulate neurovascular coupling-a process that regulates cerebral

50 conditioning experiments, and to investigate neurovascular coupling across multiple cortical regions.

51 stent reduction in CBF, but not the impaired neurovascular coupling after CSD.

52 Furthermore, disturbed neurovascular coupling after stroke can confound hemodyn

53 Capillaries are equipped to sense neurovascular coupling agents released onto the outer wa

54 trated that retinal fUS could measure robust neurovascular coupling alterations between wild-type rat

55 We apply Iliski to data on neurovascular coupling, an ensemble of cellular mechanis

56 rier or angiogenesis postnatally, it impairs neurovascular coupling and behavior in adult mice.

57 perties of the neurovascular system (such as neurovascular coupling and blood-brain barrier permeabil

58 global brain activity, suggesting a role in neurovascular coupling and brain waste clearance.

59 Piezo1 channel regulation and how it affects neurovascular coupling and cerebral blood flow.

60 tant vascular diseases, or medication on the neurovascular coupling and consequently the functional M

61 The links between neurovascular coupling and cortical craniofacial nocicep

62 Combined high-resolution assessing of neurovascular coupling and electrophysiological activiti

63 Combined high-resolution assessing of neurovascular coupling and electrophysiological activiti

64 amic response is important for understanding neurovascular coupling and elucidating the physiological

65 mutase (CuZnSOD) prevented the alteration in neurovascular coupling and endothelium-dependent respons

66 ts and controversies in the understanding of neurovascular coupling and finish by discussing current

67 altered calcium signaling that could disrupt neurovascular coupling and gliotransmission.

68 may regulate experience-dependent changes in neurovascular coupling and myelination.

69 ions of mural cells in vascular development, neurovascular coupling and neuropathology.

70 ron, a direction opposite to that of classic neurovascular coupling and referred to here as vasculo-n

71 activity, but it relies on the physiology of neurovascular coupling and requires extensive signal pro

72 ults indicate that glial cells contribute to neurovascular coupling and suggest that regulation of bl

73 nitrite were not enough to entirely restore neurovascular coupling and supra-physiological concentra

74 ting local blood vessels, a mechanism termed neurovascular coupling and the basis of BOLD functional

75 phate co-transmitter is an important step in neurovascular coupling and the regulation of cerebrovasc

76 esponses to investigate cocaine's effects on neurovascular coupling and to differentiate its effects

77 Metabolic recruitment works alongside neurovascular coupling and various averaging strategies

78 This relationship is termed 'neurovascular coupling' and it is critical for regulatin

79 hemodynamic responses, protected IP-TNTs and neurovascular coupling, and enhanced retinal neuronal fu

80 , vascular smooth muscle cell contractility, neurovascular coupling, and intraparenchymal interstitia

81 , comparable cerebral substrate delivery and neurovascular coupling, and maintained cognition.

82 d with release of arachidonic acid, impaired neurovascular coupling, and reduced cerebral blood flow

83 ms based on recent astrocyte-based models of neurovascular coupling are discussed.

84 Reduced blood flow and impaired neurovascular coupling are recognized features of glauco

85 001), indicating that cocaine did not affect neurovascular coupling at rest and that the reduction in

86 The investigation of mechanisms underlying neurovascular coupling at the capillary level requires a

87 red hippocampal cytoarchitectonics; impaired neurovascular coupling; attenuated prepulse inhibition (

88 Neurovascular coupling between resting-state neural acti

89 responses were not, suggesting differential neurovascular coupling between the two vasculatures.

90 According to the current model of neurovascular coupling, blood flow is controlled regiona

91 rstanding the complex signalling pathways of neurovascular coupling, but issues such as the contribut

92 Astrocytes play a critical role in neurovascular coupling by providing a physical linkage f

93 Here, we reexamined their role in neurovascular coupling by selectively expressing a genet

94 uman brain and that the temporal dynamics of neurovascular coupling can explain this effect.

95 Neurovascular coupling, cerebrovascular remodeling and h

96 amine neuronal activity that is invariant to neurovascular coupling changes induced by hypertension.

97 both adults and neonates, and a reduction in neurovascular coupling could deprive active neurons of a

98 red blood flow regulation at rest and during neurovascular coupling, defects in mural cell activity,

99 ked neuronal activity.SIGNIFICANCE STATEMENT Neurovascular coupling, defined as the tight relationshi

100 We conclude that neurovascular coupling depends critically on anesthesia

101 nse, showing that the degree and polarity of neurovascular coupling depends on astrocytic endfoot Ca(

102 Neurovascular coupling describes the link between neuron

103 min after cocaine injection, indicating that neurovascular coupling during stimulation was temporaril

104 he present study assessed CBF regulation and neurovascular coupling during submaximal cycling exercis

105 as reliable quantitative reporters to follow neurovascular coupling dynamics.

106 The data are consistent with a neurovascular coupling effect in the retina.

107 Ipsilateral and contralateral neurovascular coupling effects were documented, and crit

108 potential and fMRI signals validates strong neurovascular coupling, enabling cross-scale brain mappi

109 p junctions serve as a signaling highway for neurovascular coupling, enabling flexible and efficient

110 Second, neurovascular coupling ensures that, following local neu

111 future investigations on the impairments of neurovascular coupling from vascular diseases such as di

112 orts a conceptual shift in the mechanisms of neurovascular coupling, from a unidimensional process in

113 The involvement of astrocytes in neurovascular coupling has broad implications for the in

114 Early impairments to neurovascular coupling have been proposed to be a key pa

115 One widely recognized hypothesis of neurovascular coupling holds that glial cell depolarizat

116 mechanism is essential to preserving healthy neurovascular coupling; however, to our knowledge, no st

117 ral blood flow that range from physiological neurovascular coupling (hyperaemia) to pathological inve

118 change in internal carotid artery blood flow Neurovascular coupling (i.e. the relationship between lo

119 transcriptional regulator of SEMA3E-mediated neurovascular coupling in a mouse model of oxygen-induce

120 sis, and activity-induced neurometabolic and neurovascular coupling in adult (6 months) and aged (12

121 Investigating neurovascular coupling in awake rodents is becoming ever

122 Here we address this issue by examining neurovascular coupling in both ex vivo and in vivo rat r

123 n in IR-deficient astrocytes, and normalized neurovascular coupling in GFAP-IR KO mice.

124 ker-induced hyperemic responses and to study neurovascular coupling in humans.

125 indicating that nitric oxide is integral to neurovascular coupling in humans.

126 n to assess the influence of nitric oxide on neurovascular coupling in humans.

127 2Y12 receptor (P2Y12R) substantially impairs neurovascular coupling in mice, which is reiterated by c

128 Wavelet coherence analysis of neurovascular coupling in NE may identify infants at ris

129 transcriptional regulator of SEMA3E-mediated neurovascular coupling in pathological retinal angiogene

130 nd a suite of in vivo imaging tools to study neurovascular coupling in rat primary somatosensory cort

131 estigated the contribution of glial cells to neurovascular coupling in the acutely isolated mammalian

132 hyperglycemia has a detrimental influence on neurovascular coupling in the brain-an effect linked to

133 direct proportionality of volumetric spatial neurovascular coupling in the cerebral cortex.

134 Our study examines the association between neurovascular coupling in the middle cerebral artery and

135 The deficiencies of flow regulation and neurovascular coupling in the retina appear to precede n

136 Here, we investigate spatial correlations of neurovascular coupling in three dimensions, by applying

137 -dependent Ca(2+) signaling does not mediate neurovascular coupling in visual cortex of awake, lightl

138 gs demonstrate that hyperoxia does not alter neurovascular coupling in vivo, ensuring that active neu

139 hindered by uncertainty as to the nature of neurovascular coupling in young individuals.

140 article, potential alternative functions of neurovascular coupling include supplying oxygen for neur

141 Under nitroprusside infusion, a neurovascular-coupling inhibitor, the diffusion response

142 Mechanistically, the failure of neurovascular coupling involves a tau-induced dissociati

143 ystem, the olfactory glomerulus, to show how neurovascular coupling involves an elaborate dance betwe

144 This process, known as neurovascular coupling, involves rapid, coordinated vaso

145 Neurovascular coupling is a critical brain mechanism whe

146 Neurovascular coupling is a fundamental brain mechanism

147 Neurovascular coupling is a process through which neuron

148 Neurovascular coupling is a vital mechanism employed by

149 Together, these findings reveal that neurovascular coupling is aberrantly elevated before Abe

150 Fundamental to the interpretation of neurovascular coupling is determining the neuronal activ

151 or functional brain imaging(2), and impaired neurovascular coupling is implicated in neurodegeneratio

152 location within the microvascular tree where neurovascular coupling is initiated, and the role of mur

153 Neurovascular coupling is irregular, absent, or inverted

154 The breakdown of neurovascular coupling is linked to the development and

155 superiorly to the optic nerve suggests that neurovascular coupling is perturbed.

156 Neurovascular coupling is the basis for functional brain

157 Functional hyperemia, also known as neurovascular coupling, is a phenomenon that occurs when

158 Although this response, termed neurovascular coupling, is widely used to monitor human

159 Neurovascular coupling, linking neuronal activity to cer

160 lity and consequences of conditions in which neurovascular coupling may be altered, including during

161 Neurovascular coupling may be involved in compensatory m

162 Inversion of neurovascular coupling may contribute to the decreased c

163 Our results suggest that intact neurovascular coupling may help preserve mobility in eld

164 This suggests that neurovascular coupling mechanism is likely to contain a

165 may fail in situations interfering with the neurovascular coupling mechanisms (drugs, anesthesia).

166 Here, we review current candidate neurovascular coupling mechanisms and propose that previ

167 the need to revisit the current knowledge of neurovascular coupling mechanisms and the association be

168 is needed for improving our understanding of neurovascular coupling mechanisms and the related measur

169 Similar neurovascular coupling mechanisms are observed during pr

170 standing of the signalling events underlying neurovascular coupling mechanisms in the brain is a cruc

171 Study of neurovascular coupling mechanisms is especially importan

172 ivity of the brain, is met by an ensemble of neurovascular coupling mechanisms that link neuronal act

173 a unique neuromonitoring platform to explore neurovascular coupling mechanisms.

174 gulating synaptic plasticity, and defects in neurovascular coupling mediating cerebral blood flow.

175 d changes in the BOLD response could reflect neurovascular coupling modifications rather than simply

176 Together, our findings revealed a neurovascular coupling network that regulates experience

177 Proper brain function depends on neurovascular coupling: neural activity rapidly increase

178 he effects of wakefulness reflect changes in neurovascular coupling, not in neural activity.

179 ecent study established a novel non-invasive neurovascular coupling (NVC) assessment in newborns usin

180 The classical model of neurovascular coupling (NVC) implies that activity-depen

181 inical models, yet the mechanisms underlying neurovascular coupling (NVC) in humans have yet to be el

182 G (aEEG) outputs impact the determination of neurovascular coupling (NVC) in newborns with encephalop

183 Neurovascular coupling (NVC) is a key process in cerebra

184 Neurovascular coupling (NVC) is important for brain func

185 Neurovascular coupling (NVC) is the process whereby neur

186 Physiologically, neurovascular coupling (NVC) matches focal increases in

187 Several such neurovascular coupling (NVC) mechanisms have been identi

188 nimal models and the translation to critical neurovascular coupling (NVC) patterns for human fMRI.

189 a proof of concept study aiming to quantify neurovascular coupling (NVC) using wavelet analysis of t

190 They play an important role in mediating neurovascular coupling (NVC) via several astrocytic Ca(2

191 cular dysfunction in AD includes deficits in neurovascular coupling (NVC), a mechanism that ensures r

192 Neurovascular coupling (NVC), a vital physiological proc

193 several key topics in brain research such as neurovascular coupling (NVC), glymphatic pathway, and GB

194 imuli [including carbon dioxide (CO(2))]; 3) neurovascular coupling (NVC), i.e., the CBF response to

195 Here we report that stress impairs neurovascular coupling (NVC), the process that matches n

196 sodilatory prostaglandins play a key role in neurovascular coupling (NVC), the tight link between neu

197 The alteration of neurovascular coupling (NVC), where acute localized bloo

198 Neurovascular coupling (NVC), which mediates rapid incre

199 reactivity to carbon dioxide (CVR(CO2) ) and neurovascular coupling (NVC).

200 ut acute experimental metabolic alkalosis on neurovascular coupling (NVC).

201 utrients to active neurons, a process termed neurovascular coupling (NVC).

202 blood flow response to neuronal activation [neurovascular coupling (NVC)] in a model of AD precedes

203 Neurovascular coupling (NVC, "functional hyperemia") is

204 d hemodynamics, a phenomenon referred to as "neurovascular coupling" (NVC).

205 lized increases in cerebral blood flow (i.e. neurovascular coupling; NVC).

206 , we determined whether pathological inverse neurovascular coupling occurred as a mechanism of second

207 ective CREB and synaptogenesis signaling and neurovascular coupling pathways.

208 concept from the current electrochemical and neurovascular coupling principles used for brain imaging

209 -1 inhibition restores tPA activity, rescues neurovascular coupling, reduces amyloid deposition aroun

210 del that incorporates internalization into a neurovascular-coupling relationship.

211 However, the mechanisms of neurovascular coupling remain incompletely understood.

212 erlying molecular and cellular mechanisms of neurovascular coupling remain poorly understood.

213 Thus, neurovascular coupling remained preserved under a chroni

214 overed capillaries control vasomotion during neurovascular coupling remains controversial.

215 regulation of cerebral blood flow (CBF) and neurovascular coupling remains, however, under debate.

216 nitric oxide synthase inhibitor reduced the neurovascular coupling response by ~30%, indicating that

217 ling lead to a switch in the polarity of the neurovascular coupling response from vasodilation to vas

218 t improvement in cerebral blood flow and the neurovascular coupling response, as well as increased ex

219 ies such as Alzheimer's disease, would alter neurovascular coupling responses to sensory stimulation.

220 erebrovascular reactivity and whisker-evoked neurovascular coupling responses were measured at end po

221 nt for the full expression of sensory-evoked neurovascular coupling responses.

222 in slices, 100% O(2) has been shown to alter neurovascular coupling, suppressing activity-dependent v

223 measurements indicate that the mechanism of neurovascular coupling systematically affects the vascul

224 simultaneous PET/fMRI for investigations of neurovascular coupling that correlate neurochemistry wit

225 This approach crucially relies on neurovascular coupling, the mechanism that links neurona

226 ated that nitric oxide is a key component of neurovascular coupling; this has yet to be translated to

227 e microcirculatory blood flow and coordinate neurovascular coupling through interpericyte tunneling n

228 Ca(2+) signaling within the endfoot mediates neurovascular coupling; thus, these functional microdoma

229 three patients exhibited dynamic changes in neurovascular coupling to depolarizations throughout the

230 physiological concentration fully recovered neurovascular coupling to its original magnitude.

231 ebral blood flow is dynamically regulated by neurovascular coupling to meet the dynamic metabolic dem

232 These results establish inverse neurovascular coupling to spreading depolarization as a

233 This neurovascular coupling underlies blood oxygen level-depe

234 Rather, neurovascular coupling underlying BOLD response patterns

235 The mechanisms of neurovascular coupling underlying generation of BOLD fMR

236 s, and reveal a second vascular component of neurovascular coupling upon very strong stimulation.

237 its newly recognized precursor, nitrite, in neurovascular coupling using a well-established rat mode

238 sed to 14.5 (95% CI, 2.3-91.1; p = 0.004) if neurovascular coupling was also attenuated.

239 Neurovascular coupling was assessed in bilateral middle

240 Neurovascular coupling was attenuated in slow compared t

241 Persistent disruption of neurovascular coupling was demonstrated by a loss of coh

242 Further, neurovascular coupling was intact in lightly sedated, re

243 This neurovascular coupling was linked by parvalbumin-express

244 We found that neurovascular coupling was similar across states and tha

245 in awake mice recovered from brain surgery, neurovascular coupling was too fast and efficient to rev

246 To quantify changes in neurovascular coupling, we combined laser speckle contra

247 usal state impacts cerebral hemodynamics and neurovascular coupling, we monitored neural activity, be

248 show that blood flow, blood oxygenation and neurovascular coupling were decreased in the hippocampus

249 While sensory stimulus-evoked dilations (neurovascular coupling) were amplified at higher BP leve

250 , indicating that although O(2) can modulate neurovascular coupling when raised sufficiently high, th

251 both caveolae and eNOS completely abolished neurovascular coupling, whereas the single mutants exhib

252 ynaptic transmission, vascular dynamics, and neurovascular coupling, which are central to AD pathogen

253 nctional near-infrared spectroscopy) rely on neurovascular coupling, which is a useful but indirect m

254 tial to give rise to both neurometabolic and neurovascular couplings, which form the basis for the de

255 idance, this Protocol facilitates studies of neurovascular coupling with the neurochemical basis of l

256 mic responses consistent with more efficient neurovascular coupling within the left DLPFC.

257 A1 is necessary for functional hyperemia and neurovascular coupling within the somatosensory cortex o