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1 est specificity toward the NAD(+) metabolite nicotinamide riboside.
2 nd was reversible on resupplying NAD(+) with nicotinamide riboside.
3 osphorylating nicotinamide mononucleotide to nicotinamide riboside.
5 In this issue, Belenky et al. report that nicotinamide riboside, a new NAD(+) precursor, regulates
6 ion on the development of steatosis in mice, nicotinamide riboside, a precursor of NAD(+) biosynthesi
7 n be corrected by the oral administration of nicotinamide riboside, a recently discovered vitamin pre
8 ) precursors nicotinamide mononucleotide and nicotinamide riboside also increases NAD(+) levels in as
10 methotrexate, supplementation of a diet with nicotinamide riboside, an NAD precursor, replenished hep
11 y achieves stereoselective synthesis of beta-nicotinamide riboside and a series of related amide, est
12 n yeast and human cells, Nrk2 phosphorylates Nicotinamide Riboside and generates NAD+ through an alte
15 1 and Sdt1 are responsible for production of nicotinamide riboside and nicotinic acid riboside in cel
18 ommercially known as Basis, a combination of nicotinamide riboside and pterostilbene) supplementation
19 to be highly specific for phosphorylation of nicotinamide riboside and the cancer drug tiazofurin.
22 c precursors nicotinamide mononucleotide and nicotinamide riboside are reported to confer resistance
24 under standard growth conditions, Nrt1, the nicotinamide riboside carrier, is the major AICAr transp
28 Thus, like calorie restriction in the mouse, nicotinamide riboside elevates NAD(+) and increases Sir2
30 onstrate that azido substitution at 3'-OH of nicotinamide riboside enables enzymatic synthesis of an
33 idine hydrolase is 100-fold more active as a nicotinamide riboside hydrolase than as a uridine hydrol
34 ated by Sum1, Hst1, and Rfm1, fully restores nicotinamide riboside import and utilization when resupp
35 (+) and inflammation and question the use of nicotinamide riboside in the therapy of inflammatory dis
38 ly, normalizing cytosolic NADH:NAD+ ratio by nicotinamide riboside increased glycolysis and fatty aci
39 reatment with nicotinamide mononucleotide or nicotinamide riboside increases total NAD(+) content in
42 vered as a nutrient in milk, suggesting that nicotinamide riboside is a useful compound for elevation
43 challenged experimentally and revealed that nicotinamide riboside is an unanticipated NAD+ precursor
44 ion, we have shown that exogenously supplied nicotinamide riboside is imported into yeast cells by a
47 cles the nicotinamide precursor, whereas the nicotinamide riboside kinase 2 (NMRK2) that phosphorylat
50 ion largely depends on uridine hydrolase and nicotinamide riboside kinase and that nicotinic acid rib
51 namide riboside elevates NAD+ levels via the nicotinamide riboside kinase pathway and by a pathway in
52 NAD(+) precursor converted to NAD(+) via the nicotinamide riboside kinase pathway and by nucleosidase
53 dase, solute carrier family 12 member 8, and nicotinamide riboside kinase, as well as iNAD+ resetting
54 e phosphorylase is responsible for mammalian nicotinamide riboside kinase-independent nicotinamide ri
58 sults suggest that elevating NAD levels with nicotinamide riboside may allow animals with cADPR- and
62 rst time on the simultaneous quantitation of nicotinamide riboside, nicotinamide mononucleotide and N
63 iological assay, and intracellular levels of nicotinamide riboside, nicotinic acid riboside, and othe
67 ryptophan, nicotinic acid, nicotinamide, and nicotinamide riboside (NmR), via multiple enzymatic step
70 -1 or supplementation with the NAD-precursor nicotinamide riboside (NR) ameliorates energetic derange
71 he availability of NAD(+) precursors such as nicotinamide riboside (NR) and nicotinamide mononucleoti
72 centrations has stimulated investigations of nicotinamide riboside (NR) and nicotinamide mononucleoti
73 Nicotinamide and nicotinic acid as well as nicotinamide riboside (NR) and nicotinic acid riboside (
74 ide adenine dinucleotide (NAD(+) ) precursor nicotinamide riboside (NR) boosts NAD(+) levels and impr
75 Increasing mitochondrial respiration with nicotinamide riboside (NR) drives differentiation and de
76 Oral supplementation of the NAD(+) precursor nicotinamide riboside (NR) has been reported to alter me
77 Supplementation with NAD precursors such as nicotinamide riboside (NR) has been shown to enhance mit
78 mide adenine dinucleotide (NAD(+)) precursor nicotinamide riboside (NR) has emerged as a promising co
80 ons of nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) in the amidated salvage pathw
89 Additionally, deletion of SSY5 increases nicotinamide riboside (NR) levels and phosphate-responsi
90 at supplementation with the NAD(+) precursor nicotinamide riboside (NR) markedly reprograms metabolic
91 human clinical trial to report on effects of nicotinamide riboside (NR) on skeletal muscle mitochondr
92 ment of db/db mice with type 2 diabetes with nicotinamide riboside (NR) prevented several manifestati
96 before and after taking 5 to 9 days of oral nicotinamide riboside (NR), a NAD precursor.RESULTSWe de
97 the rate of liver regeneration, we supplied nicotinamide riboside (NR), an NAD precursor, in the dri
98 boosting compounds, including NAD+ precursor nicotinamide riboside (NR), confer antiinflammatory effe
99 uch as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), exhibits beneficial effects
100 such as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), protects against metabolic d
101 ge NAD synthesis from nicotinamide (NAM) and nicotinamide riboside (NR), while down-regulating other
105 assess the effects of the sirtuin activator, nicotinamide riboside, on NLRP3 inflammasome activation.
106 red to those treated with NAD(+) precursors (nicotinamide riboside) or the known CD38 inhibitor, 78c.
107 otinamide adenine dinucleotide (NAD(+)) with nicotinamide riboside partially blocked neurodegeneratio
108 ide kinase 2 (NMRK2) that phosphorylates the nicotinamide riboside precursor is increased, to a highe
109 In this study, we discovered that exogenous nicotinamide riboside promotes Sir2-dependent repression
110 ochondrial metabolism with the NAD precursor nicotinamide riboside rapidly reverses aortic aneurysm i
111 In mice subjected to pressure overload, nicotinamide riboside reduced cardiomyocyte death and co
112 de, and the newly identified NAD+ precursor, nicotinamide riboside, reviewed herein, are responsible
114 ase (Asn105, Asp112, Gly113, Met117) and the nicotinamide riboside (Ser125, Gln126, Asn163, Val165),
116 D+ synthesis, we present prospects for human nicotinamide riboside supplementation and propose areas
119 MS-based proteomic analysis revealed that nicotinamide riboside supplementation rescued hepatic le
126 eletion of a single gene, YOR071C, abrogates nicotinamide riboside uptake without altering nicotinic
131 on did not affect the bovine milk content of nicotinamide riboside, whereas UHT processing fully dest