ライフサイエンスコーパス: nitrone

1 loaddition of a glyoxylate-based homoallylic nitrone.

2 thesized starting from an l-tartaric derived nitrone.

3 r aggregation) hindering radical addition to nitrone.

4 by the antioxidant alpha-phenyl-N-tert-butyl nitrone.

5 hiated alkoxyallene to an enantiopure cyclic nitrone.

6 ments of GS.-5, 5-dimethyl1pyrroline N-oxide nitrone.

7 a novel, brain-permeable spin trap, azulenyl nitrone.

8 l hydroxylamine to provide the corresponding nitrone.

9 e-derived alpha,beta-unsaturated pyrrolidine nitrones.

10 ition reactions with both acyclic and cyclic nitrones.

11 es which are combined with aldehydes to form nitrones.

12 yn-selenoxide elimination to provide N-vinyl nitrones.

13 onic properties to those of alkoxyphosphoryl nitrones.

14 compared to those in DMPO and alkoxycarbonyl nitrones.

15 ones compared to DMPO and the alkoxycarbonyl nitrones.

16 trone is more exoergic than the carbonylated nitrones.

17 ar H-bonding is favored for alkoxyphosphoryl nitrones.

18 catalyst in the one-pot tandem synthesis of nitrones.

19 catalytic approach for the carbamoylation of nitrones.

20 bearing indoline systems to their respective nitrones.

21 es and 25.8 kcal/mol for C-(methoxycarbonyl) nitrones.

22 introduction of a cyanomethyl group onto the nitrones.

23 g this model, the k(app) for the reaction of nitrone 1, 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-

24 valuation of the BBB penetration of selected nitrones 1, 2, 10, and 11 using the PAMPA-BBB assay show

25 ated (MTT assay) studies clearly showed that nitrones 1-3 and 10 give rise to significant neuroprotec

26 d for necrotic cell death (LDH release test) nitrones 1-3, 6, 7, and 9 proved to be neuroprotective a

27 Acidic hydrolysis affords nitrone 15, which reduces quantitatively via catalytic h

28 f AMPO, and of the novel and analogous amido nitrone 2-amino-5-carbamoyl-5-methyl-1-pyrroline N-oxide

29 Permeable quinoline nitrones 2 and 3 show potent combined antioxidant and ne

30 ; and we synthesized a novel, cell permeable nitrone, 2-2-3,4-dihydro-2H-pyrrole 1-oxide (EMEPO).

31 In DMSO, the half-lives of nitrone 3 and 4-OOH adducts were double that of PBN, sug

32 eement with their high lipophilicity values, nitrone 3 was insoluble in water, while nitrone 4 exhibi

33 The Z and E nitrones 38 and 39 from condensation of aldehyde 20 with

34 The synthesis of the acid nitrone 4 and its corresponding tert-butyl ester 3 was i

35 ues, nitrone 3 was insoluble in water, while nitrone 4 exhibited a poor water solubility.

36 of an alpha-(4-pyridyl-1-oxide)-N-tert-butyl-nitrone (4-POBN)-ethanol spin-trapping system, the 4-POB

37 The nitrone 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO)

38 been able to isolate the two enantiomers of nitrone 5.

39 With enantiomerically pure nitrone 5a and 5b we explored whether one of these isome

40 emonstrate that the spin trapping of O2*- by nitrone 5a and nitrone 5b affords the identical EPR spec

41 the spin trapping of O2*- by nitrone 5a and nitrone 5b affords the identical EPR spectra and lifetim

42 ith C-(4-benzyloxyphenyl)-N-(4-fluorophenyl)-nitrone (8), intramolecular nucleophilic displacement at

43 Unique bridgehead nitrones, 8-oxa-6-azabicyclo[3.2.1]oct-6-ene 6-oxides, h

44 ,3-dipolar cycloaddition of 2H-azirines with nitrones, a straightforward approach toward the regiosel

45 The nitrone above is readily available via the intramolecula

46 e (H(2)O(2)) in the presence of DMPO, a DMPO nitrone adduct could be detected by immuno-spin trapping

47 The formation of this nitrone adduct depended on the concentrations of GSH, LP

48 te ions of both the native and the mono-DMPO nitrone adduct of human myoglobin.

49 MPO, we detected an LPO radical-derived DMPO nitrone adduct using enzyme-linked immunosorbent assay a

50 The level of this nitrone adduct was decreased significantly by azide, cat

51 The nitrone adduct was repaired on a time scale consistent w

52 , but is subsequently oxidized to the stable nitrone adduct, which can be detected and visualized by

53 roline-N-oxide (DMPO), thus forming DMPO-DNA nitrone adducts (referred to here as nitrone adducts); (

54 Because both protein and DNA nitrone adducts are formed, it is important that the DNA

55 on of nitrone adducts; and (iii) analysis of nitrone adducts by heterogeneous immunoassays using Abs

56 ally recognizes protein radical-derived DMPO nitrone adducts has been developed.

57 serum to detect protein radical-derived DMPO nitrone adducts in the hemoprotein Mycobacterium tubercu

58 k demonstrates that the formation of protein nitrone adducts is dependent on the concentrations of te

59 iments for the purpose of detecting DMPO-DNA nitrone adducts should be conducted over a range of time

60 l-1-pyrroline N-oxide (DMPO), forming stable nitrone adducts that are then detected using an anti-DMP

61 Furthermore, the formation of protein-DMPO nitrone adducts was accelerated in the presence of isoni

62 Protein-DMPO nitrone adducts were also generated by a continuous flux

63 The DMPO nitrone adducts were analyzed by mass spectrometry (MS)

64 (DMPO) was included in the reaction mixture, nitrone adducts were detected by immuno-spin trapping.

65 MPO-DNA nitrone adducts (referred to here as nitrone adducts); (ii) purification of nitrone adducts;

66 s in situ and in real time, forming DMPO-DNA nitrone adducts, but preventing both 8-oxo-7,8-dihydro-2

67 radicals, thus ensuring a high yield of DNA nitrone adducts.

68 nst protein 5,5-dimethyl-1-pyrroline N-oxide-nitrone adducts.

69 -pyrroline glytathionyl N-oxide glytathionyl nitrone adducts.

70 re as nitrone adducts); (ii) purification of nitrone adducts; and (iii) analysis of nitrone adducts b

71 DFT) calculations to assess the viability of nitrone-alkene (3 + 2) cycloaddition reactions proposed

72 Reaction of 2,4-dienals with nitrones allows for a highly regio- and stereoselective

73 ee radical scavenger alpha-phenyl-butyl-tert-nitrone (alphaPBN), and the N-methyl-D-aspartic acid (NM

74 In mice, the cyclic nitrones ameliorated the damaging effects of oxidative s

75 sannular 1,3-dipolar cycloaddition between a nitrone and an enone in a nine-membered macrocycle.

76 Spin trapping using a nitrone and electron paramagnetic resonance (EPR) spectr

77 ionalize the long-range coupling between the nitrone and the beta-CD, as well as the stability of the

78 hich the lithium atom is coordinated to both nitrone and ynolate, the reaction takes place in one sin

79 -limiting step of 29.9 kcal/mol for C-methyl nitrones and 25.8 kcal/mol for C-(methoxycarbonyl) nitro

80 (II) carboxylate catalyzed reactions between nitrones and a beta-TBSO-substituted vinyldiazoacetate.

81 Cascade reactions involving nitrones and allenes are known to facilitate the rapid s

82 dihydropyrido[1,2-a]indoles from mixtures of nitrones and allenoates has been developed.

83 synthesized by the [3 + 2] cycloaddition of nitrones and arynes.

84 r cycloadditions between d-arabinose-derived nitrones and d-mannitol-derived trans-olefins have been

85 de reaction of N-aryl-alpha,beta-unsaturated nitrones and electron-deficient allenes has been discove

86 tron demand 1,3-dipolar cycloaddition of the nitrones and imines followed by hydrodeoxygenation of th

87 The mechanism of the reaction between nitrones and lithium ynolates has been studied using DFT

88 e constants were similar among the different nitrones and not that significantly different from that

89 emonstrated with a variety of formamides and nitrones and provided a direct route to alpha-(N-hydroxy

90 The recent advances of tetramethylpyrazine nitrones and quinolylnitrones for the treatment of strok

91 Energies of optimized geometries of nitrones and their corresponding *OH adducts were calcul

92 ained by a 1,3-dipolar cycloaddition between nitrones and vinylsulfones.

93 ocatechin gallate, alpha-phenyl-N-tert-butyl nitrone, and ebselen significantly suppressed iNOS trans

94 l) cyclobutylamine to the N-hydroxyamine and nitrone, and rat P450 2B1-catalyzed and rabbit P450 2B4-

95 andem condensation to oximes, cyclization to nitrones, and 1,3-dipolar cycloaddition to tricyclic iso

96 e as a dipolarophile with azomethine ylides, nitrones, and nitrile oxides in good yields.

97 thods with facilitated access to challenging nitrones, and shown that these transformations can be co

98 itroxyl O bonds is smaller in phosphorylated nitrones, and that aspect appears to account for the lon

99 The reaction works best with alpha,N-diaryl nitrones, and the conditions are compatible with a range

100 interest in the pharmacological activity of nitrones, and there is, therefore, a pressing need to de

101 Nitrones are important building blocks for natural and b

102 This indicated the cyclic nitrones are inherently more effective radical traps tha

103 Nitrones are key intermediates in organic synthesis and

104 and showed that the redox potentials of the nitrones are largely influenced by the nature of the sub

105 Azulenyl nitrones are novel chain-breaking antioxidants with low

106 C(sp(2))-H bond functionalization in cyclic nitrones are reported.

107 Therefore, nitrones are still of great interest and in the limeligh

108 The phenylselenenyl-containing nitrones are then oxidized to selenoxides which undergo

109 BB) of (Z)-alpha-aryl and heteroaryl-N-alkyl nitrones as potential agents for stroke treatment.

110 the nucleophilic nature of O2*- addition to nitrones as well as the role of intramolecular hydrogen

111 2] 1,3-dipolar cycloadditions (with azides, nitrones, azomethine imines and ylides, nitrile oxides,

112 work, a series of alpha-phenyl-N-tert-butyl nitrones bearing one, two, or three substituents on the

113 ent oxidase that generates roquefortine L, a nitrone-bearing intermediate in the biosynthesis of oxal

114 amide or an ester as attached groups on the nitrone can be ideal in molecular tethering for improved

115 uch as spin traps (alpha-phenyl-N-tert-butyl nitrone), catalytic antioxidants (superoxide dismutase [

116 addition, is more positive in phosphorylated nitrones compared to DMPO and the alkoxycarbonyl nitrone

117 The majority of nitrones compete with DMSO for hydroxyl radicals, and mo

118 1,3-dipolar cycloaddition reaction between a nitrone component, equipped with a 9-ethynylanthracene o

119 a dimethylphenol fused to a 7-membered ring nitrone (compound 6h), inhibited lipid peroxidation in v

120 At high nitrone concentrations, a second paramagnetic species, v

121 The beta-cyclodextrin (beta-CD)-cyclic nitrone conjugate, 5-N-beta-cyclodextrin-carboxamide-5-m

122 animine N-oxide (EBN), which is the simplest nitrone containing an alpha-H and a tertiary alpha'-C at

123 ch heterocycle, or a dimethylphenol, (2) the nitrone-containing ring comprised five, six, or seven at

124 Either of these two nitrones could, in principle, be utilized for the prepar

125 irectional approach involving intramolecular nitrone cycloaddition as the key step.

126 Application of intramolecular 1,3-dipolar nitrone cycloaddition reaction on carbohydrate-derived p

127 A stereoselective intramolecular 1,3-dipolar nitrone cycloaddition useful in the synthesis of chroman

128 a bis(cyanoalkenyl)oxime and proceeding via nitrone cycloadditions have been unraveled through a ser

129 Moreover, the strategic manipulation of nitrone cycloadducts demonstrates the utility of this me

130 and employs a stereoselective intermolecular nitrone cyloaddition reaction as a key step.

131 we also tested our findings on chalcone and nitrone data from the current literature.

132 ts into the reactivity of free radicals with nitrone derivatives have been proposed.

133 A novel series of alpha-phenyl-N-tert-butyl nitrone derivatives, bearing a hydrophobic chain on the

134 itro-compounds with benzyl alcohols to yield nitrone derivatives.

135 tion between copper(I) acetylides and cyclic nitrones derived from chiral amino alcohols and glyoxyli

136 ng with alpha-(4-pyrridyl-1-oxide)-N-t-butyl-nitrone-ethanol confirmed the generation of HO., and inj

137 ng an alpha-(4-pyridyl-1-oxide)-N-tert-butyl-nitrone/ethanol spin-trapping system, we were able to de

138 The alkyne molecule approaches the nitrone exclusively anti to the large substituent next t

139 elective nucleophilic addition to the cyclic nitrone followed by a combination of two simultaneous an

140 carboxylation to give an azomethine ylide or nitrone followed by intramolecular dipolar cycloaddition

141 ifluoromethylation of beta,gamma-unsaturated nitrones followed by reduction of the double bond can ci

142 tion of enolizable cyclic 1,3-dicarbonyls to nitrones, followed by a spontaneous intramolecular reorg

143 udy demonstrates the suitability of the AMPO nitrone for use as a spin trap to study radical producti

144 rones were predicted to be the most suitable nitrones for spin trapping of *OH due to the similarity

145 Analogs of the cyclic nitrone free radical trap 1 (3,3-dimethyl-3,4-dihydroiso

146 N-oxide) of the previously described cyclic nitrone free radical trap 1 (3,3-dimethyl-3,4-dihydroiso

147 ntally benign protocol for the generation of nitrones from benzylic secondary amines via catalyst-fre

148 An electrocyclization route to azetidine nitrones from N-alkenylnitrones was discovered that prov

149 Nitrone functionality in roquefortine L was confirmed by

150 In most cases, the nitrones gave rise to a standard six-line EPR spectrum w

151 undergoes a stepwise cycloaddition with the nitrone, generating a five-membered ring intermediate.

152 e reactions results from both control of the nitrone geometry and selective partitioning of the react

153 Recently, a family of ester-containing nitrones has been prepared, which appears to have distin

154 er catalyzed reactions involving alkynes and nitrones have also been optimized for applications in bi

155 Nitrones have also found applications as therapeutic age

156 dition reactions of enoldiazoacetamides with nitrones have been developed.

157 s for superoxide radical trapping by various nitrones have been found to predict favorable formation

158 ucturally and electronically diverse N-vinyl nitrones have been synthesized by a two-step method.

159 4-elimination to provide the desired N-vinyl nitrone in good to excellent yields.

160 Subsequent treatment of the nitrone in refluxing toluene with substituted actetylene

161 ndicated that photochemical rearrangement of nitrones in benzene afforded reasonably good yields (30-

162 -Crafts addition to aryl and secondary alkyl nitrones in the presence of trimethylsilyl trifluorometh

163 c tertiary N-oxides (and with one protonated nitrone) in different mass spectrometers.

164 Ester-containing nitrones, including 5-tert-butoxycarbonyl-5-methyl-1-pyr

165 yl, thienyl, and pyridyl halides with cyclic nitrones, including DMPO.

166 FeTBAP, ebselen, and alpha-phenyl-tert-butyl nitrone) inhibited DOX-induced eNOS transcription.

167 eactions and organometallic additions to key nitrone intermediates, formed in turn by oxidation proce

168 All this makes nitrones intriguing and valuable compounds for fundament

169 Addition of *OH to a phosphoryl-substituted nitrone is more exoergic than the carbonylated nitrones.

170 Substrates in which the nitrone is part of a fused bicyclic ring system have tra

171 the first [4+2] cycloaddition of an N-vinyl nitrone is reported.

172 tituted 1,1,1-trifluoromethylstyrene-derived nitrones is described.

173 2] annulation between terminal arylynes and nitrones is described.

174 bstituted formamides and LDA to N-tert-butyl nitrones is described.

175 is of a new type of heterodiene, the N-vinyl nitrone, is described.

176 routinely used for click chemistry, azides, nitrones, isonitriles, and nitrile oxides are the most p

177 be hydrolysis products of everninomicin P, a nitrone-linked conjugate likely the result of nonenzymat

178 Herein, we report the synthesis of a nitrone-linked covalent organic framework, COF-115, by c

179 conversion method giving synthetic access to nitrone-linked covalent organic frameworks (COFs) from i

180 Synthesized nitrone matched the unknown metabolite with identical re

181 Applied to the chiral nitrone MiPNO, this transformation provides a straightfo

182 Nitrone-modified pore channels induce condensation of wa

183 fin functionality at C-1 or C-3 or C-5 and a nitrone moiety at C-2 or C-3 as appropriate has resulted

184 intermediate and subsequent amination of the nitrone moiety via the newly generated nitrogen-centered

185 ugated to the macrolide rosamicin via a rare nitrone moiety.

186 intermolecular nucleophilic addition of two nitrone molecules, was also observed but to a lesser ext

187 In this network, nitrone N bearing a 6-methylamidopyridine recognition si

188 erizes to a 3,4-dihydro-1,2,4-triazine-based nitrone, namely 6-phenyl-3-pyridin-2-yl-2,3-dihydro-1,2,

189 nd more persistent O2(*-) adduct compared to nitrones not conjugated to beta-CD.

190 h this topology using two maleimides and two nitrones of different sizes-either short or long and eac

191 Starting from a chiral furanone, the nitrone-olefin [3 + 2] cycloaddition can be used to obta

192 t involves a stereocontrolled intramolecular nitrone-olefin dipolar cycloaddition has been developed

193 addition reactions of a carbohydrate-derived nitrone on diversely functionalized calix[4]arenes.

194 rotonated aromatic tertiary N-oxides and one nitrone, only three protonated amines were found to form

195 ort-lived free radicals, consists of using a nitrone or nitroso compound to "trap" an unstable free r

196 nyl oximes are also demonstrated, leading to nitrones or cyclic oxime ethers, respectively.

197 on the high rates of addition of radicals to nitrones or nitroso compounds (spin traps; STs).

198 of the reaction is a rare case in which the nitrone oxygen acts as a nucleophile by attacking the ce

199 lies on the use of a chiral auxiliary on the nitrone partner.

200 potency of STAZN over the three alpha-phenyl nitrones PBN, S-PBN, and NXY-059.

201 he radical scavenger alpha-phenyl-tert-butyl nitrone (PBN) (100 mg/kg q8h i.p.) beginning at the time

202 The antioxidant phenyl-alpha-tert-butyl nitrone (PBN) arrested the oxidative damage-mediated los

203 f the FR scavenger alpha-phenyl-N-tert-butyl-nitrone (PBN) attenuates hypoxic-ischemic white matter d

204 New derivatives of alpha-phenyl-N-tert-butyl nitrone (PBN) bearing a hydroxyl, an acetate, or an acet

205 alpha-Phenyl-tert-butyl nitrone (PBN) is a nitrone spin trap, which has shown ef

206 nce spectroscopy and alpha-phenyl-tert-butyl nitrone (PBN) spin trapping.

207 s homogenized with alpha-phenyl-N-tert-butyl-nitrone (PBN) through electron spin resonance spectrosco

208 t of an antioxidant, alpha-phenyl-tert-butyl-nitrone (PBN) was used as a treatment strategy against o

209 Alpha-phenyl-N-t-butyl nitrone (PBN), a spin trap, scavenges hydroxyl radicals,

210 e ability of Trolox, alpha-phenyl-tert-butyl nitrone (PBN), or catalase to attenuate the methylmercur

211 spin trap inhibitor, alpha phenyl-tert-butyl nitrone (PBN).

212 ipolar cycloaddition reactions with the four nitrones present in the DCL.

213 propargylic alcohols and amines, addition to nitrones presents unique challenges, and no general chir

214 ing antioxidant vs conventional alpha-phenyl nitrones previously investigated as antioxidant therapeu

215 Thus, the mechanism of E/Z isomerization of nitrones proceeds via a diradical bimolecular process in

216 ert-leucinol derived chiral auxiliary on the nitrone provided products in good diastereoselectivity.

217 of functionalization on the free energies of nitrone reactivity with hydroxymethyl radical as well as

218 yl carbon as well as on the free energies of nitrone reactivity with O2(*-) and HO2(*) were computati

219 Initial guiding principles for the design of nitrone reagents are developed by exploring the impact o

220 ourth generation takes advantage of the keto-nitrone reductive coupling to generate the C-9/C-14 link

221 ng bicyclic oxazine and five-membered cyclic nitrone, respectively.

222 atalyzed reaction of vinyldiazoacetates with nitrones results in a formal [3+2]-cycloaddition to gene

223 to investigate the dependence of products on nitrone ring size and tether length.

224 methanimine oxide (6) is a multitarget small nitrone showing potent thrombolytic activity and free ra

225 The nitrone slowly decomposed in acidic aqueous solution at

226 real-time trapping of DNA radicals with the nitrone spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO

227 We have found that the nitrone spin trap DMPO (5,5-dimethyl-1-pyrroline N-oxide

228 These techniques show that the nitrone spin trap DMPO covalently binds to one or more a

229 In this work, the synthesis of a nitrone spin trap, 4, that is tethered via amide bonds t

230 alpha-Phenyl-tert-butyl nitrone (PBN) is a nitrone spin trap, which has shown efficacy in animal mo

231 We conclude that nitrone spin traps and ebselen inhibit the DOX-induced a

232 Nitrone spin traps are commonly employed as probes for t

233 tations exist among the commonly used cyclic nitrone spin traps for biological free radical detection

234 Nitrone spin traps have been shown to scavenge O(2) (.-)

235 lysis because O(2)(*)(-) adducts with common nitrone spin traps have shorter half-lives than typical

236 Nitrone spin traps significantly inhibited the formation

237 Charge and spin densities on the nitrone spin traps were correlated with their rates of a

238 Pretreatment of cells with 100 microm nitrone spin traps, N-tert-butyl-alpha-phenylnitrone (PB

239 unprecedented among archetypal alpha-phenyl nitrone spin traps.

240 (SOD), glutathione peroxidase mimetics, and nitrone spin traps.

241 Stilbazulenyl nitrone (STAZN) is a potent antioxidant that, in a rat m

242 Stilbazulenyl nitrone (STAZN), 8, a nitronyl-substituted hydrocarbon,

243 -generation azulenyl nitrone, stilbazunenlyl nitrone (STAZN), in focal ischemic stroke.

244 We tested the second-generation azulenyl nitrone, stilbazunenlyl nitrone (STAZN), in focal ischem

245 d its deuterium-labeled analogue suggested a nitrone structure for the unknown metabolite.

246 N was orders-of-magnitude greater than other nitrones such as NXY-059.

247 Rarely observed in this class are indolic nitrones, such as avrainvillamide and waikialoid, which

248 work describes the first implementation of a nitrone synthase as a biocatalyst and establishes a nove

249 All cyclic nitrones tested were much more potent as inhibitors of l

250 this approach is a six-membered cyclic sugar nitrone that is generated in situ and trapped by an alke

251 e oxime onto the diene to afford a transient nitrone that then undergoes an intramolecular dipolar cy

252 stituted 4-chlorobutanals gives intermediate nitrones that undergo tandem cyclization and then intram

253 acetylide dianion addition to a serine-based nitrone, thereby facilitating the preparation of STX in

254 Acidic deprotection of the nitrone/TMSCF(3) adducts generates alpha-(trifluoromethy

255 Nitrone/TMSCF(3) adducts with strong electron-withdrawin

256 e formed resulting from rearrangement of the nitrone to an oxaziridine.

257 ansannular Mannich-type reaction of a cyclic nitrone to stitch the C4 and C13 together, and a cycloco

258 ethyl)trimethylsilane (TMSCF(3)) reacts with nitrones to afford alpha-(trifluoromethyl)hydroxylamines

259 pping of (.)OH and O2(-.) suggest the cyclic nitrones to be ideal reagents for the study of oxidative

260 efficient catalyst for the cycloaddition of nitrones to donor-acceptor cyclopropanes.

261 fied by dipolar cycloaddition reactions with nitrones to give highly substituted 4-nitro-4-isoxazolin

262 situ under mild conditions and trapped with nitrones to give isoxazolidine products in synthetically

263 The rearrangement of nitrones to lactams can be carried out by photochemical

264 Finally, we use nitrones to profile reactive residues across the proteom

265 dichloromethane with subsequent transfer to nitrones under smooth conditions.

266 rmed hydroxyamines and affords the requisite nitrones under weak alkaline conditions, and the subsequ

267 presence of the Lewis acid Al(O(t)Bu)(3) the nitrones undergo an intramolecular [3 + 2] cycloaddition

268 s the first examples of one-pot synthesis of nitrones using recyclable multifunctional heterogeneous

269 tant thus far observed at neutral pH for any nitrones using the kinetic method employed.

270 atalyzed enantioselective alkyne addition to nitrones utilizing tunable axially chiral imidazole-base

271 oaddition of an intermediate homoallylic (E)-nitrone via a pathway that is stereochemically unscathed

272 viability and the oxidation potential of the nitrones was observed.

273 These nitrones were also found to efficiently trap carbon-cent

274 f superoxide radical (O2(*-)) reactions with nitrones were determined using a UV-vis stopped-flow met

275 stants for the reactivity of O2*- with model nitrones were found to correlate with the experimentally

276 cile transformation, in which the bridgehead nitrones were isolated in high yields.

277 ay crystal structures of substituted N-vinyl nitrones were obtained.

278 Amido and spiroester nitrones were predicted to be the most suitable nitrones

279 ries of mono-, bi-, and tricyclic ring-fused nitrones were prepared to investigate the dependence of

280 The cyclic nitrones were shown to trap (.)OH with MDL 101,002 being

281 Two bifunctional alpha-phenyl-N-cyclohexyl nitrones were synthesized with the expectation that the

282 of carinatine A, a rare naturally occurring nitrone, were formed in a single operation.

283 m of PBN, N-tert-butyl-alpha-(2-sulfophenyl) nitrone, which has similar free radical trapping activit

284 dduct formation is favored in alkoxycarbonyl nitrones, while cis adducts with intramolecular H-bondin

285 entry to densely functionalized homoallylic nitrones whose intramolecular annulation can be controll

286 excess MeMgCl resulted in the formation of a nitrone, whose structure was confirmed by X-ray crystall

287 Reaction of azulenyl nitrone with a free radical forms a nitroxide adduct tha

288 The reaction of the nitrone with diethyl acetylenedicarboxylate readily gene

289 A spirolactonyl-nitrone with rigid H-bond acceptor, 7-oxa-1-azaspiro[4.4

290 arbon, is a novel second-generation azulenyl nitrone with significantly enhanced potency as a chain-b

291 Nitrones with alkyl groups bound directly to the 1,3-dip

292 1,3-Dipolar cycloaddition reactions of nitrones with alpha,beta-unsaturated aldehydes catalyzed

293 n and efficient 1,3-dipolar cycloaddition of nitrones with different styrenes and cinnamates using a

294 re is, therefore, a pressing need to develop nitrones with improved spin trapping properties and cont

295 The mechanism of cycloaddition reactions of nitrones with isocyanates has been studied using density

296 The heterogeneous synthesis of nitrones with multifunctional catalysts is extremely att

297 minoxyls, derived from the reaction of these nitrones with O2*-.

298 Structures of nitrones with trifluoromethyl-, trifluoromethylcarbonyl-

299 to unknown mechanism of E/Z isomerization of nitrones, with important implications in 1,3-dipolar cyc

300 reaction between a novel type of ylide, i.e. nitrone ylides, and alkenes has been carried out.