ライフサイエンスコーパス: niche

1 we can all now see how HSCs behave in their niches!

2 t appear to correlate to their environmental niche.

3 ating a br-met-promoting, immune-suppressive niche.

4 und structural perturbations in the aging SC niche.

5 s led to a disruption of the BM perivascular niche.

6 wild-type CSF1R to repopulate the microglial niche.

7 tem cells to represent DTCs in a bone marrow niche.

8 that more closely recapitulate the embryonic niche.

9 antigen-specific Trm cells in the epidermal niche.

10 o cancer, which localized to a fibrovascular niche.

11 , migration and permanent depletion from the niche.

12 of small proteins predicted to exist in this niche.

13 tituent of the hematopoietic stem cell (HSC) niche.

14 modifications of the cholinergic intestinal niche.

15 by altering cellular output of the stem cell niche.

16 ires an accurate assessment of their trophic niche.

17 develops in an immunologically unique br-met niche.

18 morphologies will adapt to their ecological niche.

19 e basement membrane as part of the stem cell niche.

20 ted from the adult mouse subventricular zone niche.

21 caused by the interaction with an altered BM niche.

22 specialized cell types in the root stem cell niche.

23 cells and patterns the surrounding stem cell niche.

24 hematopoiesis by remodeling the mesenchymal niche.

25 ionary adaptations based on their ecological niche.

26 llular processes and establish a replicative niche.

27 to establish and maintain their replicative niche.

28 tegral component of neural stem cells (NSCs) niches.

29 chanisms to gain an advantage in competitive niches.

30 s' and thereby establish peri-vascular micro-niches.

31 ed microenvironments, such as stem cell (SC) niches.

32 allow populations to colonize new ecological niches.

33 ns have access to many unoccupied ecological niches.

34 prove fitness in their particular ecological niches.

35 relative to cultivar fundamental nutritional niches.

36 unraveling unique compositions of neurogenic niches.

37 xploiting a complex configuration of trophic niches.

38 ary progress and constantly shape ecological niches.

39 + by obligate anaerobes inhabiting high Fe2+ niches.

40 g dissemination of cancer cells to secondary niches.

41 reflect adaptation to various environmental niches.

42 s during development and in adult neurogenic niches.

43 cteria isolated from hot and arid ecological niches.

44 imit K. pneumoniae colonization within these niches.

45 ria during the colonization of novel thermal niches.

46 and exploitation of inaccessible ecological niches [1, 2], driving evolutionary innovation and impor

47 s and the establishment of modern ecological niches(12,13).

48 iting mosquitoes occupy distinct time-of-day niches [2, 3].

49 athetic nerves are known to regulate the HSC niche(3-6), the contribution of nociceptive neurons in t

50 een isolated from almost every environmental niche across the planet, including from air, soil, fresh

51 c endothelial inflammation adversely impacts niche activity and HSC function which is reversible upon

52 ively, the microenvironment at the synthetic niche acts as a sentinel by reflecting both progression

53 nmental); 2) the megaplasmids encode diverse niche-adaptive accessory traits, including multidrug res

54 erential gene expression in cells from these niches allow monitoring of disease dynamics and gauging

55 The scaffold mimics the cartilage niche, allowing both cell populations to maintain their

56 A specialized neurogenic niche along the ventricles accumulates millions of proge

57 al components of the hematopoietic stem cell niche and are thought to protect hematopoietic cells und

58 Trophic niche and diet comparisons among closely sympatric marin

59 zed, functional units with a basal stem cell niche and luminal differentiated cell zone, stable, line

60 hat drives follicle regression for reuniting niche and stem cells in order to regenerate tissue struc

61 PTX3 protein cargo primes the premetastatic niche and suggests that inhibition of either sEV uptake

62 phic and functional determinants of species' niches and geographic distributions.

63 life history explains variation in species' niches and niche-distribution mismatches.

64 ntribute to the development of premetastatic niches and settlement of residual tumour cells.

65 osstalk among HSPCs, leukemia, and their MSC niche, and a molecular mechanism whereby AML impairs nor

66 determines a plant's realized environmental niche, and is important for adaptation to climate.

67 ontribute to persistent colonization of this niche, and many are important in mucosal immunity and va

68 lla entry, establishment of an intracellular niche, and modulation of immune responses.

69 Although polyrotaxanes have already found niche applications in exotic materials with specialized

70 oietic stem cells (HSCs) within the leukemic niche are poorly understood, especially in the human con

71 These acidic niches are absent in athymic Nu/Nu and lymphodepleted mi

72 in the mouth and that microbial habitats and niches are defined by micron-scale gradients in combinat

73 Climatic niches are essential in determining where species can oc

74 Niches are generally wider for species with high seed di

75 e more likely to coexist if their ecological niches are segregated either in time, space or in trophi

76 mones and proteinaceous corals filling empty niches as tropical reef builders went extinct.

77 al survival probability on distance from the niche, as well as the emergence of a well-defined number

78 e allocation of proteins to new sub-cellular niches, as well as in the number of newly discovered com

79 o provide a comprehensive description of key niche-associated pathways that are shared across multipl

80 ndence between a regenerative tissue and its niche at different stages and demonstrate sympathetic ne

81 ronary lymphatic development through a local niche at the base of the great arteries.

82 e quantified a 2.9-fold stiffening of the SC niche at time-points associated with planar-oriented sym

83 ric lymph nodes, to delineate colonic immune niches at steady state.

84 neth cells, a critical component of the ISCs niche, augment the ISCs function in response to L-argini

85 alization evolves independently on different niche axes.

86 defined by the partitioning of three primary niche axes: space, time, and resources.

87 However, as niches become increasingly filled, diversity hits a plat

88 lts provide new insights into the role of 3D niche biomechanics in regulating SC fate choice.

89 places positions (points and distances) with niches (boxes and overlap).

90 ricts resource use, and thus limits realized niche breadth and geographic range size [1-3].

91 oenergy landscapes, our results suggest that niche breadth and trophic diversification depend more on

92 asal resource richness on food chain length, niche breadth and trophic position.

93 elated with both food limitation and dietary niche breadth of populations, indicating that moose fora

94 results suggest that latitudinal patterns in niche breadth represent a transient and emergent propert

95 depends on the range of potential partners (niche breadth), the benefits obtained and ability to mai

96 benefits were not attributed to increases in niche breadth, but instead reflect increased rewards fro

97 pecies have similar mean niche breadths, and niche breadths show similar relationships with latitude

98 lar mean rates and species have similar mean niche breadths, and niche breadths show similar relation

99 imen, given in response to signal within the niche but before symptoms appeared, substantially reduce

100 el their neighboring cells (within the tumor niche) by transferring a liposoluble fluorescent protein

101 To establish this unique niche, C. burnetii requires the Dot/Icm type IV secretio

102 We show that the niche cell pool is not only replenished by hemocyte inte

103 mechanisms by which the activity of multiple niche cell types may be coordinated to communicate signa

104 irst discuss representative contributions of niche cell types to regulation of neural stem cell (NSC)

105 First, niche cell wrapping templates a laminin-based basement m

106 e receptor dystroglycan function to maintain niche cell wrapping, which is critical for normal gonad

107 the cellular compositions within functional niches, cell-cell signaling in homeostatic health, the r

108 e CCK interneurons, in regulating neurogenic niche cells and NSCs.

109 Live niche cells can be isolated and compared with cells dist

110 irradiation selectively kills epidermal and niche cells in the shoot apex.

111 Niche cells often wrap membrane extensions around stem c

112 stem and progenitor cells, and frequency of niche cells were not significantly improved by MSC thera

113 For example, in both groups, climatic niches change at similar mean rates and species have sim

114 e reveal extensive phenotypic plasticity and niche complementarity in oleaginous microbial population

115 Each of these SC niche components has been shown to influence HF regenera

116 ." Effective dissection of critical leukemic niche components using single-cell approaches has allowe

117 e results support the tolerance and climatic niche conservatism hypotheses for climate-diversity rela

118 to highlight similarities and differences in niche constituents and how SCs mediate natural tissue re

119 earning processes at the longer timescale of niche construction and cultural practices, as discussed

120 ng the accumulation of further diversity via niche construction and other interactions.

121 iant due to a singularity arising from large niche construction fluctuations that follow extinction e

122 hat integrating knowledge of how bone marrow niches contribute to haematological disease predispositi

123 he microenvironment within the SVZ stem cell niche controls NSPC fate.

124 rovide in vivo evidence that the mesenchymal niche controls tumour initiation in trans.

125 persal and strong predation in the ancestral niche coupled with the lack of it in the new niche(s).

126 suggest that the MDSC-mediated premetastatic niche created in the lymph node of TRL-positive patients

127 hness scales with area, and surface area and niche density increase with three-dimensional complexity

128 We identify SCGF as a niche-derived factor that suppresses BM inflammation and

129 nalyses, our results confirm that ecological niche differentiation is an important component of polyp

130 t component of polyploid speciation and that niche differentiation is often significantly faster in p

131 generally have higher rates of multivariate niche differentiation than their diploid relatives.

132 These relationships suggest a role of niche dimensional complementarity on the structuring of

133 Deletion of Sel1l led to niche displacement of HSCs and a complete loss of HSC id

134 It is still unclear how relevant these niche-distribution mismatches are for biodiversity dynam

135 ry explains variation in species' niches and niche-distribution mismatches.

136 fication of factors that can protect the HSC niche during an injury could offer a significant therape

137 Competitive interactions in the feeding niches during the low water season, plus temporal overla

138 matory mediators that upregulate endothelial niche E-selectin expression.

139 ts occupy specific cellular and biochemical "niches." Effective dissection of critical leukemic niche

140 A spatial niche enabled in situ cellulolytic enzyme production by

141 d FCSCs localized within the TMJ superficial niche exhibit Notch activity during TMJ morphogenesis.

142 le that similar structures actively regulate niche exit in other systems.

143 ls to promote exit of ISCs from their niche (niche exit) and control the binary fate decision (secret

144 ion that the width of a population's dietary niche expands as food becomes limiting, the Niche Variat

145 Ecological release, originally conceived as niche expansion following a reduction in interspecific c

146 Once specified in the niche, first generation NPs act as transit-amplifying in

147 d when involving the bone marrow, provides a niche for asexual replication and gametocyte development

148 trap based on psyllid behavior would fill a niche for monitoring and control.

149 mune cells share a common microenvironmental niche for surveying tissue integrity.

150 of metabolism, shaping a maladapted survival niche for tumor cells.

151 ells and their ability to form premetastatic niches for pancreatic cancer cells in mice.

152 rom organisms inhabiting a shared ecological niche-for example, ammonia-oxidizing archaea.

153 previously undescribed roles for motility in niche formation and collective expulsion-containment str

154 Mechanisms underlying the pre-metastatic niche formation are poorly understood.

155 tep of cancer progression and pre-metastatic niche formation.

156 The set of possible niches forms the niche space, a conceptual space delinea

157 e animals predicts a variety of geographical niches-from the tropics to high latitudes and from shall

158 neages, phosphate binding emerged later as a niche functionality, but for the oldest protein lineages

159 d proangiogenic pathways within the vascular niche have been inefficient.

160 s between gametocytes and this hematopoietic niche have not been investigated.

161 rvival of normal and malignant PCs in the BM niche, highlighting the diverse roles of immune cells be

162 survival and self-renewal in the bone marrow niche; how to apply this process to HSC maintenance and

163 rain development and maintenance of neuronal niches, however, whether and how their activation is inv

164 sition between the cultural versus cognitive niche hypothesis of cumulative technological culture.

165 mapping, we demonstrate our approach in two niche implementations: hyperspectral imaging and ultrafa

166 d the differentiation potential of the V-SVZ niche in a cell-autonomous fashion.

167 cells from VAT are determined by the tissue niche in a sex-hormone-dependent manner to limit adipose

168 ox2(+) labial cervical loop (LaCL) stem cell niche in concert with two signaling centers: the initiat

169 that the visualization of HSCs in the native niche in live animals has not, to our knowledge, been ac

170 a fetal cell type that expands the stem cell niche in normal human cortex.

171 te that GL can target the prostate stem cell niche in patient-derived cells, in docetaxel-resistant s

172 and regenerative function of the epithelial niche in ST2(-/-) mice.

173 interact to determine an organism's trophic niche in the context of one of the largest global trends

174 recent evidence suggests that the neurogenic niche in the crayfish DPS lacks self-renewing stem cells

175 h CD34(+) HSPCs creates an in vivo synthetic niche in the dermis of immunodeficient mice driving the

176 cell-surface targets are gradually finding a niche in the diagnostic armamentarium.

177 r further functional characterization of the niche in the future.

178 y enabling the generation of a premetastatic niche in the inflammatory site.

179 worms embedded in a partially intracellular niche in the large intestine, whereas A. lumbricoides la

180 and stromal cells together created distinct niches in each tissue.

181 ate is an abundant metabolite in a number of niches in host organisms and represents an important car

182 repeatedly colonised a series of ecological niches in marine ecosystems, producing textbook examples

183 e performance of the package kernel isotopic niches in r (rKIN) under various scenarios.

184 genitor cells are mobilized from bone marrow niches in response to remote ischemic injury and migrate

185 phytoplankton are shaped by more nuanced Fe niches in the oceans than previously implied from mostly

186 genome structure to reflect "transcriptional niche" in the nucleus.

187 l of tumor cells (i.e., in the premetastatic niche) in the models of breast carcinoma.

188 ix (ECM), a critical component of metastatic niches, in metastases to the brain, lungs, liver, and bo

189 res (SST) are within Trichodesmium's thermal niche increased by 32% from the LGM to present, but furt

190 s ocean stewardship through incorporation of niche innovations within and across economic sectors and

191 anding mechanisms for stem cell maintenance, niche interactions and fate determination.

192 our findings highlight the importance of SC:niche interactions and favor a model where youthfulness

193 To understand HSC-niche interactions in altered nonmalignant homeostasis,

194 ution could drive a pathogen to colonize new niches, interrogation of sequenced E. coli O157:H7 genom

195 Cherry-niche is a powerful new method that enables cells expres

196 dicate that the quality of the developmental niche is associated with the condition-dependent express

197 However, it remains unclear whether the niche is compartmentalized to control stem cell self-ren

198 Moreover, after the RMs niche is emptied, peripheral monocytes rapidly different

199 Climatic niche is negatively associated with diversification rate

200 his study has structurally revealed that the niche is organized into multiple compartments for orches

201 in the formation of a permissive metastatic niche is unresolved.

202 ficiently large carrying capacity of the new niche - is already well recognized.

203 (1) providing an exclusive interface for the niche ligand-receptor interaction; and (2) limiting the

204 ation of macrophages to the discrete nervous niche may exert axon guidance and nerve regeneration and

205 I-1271/Uproleselan effectively inhibits this niche-mediated pro-survival signaling, dampens AML blast

206 and favor a model where youthfulness of the niche microenvironment plays a dominant role in dictatin

207 ell RNA-sequencing analyses of a mesenchymal niche model showed that fibroblast-derived PGE(2) drives

208 The climatic niche model was corroborated with independent observed f

209 We used CLIMEX, a process-oriented climatic niche model, to explore if this pandemic was linked to r

210 Additionally, we use ecological niche modeling to infer current and past (Last Glacial M

211 -wide genetic variation with demographic and niche modeling to investigate the historical biogeograph

212 We used environmental niche modelling along with the best available species oc

213 We applied an ensemble forecasting niche modelling approach to project the climatic suitabi

214 concomitant to a poleward migration, future niche models suggest a considerable reduction of its ran

215 This information is used to develop niche models, and to estimate their cultivation potentia

216 tor cells to promote exit of ISCs from their niche (niche exit) and control the binary fate decision

217 ic mutations are propagated in the stem cell niche not just through cell-intrinsic advantages, but al

218 aims at assessing resource and habitat use, niche occupation and trophic interactions from a stable

219 and biogeographic histories on the isotopic niches occupied by mammals in analogous tropical ecosyst

220 rie), and to quantify changes in the trophic niche of a widespread generalist ant species across habi

221 The fundamental trophic niche of Callilepis species included mainly ants, while

222 lly resembling the immature active-stem cell niche of neonatal animals.

223 tudies have suggested that the hematopoietic niche of the bone marrow (BM) is a major reservoir for p

224 ls for platelets, migrate from the endosteal niche of the bone marrow (BM) toward the vasculature, ex

225 First, the fundamental nutritional niches of cultivars narrowed over ~60 million years of n

226 un metagenomics unveiled distinct ecological niches of microbes and antibiotic resistance genes chara

227 cular plants, we tested whether the climatic niches of polyploid species are more differentiated than

228 their diploid relatives and if the climatic niches of polyploid species differentiated faster than t

229 e expansion of C(4) vegetation opened up new niche opportunities, probably alleviating resource compe

230 how the alignment between different forms of niche opportunity and niche use shape the initiation, pr

231 either may not be constrained by ecological niches or population immunity to the M protein, or they

232 Among carnivores, niche overlap can trigger interspecific competition and

233 We characterize the areas of niche overlap that may lead to competition between nativ

234 ertebrates) and direct evidence of sympatric niche partitioning (Rhamphorhynchus as a piscivore; Pter

235 We assessed resource consumption and trophic niche partitioning as a function of human disturbance at

236 We explore niche partitioning between studied NE cats and the conte

237 bserved among cave bears in Romania reflects niche partitioning but in a general trophic context of h

238 sms that underpin dietary specialization and niche partitioning is crucial to understanding the maint

239 This niche partitioning may relax competition and ultimately

240 Overall, our findings suggest a niche partitioning of habitat and feeding sources amongs

241 Understanding how the niche performs its functions may guide strategies to mai

242 rovide a model for exploring implications of niche plasticity because they are a highly adaptable, wi

243 altered retinoic acid metabolism within the niche, promote HBC lineage commitment toward two types o

244 Local niches, rather than progenitor origin, or the developmen

245 ing myocyte fusion, Myog influences the MuSC:niche relationship, demonstrating a multi-level contribu

246 cells that are growing out in the metastatic niche rely on the same nutrients and metabolic pathways

247 0.7%, but that this would lead to inadequate niche representation for 7,798 (39.1%) species.

248 niche coupled with the lack of it in the new niche(s).

249 protein (HDL), which signals via endothelial niche S1PR1 to spur regeneration over fibrosis.

250 amount of stem cell receptors available for niche signal reception.

251 al roles to ensure the short-range nature of niche signaling by (1) providing an exclusive interface

252 Stem-cell niche signaling is short-range in nature, such that only

253 es also serve a second purpose to dampen the niche signaling.

254 le Stem Cells (FSCs) by spatially-restricted niche signals.

255 me-lapse microscopy revealed that a stiff 3D niche significantly increased the proportion of planar-o

256 everal tools have been developed to quantify niche size and overlap.

257 of the mechanisms driving reduced geographic niche space and population decline at broad spatiotempor

258 The results suggest a metabolic niche space comprising a collection of discrete clusters

259 host-symbiont state and (ii) the opening of niche space for potential pathogens during thermal stres

260 The set of possible niches forms the niche space, a conceptual space delineating ways in whic

261 AOA) present a convenient model for studying niche specialization.

262 umor and stromal cells cooperated in forming niches; stromal cells produced predominantly core, struc

263 biting neural circuits within the neurogenic niche, suggesting a potential of GABAergic potentiators

264 ed by shape, food, metabolism, or ecological niche-surely rivals (if not exceeds) that of the multice

265 initiation is transformed into a metastatic niche that captures aggressive circulating tumor cells.

266 Mucus is a densely populated ecological niche that coats all non-keratinized epithelia, and play

267 e that R-VECs establish an adaptive vascular niche that differentially adjusts and conforms to organo

268 opoietic stem cells develop in a specialized niche that includes extracellular matrix and supporting

269 upregulate BMP antagonism in the progenitor niche that promotes metaplasia.

270 s in creating spatially distinct geochemical niches that enable the co-existence of multiple taxa tha

271 tiple spatiotemporally dynamic Wnt-secreting niches that regulate functionally distinct phases of air

272 tibodies isolated from various immunological niches, the biophysical properties that allow for promis

273 Changes in trophic niche-the pathways through which an organism obtains ene

274 to control BMP activation in the progenitor niche to determine regenerative outcome in fibrosis.

275 h the production of daughters that leave the niche to differentiate.

276 Stem cells reside in and rely upon their niche to maintain stemness but must balance self-renewal

277 and sympathetic nerves form a dual-component niche to modulate hair follicle stem cell (HFSC) activit

278 show that during the LGM, ibex adapted their niche to survive, and became a major prey species for hu

279 communicating with their microenvironmental "niche" to transition between quiescent and regenerative

280 nd how this relates to broad- and fine-scale niche transitions within the family.

281 Telepsychotherapy, until now a promising but niche treatment, has suddenly become treatment as usual.

282 een different forms of niche opportunity and niche use shape the initiation, progression, and complet

283 niche expands as food becomes limiting, the Niche Variation Hypothesis (NVH) and Optimal Foraging Th

284 tion of cell release from the haematopoietic niche via Mcp1 silencing reduced leukocytes in the disea

285 ent C1q from macrophages in the inflammatory niche was identified as the unorthodox signal that activ

286 s potentially involved in the pre-metastatic niche were significantly different in MBC patients with

287 Changes in thermal niches were accompanied by adaptations in genes that gov

288 taxa that occupy the same apparent metabolic niche when the system is viewed in bulk.

289 ing the diversity of terrestrial and aquatic niches where plant and/or algal cellulosic cell walls ar

290 Cs) reside in the bone marrow (BM) stem cell niche, which provides a vital source of HSC regulatory s

291 Concomitantly, specific alterations of the niches, which support haematopoietic stem cells and thei

292 refinement and adaptation to the new citrate niche, while also suggesting a recalcitrant mismatch bet

293 The isotopic niche width (SEAs) of Carn Mor mice in each season were

294 e-mediated biotic interactions shape thermal niche width is critical in an era of global change.

295 eppe over time, and an expansion of isotopic niche widths, indicate that historic Mongolian empires w

296 ole in lipid metabolism, peroxisomes share a niche with lipid droplets within the endomembrane-secret

297 Ultimately, linking the engineered niches with advances in sensor development and synthetic

298 LT-HSCs are not found in bone marrow niches with the deepest hypoxia and instead are found in

299 age-depletable neural progenitor cell (NPC) niche, with unique characteristics and culture requireme

300 ional functions of wrapping, we investigated niche wrapping of primordial germ cells (PGCs) in the C.