ライフサイエンスコーパス: nitroreductase

1 n response to the prokaryote-specific enzyme nitroreductase.

2 catalytic activity of a dehalogenase into a nitroreductase.

3 nicotinamide adenine dinucleotide dependent nitroreductase.

4 ophenylcyclophosphamide analogues by E. coli nitroreductase.

5 on mutations in genes encoding RdxA and FrxA nitroreductases.

6 omatid parasites, this is mediated by type I nitroreductases.

7 ical state commonly seen in oxygen-sensitive nitroreductases.

8 s, which we annotated as rdxAB, encoding two nitroreductases.

9 Nitroreductase A catalyzes the divalent reduction of nit

10 In this paper, nitroreductase A is induced in Escherichia coli by expos

11 Nitroreductase A thus appears to be a member of the soxR

12 ing a mutational defect in the gene encoding nitroreductase A, but it was approximately 3-fold induce

13 irected enzyme prodrug therapy using E. coli nitroreductase, a series of nitrobenzylphosphoramide mus

14 d dosS and dosT genes encoding DosR kinases, nitroreductases (acg; Rv3131), diacylglycerol acyltransf

15 es for B-galactosidase activity (PA-HD-Gal), nitroreductase activity (PA-HD-NTR), and H(2) O(2) (PA-H

16 or reduction (fgd), or deazaflavin-dependent nitroreductase activity (rv3547), indicating that reduct

17 Nitroreductase activity declined 80% after the control d

18 deiodinase activity and leads to significant nitroreductase activity that supports full reduction to

19 Nitroreductase activity was only slightly induced by par

20 he >30-fold improvement of prodrug activator nitroreductase activity with an UAA over that of the nat

21 to either non-oxygen-dependent variations in nitroreductase activity, drug metabolism, and/or actual

22 ng equivalents from NAD(P)H, nor demonstrate nitroreductase activity.

23 rvations are not due to tissue variations in nitroreductase activity.

24 first time, the activity of a mycobacterial nitroreductase against 1 analogs, highlighting the diffe

25 mustard analogues were activated by E. coli nitroreductase, an enzyme explored in GDEPT.

26 ing was achieved by expressing the bacterial nitroreductase, an enzyme that catalyzes its substrate i

27 lved in the breakdown of explosives, such as nitroreductase and cytochrome P450, have been introduced

28 ies also demonstrate differences between the nitroreductase and M2 systems that influence their effic

29 This zebrafish screening strain expresses nitroreductase and the red fluorescent protein mCherry e

30 protein, a mini singlet oxygen generator, a nitroreductase, and an old yellow enzyme-type ene reduct

31 cteria, and to assay for beta-glucuronidase, nitroreductase, and glycocholic acid hydroxylase.

32 alysis of large gene families encoding USPs, nitroreductases, and DGATs demonstrates a mosaic distrib

33 Bacterial nitroreductases are NAD(P)H-dependent flavoenzymes which

34 r of the same structural superfamily as many nitroreductases but does not directly consume reducing e

35 Nitroreductase catalyzes the reduction of TNT to hydroxy

36 ne deaminase/5-fluorocytosine (yCD/5-FC) and nitroreductase/CB1954 (NTR/CB1954) have been used for st

37 a replication-defective adenovirus encoding nitroreductase (CTL102) in patients with liver tumors.

38 We demonstrated that deazaflavin-dependent nitroreductase (Ddn) could act effectively on nitroimida

39 te oxidase (PPOX), and deazaflavin-dependent nitroreductase (DDN) families.

40 tb mutants lacking the deazaflavin-dependent nitroreductase (Ddn) retained anaerobic sensitivity to s

41 found that Rv3547 is a deazaflavin-dependent nitroreductase (Ddn) that converts PA-824 into three pri

42 prominent case: species expressing specific nitroreductases degraded niclosamide, thereby protecting

43 D, we targeted an unannotated predicted ThiF-nitroreductase di-domain enzyme found in more than 50 pr

44 The monomers of the nitroreductase dimer adopt an alpha+beta fold and togeth

45 the monomeric protein resembles a classical nitroreductase dimer but with one active site deleted an

46 In metronidazole-treated myl7:nitroreductase embryos, myocardial cells were targeted f

47 The E. coli nitroreductase enzyme (NTR) has been widely used in suic

48 The crystal structure of the nitroreductase enzyme from Enterobacter cloacae has been

49 transgenic lines that expressed the E. coli nitroreductase enzyme fused to EGFP (NTR-EGFP) in only r

50 enes to regulate expression of the bacterial nitroreductase enzyme in combination with the pro-drug C

51 nce similarity to an FMN-dependent family of nitroreductase enzymes.

52 ile of glutathione S-transferases (GSTs) and nitroreductases enzymes.

53 howed 167 500x selective cytotoxicity toward nitroreductase-expressing V79 cells with an IC(50) as lo

54 Dose-related increases in tumoral nitroreductase expression measured by immunohistochemica

55 The high level of nitroreductase expression observed at 1 to 5 x 10(11) vi

56 enoviral vectors showed cancer cell-specific nitroreductase expression.

57 e NADH/flavin mononucleotide (FMN)-dependent nitroreductase family, and we propose that it is involve

58 ne groups (regulators, kinases, USPs, DGATs, nitroreductases, ferredoxins, heat shock proteins, and t

59 as the first protein known to repurpose the nitroreductase fold solely for protein-protein interacti

60 on at 2.2 A resolution, revealing a modified nitroreductase fold with surprising homology to MMACHC d

61 The nitroreductase from Bacillus amyloliquefaciens, in syner

62 The oxygen-insensitive nitroreductase from Enterobacter cloacae (NR) catalyzes

63 The exploitation of an alternative nitroreductase from Enterobacter cloacae enables the tai

64 fundamental differences in the activities of nitroreductases from epsilonproteobacteria.

65 at H. pylori strains differ in regulation of nitroreductase gene expression.

66 Placing the nitroreductase gene under the control of the telomerase

67 tissue-specific cell death using a bacterial nitroreductase gene under UAS control.

68 d that plants transformed with the bacterial nitroreductase gene, nfsI have increased ability to tole

69 KEY MESSAGE: Expression of the bacterial nitroreductase gene, nfsI, in tobacco plastids conferred

70 The relative importance of the frxA and rdxA nitroreductase genes of Helicobacter pylori in metronida

71 Natural and engineered nitroreductases have rarely supported full reduction of

72 ey could be used in combination with E. coli nitroreductase in enzyme prodrug therapy.

73 toxic effects of TNT, we expressed bacterial nitroreductase in tobacco plants.

74 HyCL-2 can image exogenous nitroreductase in vitro and in vivo in living mice, and

75 Escherichia coli nitroreductase is a flavoprotein that reduces a variety

76 Nitroreductase is a member of a group of enzymes that re

77 chemical basis for the recent finding that a nitroreductase is a member of the soxRS oxidative defens

78 eishmania major, expresses an FMN-containing nitroreductase (LmNTR) that metabolizes a wide range of

79 To investigate this, we applied the nitroreductase/metronidazole zebrafish model of podocyte

80 uctase and the non-bifurcating flavoproteins nitroreductase, NADH oxidase, and flavodoxin.

81 MarA upregulation of the oxygen-insensitive nitroreductase nfnB gene.

82 e repression of the gene nfnB coding for the nitroreductase NfnB was responsible for the natural resi

83 N137 directly represses the synthesis of the nitroreductase NfsA, which catalyzes the reduction of th

84 ciated upregulation of the flavin-containing nitroreductase, NfsA, was then shown to be critical for

85 1,4-naphthoquinone (HNQ) via the cytoplasmic nitroreductases NfsB and NfsA enables E. coli respiratio

86 The enzyme nitroreductase, NfsB, from Escherichia coli has entered

87 ally encoded cell-ablation technologies: the nitroreductase/nitrofuran system and a cytotoxic variant

88 ilization of a maltose binding protein (MBP) nitroreductase (NR) fusion (MBP-NR) onto an electrode mo

89 Our work suggests that expression of nitroreductase (NR) in plants suitable for phytoremediat

90 onucleotide cofactor of Enterobacter cloacae nitroreductase (NR), determined under a variety of solut

91 Nitroreductases (Nrs) play important roles in redox syst

92 Nitroreductase (NTR) activities have been known for deca

93 oping the first NIR bioluminescent probe for nitroreductase (NTR) activity and applied it to visualiz

94 luoroquinolone, ciprofloxacin, responsive to nitroreductase (NTR) and/or hydrogen sulfide (H(2)S), wa

95 Transgenic expression of bacterial nitroreductase (NTR) enzymes sensitizes eukaryotic cells

96 roup showed potent selective cytotoxicity in nitroreductase (NTR) expressing cells, while analogues 4

97 ple of suicide gene therapy is the bacterial nitroreductase (NTR) gene, which bioactivates the prodru

98 Escherichia coli nitroreductase (NTR) is a flavoprotein that reduces a va

99 Bacterial Nitroreductase (NTR) is used to catalyze the reduction o

100 ompounds are excellent substrates for type I nitroreductase (NTR) located in the mitochondrion of try

101 ters, we found much higher expression of the nitroreductase (NTR) protein in the E. coli host compare

102 tein) reporter fused to the Escherichia coli nitroreductase (NTR) selection enzyme.

103 ally diverse flavin mononucleotide-dependent nitroreductase (NTR) superfamily (>24,000 sequences from

104 yzC, a flavin-dependent oxidase (FDO) of the nitroreductase (NTR) superfamily, catalyzed the O(2)-dep

105 templates can be used to knock-in bacterial nitroreductase (ntr) to facilitate lineage ablation of s

106 on of metronidazole (Mtz) to fish expressing nitroreductase (NTR) under a liver-specific promoter dam

107 aevis expressing the Escherichia coli enzyme nitroreductase (NTR) under the control of the rod-specif

108 hondrially localized, bacterial-like, type I nitroreductase (NTR), and that down-regulation of this e

109 oCy5S), which is reduced by Escherichia coli nitroreductase (NTR), resulting in a near-infrared fluor

110 cil phosphoribosyltransferase (yCD:UPRT) and nitroreductase (NTR).

111 These prodrugs are activated by bacterial nitroreductases (NTR), which are overexpressed in hypoxi

112 Nitroreductases (NTRs) constitute an important class of

113 dinase based on the coordinates of the minor nitroreductase of Escherichia coli indicates that a Cys

114 te the presence of the nimA gene, encoding a nitroreductase previously shown to mediate resistance to

115 ing activation by a parasite specific type I nitroreductase, produce metabolites that promote formati

116 -NBA is predominantly activated by cytosolic nitroreductases rather than microsomal POR.

117 d NDP-NAC, decomposed in response to E. coli nitroreductase, resulting in release of NAC-SSH.

118 Using a modified nitroreductase scaffold tailored to bind cobalamin and g

119 de gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-d

120 Transgenic plants expressing nitroreductase show a striking increase in ability to to

121 of ctgfa-expressing cells using a transgenic nitroreductase strategy impaired glial bridging and reco

122 tion and fusion from a classical homodimeric nitroreductase such that the monomeric protein resembles

123 S24 requires activation by the NfsA and NfsB nitroreductases, suggesting that the formation of highly

124 The nitroreductase superfamily of enzymes encompasses many f

125 Many functioned as type I nitroreductase (TbNTR) or cytochrome P450 reductase (TbC

126 ted within the parasite by the mitochondrial nitroreductase TcNTR-1, leading to the generation of rea

127 tations in the gene encoding a mitochondrial nitroreductase (TcNTR) can give rise to distinct drug-re

128 y parasites via an enzyme, distinct from the nitroreductase that activates fexinidazole.

129 ains: type I, in which frxA (which encodes a nitroreductase that contributes to Mtz susceptibility) i

130 o mutation in rdxA (HP0954), which encodes a nitroreductase that converts Mtz from prodrug to bacteri

131 th pyridoxal 5'-phosphate synthases and aryl nitroreductases, these proteins form a large and versati

132 The use of the bacterial enzyme nitroreductase to activate CB1954 (5-(aziridin-1-yl)-2,4

133 The results highlight the usefulness of nitroreductases to create selective photoenzymatic syste

134 Nitrofurazone is reduced by cellular nitroreductases to form N(2)-deoxyguanine (N(2)-dG) addu

135 , alcohol dehydrogenase, imine reductase and nitroreductase variants with desired selectivity modific

136 as well as an ABC transporter and a probable nitroreductase, were highly induced by TNT exposure.

137 (pod::NTR-mCherry) by expressing a bacterial nitroreductase, which converts metronidazole to a cytoto

138 elong to an unusual superfamily of classical nitroreductases, which may have a role for bacteria with

139 hemiLuminescent Probe 2 (HyCL-2) responds to nitroreductase with approximately 170-fold increase in l

140 ll analogues were good substrates of E. coli nitroreductase with half-lives between 2.9 and 11.9 min

141 One of these, the putative NAD(P)H nitroreductase YfkO, has been reported to be involved in