ライフサイエンスコーパス: neutrophil activation

1 racellular ATP mitigates pneumolysin-induced neutrophil activation.

2 d as fluid shear stress sensors that control neutrophil activation.

3 molysin was identified as a major trigger of neutrophil activation.

4 rmed that ATP inhibits pneumolysin-dependent neutrophil activation.

5 ompetitively inhibits the FPR1-induced human neutrophil activation.

6 alize at the cell surface without triggering neutrophil activation.

7 ficiency was shown to contribute to impaired neutrophil activation.

8 hat, unlike M1 or fibrinogen alone, leads to neutrophil activation.

9 t kinase isoforms have distinct functions in neutrophil activation.

10 utagenesis to identify LVS genes that affect neutrophil activation.

11 P2], a lipid second messenger generated upon neutrophil activation.

12 tinct from those that are involved in normal neutrophil activation.

13 rnea, including corneal fibroblasts, and for neutrophil activation.

14 ther inflammatory conditions associated with neutrophil activation.

15 ement activates tyrosine kinases, leading to neutrophil activation.

16 to examine the role of SHIP in TLR2-induced neutrophil activation.

17 ma-hemorrhagic shock-induced lung injury and neutrophil activation.

18 s the degree of T/HS-induced lung injury and neutrophil activation.

19 and Hsp27 dissociates from the complex upon neutrophil activation.

20 etabolic enzyme trafficking affects maternal neutrophil activation.

21 ating endothelial barrier dysfunction during neutrophil activation.

22 ore IR prevented endothelial dysfunction and neutrophil activation.

23 stained endothelial dysfunction and systemic neutrophil activation.

24 es including receptor-mediated responses and neutrophil activation.

25 e interaction would be sufficient to trigger neutrophil activation.

26 on of capillary endothelium by prevention of neutrophil activation.

27 cts of cytokines such as TNF and by blocking neutrophil activation.

28 both be active participants in ANCA-induced neutrophil activation.

29 owth factor-beta (TGF-beta), which inhibited neutrophil activation.

30 in initiating and perpetuating ANCA-induced neutrophil activation.

31 ent; secretory component showed no effect on neutrophil activation.

32 little is known of their individual roles in neutrophil activation.

33 pears to function as a negative regulator of neutrophil activation.

34 however, drove DNA externalisation following neutrophil activation.

35 oiesis in the bone marrow and not peripheral neutrophil activation.

36 ed by the helminths on either eosinophil nor neutrophil activation.

37 or Stim2 to investigate the role of STIM2 in neutrophil activation.

38 trophil binding to erythrocytes and restored neutrophil activation.

39 yeloperoxidase from neutrophils, a marker of neutrophil activation.

40 ilable, could prove an accurate biomarker of neutrophil activation.

41 matory actions of macrophages and subsequent neutrophil activation.

42 n the extracellular space leading to reduced neutrophil activation.

43 -CSF, at concentrations sufficient to affect neutrophil activation.

44 nal assays, including analysis of downstream neutrophil activation.

45 signaling activity can set the timescale of neutrophil activation, adhesion, and diapedesis.

46 a indicate that the pathways leading to lung neutrophil activation after hemorrhage are different fro

47 Aldehyde generation required neutrophil activation and a free hydroxy-amino acid; it

48 than or equal to 55[corrected]%, indicating neutrophil activation and a reduced phagocytic capacity

49 In its early exudative phase, neutrophil activation and accumulation in the lung lead

50 However, neutrophil activation and accumulation into tissues trig

51 This study suggests that the neutrophil activation and adhesion may vary, depending o

52 We hypothesized that human neutrophil activation and adhesion vary, depending on th

53 e maladaptive activation of genes that cause neutrophil activation and adhesion, and induction of NO

54 demonstrated by the dose-related increase in neutrophil activation and adhesion.

55 tate in SCD between painful crises involving neutrophil activation and an abnormality of cytokine-reg

56 In this study, the relationship of neutrophil activation and apoptosis as related to releas

57 is work, we construct an integrated model of neutrophil activation and arrest that combines a biomech

58 local innate immune responses (monocyte and neutrophil activation and chemoattractant molecules) was

59 2 has the ability to specifically potentiate neutrophil activation and chemotaxis in response to a ra

60 IL-8 involvement in neutrophil activation and chemotaxis may be important in

61 ravascular and extravascular fibrinogenesis, neutrophil activation and clearance, and alveolar fluid

62 impact of streptococcus-secreted factors on neutrophil activation and degranulation.

63 or that, in the absence of SpeB, can trigger neutrophil activation and degranulation.

64 s associated with systemic polymorphonuclear neutrophil activation and degranulation.

65 TLR2 mediates O. volvulus/Wolbachia-induced neutrophil activation and development of corneal haze.

66 receptors may act synergistically to amplify neutrophil activation and emigration in the inflamed vas

67 ired fibrinogen function are associated with neutrophil activation and enhanced reactive oxygen speci

68 rolling to firm adhesion is a key element of neutrophil activation and essential to the inflammatory

69 uggest that TF/FVIIa/PAR2 signaling mediates neutrophil activation and fetal death in APS and that st

70 These data suggest possible roles for neutrophil activation and for fibronectin in mediating s

71 ith SLE or RA have differential effects upon neutrophil activation and function.

72 y state granulopoiesis, as well as in mature neutrophil activation and function.

73 findings, inhibition of PGE2 led to enhanced neutrophil activation and host mortality after infection

74 Given roles for FcRs in ANCA-mediated neutrophil activation and IgA antibodies in mucosal immu

75 s a negative regulatory role in TLR2-induced neutrophil activation and in the development of related

76 Moreover, downregulated neutrophil activation and increased levels of serum CXCL

77 -supplemented CHAB was sufficient to prevent neutrophil activation and intramacrophage killing and su

78 ts Cl, Br, or I) are metabolites mediated by neutrophil activation and its accompanying respiratory b

79 te that a main role of exogenous hVPLA(2) in neutrophil activation and LTB(4) biosynthesis is to acti

80 onstrate that LTB(4) plays a central role in neutrophil activation and migration to formyl peptides.

81 We first describe the discrete steps of neutrophil activation and migration to the site of infec

82 ntial for vagus nerve-mediated regulation of neutrophil activation and migration.

83 ion of proinflammatory genes associated with neutrophil activation and molecular pathways important t

84 w PSDP structural mimetic that blocked human neutrophil activation and mouse lung PI3K activity and i

85 In falciparum malaria, neutrophil activation and NET counts positively correlat

86 In patients with symptomatic malaria, neutrophil activation and NET counts were increased in a

87 Type I IFN-mediated neutrophil activation and NET formation may contribute t

88 eded to determine the utility of circulating neutrophil activation and NET markers, alone or in conce

89 owth in asymptomatic P falciparum infection, neutrophil activation and NET release may contribute to

90 nflammation and coagulation, suggesting that neutrophil activation and NETs may exert proinflammatory

91 Neutrophil activation and NETs were quantified by immuno

92 2-/- mice treated with aPL exhibited reduced neutrophil activation and normal pregnancies, which indi

93 sed neutrophil recruitment, while increasing neutrophil activation and p38 activity at the site of in

94 r pathological venous thrombosis and present neutrophil activation and PAD4 as potential drug targets

95 Signatures included T cells, macrophages, neutrophil activation and poly:IC signatures, representi

96 One hallmark of inflammation is neutrophil activation and production of reactive oxygen

97 Analysis of signaling molecules mediating neutrophil activation and recruitment indicates reductio

98 ominance of a type I interferon response and neutrophil activation and recruitment, together with a l

99 he adhesion protein P-selectin would prevent neutrophil activation and reduce myocardial reperfusion

100 nks stress-induced inflammatory attacks with neutrophil activation and release of IL-1beta-bearing ne

101 estigate the relationships between H. pylori neutrophil activation and reported variations in HpNAP e

102 tic cell transplantation (allo-HCT) triggers neutrophil activation and requires antibiotic interventi

103 The effect was due to their regulation of neutrophil activation and sequestration.

104 n was inhibited by EDTA, which suggests that neutrophil activation and sheddase cleavage occurred.

105 trates that stimulation of FPRL-1 results in neutrophil activation and suggests that the receptor fun

106 evidence of platelet-neutrophil aggregates, neutrophil activation and surface MPO, and plasma MPO el

107 polymers act as a decoy mechanism to prevent neutrophil activation and that this represents an import

108 However, no relationship was found between neutrophil activation and the expression of HpNAP or dif

109 igens in FS implies a direct contribution of neutrophil activation and the production of NET-associat

110 e human-specific variant of resistin affects neutrophil activation and the severity of LPS-induced ac

111 epi LXA4), plays a critical role in limiting neutrophil activation and tissue inflammation, thus prom

112 The neutrophil uptake of NPs does not alter neutrophil activation and transmigration.

113 Here we analyzed how TF contributes to neutrophil activation and trophoblast injury in this mod

114 substantial tissue damage through excessive neutrophil activation and uncontrolled granule release.

115 The association between neutrophil activation and vacuolating cytotoxin activity

116 Blocking FcalphaRI inhibited neutrophil activation and, as such, may represent an add

117 Our findings suggest that neutrophil activation and, in particular, activated T ce

118 and lung microvascular thrombosis, decreased neutrophil activation, and averted histone-induced produ

119 es, production of proinflammatory mediators, neutrophil activation, and bacterial clearance.

120 recruitment, humoral and adaptive immunity, neutrophil activation, and cachexia.

121 increased neutrophil recruitment, decreased neutrophil activation, and decreased p38 activity at the

122 poor outcome are degree of oxidative stress, neutrophil activation, and infiltration of tissues, espe

123 hout affecting Mac-1 mobilization or general neutrophil activation, and inhibit cleavage of L-selecti

124 downregulation of PECAM-1 indicates an early neutrophil activation, and its inhibition may represent

125 Increased airway cell IFN signaling, neutrophil activation, and NET production is associated

126 risk factors, biomarkers of inflammation and neutrophil activation, and the presence of magnetic reso

127 f ADAM17 is highly inducible and occurs upon neutrophil activation as well as apoptosis.

128 roparticles/neutrophil count, a surrogate of neutrophil activation associated with septic shock-induc

129 Mucosal neutrophil activation before exposure was highly predict

130 supramolecular network that was required for neutrophil activation but was distinct from a fibrin clo

131 marrow chimeric mice and in vitro studies of neutrophil activation by anti-MPO IgG indicated that sev

132 pand on the possible roles of complement and neutrophil activation by dialysis membranes, which may p

133 ukocyte surface chondroitin sulfates promote neutrophil activation by enhancing immune-complex bindin

134 Neutrophil activation by FN, but not other extracellular

135 These studies demonstrate neutrophil activation by influenza virus and highlight t

136 depending on other stimuli, HS can suppress neutrophil activation by intercepting multiple receptor

137 r integrity, enterohepatic recirculation and neutrophil activation by luminal contents including bact

138 integrity, enterohepatic recirculation, and neutrophil activation by luminal contents, including bac

139 I3K) and PI3K-associated signaling events in neutrophil activation by MBP.

140 We evaluated neutrophil activation by measuring degranulation marker

141 fects of LPS required the presence of serum, neutrophil activation by MTB 19-kDa lipoprotein occurred

142 analysis, alanine aminotransferase, hepatic neutrophil activation by myeloperoxidase activity, and c

143 e that fluid shear stress exposure increases neutrophil activation by PAF, and, taken together with p

144 examined the intracellular signals following neutrophil activation by soluble E-selectin.

145 ns that mediate these functions, we examined neutrophil activation by the basement membrane protein,

146 eutrophil attractant IL-8, while PEPI blocks neutrophil activation by tumor necrosis factor, preventi

147 hrombosis, and specifically examined whether neutrophil activation can affect fibrinogen modification

148 Excessive neutrophil activation causes posttraumatic complications

149 ing gene expression profiles of monocyte and neutrophil activation characterize clinical cure after t

150 a multifunctional phosphoprotein involved in neutrophil activation, compared to controls.

151 In this study, neutrophil activation conditions generating high-affinit

152 Inappropriate neutrophil activation contributes to the pathogenesis of

153 Excessive neutrophil activation correlates with worsening oxygenat

154 eted treatment options and downregulation of neutrophil activation could be of importance in this dis

155 zonensis or its lipophosphoglycan can induce neutrophil activation, degranulation, and LTB4 productio

156 l tumor cells, there is growing evidence for neutrophil activation driving tumor progression and meta

157 Acute CO poisoning causes intravascular neutrophil activation due to interactions with platelets

158 gocytic activation, and provides a marker of neutrophil activation during infection and inflammation.

159 ajor protein targets of calcium signaling in neutrophil activation during inflammatory disease.

160 An increase in markers of neutrophil activation (e.g., serum elastase) accompanies

161 ely with rising concentrations of markers of neutrophil activation (elastase/alpha 1 antitrypsin) and

162 Further supporting the role in neutrophil activation, EMR2 expression on circulating ne

163 On neutrophil activation, EMR2 is rapidly translocated to m

164 We discovered that erythrocytes suppressed neutrophil activation ex vivo and in vitro, including re

165 monocyte production of interleukins (IL) and neutrophil activation factors.

166 Neutrophil activation follows a 2-step process in which

167 Conversely, neutrophil activation for generation of Mac-1/CR3/uPAR c

168 This differential pattern of neutrophil activation has implications for understanding

169 f uPA to participate directly in LPS-induced neutrophil activation has not been examined.

170 d calcium entry (SOCE) are known to regulate neutrophil activation; however, the precise mechanism of

171 inflammatory monocytes can directly inhibit neutrophil activation in a PGE2-dependent manner.

172 Finally, LGALS3BP was able to inhibit neutrophil activation in a sialic acid- and Siglec-depen

173 ion between TF and PAR2, reduced aPL-induced neutrophil activation in aPL-treated mice.

174 We have previously reported a defect in neutrophil activation in children with polyarticular juv

175 are characterized by excessive platelet and neutrophil activation in comparison with healthy control

176 ween acute respiratory distress syndrome and neutrophil activation in experimental pancreatitis in ra

177 ignaling through PAR2, inhibited aPL-induced neutrophil activation in mice that expressed human TF.

178 e than a decade ago it was demonstrated that neutrophil activation in plasma results in the time-depe

179 Mechanisms of neutrophil activation in response to chemoattractants re

180 is study identified one novel marker ALPL of neutrophil activation in response to obesity and provide

181 d represent therapeutic approaches to reduce neutrophil activation in SCA.

182 shear stress exposure increased PAF-induced neutrophil activation in terms of L-selectin shedding, a

183 Together, these events induce neutrophil activation in the lungs, causing endothelial

184 was shown to increase, rather than decrease, neutrophil activation in the presence of platelet activa

185 in the microvasculature was shown to reduce neutrophil activation in the presence of the chemoattrac

186 d myeloperoxidase activity (one indicator of neutrophil activation in the recruited cells).

187 ular signaling pathways that are involved in neutrophil activation in the setting of ALI.

188 lylated, capacitated, sperm did not increase neutrophil activation in vitro However, we observed expr

189 TAFIa abrogated C5a-induced neutrophil activation in vitro.

190 itiated phenotypic changes characteristic of neutrophil activation, including down-regulation of CD62

191 found that a variety of stimuli involved in neutrophil activation, including fMet-Leu-Phe (fMLP), pl

192 ral position in regulating endotoxin-induced neutrophil activation, including that involved in ALI.

193 rrelate with fluid shear stress exposure, as neutrophil activation increased in a shear stress magnit

194 OspA induce surface markers associated with neutrophil activation: increased CD10 and CD11b expressi

195 n function of chloroquine is involved in the neutrophil activation induced by ICs.

196 However, neutrophil activation induced by RNA- and DNA-containing

197 tors for RNA and DNA, had no effect on mouse neutrophil activation induced by RNA-containing and immo

198 Recently, spinorphin was reported to block neutrophil activation induced by the chemotactic N-formy

199 inhibited the recruitment of T lymphocytes, neutrophil activation/infiltration, and repressed the ex

200 -induced matrix degradation, originated from neutrophil activation, initiated the formation of an amp

201 Neutrophil activation (intracellular oxidative burst act

202 tis (SAH) patients and their contribution to neutrophil activation, intracellular stress, and alterat

203 Limitation of unnecessary intravascular neutrophil activation is also important to prevent serio

204 However, neutrophil activation is also linked to autoimmune disea

205 Taken together, these findings indicate that neutrophil activation is an important mechanism by which

206 The appropriate regulation of neutrophil activation is critical for maintaining host d

207 ri factors previously suggested to stimulate neutrophil activation is the H. pylori neutrophil-activa

208 Thus, mechanically induced neutrophil activation is understood as the competition b

209 m, and especially the C5a/C5aR1 axis driving neutrophil activation, is critical for EBA pathogenesis.

210 Upon neutrophil activation, L-selectin is rapidly and efficie

211 bacterial pattern recognition receptors and neutrophil activation marker genes.

212 ecidual neutrophils expressed high levels of neutrophil activation markers and the angiogenesis-relat

213 phase) were used to identify obesity related neutrophil activation markers and their roles on CVD ris

214 nfected with bacteria had elevated levels of neutrophil activation markers but paradoxically exhibite

215 We analyzed the expression of eosinophil and neutrophil activation markers in peripheral blood by flo

216 included altered B-cell pathways, increased neutrophil activation markers, and increased reactive ox

217 n impaired host defenses, while simultaneous neutrophil activation may aggravate inflammation.

218 Although neutrophil activation may be beneficial at early stages

219 Aberrant neutrophil activation may play a crucial role in the sha

220 Neutrophil activation may play an important role in the

221 Understanding the mechanisms that underlie neutrophil activation, migration, survival and their var

222 During neutrophil activation, NE translocates to the nucleus to

223 fied a mechanistic link between ANCA-induced neutrophil activation, necroptosis, NETs, the AP, and en

224 cantly elevated plasma levels of a marker of neutrophil activation neutrophil gelatinase-associated l

225 Upon neutrophil activation, NSP4 was released into the supern

226 Methods: Neutrophil activation of IL4Ra (IL-4 receptor alpha) sig

227 These data indicate that in neutrophils activation of MEKK in addition to Raf may un

228 epletion of DCs did not require infiltrating neutrophils, activation of nuclear factor-kappaB, or sig

229 In this study, we investigated the effect of neutrophil activation on endothelial monolayer integrity

230 ferences between the 2 major Akt isoforms in neutrophil activation on the basis of studies in which w

231 gen species production, suggesting decreased neutrophil activation or increased neutrophil exhaustion

232 ed cytokine and chemokine genes required for neutrophil activation or recruitment, growth factor rece

233 ate TREM-1 signaling to evaluate its role in neutrophil activation, pathogen clearance, proinflammato

234 ons between Proteobacteria dominance and the neutrophil activation pathway in sputum.

235 This identifies a second neutrophil-activation pathway that is as important as ac

236 In summary, our data demonstrate a novel neutrophil activation pattern upon FPR2 sensing of PSMal

237 gnificantly correlated with peripheral blood neutrophil activation patterns (r = 0.75, p = 0.001 for

238 se results suggest that early alterations in neutrophil activation patterns, particularly involving t

239 ammatory diseases characterized by excessive neutrophil activation, PIPPs can serve as structural tem

240 ring episodes of vascular occlusion in which neutrophil activation plays a major role.

241 Neutrophil activation plays an important role in the inf

242 On neutrophil activation, polyisoprenyl diphosphate phospha

243 e investigated the role of B. cepacia LPS in neutrophil activation processes.

244 n levels, which highlights the importance of neutrophil activation, rather than the presence of neutr

245 lack of leukocyte infiltrate but evidence of neutrophil activation, recapitulated in The Cancer Genom

246 ophil proteins, which leads to ANCA-mediated neutrophil activation, recruitment and injury, with effe

247 Neutrophil activation releases granule proteins together

248 However, significant reduction in neutrophil activation remained compared to that of PBS a

249 Whether neutrophil activation represents cause or consequence of

250 presence of surface bound factor H enhanced neutrophil activation resulting in a two- to fivefold in

251 the vinyl ether bond of plasmalogens during neutrophil activation resulting in the production of alp

252 is secreted from mononuclear cells, causing neutrophil activation, resulting in the secretion of bac

253 Neutrophil activation results in Plasmodium parasite kil

254 ts (P < 0.01) which strongly correlated with neutrophil activation, rolling ligand P-selectin glycopr

255 Genes associated with neutrophil activation, ROS production, intracellular ant

256 ) binding to anti-PF4 antibody can stimulate neutrophil activation, similar to previous reports with

257 lasma levels of myeloperoxidase (a marker of neutrophil activation), soluble (s) CD25 (sCD25) and sol

258 Neutrophil activation studies suggest that Pactolus does

259 lar diseases, this can result in exacerbated neutrophil activation, subsequent vascular injury and ob

260 ole of shear forces on earlier indicators of neutrophil activation, such as L-selectin shedding and a

261 degranulation, and Alternaria did not induce neutrophil activation, suggesting specificity for fungal

262 tor usage, and differential peripheral blood neutrophil activation that could contribute to HCMV diss

263 a novel approach to reduce the uncontrolled neutrophil activation that promotes early GVHD and opens

264 otential for rapid release of IFN-gamma upon neutrophil activation, the first step during responses t

265 e repairing the vascular damage inflicted by neutrophil activation, thereby maintaining vascular inte

266 atients, vary in level over time, and induce neutrophil activation through engagement with Fc recepto

267 olipids (lyso-PLs) may also signal for human neutrophil activation through G2A.

268 rocesses and also can potentiate LPS-induced neutrophil activation through interactions with its krin

269 sera of SLE patients induce human and mouse neutrophil activation through TLR-independent mechanisms

270 Conversely, neutrophil activation through TLR4, as well as through a

271 Neutrophil activation to release granules containing pro

272 R2), and stimulation of this receptor led to neutrophil activation, trophoblast injury, and fetal dea

273 loss of lung barrier integrity and increased neutrophil activation upon S pneumoniae stimulation.

274 ce posttraumatic complications by preventing neutrophil activation via chemotactic factors released d

275 uggest that physiological shear forces alter neutrophil activation via FPR by reducing L-selectin she

276 Neutrophil activation via PAF was found to correlate wit

277 Neutrophil activation was assessed by measurement of sec

278 Neutrophil activation was assessed by measurement of sec

279 Neutrophil activation was assessed by measuring down-reg

280 egulation of inflammatory mediators of human neutrophil activation was investigated.

281 Neutrophil activation was observed at 30 min after reper

282 eaction was followed for 90 minutes, and the neutrophil activation was recorded as the total integrat

283 IgA and IgG ANCA together, IgG ANCA induced neutrophil activation was reduced (P = 0.0001).

284 Neutrophil activation was reduced by curcumin treatment

285 use intact anti-CD177 antibodies also caused neutrophil activation, we prepared nonactivating Fab fra

286 24 h, interleukin 6 (IL-6) serum levels and neutrophil activation were analyzed.

287 In this study, the effects of CD50 mAbs on neutrophil activation were examined.

288 Genes associated with platelet and neutrophil activation were expressed at higher levels in

289 Degranulation was enhanced upon suboptimal neutrophil activation, whereas production of reactive ox

290 LPS has been shown to be a major mediator of neutrophil activation which is accompanied by an early d

291 us, the secreted glycoprotein inhibits early neutrophil activation, which likely affects the host res

292 We also present a state diagram for neutrophil activation, which relates beta(2)-integrin de

293 different from ADAM17 stimulation upon overt neutrophil activation, which requires MAPK p38 or ERK, b

294 nate substances in blood products, result in neutrophil activation, which, in a susceptible patient,

295 to our knowledge, fully stochastic model of neutrophil activation, which, though simplified, can rec

296 ne the microvascular endothelial response to neutrophil activation with a focus on myosin light chain

297 nemia to link acute infection and subsequent neutrophil activation with acceleration of vascular infl

298 -stage and midstage disease, and evidence of neutrophil activation with advanced disease.

299 n of both IL-12 and CCL2 was increased after neutrophil activation with IFN-gamma.

300 esponse to RSV infection was associated with neutrophil activation (within 1 h) and neutrophil degran