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1 ikely contributes to the cytotoxicity of the nitrogen mustard.
2 ed by antitumor agents such as cisplatin and nitrogen mustards.
3 by conventional cross-linking agents such as nitrogen mustards.
4 ounds in all series are prodrugs of bis-iodo nitrogen mustards.
5 rom o- and p-amino and p-methylamino aniline nitrogen mustards.
6 lesions in a pattern similar to conventional nitrogen mustards.
7 rtime discovery of the lymphotoxic action of nitrogen mustards.
8  with or without prior chemotherapy received nitrogen mustard 3 mg/m2 or 6 mg/m2, respectively, intra
9 ontributions of NER and BER to the repair of nitrogen mustard adducts may not be the same genome wide
10 ortance of the two pathways in the repair of nitrogen mustard adducts.
11 se (GST) isoforms P1-1 and A1-1 to produce a nitrogen mustard alkylating agent.
12                                 BR384 is the nitrogen mustard analog of [4-[[N-(3-chlorophenyl)carbam
13  radiation and two DNA cross-linking agents, nitrogen mustard and cisplatinum.
14 covalent sequence specificity of a series of nitrogen mustard and imidazole-containing analogues of d
15 posure to three cytotoxic agents (Cisplatin, Nitrogen Mustard and N-methyl-N-nitrosourea (NMNU/MNU))
16          The former moiety is a DNA damaging nitrogen mustard and the latter is a ligand for the ER.
17 ing treatment with bis-electrophiles such as nitrogen mustards and cisplatin is the N7 position of gu
18 nes and DNA-guanine-N7 active agents such as nitrogen mustards and cisplatin.
19 utic alkylating agents, such as bifunctional nitrogen mustards and cisplatins, generate interstrand D
20               Cisplatin and its derivatives, nitrogen mustards and mitomycin C, are used widely in ca
21 k formation, produced by the clinically used nitrogen mustard antitumour drug mechlorethamine (HN2),
22  tallimustine, which contains a benzoic acid nitrogen mustard appended to the minor groove DNA-bindin
23  chemical basis for why DPCs produced by the nitrogen mustard are not repaired by the proteasome.
24 owing the administration of "super" doses of nitrogen mustard, autologous bone marrow was infused int
25  to study translesion synthesis (TLS) past a nitrogen mustard-based interstrand crosslink (ICL) with
26 sponding 3,5-difluorophenol and -aniline (4)-nitrogen mustards by the enzyme carboxypeptidase G2 (CPG
27                                          The nitrogen mustard Chlorambucil (Chl) generates covalent a
28 yribonucleotides (ODNs) bearing the reactive nitrogen mustard chlorambucil have been used as sequence
29 or, a triphenylphosphonium derivative of the nitrogen mustard chlorambucil.
30  to protect cells from the cytotoxicity of a nitrogen mustard, chlorambucil.
31 d kinetics for the monofunctional binding of nitrogen mustard class of anticancer drugs to purine bas
32                       The use of macrocyclic nitrogen mustard complexes represents a promising new st
33                                     Nine new nitrogen mustard compounds derived from 2,6-difluoro-4-h
34 emonstrated in a shuttle vector system using nitrogen mustard-conjugated oligodeoxyribonucleotides (O
35                                              Nitrogen mustard cross-linking studies on a family of GA
36                            Specifically, the nitrogen mustard cyclophosphamide induces an acute secre
37 ation reveals a previously unknown source of nitrogen mustard cytotoxicity and indicates that MEBAC a
38                               In the case of nitrogen mustard DNA adduct processing, equal involvemen
39                                              Nitrogen mustard drugs are cytotoxic, but usually unsele
40  with that required for cross-linking by two nitrogen mustard drugs, mechlorethamine and melphalan.
41 mation of interstrand N+2 DNA cross-links by nitrogen mustards, e.g., melphalan and mechlorethamine.
42                      Antitumor agents of the nitrogen mustard family and mitomycin C form interstrand
43  of HeLa cells to camptothecin, etoposide or nitrogen mustard for 1 h in S phase resulted in delayed
44  The bifunctional alkylating anticancer drug nitrogen mustard forms a variety of DNA lesions, includi
45                      A plasmid with a single nitrogen mustard (HN2) interstrand cross-link (inter-HN2
46 itivity to methyl methanesulfonate (MMS) and nitrogen mustard (HN2).
47  to CDDP and another DNA crosslinking agent, nitrogen mustard (HN2).
48 e effects of a DNA alkylating agent known as nitrogen mustard (HN2).
49 inking agents, such as mitomycin C (MMC) and nitrogen mustard (HN2).
50 A2780(100) was 5 - 10-fold more resistant to nitrogen mustards (IC50 of 50 - 60 microM) and other DNA
51 e have synthesized a panel of model unhooked nitrogen mustard ICLs to systematically investigate how
52 d C studies, with a 75% to 83% lower dose of nitrogen mustard in addition to omission of procarbazine
53 ure AP sites induced by the chemotherapeutic nitrogen mustard in vitro.
54 and mag1 disruptants show elevated levels of nitrogen mustard-induced forward mutation.
55 re used to construct a plasmid with a single nitrogen mustard interstrand cross-link (inter-HN2-pTZSV
56 A polymerase II (polB) are hypersensitive to nitrogen mustard killing, E. coli appears to have two pa
57 me of processing of a substrate containing a nitrogen mustard-like ICL two nucleotides in the duplex
58 expression of ycaQ sensitizes E. coli to the nitrogen mustard mechlorethamine.
59 s were found to be involved in the repair of nitrogen mustard (mechlorethamine)- and cisplatin-induce
60                                Compared to a nitrogen mustard (mechlorethamine, MCE) MEBAC produces h
61  by conventional crosslinking agents such as nitrogen mustard, melphalan or cisplatin which bind in t
62           These agents include procarbazine, nitrogen mustard, melphalan, nitrosoureas (> or = 2 cycl
63                                          The nitrogen mustards, melphalan and chlorambucil, were both
64 ation frequencies, we found that cisplatin-, nitrogen mustard-, mitomycin-, and carmustine-induced DN
65 tion of interstrand 5'-GNC-3' cross-links by nitrogen mustards, modify the electrostatics of the majo
66              Measurements of repair rates of nitrogen mustard N-alkylpurine adducts in the highly tra
67 stogenic effects of several chemotherapeutic nitrogen mustards (namely, mechlorethamine, melphalan, a
68                   DNA alkylating agents like nitrogen mustard (NM) are easily absorbed through the sk
69                                              Nitrogen mustards (NMs) are DNA-alkylating compounds tha
70 ent cell death in the presence of cisplatin, nitrogen mustard or thapsigargin.
71 r detecting other alkylating agents, such as nitrogen mustard, our approach eliminates the need for p
72                                            A nitrogen mustard placed on the 5'-end of the purine moti
73  leukaemogenic DNA crosslinking chemotherapy nitrogen mustard predicted to elicit HRR, selected again
74 rt a novel H(2)O(2)-responsive phenylboronic nitrogen mustard prodrug (10a) and its precisely deutera
75  with PR104A, an experimental DNA alkylating nitrogen mustard prodrug currently under investigation f
76 -104 is converted systemically to PR-104A, a nitrogen mustard prodrug designed to target tumor hypoxi
77             PR-104, a phosphate ester of the nitrogen mustard prodrug PR-104A, has shown evidence of
78    We designed and synthesized a new type of nitrogen mustard prodrug that can be activated by high l
79 ropionyl-( R)- (-) phenylglycine] is a novel nitrogen mustard prodrug that is preferentially activate
80 e fluorescent curcumin scaffold with an aryl nitrogen mustard provides a stable Hck inhibitor (K(d) =
81 agents, such as methylators and crosslinking nitrogen mustards, represent a major risk factor for acu
82 ty and stability of the intermediate in both nitrogen mustards, respectively.
83 ent with the alkylating agents melphalan and nitrogen mustard resulted in 3.8- to 7.3-fold greater se
84 air pathways are epistatic to each other for nitrogen mustard sensitivity.
85                                              Nitrogen mustards such as mechlorethamine have previousl
86 We report a series of ROS-activated aromatic nitrogen mustards that selectively kill chronic lymphocy
87            In the case of cells treated with nitrogen mustard the higher levels coincided with cells
88             Therefore, selectively targeting nitrogen mustards to cancer cell mitochondria based on D
89 site-specific ICLs mimicking those formed by nitrogen mustards to facilitate the studies of cellular
90 e of the tirapazamine analogue 18a bearing a nitrogen mustard unit at the 6-position, it was found th
91 ard this end, tirapazamine analogues bearing nitrogen mustard units were prepared.
92 ridinoadenylates of the form 1 and a related nitrogen mustard variant have been constructed using a n
93 2% of patients treated with mechlorethamine (nitrogen mustard), vincristine, and procarbazine (MOP) f
94 te, cytarabine, cyclophosphamide, etoposide, nitrogen mustard, vincristine, procarbazine, and prednis
95 ix, and the suppression was minimal when the nitrogen mustard was conjugated at only one end.
96 of diaryl and alkylaryl sulfoxide-containing nitrogen mustards were synthesized and evaluated for the
97                                              Nitrogen mustards, widely used as chemotherapeutics, hav