ライフサイエンスコーパス: neutrophil chemotaxis

1 me dynamic effects of specific modulators of neutrophil chemotaxis.

2 further revealed an indirect effect of PT on neutrophil chemotaxis.

3 ectodomain was assessed in wound healing and neutrophil chemotaxis.

4 macrophage- and DC-mediated monocyte but not neutrophil chemotaxis.

5 cell migration and is involved in regulating neutrophil chemotaxis.

6 his in turn results in elevated monocyte and neutrophil chemotaxis.

7 umulation of leukocytes in the airspaces and neutrophil chemotaxis.

8 a lower secretion of cytokines and a lack of neutrophil chemotaxis.

9 actin synthesis and cell polarization during neutrophil chemotaxis.

10 Akt activity also inhibited fMLP-stimulated neutrophil chemotaxis.

11 The chemokine receptor CXCR2 mediates neutrophil chemotaxis.

12 important role in regulation of IL-8-induced neutrophil chemotaxis.

13 ningitis through inhibition of IL-8-mediated neutrophil chemotaxis.

14 onse to HRV-bacterial coinfection as well as neutrophil chemotaxis.

15 LPS-stimulated alveolar macrophages induced neutrophil chemotaxis.

16 does simple diffusion, which may facilitate neutrophil chemotaxis.

17 HLA-DR alleles was associated with impaired neutrophil chemotaxis.

18 th 875 microg/mL of surfactant did not alter neutrophil chemotaxis.

19 duced the ability of keratinocytes to induce neutrophil chemotaxis.

20 e and stroke led to reduced effectiveness of neutrophil chemotaxis.

21 s lipid peroxidation in S. aureus, promoting neutrophil chemotaxis.

22 d are crucial for directional sensing during neutrophil chemotaxis.

23 could be, in part, the result of defects in neutrophil chemotaxis.

24 lted in reduced CXCR2 expression and blocked neutrophil chemotaxis.

25 notype, which was confirmed by inhibition of neutrophil chemotaxis.

26 ion of pathogenic immune pathways, including neutrophil chemotaxis.

27 of proteins involved in IL-17 signaling and neutrophil chemotaxis.

28 ucidate the role of microenvironmental pH in neutrophil chemotaxis.

29 y were associated with pathways that control neutrophil chemotaxis.

30 drivers of the motile machinery involved in neutrophil chemotaxis.

31 here H(2)O(2) activates the SFK Lyn to drive neutrophil chemotaxis.

32 renines, which act through the AHR to impair neutrophil chemotaxis.

33 o degrade CXC chemokines, thereby preventing neutrophil chemotaxis.

34 ntial, and impaired cellular ATP release and neutrophil chemotaxis.

35 d cell differentiation, cell activation, and neutrophil chemotaxis.

36 eta-glucan-stimulated B lymphocytes elicited neutrophil chemotaxis.

37 rophil chemokine production but promotion of neutrophil chemotaxis.

38 tant of Cl66-Dox and Cl66-Pac cells enhanced neutrophil chemotaxis.

39 ablish domains for asthma diagnosis based on neutrophil chemotaxis.

40 nt AC9 activation and back retraction during neutrophil chemotaxis.

41 and mechanism of Rictor in the regulation of neutrophil chemotaxis.

42 ng assembly of the actin cytoskeleton during neutrophil chemotaxis.

43 receptors, causing significant impairment of neutrophil chemotaxis.

44 LR) activation motif and activates CXCR2 for neutrophil chemotaxis.

45 - and beta2-integrin activation and controls neutrophil chemotaxis.

46 ed Rac activation is necessary for efficient neutrophil chemotaxis.

47 fully automated, quantitative assessment of neutrophil chemotaxis.

48 t sacrificing the animal; and both 2D and 3D neutrophil chemotaxis.

49 ective for understanding the signals driving neutrophil chemotaxis.

50 ation experiment demonstrates MCP-1-mediated neutrophil chemotaxis.

51 of ARAP3 interferes with integrin-dependent neutrophil chemotaxis.

52 independently of actin reorganization during neutrophil chemotaxis.

53 in 1 and flotillin 2 in uropod formation and neutrophil chemotaxis.

54 neutrophil mobilization and MIP-2-dependent neutrophil chemotaxis.

55 d protein glycosylation (2 of 2), and normal neutrophil chemotaxis (1 of 1), and bactericidal activit

56 arget of rapamycin complex 2 (mTORC2) during neutrophil chemotaxis, a process that is mediated throug

57 ffects of anthrax lethal toxin (LT) on human neutrophil chemotaxis, a process that requires actin fil

58 In vitro, 14,15-DHET impaired neutrophil chemotaxis, acidification, CXCR1/CXCR2 expres

59 pha9beta1 and alpha4 integrins contribute to neutrophil chemotaxis across activated endothelial monol

60 th human leukocytes each n-3 DPA-SPM reduced neutrophil chemotaxis, adhesion and enhanced macrophage

61 (4), LXA(4) analogs, and ATL analogs inhibit neutrophil chemotaxis, adhesion to epithelium, and epith

62 .5% mucus, whereas 2.5% mucus best supported neutrophil chemotaxis against gravity.

63 potent in stimulating eosinophil as well as neutrophil chemotaxis, also capable of initiating actin

64 ng pH(e) below pH 6.8, predominantly affects neutrophil chemotaxis, although the velocity is largely

65 Likewise, patient plasma induced neutrophil chemotaxis, an effect decreased by reduction

66 It is established that H. pylori stimulates neutrophil chemotaxis and a robust respiratory burst, bu

67 ding of syndecan-1 is an underlying cause of neutrophil chemotaxis and aberrant wound healing that ma

68 tudy the mechanism by which mTORC2 regulates neutrophil chemotaxis and AC9 activity.

69 s on these cells will promote macrophage and neutrophil chemotaxis and activation and thereby play a

70 y of chemokines that play a critical role in neutrophil chemotaxis and activation both in vitro and i

71 Although the effects of leukotrienes on neutrophil chemotaxis and activation have been establish

72 e with this, the response was accompanied by neutrophil chemotaxis and activation of the superoxide-p

73 Regulation of neutrophil chemotaxis and activation plays crucial roles

74 ne response to bacterial infections includes neutrophil chemotaxis and activation, but regulation of

75 own to contribute to monocyte/macrophage and neutrophil chemotaxis and activation.

76 cking N-formyl-Met-Leu-Phe- and IL-8-induced neutrophil chemotaxis and activation.

77 athogens must devise means to interfere with neutrophil chemotaxis and activation.

78 behavior and how the finely tuned balance of neutrophil chemotaxis and arrest counteracts bacterial e

79 by recurrent pyogenic infections, defective neutrophil chemotaxis and bactericidal activity, and lac

80 disorders, GPP, PPP, and AGEP, converged on neutrophil chemotaxis and diapedesis and cytokines known

81 Accordingly, calpain inhibition decreased neutrophil chemotaxis and directional persistence in a g

82 8 MAPK pathway responsible for regulation of neutrophil chemotaxis and exocytosis are unknown.

83 Our results suggest that Hsp27 regulates neutrophil chemotaxis and exocytosis in an actin-depende

84 he calcium-dependent protease calpain during neutrophil chemotaxis and found that calpain inhibition

85 Neutrophil chemotaxis and glucose metabolism were not si

86 Although DPPI(-/-) mice have normal in vitro neutrophil chemotaxis and in vivo neutrophil accumulatio

87 Here, we show that FGP phage stimulate neutrophil chemotaxis and induce a pertussis toxin-sensi

88 We observed an increase in neutrophil chemotaxis and leukotriene B4 production and

89 nin receptor agonists inhibited IL-8-induced neutrophil chemotaxis and LPS-induced neutrophil recruit

90 ndings suggest that CXCR2 is responsible for neutrophil chemotaxis and margination induced by IL-8.

91 al, purinergic, and mTOR signaling regulates neutrophil chemotaxis and may be a pharmacological targe

92 iate an inflammatory cascade that can elicit neutrophil chemotaxis and neovascularization of the corn

93 n vivo effects of betaarr2 on CXCR2-mediated neutrophil chemotaxis and on cutaneous wound healing.

94 protein coupled receptor signaling, inhibits neutrophil chemotaxis and other inflammatory responses i

95 chemokine receptor-2 (CXCR2) ligand-mediated neutrophil chemotaxis and subsequent clearance of the in

96 kinase B) plays a central role in modulating neutrophil chemotaxis and superoxide generation in respo

97 ion and determine the specificity of Rac2 in neutrophil chemotaxis and superoxide generation.

98 isoform exhibit agonist-specific defects in neutrophil chemotaxis and superoxide production, despite

99 tion through p38 MAP kinase is necessary for neutrophil chemotaxis and that CRP intercedes through th

100 ntation of hyaluronan results in polymorphic neutrophil chemotaxis and that EC-SOD can completely pre

101 Baclofen, stimulated neutrophil chemotaxis and tubulin reorganization in a PI

102 vivo studies suggest that PT and ACT affect neutrophil chemotaxis and/or function, thereby altering

103 toration of innate immune functions of blood neutrophils (chemotaxis and reactive oxygen species prod

104 al allografts induced epithelial activation, neutrophil chemotaxis, and a shift toward a Th17 adaptiv

105 mune response, chemokine-mediated signaling, neutrophil chemotaxis, and chemokine activity and distin

106 ade and tested for heparin binding, in vitro neutrophil chemotaxis, and in vivo neutrophil recruitmen

107 In vitro, thymosin beta4 sulfoxide inhibited neutrophil chemotaxis, and in vivo, the oxidized peptide

108 SLURP1 also suppressed the primary human neutrophil chemotaxis, and interaction with HUVEC.

109 he neuro-repellent, SLIT2, potently inhibits neutrophil chemotaxis, and might, therefore, be expected

110 e tetrazolium tests, myeloperoxidase assays, neutrophil chemotaxis, and neutrophil chemotaxis assays,

111 aureus has the potential to thwart effective neutrophil chemotaxis, and phagocytosis, and succeeds in

112 ntribute to chronic inflammation by inducing neutrophil chemotaxis, and the reduction of these microv

113 ell arrays; microenvironment fabrication for neutrophil chemotaxis; and complex, covert tags by the t

114 effects of E. coli capsule and O antigen on neutrophil chemotaxis are novel, and they expand our und

115 mechanisms that regulate 3-dimensional (3D) neutrophil chemotaxis are poorly understood.

116 n response to deltaPT infection, implicating neutrophil chemotaxis as a possible target of PT activit

117 he stimulated alveolar macrophages increased neutrophil chemotaxis as compared with unstimulated alve

118 In addition, the FMLP-induced neutrophil chemotaxis as well as superoxide generation w

119 emokines involved in monocyte/macrophage and neutrophil chemotaxis, as well as numerous receptors and

120 action (2 and 24 hours), ELISA (6 hours), or neutrophil chemotaxis assay (24 hours).

121 Second, we validated the mouse neutrophil chemotaxis assay by comparing the adhesion an

122 ity of the cell supernatants was tested by a neutrophil chemotaxis assay.

123 Improvements in neutrophil chemotaxis assays have advanced our understan

124 Neutrophil chemotaxis assays were also used to evaluate

125 eroxidase assays, neutrophil chemotaxis, and neutrophil chemotaxis assays, revealed no identifiable a

126 e, and sample volume requirements to perform neutrophil chemotaxis assays.

127 )) from S. aureus were found to induce mouse neutrophil chemotaxis at 1-10 nM and superoxide producti

128 NHE1) with cariporide drastically attenuates neutrophil chemotaxis at the optimal pH(i) irrespective

129 Although SHIP1 has been shown to regulate neutrophil chemotaxis, B-cell signaling, and cortical os

130 ata suggest that NO does not directly affect neutrophil chemotaxis but may indirectly alter chemotact

131 Thus, spinorphin blocks fMLF-induced neutrophil chemotaxis by acting as a specific antagonist

132 ScpB inhibits neutrophil chemotaxis by enzymatically cleaving the comp

133 esponse involves both a direct inhibition of neutrophil chemotaxis by estrogen and an altered express

134 mportant function of fever may be to enhance neutrophil chemotaxis by facilitating calcium influx thr

135 PDase1 plays an important role in regulating neutrophil chemotaxis by facilitating the hydrolysis of

136 These results suggest that PECAM-1 regulates neutrophil chemotaxis by modulating cell motility and di

137 Third, we show that 2D and 3D neutrophil chemotaxis can be directly compared using our

138 to chronic outcomes, and show that aberrant neutrophil chemotaxis can move an otherwise healthy outc

139 Therefore, the neutrophil chemotaxis defect of IDDM appears to be indep

140 , growth factor activity, and eosinophil and neutrophil chemotaxis differing between subjects with se

141 Mouse MCP-6 did not induce neutrophil chemotaxis directly in an in vitro assay, but

142 oepithelial layer; YbcL(UTI) did not inhibit neutrophil chemotaxis directly.

143 modulation of calpain activity may regulate neutrophil chemotaxis downstream of G-protein-coupled re

144 Molecules and pathways related to neutrophil chemotaxis emerged as common alterations in p

145 Rho GTPases control fundamental aspects of neutrophil chemotaxis: establishment of front and back a

146 , N-t-BOC-sensitive, and N-t-BOC-insensitive neutrophil chemotaxis ex vivo when cell-free bronchoalve

147 patients with OB was bioactive, we performed neutrophil chemotaxis experiments that showed that IL-8

148 Decreased neutrophil chemotaxis following exposure to rhAPC was co

149 ementation of neutrophils, and assessment of neutrophil chemotaxis following FL treatment.

150 Ad19 infection of HCFs increased neutrophil chemotaxis from a baseline of 0.4+/-0.7 cells

151 Neutralization of CXCL1 and IL-8 reduced neutrophil chemotaxis >50% to supernatants from IL-1beta

152 Depressed neutrophil chemotaxis has been demonstrated in IDDM and

153 cyl-phenylalanine (fMLP) and plays a role in neutrophil chemotaxis, has been implicated as a fluid sh

154 Blockade of interleukin-1, or of neutrophil chemotaxis, has reduced infarct volume in mod

155 bind to chemoattractants and play a role in neutrophil chemotaxis, have been implicated as fluid she

156 Vitamin D deficiency modestly impairs neutrophil chemotaxis; however, it does not affect lung

157 Discoidin domain receptor 2 (DDR2) promotes neutrophil chemotaxis in 3D by triggering matrix metallo

158 2D surfaces but is an important regulator of neutrophil chemotaxis in 3D collagen matrices.

159 lagen-derived extracellular signaling during neutrophil chemotaxis in 3D matrices.

160 (10 to 500 micrograms/ml) inhibited in vitro neutrophil chemotaxis in a concentration-dependent fashi

161 on of HLA-DR3, -DR4, and -DR53 with impaired neutrophil chemotaxis in an IDDM sample.

162 We describe neutrophil chemotaxis in response to a combination of a

163 Functionally, this was related to impaired neutrophil chemotaxis in response to CWF-conditioned med

164 Neutrophil chemotaxis in response to exogenous interleuk

165 This study brings new knowledge about neutrophil chemotaxis in the context of cell-to-cell com

166 Neutrophil chemotaxis in the direction of gravity was op

167 tic dorsal root ganglia suggested a role for neutrophil chemotaxis in the IPA-dependent regenerative

168 PAF mediates both apoptosis and neutrophil chemotaxis in the pancreas.

169 gly inhibits IL-8-induced and CXCR2-mediated neutrophil chemotaxis in vitro and alleviates hCXCR2-dep

170 dogenous anti-inflammatory agents that block neutrophil chemotaxis in vitro and inhibit neutrophil in

171 Consistent with this, neutrophil chemotaxis in vitro and neutrophil mobilizati

172 e bioactivity of the parent NPD1, inhibiting neutrophil chemotaxis in vitro and neutrophil tissue inf

173 oncentrations of 2-chlorohexadecanal induced neutrophil chemotaxis in vitro suggesting that alpha-chl

174 We investigated the involvement of STIM1 in neutrophil chemotaxis in vitro, as well as during chroni

175 , N-t-BOC-sensitive, and N-t-BOC-insensitive neutrophil chemotaxis in vitro.

176 RP shown to inhibit C5a- and FMLP-stimulated neutrophil chemotaxis in vitro.

177 The mutants have a 10-fold decrease in neutrophil chemotaxis in vitro.

178 iously unknown mechanism of bacterial-guided neutrophil chemotaxis in vivo, providing insight into th

179 cally activates IL-8 and, thereby, regulates neutrophil chemotaxis in vivo.

180 The neutrophil chemotaxis index of 41 diabetics and 27 contr

181 B 225002 potently inhibited human and rabbit neutrophil chemotaxis induced by both IL-8 and GROalpha.

182 Spinorphin did not affect mouse neutrophil chemotaxis induced by concentrations of fMLF

183 chemotactic agonist and effectively blocked neutrophil chemotaxis induced by fMLF at concentrations

184 Recombinant IL-26 potentiated neutrophil chemotaxis induced by IL-8 and fMLP but decre

185 In addition, neutrophil chemotaxis induced by interleukin-8 was signi

186 d and exogenous syndecan-1 ectodomain induce neutrophil chemotaxis, inhibit alveolar epithelial wound

187 Neutrophil chemotaxis is a critical component of the inn

188 In vitro, neutrophil chemotaxis is affected in the mutant.

189 poxilin A3-driven transepithelial migration, neutrophil chemotaxis is amplified through neutrophil pr

190 of neutrophils, and in the absence of PDK1, neutrophil chemotaxis is impaired.

191 ther well-known eicosanoid mediating general neutrophil chemotaxis is leukotriene B4 (LTB4).

192 relevance of this TRPC6-depending defect in neutrophil chemotaxis is underscored by our in vivo find

193 CP-105,696 inhibited LTB4-mediated monkey neutrophil chemotaxis (isolated cells, LTB4 = 5 nM) and

194 howed that Rac2 is an essential regulator of neutrophil chemotaxis, L-selectin capture and rolling, a

195 trophils and is responsible for the abnormal neutrophil chemotaxis LAP.

196 r understanding of biochemical regulation of neutrophil chemotaxis, little is known about how mechani

197 understanding of the molecules that control neutrophil chemotaxis may impact our knowledge of autoim

198 nt mutations also allowed S. aureus to evade neutrophil chemotaxis, mediated by the reduction in bact

199 kt signaling in ICC cells, directly enhanced neutrophil chemotaxis, mediated tumor-associated neutrop

200 examined the involvement of CD38 in abnormal neutrophil chemotaxis of LAgP patients.

201 As shown previously for neutrophils, chemotaxis of primary dermal fibroblasts to

202 First, the neutrophil chemotaxis on endothelial cells revealed 2 di

203 o-L-arginine) altered FMLP- or IL-8-elicited neutrophil chemotaxis (P > .25 for all).

204 AhR activation suppressed the neutrophil chemotaxis pathway involving Cxcl2, Cxcl3, an

205 In diabetic states, there is a reduction in neutrophil chemotaxis, phagocytosis, and reactive oxygen

206 Neutrophil chemotaxis plays an essential role in innate

207 These data suggest that PI3Kgamma regulates neutrophil chemotaxis primarily by controlling the direc

208 ed to affect primarily the directionality of neutrophil chemotaxis rather than motility, whereas knoc

209 ontribution of this GSK3-mediated pathway to neutrophil chemotaxis regulation depended on neutrophil

210 Neutrophil chemotaxis requires excitatory signals at the

211 and CXCL8 concentrations for mouse and human neutrophil chemotaxis, respectively.

212 Day 4 secondary endpoints included neutrophil chemotaxis, safety and tolerability, Sequenti

213 In vitro human polymorphic neutrophil chemotaxis studies indicate that oxidative fr

214 t with 292 microg/mL significantly decreased neutrophil chemotaxis suggesting that at low concentrati

215 ynergy between intact SAA1alpha and CXCL8 in neutrophil chemotaxis, suggesting that this peptide bind

216 ability to recruit beta-arrestin and induce neutrophil chemotaxis, supporting the previous notion th

217 s mitochondrial protein biosynthesis, induce neutrophil chemotaxis, the generation of reactive oxygen

218 the CXC subfamily of chemokines, induces in neutrophils chemotaxis, the respiratory burst, granule r

219 macrophage polarization, and stimulation of neutrophil chemotaxis-these activities have been attribu

220 otaxis, but it also inhibited CXCL1-mediated neutrophil chemotaxis through CXCR2 antagonism.

221 rin and reversed fMLP's inhibitory effect on neutrophil chemotaxis through fibrin.

222 k-in neutrophils to fibrinogen and decreased neutrophil chemotaxis to a formyl-Met-Leu-Phe gradient.

223 Thus, CD38 controls neutrophil chemotaxis to bacterial chemoattractants thro

224 was used to explore conditions that trigger neutrophil chemotaxis to Chlamydia trachomatis infected

225 Finally, we demonstrate that neutrophil chemotaxis to fMLP is dependent on Ca++ mobil

226 al-relay molecule that exquisitely regulates neutrophil chemotaxis to formyl peptides, which are prod

227 Similarly, C5a inhibited neutrophil chemotaxis to IL-8 and Gro-alpha.

228 use of morpholino oligonucleotides restores neutrophil chemotaxis to wounds.

229 Neutrophil chemotaxis toward C5a has an optimum at pH(i)

230 lusion, we propose that the pH dependence of neutrophil chemotaxis toward C5a is caused by a pH(i)-de

231 dentify Fer as a novel inhibitory kinase for neutrophil chemotaxis toward end target chemoattractants

232 -induced upregulation of proinflammatory and neutrophil chemotaxis transcripts and there was downregu

233 The dynamics of neutrophil chemotaxis under competing chemoattractant gr

234 Whereas dasatinib inhibited neutrophil chemotaxis under static conditions in 2 dimen

235 This study identifies neutrophil chemotaxis velocity as a potential biomarker

236 proteins, we hypothesized that CRP inhibits neutrophil chemotaxis via inhibition of MAP kinase activ

237 In addition, IL-17-induced neutrophil chemotaxis was dependent on CXCR2 signaling.

238 Ex vivo neutrophil chemotaxis was evaluated, using neutrophils f

239 reduced in Tph1(-/-) mice, whereas in vitro neutrophil chemotaxis was independent of serotonin.

240 Neutrophil chemotaxis was significantly suppressed by th

241 In vitro, neutrophil chemotaxis was stimulated by PTHrP 1-34.

242 he hemopoietic cell-restricted PI3K delta in neutrophil chemotaxis, we have developed a potent and se

243 The random migration and neutrophil chemotaxis were significantly reduced.

244 thelial barrier function along with impaired neutrophil chemotaxis were the underlying mechanisms tha

245 Exudate levels of NO, a known inhibitor of neutrophil chemotaxis, were higher in F344, compared wit

246 of virulence genes and reduced hemolysis and neutrophil chemotaxis, while exhibiting increased surviv

247 each chemoattractant contributes to overall neutrophil chemotaxis within complex physiological envir

248 rophils under inflammatory conditions; mouse neutrophil chemotaxis without sacrificing the animal; an