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1  in the presence of its ligands butyrate and nicotinate.
2 to a 1,6-dihydropyridine derived from methyl nicotinate.
3 cleotide (NMN) but shows specificity for the nicotinate.
4 % polarization in the case of methyl-4,6-d2 -nicotinate.
5 te (K(m)(L-lactate) = 0.17 +/- 0.02 mM, K(m)(nicotinate) = 0.54 +/- 0.12 mM at -150 mV) than zSMCTn (
6                                              Nicotinate [(18)F]12 exhibited nanomolar affinity and sp
7 Tn (K(m)(L-lactate) = 1.81 +/- 0.19 mM, K(m)(nicotinate) = 23.68 +/- 4.88 mM).
8             An efficient synthesis of methyl nicotinates/6-halonicotinates by the domino isomerizatio
9 aMN) with ATP is coupled to the formation of nicotinate adenine dinucleotide (NaAD) and inorganic pyr
10 ensable downstream enzymes of NAD synthesis, nicotinate adenylyltransferase (NadD family) and NAD syn
11 mation of ethyl 5-(2-(phenylsulfonamido)aryl)nicotinates along with gamma-carbolines, via nitrene ins
12                             The ability of a nicotinate analog to reduce NAH (disappearance of 2.067
13 g only two commercial building blocks, ethyl nicotinate and 2-iodoaniline.
14 ion occurred in the crystal lattice to yield nicotinate and alpha-ribazole-5'-phosphate.
15  complex of CobT with its reaction products, nicotinate and alpha-ribazole-5'-phosphate.
16 egrees C manifested elevated amino acids and nicotinate and depleted short chain fatty acids compared
17 LC method, capable of separating picolinate, nicotinate and isonicotinate, was developed and used in
18 ciation study of colon cancer and identified nicotinate and nicotinamide metabolism and transforming
19                         Extensive changes in nicotinate and nicotinamide metabolism genes were corrob
20 dentified, including amino acid, purine, and nicotinate and nicotinamide metabolism that differentiat
21 tection against the aging-related decline in nicotinate and nicotinamide metabolism.
22 ne, aspartate, and glutamate metabolism; (2) nicotinate and nicotinamide metabolism; and (3) cysteine
23 ssess dual substrate specificity toward both nicotinate and nicotinamide mononucleotide substrates, w
24 and reversed the age-induced declines of the nicotinate and nicotinamide pathway both in serum and sk
25     The role of the NiaP transporter in both nicotinate and nicotinamide salvage was confirmed.
26 rtate, aspartate and asparagine, vitamin b3 (nicotinate and nicotinamide), and arginine and proline.
27 ons of DHTKD1 and OGDH are comparable, while nicotinate and non-phosphorylated sugars are when DHTKD1
28         Here we characterized the effects of nicotinate and related modulators on the BvgS periplasmi
29        The remainder of the cavity binds the nicotinate and ribose-5'-phosphate moieties, which are n
30 carboxylates (MC) such as lactate, pyruvate, nicotinate, and butyrate.
31 at zSMCTe has a higher affinity for lactate, nicotinate, and pyruvate (K(m)(L-lactate) = 0.17 +/- 0.0
32 t of monocarboxylates such as propionate and nicotinate, and we show that SMCT may play a role in col
33 ologically relevant nicotinamides and methyl nicotinates are detailed.
34 ively correlated with phosphoniodidous acid, nicotinate beta-D-ribonucleotide and citric acid concent
35 rations of phosphoniodidous acid, bilirubin, nicotinate beta-D-ribonucleotide and citric acid were de
36                         The pH-dependence of nicotinate binding for rLb and Y30A was consistent with
37  GPR109A is a G-protein-coupled receptor for nicotinate but recognizes butyrate with low affinity.
38 ed to tert-butyl 4-(tert-butoxycarbonylamino)nicotinates by treatment with LDA in THF.
39       The crystal structures reveal that the nicotinate carboxylates of NaAD are recognized by intera
40            DMML is a key enzyme in bacterial nicotinate catabolism, catalyzing the last of nine enzym
41 e homeostasis, known in OADH mutants, to the nicotinate-dependent NAD metabolism.
42     Reduction potentials for the rLb and rLb-nicotinate derivatives were 29 +/- 2 mV (pH 5.40, 25.0 d
43 pounds were prepared through a triacetylated-nicotinate ester nucleoside, via coupling of either ethy
44 ervation adaptation involved upregulation of nicotinate fermentation and downregulation of 3-hydroxyb
45 ure for the preparation of fully substituted nicotinates from ketone enamines and 4-methylideneisoxaz
46 ely associated metabolites (1-methylxantine, nicotinate, glucuronate, uridine, cholesterol, serine, c
47 ich to minimal medium containing thiamin and nicotinate, growth is preceded by a considerable lag per
48 otinate hydrochloride to place 2.4 hydrazino nicotinate (Hn) chelating groups per peptide molecule.
49 nificantly upon administration of Ac3ManNBut-nicotinate hybrid, but not with Ac4ManNBut.
50 s were reacted with succinimidyl-4-hydrazino nicotinate hydrochloride to place 2.4 hydrazino nicotina
51 the bifunctional chelator molecule hydrazino nicotinate (HYNIC).
52  activity in response to modulators, notably nicotinate ions.
53 tion of the carboxylate functionality on the nicotinate ligand.
54 dings suggest that tryptophan, tyrosine, and nicotinate metabolism are upregulated among IIV-AS03 rec
55 aled enrichment of tryptophan, tyrosine, and nicotinate metabolism in urine and serum among IIV-AS03
56                    They demonstrate that the nicotinate moiety and phosphate do not appear to move si
57                           Interestingly, the nicotinate moiety of NAMN is intercalated between highly
58 rance of the active site pocket, whereas the nicotinate moiety of NAMN is located deep inside.
59 nd (apo), (ii) structures of MjCobT bound to nicotinate mononucleotide (NaMN) and alpha-ribazole 5'-p
60 ichiometric ATP hydrolysis with formation of nicotinate mononucleotide (NAMN) from nicotinic acid and
61 syltransferase (QAPRTase, EC 2.4.2.19) forms nicotinate mononucleotide (NAMN) from quinolinic acid (Q
62  with phosphoribosylpyrophosphate (PRPP) and nicotinate mononucleotide (NAMN) showed, surprisingly, t
63 e that transfers the phosphoribosyl group of nicotinate mononucleotide (NaMN) to phenol or p-cresol,
64  converge at the point where the reaction of nicotinate mononucleotide (NaMN) with ATP is coupled to
65                                              Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazo
66                                              Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazo
67 In such microbes, alpha-RP is synthesized by nicotinate mononucleotide (NaMN):DMB phosphoribosyltrans
68                                 Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase
69 nvolved in the last steps of NAD biogenesis, nicotinate mononucleotide adenylyltransferase (NadD) and
70                This reaction is catalyzed by nicotinate mononucleotide adenylyltransferase (NMAT), wh
71                                    Bacterial nicotinate mononucleotide adenylyltransferase encoded by
72                                              Nicotinate mononucleotide adenylyltransferase NadD is an
73                   The gene (ybeN) coding for nicotinate mononucleotide adenylyltransferase, an NAD(P)
74 o known as alpha-ribazole-5'-phosphate) from nicotinate mononucleotide and 5,6-dimethylbenzimidazole,
75  of ATP hydrolysis to drive the synthesis of nicotinate mononucleotide and pyrophosphate from nicotin
76 zyme catalyzes the reversible adenylation of nicotinate mononucleotide and shows product inhibition.
77 gene in yeast and catalyzes the formation of nicotinate mononucleotide from quinolinate and 5-phospho
78                   The rate of adenylation of nicotinate mononucleotide is at least 20 times faster th
79  the structure of a complex with the product nicotinate mononucleotide suggests a mechanism for deami
80                          The apparent Km for nicotinate mononucleotide was 680 microM; the apparent K
81 , the crystals containing DMB were soaked in nicotinate mononucleotide whereupon the physiological re
82 nosylcobinamide, 5, 6-dimethylbenzimidazole, nicotinate mononucleotide, and GTP.
83 oxylation reaction to form the NAD precursor nicotinate mononucleotide, carbon dioxide, and pyrophosp
84 ase, EC 2.4.2.19) catalyzes the formation of nicotinate mononucleotide, carbon dioxide, and pyrophosp
85                                              Nicotinate mononucleotide:5,6-dimethylbenzimidazole phos
86 ization of the cobalamin biosynthetic enzyme nicotinate-mononucleotide:5, 6-dimethylbenzimidazole pho
87       PncA is dispensable in the presence of nicotinate (Na), ruling it out as a viable antibacterial
88 amino acids, only genes for the synthesis of nicotinate, NAD+, NADP+ and coenzyme A were detected amo
89 etabolic pathways in the HM group, including nicotinate, nicotinamide, purine, glyoxylate, dicarboxyl
90 ances in sugar, phospholipid, nucleotide and nicotinate/nicotinamide metabolism were noted.
91 s, phospholipids, ascorbate, nucleotides and nicotinate/nicotinamide.
92 DnaK, IGP synthase cyclase subunit, probable nicotinate-nucleotide adenylyltransferase, NADH-quinone
93  reductase is inactive with LB3+ is bound to nicotinate or NO2-.
94 wnregulating the NAD+ salvage pathway enzyme nicotinate phosphoribosyltransferase (Naprt1), sensitizi
95 ared with those without renal-risk variants; nicotinate phosphoribosyltransferase also displayed gene
96 ow that increased dosage of NPT1, encoding a nicotinate phosphoribosyltransferase critical for the NA
97  We have determined the crystal structure of nicotinate phosphoribosyltransferase from Themoplasma ac
98  cells from black patients revealed that the nicotinate phosphoribosyltransferase gene, responsible f
99 d with loss of activity, suggesting that the nicotinate riboside moiety is recognized as a neutral zw
100 ing, the Leu44 side-chain interacts with the nicotinate ring by van der Waals contact.
101 nserved histidine residue interacts with the nicotinate ring, the Leu44 side-chain interacts with the
102 he VFT lobes prevent BvgS from responding to nicotinate, showing that BvgS shifts from kinase to phos
103 0 M, 25.0 +/- 0.1 degrees C), for binding of nicotinate to ferric rLb, H61A and Y30A were 1.4 +/- 0.3
104 1 and 6.7 +/- 0.2, respectively); binding of nicotinate to H61A was independent of pH.
105 active-site hydrogen bonds in the binding of nicotinate to recombinant ferric soybean leghaemoglobin
106              Coupled decreases in sugars and nicotinate upon the OADH inhibition link the perturbatio
107                              Na(+)-dependent nicotinate uptake by SMCT, however, was unaffected.
108 e partially mediated by 1-methylxanthine and nicotinate (variance accounted for mean 14.4% [SD 5.1],
109 nts (2.6-fold), alpha-tocopherol (3.1-fold), nicotinate/vitamin B(3) (9.4-fold), choline (1.2-fold),
110                                Extracellular nicotinate was depleted and metabolites of the deamidate
111                                6-(Pyrid-2-yl)nicotinates were synthesized by a Stille-type coupling o
112 fumaric acid, N-methylpyridinium, and methyl nicotinate, whereas Chapada Diamantina coffees showed hi
113  6-[2-(4,4-dimethylthiochroman-6-yl)-ethynyl]nicotinate), which is effective in the treatment of psor

 
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