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1 imately 11% of sera, which had low levels of neutralizing antibody.
2 nalysis of the viral fusogen together with a neutralizing antibody.
3 an AMPA receptor antagonist or an anti-BDNF neutralizing antibody.
4 , there was no difference in the presence of neutralizing antibodies.
5 ain reaction) and had >=4-fold rise in serum-neutralizing antibodies.
6 ry into host cells and is the main target of neutralizing antibodies.
7 and receptor binding domain) are targets for neutralizing antibodies.
8 he complexes formed are important targets of neutralizing antibodies.
9 thereby contribute to the failure to produce neutralizing antibodies.
10 inant of host range and a dominant target of neutralizing antibodies.
11 inferred germline sequences, to HIV broadly neutralizing antibodies.
12 , CPO RSVs induced lower levels of serum RSV-neutralizing antibodies.
13 approaches for passive delivery of anti-HIV neutralizing antibodies.
14 specific antigenic sites from recognition by neutralizing antibodies.
15 eroreactivity to both RBD and S2 that lacked neutralizing antibodies.
16 alization screening resulted in 268 in vitro neutralizing antibodies.
17 of vascular endothelial growth factor (VEGF)-neutralizing antibodies.
18 ibodies, and decreased the binding of poorly neutralizing antibodies.
19 versified, impeding efforts to isolate cross-neutralizing antibodies.
20 ion resulted in generation of high levels of neutralizing antibodies.
21 r B and T follicular helper cells and plasma neutralizing antibodies.
22 1:1000, of whom 12 had positive results for neutralizing antibodies.
23 contains epitopes for at least four broadly neutralizing antibodies.
24 proteins and the induction of high levels of neutralizing antibodies.
25 cination serum samples were tested for polio-neutralizing antibodies.
26 f high concentrations of SARS-CoV-2-specific neutralizing antibodies.
27 t has not previously emerged as a target for neutralizing antibodies.
28 anti RSV-F immunoglobin (Ig) G, and ChAd155 neutralizing antibodies.
29 cellular immune responses, including potent neutralizing antibodies.
30 , including 10 epitopes likely recognized by neutralizing antibodies.
31 coprotein B (gB) serves as a major target of neutralizing antibodies.
32 of vaccines designed to induce production of neutralizing antibodies.
33 ple HVD/capsid mutants induce high levels of neutralizing antibodies.
34 s as a target for some highly potent broadly neutralizing antibodies.
35 2 spike glycoprotein, the primary target for neutralizing antibodies.
36 after vaccinations was tested for poliovirus-neutralizing antibodies.
37 induced a significant increase in serum RSV-neutralizing antibodies.
38 efforts to design vaccines to induce broadly neutralizing antibodies.
39 haracterized by a fast rise in serum IgG and neutralizing antibodies.
41 lls from natural controllers mainly produced neutralizing antibodies able to cross-react with several
46 s in mice, and mice were given injections of neutralizing antibodies against chemokines, antagonists,
47 ulating factor (G-CSF) and administration of neutralizing antibodies against G-CSF only partially res
49 posed to restrict the development of broadly neutralizing antibodies against HIV-1, but this has not
50 tective in several animal models and induces neutralizing antibodies against protective antigen (PA),
52 present the potential for the development of neutralizing antibodies against the C-terminal motif of
54 noglobulin preparations that need to contain neutralizing antibodies against the pathogens in their e
55 late of such countermeasures is the level of neutralizing antibodies against the SARS-CoV-2 spike pro
58 nscription in neural progenitor cells, and a neutralizing antibody against CNTF reduced the astrogeni
61 as described the high prevalence of anti-AAV neutralizing antibodies among domestic cats in Switzerla
62 otiter plates resulted in 22 unique in vitro neutralizing antibodies and a panning in solution combin
65 The vaccine was tolerated, with induction of neutralizing antibodies and antigen-specific T cells aga
66 ted reactogenicity; we measured IgG binding, neutralizing antibodies and cellular immune responses to
69 s on the Spike protein, as it is targeted by neutralizing antibodies and plays a key role in viral en
70 ies in mice found these epitopes induce EBOV-neutralizing antibodies and protect against lethal EBOV
71 erse genetics and evaluated the induction of neutralizing antibodies and protection by rAPMV3 and rND
73 Prefusion SARS-CoV-2 S is the main target of neutralizing antibodies and the focus of vaccine design.
74 ere accompanied by a decline of HCV-specific neutralizing antibodies and the germinal center activity
75 IV-1 envelope protein (Env) is the target of neutralizing antibodies and the template for vaccine imm
76 protein B of HCMV is an important target for neutralizing antibodies and, hence, is often included as
77 recombinant viruses elicited high levels of neutralizing antibody and provided complete protection a
78 lpha, we examined the effects of a TNF-alpha neutralizing antibody and recombinant TNF-alpha soluble
79 ower anti-RSV neutralizing antibodies, where neutralizing antibody (and local IgA) may be a correlate
80 rms can differentially shield the virus from neutralizing antibodies, and (iii) effects of gO polymor
81 ed or maintained the binding of most broadly neutralizing antibodies, and decreased the binding of po
82 city by enzyme-linked immunospot, functional neutralizing antibodies, anti RSV-F immunoglobin (Ig) G,
84 V-2 S variants that resist commonly elicited neutralizing antibodies are now present at low frequenci
89 suggest that 1 in 5 17D vaccinees will lack neutralizing antibodies at ~10 years postvaccination, an
90 hermore, monotherapy with the potent broadly neutralizing antibody Bc1.187 suppressed viremia in vivo
91 ingle subcutaneous administration of broadly neutralizing antibody (bNAb) 10-1074 conferred durable p
92 g and >100-fold more potent than the broadly neutralizing antibody (bNAb) 3BNC117, with >12,000-fold
93 Abs.IMPORTANCE The efficacy of HIV-1 broadly neutralizing antibody (bnAb) therapies may be compromise
94 cacy of two vaccine candidates and a broadly neutralizing antibody (bNAb) to prevent HIV-1 infection
95 over whether passive infusion of the broadly neutralizing antibody (bNAb) VRC01 can protect against H
96 1 vaccine development aims to elicit broadly neutralizing antibodies (bnAbs) against diverse viral st
98 on of HIV-1- infected humans develop broadly neutralizing antibodies (bNAbs) against HIV-1 that prote
99 ing of viral infection by a class of broadly neutralizing antibodies (bnAbs) against human immunodefi
100 imers) present multiple epitopes for broadly neutralizing antibodies (bNAbs) and their germline precu
101 IP trimers retained their binding to broadly neutralizing antibodies (bNAbs) and to their unmutated c
107 Eliciting protective titers of HIV-1 broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vacci
109 complexes with front layer-specific broadly neutralizing antibodies (bNAbs) isolated from HCV-infect
110 de of recognition like that of human broadly neutralizing antibodies (bNAbs) PGT145 and PCT64-35S.
113 C virus (HCV) is the major target of broadly neutralizing antibodies (bNAbs) that are critical for th
114 ndividuals produced shared clones of broadly neutralizing antibodies (bNAbs) that targeted 3 non-over
117 iverse strains of the virus-known as broadly neutralizing antibodies (bnAbs)-could protect against hi
121 ormer mechanism suggests the need to enhance neutralizing antibody breadth; the latter suggests the n
122 ard an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing
123 xpressing HA protein induced higher level of neutralizing antibodies compared to that of rNDV express
124 pose a serious concern to global health, and neutralizing antibodies constitute a promising area of a
127 r blocking relevant scavenger receptors with neutralizing antibodies could, therefore, be of value in
128 ly, inhibition of IL-9 or IL-17 cytokines by neutralizing antibodies decreased EMT and slowed lung ca
129 cipients and infants infected in utero Virus-neutralizing antibodies defined in vitro have been propo
130 nse prior to Env trimer immunization elicits neutralizing antibody development and production of anti
132 re also important for viral sensitization to neutralizing antibodies, directly linking the antiviral
135 ich to understand interactions between S and neutralizing antibodies during infection or vaccination.
136 by DeltagD-2 provide greater protection than neutralizing antibodies elicited by rgD-2 against primar
137 classify the antibodies into categories: (1) neutralizing antibodies encoded by the VH3-53 gene segme
138 results provide structural insight as to how neutralizing antibody engagement of CHIKV inhibits diffe
140 velope (E) protein is the dominant target of neutralizing antibodies for dengue virus (DENV) and yell
141 the biodistribution, blood circulation time, neutralizing antibody formation, and targeted delivery a
145 are capable of inducing strain-transcendent neutralizing antibodies has renewed enthusiasm for the p
149 ed the technology to the production of human neutralizing antibodies in a transchromosomic (Tc) bovin
150 for the presence of anti SARS-CoV-2 specific neutralizing antibodies in convalescent patient serum.
151 neutralization assay that detects SARS-CoV-2 neutralizing antibodies in COVID-19 patient specimens an
152 rofile and induces high levels of SARS-CoV-2 neutralizing antibodies in hamsters (Mesocricetus auratu
154 wed evidence of virus replication but not of neutralizing antibodies in her nasopharyngeal swabs.
155 envelope (E) protein is the major target of neutralizing antibodies in infected hosts and thus repre
156 COV-2 Spike were successfully used to detect neutralizing antibodies in plasma from coronavirus disea
157 rve virus replication in the near absence of neutralizing antibody in this unique mouse model.IMPORTA
159 assive immunization treatments using broadly neutralizing antibodies is a promising therapeutic appro
161 high-throughput assay to measure SARS-CoV-2 neutralizing antibodies is urgently needed for COVID-19
162 er therapeutic response without the need for neutralizing antibodies isolated from convalescent patie
165 is of a phase 2 trial, one of three doses of neutralizing antibody LY-CoV555 appeared to accelerate t
166 to receive a single intravenous infusion of neutralizing antibody LY-CoV555 in one of three doses (7
168 greatly increased germinal center, antibody, neutralizing antibody, memory and long-lived plasma cell
169 Therapeutic prevention of IL11 activity with neutralizing antibodies mirrored the effects of genetic
172 dinal antibody responses were identified for neutralizing antibody (Nab) potential, and differences i
173 the AMC009 trimers did not induce autologous neutralizing antibody (NAb) responses efficiently while
174 IgG3 bAb responses, IgG bAb breadth scores, neutralizing antibody (nAb) responses, antibody-dependen
175 nts during the 2017-2018 season to determine neutralizing antibody (nAb) titers and for influenza vir
179 ile methodology for rapid epitope mapping of neutralizing antibodies (NAbs) against HIV-1 Envelope (E
180 neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses ma
182 Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2 in
183 advances in the research and development of neutralizing antibodies (nAbs) for the prevention and tr
184 ns are vaccine components intended to induce neutralizing antibodies (NAbs) that prevent cells from i
186 t chimeric SOSIP trimers and elicited tier 2 neutralizing antibodies of higher potency than noncomple
187 zation assay-geometric mean titers (GMTs) of neutralizing antibodies of the vaccine group (46; 95% CI
188 better than did TB or TR in the presence of neutralizing antibodies on both cell types, indicating t
189 Geometric mean titres of SARS-CoV-2 serum-neutralizing antibodies on day 43 were 0.7-fold (1-mug d
190 ypes of studies, such as characterization of neutralizing antibodies or development of fusion-inhibit
192 able regions 1 and 2 (V1V2)-targeted broadly neutralizing antibody PG9 to block productive infection,
193 etermined the crystal structure of CR3022, a neutralizing antibody previously isolated from a convale
195 of ChAd-SARS-CoV-2-S induces high levels of neutralizing antibodies, promotes systemic and mucosal i
196 escribed REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987 and REGN10933) that t
199 precursor B cell receptors of HIV-1 broadly neutralizing antibodies requires specifically designed i
201 not cause diarrhea in animals and elicits a neutralizing antibody response in virus-infected animals
203 ically, primary infection generates a robust neutralizing antibody response that mediates viral contr
204 er, we document that cats developed a robust neutralizing antibody response that prevented reinfectio
207 n G (IgG) antibody responses and mumps virus-neutralizing antibody responses (based on the focus-redu
209 n should be considered for inducing strongly neutralizing antibody responses against SARS-CoV-2.
210 ARS-CoV-2 spike protein elicited binding and neutralizing antibody responses and protected against SA
211 The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or
212 Additionally, we detect robust and sustained neutralizing antibody responses and the antibodies elici
213 therapeutics and are a major contributor to neutralizing antibody responses elicited by infection.
214 Here we show that mRNA-1273 induces potent neutralizing antibody responses to both wild-type (D614)
218 obulin (Ig)M, IgA, IgG) in >95% of cases and neutralizing antibody responses when sampled beyond 8 d
219 als who developed unusually broad and potent neutralizing antibody responses, might serve as blueprin
220 To gain a deeper understanding of cross-neutralizing antibody responses, we mined the memory B c
229 rization of two ultrapotent SARS-CoV-2 human neutralizing antibodies (S2E12 and S2M11) that protect h
230 y the FDA in 2019, is a humanized sclerostin-neutralizing antibody (Scl-Ab) indicated in postmenopaus
231 ne variant that displayed a >=4-fold reduced neutralizing antibody sensitivity against at least one M
236 e HMPV entry was fully inhibited by 54G10, a neutralizing antibody, spread was only modestly reduced,
238 ical to the infection cycle of HIV, and most neutralizing antibodies target the high-mannose glycans
240 ecific plasma cells are capable of producing neutralizing antibodies that are essential for clearance
241 nd bind only to 'up' RBDs; (2) ACE2-blocking neutralizing antibodies that bind both up and 'down' RBD
242 own' RBDs and can contact adjacent RBDs; (3) neutralizing antibodies that bind outside the ACE2 site
243 l of NoV, and recent studies have identified neutralizing antibodies that bind the capsid protein VP1
244 us is the induction of cross-reactive poorly neutralizing antibodies that can cause antibody-dependen
245 4-induced (CD4i) exposure of epitopes of non-neutralizing antibodies that can potentially hinder indu
246 valuable insights into epitopes targeted by neutralizing antibodies that could be potent targets for
247 cific and flavivirus cross-reactive potently neutralizing antibodies that have been mapped to quatern
248 we show that older individuals make broadly neutralizing antibodies that have no hemagglutination-in
249 e were able to identify target structures of neutralizing antibodies that potently block gB-induced m
250 mary ZIKV infection generates high titers of neutralizing antibodies that protect from detectable pla
251 e, a goal of HCV vaccine design is to induce neutralizing antibodies that target conserved epitopes.
253 vaccine strategies focus on the induction of neutralizing antibodies, there is substantial evidence t
256 sed as percentage of those with rabies virus neutralizing antibodies titers >= 0.5 IU/mL on day 14.
257 accinees had >=4-fold increases in serum RSV-neutralizing antibody titers after the RSV season withou
258 ral and cellular immune responses, including neutralizing antibody titers at levels comparable to tho
262 cline, low to undetectable viremia, and high neutralizing antibody titers throughout the disease cour
265 The 100-mug dose induced higher binding- and neutralizing-antibody titers than the 25-mug dose, which
266 infective dose (ID(50) > 10,000) maintained neutralizing antibody titres >1,000 at >60 d POS, some w
267 ort, there was also a significant decline in neutralizing antibody titres against ZIKV, but not again
268 t >60 d POS, some with lower peak ID(50) had neutralizing antibody titres approaching baseline within
269 of an acute viral infection, with declining neutralizing antibody titres observed after an initial p
276 d blood spot (DBS) specimens were tested for neutralizing antibodies to poliovirus types 1, 2, and 3
278 elevated expression of alpha5 subunit, and a neutralizing antibody to alpha5 subunit reduced adhesion
281 nduce cross-reactive, potentially even cross-neutralizing, antibodies to the new species in humans is
284 TDF and FTC in combination with the broadly neutralizing antibody VRC01-N using a highly reproducibl
286 FGF2 signaling by central injection of FGFR3-neutralizing antibody was able to reverse the diminishme
294 onverting enzyme 2 (ACE2) and cross-reacting neutralizing antibody were found to be conserved among t
295 severity in adults were: (1) lower anti-RSV neutralizing antibodies, where neutralizing antibody (an
296 findings suggest that the potency of poorly neutralizing antibodies, which are commonly elicited in
297 djuvant AddaVax, the RBD derivative elicited neutralizing antibodies with an endpoint geometric mean
300 zation assay is specific to measure COVID-19 neutralizing antibodies without cross reacting with pati