ライフサイエンスコーパス: neutrophil elastase

1 lung against proteolytic damage (e.g., from neutrophil elastase).

2 n lead to emphysema by loss of inhibition of neutrophil elastase.

3 in that retained inhibitory activity against neutrophil elastase.

4 tion of injury, depending on the presence of neutrophil elastase.

5 uding myeloperoxidase (MPO), azurocidin, and neutrophil elastase.

6 rations and reduced levels of membrane-bound neutrophil elastase.

7 acids to explore the S1-S4 pockets of human neutrophil elastase.

8 een in normal HBECs, even in the presence of neutrophil elastase.

9 nsisted of eDNA, histones, cathelicidin, and neutrophil elastase.

10 ly on the NADPH oxidase, myeloperoxidase, or neutrophil elastase.

11 ture of the EAP family member EapH1 bound to neutrophil elastase.

12 oding the neutrophil granule serine protease neutrophil elastase.

13 realized a selectivity of 307 against human neutrophil elastase.

14 ect the lung against proteolytic damage from neutrophil elastase.

15 role is to protect lung tissue by inhibiting neutrophil elastase.

16 GMs) led to the discovery of 23 hits against neutrophil elastase.

17 of its key roles is that of an activator of neutrophil elastase.

18 oorly reflect the pool of active, functional neutrophil elastase.

19 restore specificity against trypsin or human neutrophil elastase.

20 ecies, the enzymes myeloperoxidase (MPO) and neutrophil elastase.

21 granule enzymes, myeloperoxidase, and human neutrophil elastase.

22 with human histone H3 and with the specific neutrophil elastase.

23 helial cells was upregulated by wounding and neutrophil elastase.

24 with severe asthma were stained for OSM and neutrophil elastase.

25 in significant levels of the histone H2Ax or neutrophil elastase.

26 xpression of matrix metalloproteinase-12 and neutrophil elastase.

27 rease of the stoichiometry of inhibition for neutrophil elastase.

28 cting its selectivity against pancreatic and neutrophil elastases.

29 We investigated whether neutrophil elastase, a biased agonist of PAR(2), causes

30 Neutrophil elastase, a component of the innate host defe

31 with anthrax lethal toxin release bioactive neutrophil elastase, a proinflammatory mediator of tissu

32 h is synthesized by the liver, is to inhibit neutrophil elastase, a protease that degrades connective

33 for ensuring tissue integrity by inhibiting neutrophil elastase, a protease that degrades elastin.

34 gic basis for the prognostic significance of neutrophil elastase, a serine protease found in neutroph

35 ses have mutations in the ELA2 gene encoding neutrophil elastase, a significant proportion remain und

36 cyte viability, and inhibited the release of neutrophil elastase--a marker of neutrophil extracellula

37 We apply PK105b to measure neutrophil elastase activation in an acute model of expe

38 l breath tests to monitor dynamic changes in neutrophil elastase activity during lung infection and t

39 , 2.27; 95% CI, 1.24 to 4.14; P=0.008), free neutrophil elastase activity in BAL fluid (odds ratio, 3

40 Free neutrophil elastase activity in BAL fluid at 3 months of

41 Neutrophil elastase activity in BAL fluid in early life

42 , measured as matrix metalloproteinase 9 and neutrophil elastase activity in culture supernatant, as

43 Thus, PK105b facilitates detection of neutrophil elastase activity in tissue lysates, and we h

44 n anthrax lethal toxin-dependent increase in neutrophil elastase activity in vivo as well.

45 Sputum neutrophil elastase activity is a biomarker of disease s

46 Neutrophil elastase activity is detected in inflamed, bu

47 elivery and utilize more specific markers of neutrophil elastase activity to inform on the efficacy o

48 With both brensocatib doses, sputum neutrophil elastase activity was reduced from baseline o

49 Furthermore, neutrophil elastase activity was significantly increased

50 lay low cytotoxicity in vitro, inhibit human neutrophil elastase activity, and inhibit the migration

51 exacerbations (secondary end point), sputum neutrophil elastase activity, and safety were assessed.

52 bacterial coinfections had higher levels of neutrophil elastase activity, as well as myeloperoxidase

53 c substrate probes have been used to measure neutrophil elastase activity, though these tools lack sp

54 Hydroxy-2'-deoxyguanosine (8-OHdG) and human neutrophil elastase/alpha1-proteinase inhibitor (HNE/alp

55 ors shed volatile reporters upon cleavage by neutrophil elastase, an inflammation-associated protease

56 P96), are produced through cleavage by human neutrophil elastase and aggregate lipopolysaccharide (LP

57 ced mucin secretion induced by PAR agonists, neutrophil elastase and ATP in two airway epithelial cel

58 pithelial surface, and allows the control of neutrophil elastase and cathepsin G by their natural inh

59 of cathepsin C and its downstream proteases (neutrophil elastase and cathepsin G) and serum levels of

60 ucted yeast two-hybrid screens with Gfi1 and neutrophil elastase and detected a novel protein, PFAAP5

61 ioration in airway obstruction, reduction in neutrophil elastase and inflammation.

62 The inverse relationship identified between neutrophil elastase and IRS-1 in LSL-K-ras mice was also

63 Proteases, including neutrophil elastase and MMPs (matrix metalloproteases),

64 11b and myeloperoxidase and higher levels of neutrophil elastase and myeloperoxidase activity in apic

65 the loss of function of AAT in neutralizing neutrophil elastase and other pro-inflammatory enzymes.

66 ode proinflammatory molecules; and levels of neutrophil elastase and p50 nuclear factor kappaB) were

67 l-like receptor 9 (TLR9)-mediated release of neutrophil elastase and proteinase 3 and subsequent down

68 bone marrow that lacked DPPI or lacked both neutrophil elastase and proteinase 3 protected mice from

69 We report here that both neutrophil elastase and proteinase-3 cleave the human PA

70 t non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3, as well as synthet

71 RATIONALE: Sputum neutrophil elastase and serum desmosine, which is a link

72 d with SIV, which dose-dependently inhibited neutrophil elastase and shortened resolution intervals.

73 ishmania major by macrophages in response to neutrophil elastase and TLR4 via TNFalpha and IFNbeta.

74 Neutrophil elastase and TNF, present in higher amounts i

75 y of purified Q0(bolton)-AAT protein to bind neutrophil elastase and to inhibit protease activity.

76 staining using neutrophil markers (CD66b and neutrophil elastase) and NET markers (citrullinated hist

77 bset markers (CD68, CD3, CD8, CD4, CD20, and neutrophil elastase) and selected inflammatory markers (

78 n of azurophilic (CD63, myeloperoxidase, and neutrophil elastase) and specific (CD66b and lactoferrin

79 matrix metalloproteinases, cathepsin K, and neutrophil elastase, and a variety of invertebrates and

80 ociated with increases in neutrophil counts, neutrophil elastase, and IL-1beta and declines in NEAPCs

81 granule proteases, such as myeloperoxidase, neutrophil elastase, and matrix metalloproteinase 9, act

82 trophil serine proteases (NSPs) cathepsin G, neutrophil elastase, and proteinase 3, which are enzymes

83 h the proteases trypsin, chymotrypsin, human neutrophil elastase, and Pseudomonas aeruginosa elastase

84 e have a significant survival advantage over neutrophil elastase(+/+) animals following exposure to a

85 nduced intestinal ulceration and bleeding in neutrophil elastase(+/+) animals, but not in neutrophil

86 neutrophil elastase(+/+) animals, but not in neutrophil elastase(-/-) animals.

87 , and TNF-alpha increased over time, whereas neutrophil elastase antiprotease complexes (NEAPCs) and

88 size that small molecule inhibitors of human neutrophil elastase are ineffective because of rapid cle

89 Inhibitors of neutrophil elastase are now entering clinical trials wit

90 ty of neutrophil serine proteases, including neutrophil elastase, are increased in the sputum of pati

91 Mutations of ELA2, encoding neutrophil elastase, are present in approximately 50% of

92 identified serine proteases, and especially neutrophil elastase, as candidates.

93 P. aeruginosa to the bactericidal effect of neutrophil elastase, as well as this organism's ability

94 sis and chemotaxis), a reduction in systemic neutrophil elastase burden, and improved Sequential Orga

95 as attenuated significantly by inhibition of neutrophil elastase but not caspase-1.

96 ecombinant proteins, we have identified that neutrophil elastase, but not other neutrophil derived pr

97 Mutations of ELA2, encoding the protease neutrophil elastase, can cause both disorders.

98 spirometry decline (n = 60) and plasma anti-neutrophil elastase capacity (n = 20).Measurements and M

99 Finally, anti-neutrophil elastase capacity did not differ between form

100 yeloid molecular markers such as PRTN3, MPO, Neutrophil elastase, Cathepsin G, and Eosinophil peroxid

101 man patients we also excluded ADAM10, ADAM8, neutrophil elastase, cathepsin G, and proteinase 3 from

102 Whereas neutrophil elastase, cathepsin G, and proteinase 3 have

103 The activities of three serine proteases (neutrophil elastase, cathepsin G, and proteinase 3), whi

104 anule-associated serine proteases, including neutrophil elastase, cathepsin G, and proteinase 3.

105 hibit the neutrophil serine proteases (NSPs) neutrophil elastase, cathepsin-G, and proteinase-3.

106 utrophil serine proteases polymorphonuclear (neutrophil) elastase, cathepsin G, and proteinase 3, but

107 e we show that treatment of hepatocytes with neutrophil elastase causes cellular insulin resistance a

108 le-3-Grabbing Non-integrin (DC-SIGN), CD123, neutrophil elastase, CD31, and carbonic anhydrase 9.

109 ient in the serine proteases cathepsin G and neutrophil elastase (CG/NE neutrophils) exhibit severe d

110 Here, we show that human neutrophil elastase cleaves thrombin, generating 11-kDa

111 L-1beta, TNFalpha, IL-6, procathepsin B, and neutrophil elastase concentrations in SF from injured kn

112 lavage fluid, which correlated with IL-8 and neutrophil elastase, consistent with neutrophil recruitm

113 Systemic expression of CXCL1, CXCL5, and neutrophil elastase correlated with measures of MS lesio

114 PMN lysates and neutrophil elastase could degrade recombinant human IL-1

115 , thus delineating a mechanism through which neutrophil elastase could regulate its own synthesis.

116 In contrast to neutrophil elastase, CTSS activity was detectable in 100

117 sforming growth factor beta1), downstream of neutrophil elastase, decreased mucociliary parameters in

118 , we show that IC-activated cathepsin G- and neutrophil elastase-deficient (CG/NE) PMNs adhered norma

119 ting NET components by DNAse1 application or neutrophil elastase-deficient mice protected mice from A

120 Immunoprecipitation studies showed that, as neutrophil elastase degraded IRS-1, there was increased

121 -related enzymes such as myeloperoxidase and neutrophil elastase did not contribute in mounting CNS i

122 ane(+/+) mice died, none of the mice lacking neutrophil elastase died.

123 Neutrophil elastase directly induced tumor cell prolifer

124 synthesis is initiated at the codon ATG) of neutrophil elastase (ELANE) result in the production of

125 Mutations in the gene for neutrophil elastase, ELANE, cause cyclic neutropenia (Cy

126 To determine the role of neutrophil elastase (encoded by Elane) on tumor progress

127 n and early emphysema in a low AAT, and high neutrophil elastase environment in the lungs of affected

128 the microenvironment that was independent of neutrophil elastase enzymatic activity.

129 lar-mass forms by direct inhibition of human neutrophil elastase enzymatic activity.

130 -17 upregulated matrix-metalloprotease-9 and neutrophil elastase expression, two proteases involved i

131 e sheep model, ewes inhaled CFTR(inh)172 and neutrophil elastase for 3 days, which resulted in prolon

132 cy of a protease inhibitor therapy targeting neutrophil elastase for the treatment of alpha-1 antitry

133 defective translocation of VLA-3, VLA-6, and neutrophil elastase from intracellular vesicles to the s

134 xhibited striking antigen-specific uptake of neutrophil elastase from the microenvironment that was i

135 Mast cell/neutrophil cathepsin G and neutrophil elastase generate similar fragments of HGF by

136 demonstrated that the initial measurement of neutrophil elastase had the highest individual predictiv

137 Neutrophil elastase has been shown to be present in the

138 rmination of sputum biomarkers, particularly neutrophil elastase, has predictive value for subsequent

139 Recent descriptions of antibodies to human neutrophil elastase have provided insight into the occur

140 rated that SPLUNC1 enhanced Mp-induced human neutrophil elastase (HNE) activity, and HNE directly inh

141 inhibitor of serine proteases such as human neutrophil elastase (HNE) and a NF-kappaB regulatory age

142 the TSP-1 type 3 repeats that inhibits human neutrophil elastase (HNE) and binds to human neutrophils

143 ical inflammatory salivary biomarkers, Human Neutrophil Elastase (HNE) and Cathepsin-G, was construct

144 The serine proteases, neutrophil elastase (HNE) and proteinase 3 (PR3), are ab

145 Human Neutrophil Elastase (HNE) is a serine protease that is h

146 Human neutrophil elastase (HNE) is an attractive target for tr

147 Human neutrophil elastase (HNE) is an important therapeutic ta

148 ha1PI complexes with trypsin, PPE, and human neutrophil elastase (HNE) showed similar rates of deacyl

149 lafin and cathelicidin, and the enzyme human neutrophil elastase (HNE) were measured in over 1,000 ce

150 bodies that inhibit bovine trypsin and human neutrophil elastase (HNE) with low nanomolar affinities.

151 rine proteases, proteinase 3 (PR3) and human neutrophil elastase (HNE), are considered as targets for

152 components, myeloperoxidase (MPO) and human neutrophil elastase (HNE), are inflammatory markers in C

153 ibitors of serine proteases, including human neutrophil elastase (HNE), has been elucidated by determ

154 s it different from its structural homologue neutrophil elastase (HNE).

155 requirements of heparin inhibition of human neutrophil elastase (HNE).

156 optimization of covalent inhibitors of human neutrophil elastase (hNE).

157 tion of 2'-F purine aptamers that bind human neutrophil elastase (HNE).

158 epsin-G differed considerably from that with neutrophil elastase, however, with far greater contribut

159 deficient patients is based on inhibition of neutrophil elastase; however, the benefit of this treatm

160 or subsequent lung function decline, whereas neutrophil elastase, IL-8, and IL-6 had the highest comb

161 Although neutrophil elastase immunostaining was intense in the ep

162 rescent activity-based probe, which binds to neutrophil elastase in an activity-dependent manner.

163 ular insulin resistance and that deletion of neutrophil elastase in high-fat-diet-induced obese (DIO)

164 l toxin, thereby establishing a key role for neutrophil elastase in mediating the deleterious effects

165 ted study from our laboratory had identified neutrophil elastase in mucus as the molecule responsible

166 A model is proposed wherein neutrophil elastase in mucus proteolytically cleaves the

167 lso no role for lysosomal destabilization or neutrophil elastase in pneumolysin-mediated IL-1beta pro

168 omenon occurs in response to the presence of neutrophil elastase in such mucus.

169 t validation cohort, a high concentration of neutrophil elastase in the wound was associated with inf

170 ly reported that in addition to neutralizing neutrophil elastases in the extracellular compartment, A

171 Matrix metalloproteinase-7 and neutrophil elastase induced the release of MUC16 but not

172 We used this construct to prevent human neutrophil elastase-induced emphysema in a rodent model.

173 Rottlerin also reduced PMA- or human neutrophil elastase-induced phosphorylation of myristoyl

174 We tested whether co-administration of a neutrophil elastase inhibitor (NEI) could rescue the abi

175 dy blocker of AQP4-IgG binding), sivelestat (neutrophil elastase inhibitor), and eculizumab (compleme

176 Sivelestat, a neutrophil elastase inhibitor, and aquaporumab, a nonpat

177 abrogated by NET inhibition with DNAse or a neutrophil elastase inhibitor.

178 tor, alpha(1)-antichymotrypsin, and monocyte-neutrophil elastase inhibitor.

179 from Hibiscus sabdariffa, as a knottin-type neutrophil elastase inhibitor.

180 Clinical trials with neutrophil elastase inhibitors in lung and cardiovascula

181 nslating results of preclinical studies with neutrophil elastase inhibitors remains challenging.

182 biological characterization of potent human neutrophil elastase inhibitors, which offer reversible c

183 aminoalkylphosphonate diaryl esters as human neutrophil elastase inhibitors.

184 ng to azurophilic granules causes leakage of neutrophil elastase into the cytosol, resulting in secon

185 d that mucin hypersecretion induced by human neutrophil elastase involves activation of protein kinas

186 In vitro studies demonstrate that neutrophil elastase is a key player in the LTB4 inflamma

187 Neutrophil elastase is a likely effector of Mac-1 becaus

188 Neutrophil elastase is a serine protease that has been i

189 Elafin, an endogenous inhibitor of neutrophil elastase, is expressed in human mammary epith

190 components of neutrophil granules, including neutrophil elastase, lactoferrin, cathepsin G, proteinas

191 Using caspase-3, caspase-7, caspase-8, neutrophil elastase, legumain, and two matrix metallopro

192 roteases, including dipeptidyl peptidase-IV, neutrophil elastase, matrix metalloproteinase-2 (MMP-2),

193 al peptides SLPI and elafin by virus-induced neutrophil elastase may precipitate these secondary bact

194 e and aprotinin), affords protection against neutrophil elastase-mediated ENaC activation and Pseudom

195 Moreover, neutrophil elastase(-/-) mice have a significant surviva

196 Measurements and Main Results: Neutrophil elastase, MMP-2, and MMP-9 activities and pro

197 ed by the enzymes proteinase 3, cathepsin G, neutrophil elastase, MMP7 or MMP9/12 were prognostic bio

198 Neutrophil elastase modulated killing of breast cancer c

199 The propensity of individual neutrophil elastase mutants to misfold may determine the

200 Nucleosomes, double-stranded DNA, neutrophil elastase, myeloperoxidase, and myeloid-relate

201 observed in NPs, showed colocalization with neutrophil elastase (n = 10), and did not colocalize wit

202 7BL/6 mice (controls), mice with deletion of neutrophil elastase (NE(-/-)) or peptidyl arginine deimi

203 ases characterized by the presence of excess neutrophil elastase (NE) activity in tissues, including

204 ent inhibitor of neutrophil serine proteases neutrophil elastase (NE) and cathepsin G (CG).

205 y related to neutrophil proteases, including neutrophil elastase (NE) and cathepsin G.

206 The expression of neutrophil elastase (NE) and CCAAT enhancer-binding prot

207 densation dependent upon the enzymes (PAD4), neutrophil elastase (NE) and myeloperoxidase (MPO).

208 hil cytoplasmic antibodies (ANCA) binding to neutrophil elastase (NE) and proteinase 3 (PR3) are dete

209 on fine-tunes the RCL cleavage rate by human neutrophil elastase (NE) and Pseudomonas aeruginosa elas

210 Levels of neutrophil elastase (NE) and the nuclear factors CCAAT/e

211 rophil serine proteases cathepsin G (CG) and neutrophil elastase (NE) are involved in immune-regulato

212 Mutations of the ELA2 gene encoding neutrophil elastase (NE) are responsible for most cases

213 Neutrophil elastase (NE) can be rapidly taken up by tumo

214 s), and beta-arrestins, cathepsin-S (CS) and neutrophil elastase (NE) cleave PAR(2) at distinct sites

215 nstrated that the azurophil granule protease neutrophil elastase (NE) cleaves promyelocytic leukemia-

216 Local proteolytic cleavage of EC JAM-C by neutrophil elastase (NE) drove this cascade of events as

217 /CD66b(+) nanovesicles acquire surface-bound neutrophil elastase (NE) during PMN degranulation, NE be

218 inhibitor) expression and downregulation of neutrophil elastase (NE) expression induced by obstructi

219 The protease neutrophil elastase (NE) has been implicated in the form

220 Mutations in ELANE encoding neutrophil elastase (NE) have been identified in the maj

221 to enhanced permeability, elevated levels of neutrophil elastase (NE) have been reported in inflamed

222 ation constant with its primary target human neutrophil elastase (NE) in lipoprotein-containing plasm

223 of MMP (TIMP)-1, myeloperoxidase (MPO), and neutrophil elastase (NE) in patients with hypertension a

224 BACKGROUND.: A neutrophil elastase (NE) inhibitor, Sivelestat, has been

225 Neutrophil elastase (NE) is a neutrophil-derived serine

226 Neutrophil elastase (NE) is a serine protease of relevan

227 Human neutrophil elastase (NE) plays an important role in the

228 or of serine peptidases (ISP) 2, inactivates neutrophil elastase (NE) present at the macrophage surfa

229 von Willebrand factor and reveal significant neutrophil elastase (NE) proteolytic activity.

230 We show that C-sep isolated PMNs show higher neutrophil elastase (NE) release following activation by

231 evidence from clinical studies suggests that neutrophil elastase (NE) released in neutrophilic airway

232 tern and regulated hepatocyte clock-genes by neutrophil elastase (NE) secretion.

233 ssociated peptide from proteinase 3 (P3) and neutrophil elastase (NE) that is recognized by PR1-speci

234 lease by downregulating the translocation of neutrophil elastase (NE) to the nucleus.

235 ease inhibitors and was impaired in infected neutrophil elastase (NE)(-/-) corneas.

236 We investigated neutrophil elastase (NE), a potent serine protease detec

237 ied with the extracellular release of active neutrophil elastase (NE), a potent serine protease.

238 Neutrophil elastase (NE), a serine protease stored in th

239 loproteinase (MMP)-9, myeloperoxidase (MPO), neutrophil elastase (NE), and MMP-9/tissue inhibitor of

240 Purified NSPs cathepsin G (CG), neutrophil elastase (NE), and proteinase 3 cleaved C5aR

241 A2 encoding the neutrophil granule protease, neutrophil elastase (NE), are the major cause of the 2 m

242 decades, only three active serine proteases, neutrophil elastase (NE), cathepsin G (CG), and proteina

243 azurophil granule serine proteinases, human neutrophil elastase (NE), cathepsin G (CG), and proteina

244 llowing neutrophil and macrophage proteases: neutrophil elastase (NE), cathepsin G, proteinase-3, and

245 itor (ISP2; Deltaisp2/isp3), an inhibitor of neutrophil elastase (NE), died in RAW cells or macrophag

246 rine proteases, such as cathepsin G (CG) and neutrophil elastase (NE), have been implicated in the pr

247 To investigate the levels of neutrophil elastase (NE), matrix metalloproteinases (MMP

248 ivity of neutrophil serine proteases (NSPs): neutrophil elastase (NE), proteinase 3, and cathepsin G.

249 iminished levels of the natural inhibitor of neutrophil elastase (NE), secretory leukocyte protease i

250 Plasma levels of neutrophil elastase (NE), total and active matrix metall

251 phil granule proteases proteinase 3 (P3) and neutrophil elastase (NE), which are both found in the tu

252 gous point mutations in ELANE, which encodes neutrophil elastase (NE).

253 component of the epithelial barrier against neutrophil elastase (NE).

254 elop emphysema, much interest has focused on neutrophil elastase (NE).

255 ermline mutations in the ELANE gene encoding neutrophil elastase (NE).

256 y mutations of the ELANE gene, which encodes neutrophil elastase (NE).

257 onstrate that inhibiting NETosis by blocking neutrophil elastase or by degrading NETs with DNase prot

258 Therapy targeting neutrophil elastase or enhancing innate immunity may be

259 ADAMTS13 treated with either neutrophil elastase or plasmin was inhibited to a lesser

260 hydrophobic 2' substituents that bind human neutrophil elastase or the blood coagulation protein fac

261 hange in bronchiectasis score was related to neutrophil elastase (P < 0.001) with CF-CT.

262 Bx (P = 0.001) with PRAGMA-CF was related to neutrophil elastase presence at age 3, whereas only the

263 The lead NSGM so identified neutralized neutrophil elastase present in the sputum of CF patients

264 Neutrophil elastase promotes Leishmania donovani infecti

265 Finally, siRNA ablation of neutrophil elastase protein production in MDA-MB-231 cel

266 ations result in the production of misfolded neutrophil elastase protein, activation of the unfolded

267 a deficiency of Mac-1 or the kinases blocked neutrophil elastase release in vitro.

268 This led to neutrophil elastase release, causing hemorrhage, fibrin

269 es, as well as significantly lower levels of neutrophil-elastase release, O(2)(-) production and phag

270 Neutrophil elastase removed 68% of MUC16, 78% of which w

271 ent irreversible peptidyl inhibitor of human neutrophil elastase reported to date.

272 d, we fabricated both trypsin-responsive and neutrophil elastase-responsive polymeric Nano-in-Microge

273 Immunostaining of human NMO lesions for neutrophil elastase revealed many degranulating perivasc

274 that seen in the previously determined EapH1-neutrophil elastase structure.

275 weaker than the K(i) for EapH1 inhibition of neutrophil elastase, the time dependence of inhibition w

276 Sputum neutrophil elastase, tissue inhibitor of metalloproteina

277 These findings strongly indicate neutrophil elastase to be a key enzyme in the biological

278 Expression of PFAAP5 allows neutrophil elastase to potentiate the repression of Gfi1

279 l application of recombinant mMCP-5 or human neutrophil elastase to the scalded area increases epider

280 phil extracellular trap (NET) formation, and neutrophil elastase translocation.

281 Neutrophil elastase-treated HCLE cells showed significan

282 ease or shedding of MAMs in other epithelia (neutrophil elastase, tumor necrosis factor [TNF]), TNF-a

283 Furthermore, neutrophil elastase uptake increased expression of low m

284 rostasin (RKRK(178)), plasmin (Lys-189), and neutrophil elastase (Val-182 and Val-193) sites.

285 Higher detectable baseline neutrophil elastase was associated with more rapid lung

286 We established that neutrophil elastase was expressed by TAN within breast c

287 Neutrophil elastase was identified to cleave an N-termin

288 Sputum neutrophil elastase was significantly increased and SLPI

289 the phenotype in mice deficient in Mac-1 or neutrophil elastase was similar.

290 Based on our results, sputum neutrophil elastase was the most informative biomarker t

291 eared to be mediated via their production of neutrophil elastase, was rendered less effective.

292 rocidin (CAP37/heparin-binding protein), and neutrophil elastase were each found to be single copy pe

293 ensins and beta-defensin-2, and the protease neutrophil elastase were measured in sputum supernatants

294 Similar results for neutrophil elastase were observed in a validation cohort

295 Immunostains for gel-forming mucins and neutrophil elastase were quantified.

296 ), and catabolic enzymes (procathepsin B and neutrophil elastase) were measured in SF from injured an

297 s secrete several proteases, one of which is neutrophil elastase, which can promote inflammatory resp

298 ay be cleaved away from the main molecule by neutrophil elastase, which suggests that it may still be

299 agents targeting the heparin-binding site of neutrophil elastase would offer a therapeutic paradigm.

300 eavage site shared by human proteinase 3 and neutrophil elastase, yielded an agonist that was resista