ライフサイエンスコーパス: nitrosate

1 potentially toxic effects they may have once nitrosated.

2 dines hydrolyzed much more rapidly than they nitrosated.

3 s) in carboxymethyl-bovine serum albumin was nitrosated.

4 Reduced Trx (rTrx) was nitrosated 2.7-times faster than oxidized Trx (oTrx), an

5 NO and NO-related reactive nitrogen species nitrosate 4,5-diaminofluorescein to yield the highly flu

6 can be inhibited by mitochondria-targeted S-nitrosating agent (MitoSNO), alleviating lipotoxicity.

7 (HOCl) to form the nitrosyl chloride (ClNO) nitrosating agent but has not experimentally verified it

8 diffusion limits and the true nature of the nitrosating agent for nitrous acid initiated reactions.

9 The endogenous nitrosating agent N2O3 (dinitrogen trioxide, nitrous anh

10 autoxidation of nitric oxide (NO.) forms the nitrosating agent N2O3, which can directly damage DNA by

11 loride presumably by anion scavenging of the nitrosating agent nitrous anhydride, N2O3.

12 ptional responses of Escherichia coli to the nitrosating agent S-nitrosoglutathione (GSNO) in both ae

13 (2) interactions, thereby increasing *OH and nitrosating agent yields while lowering residual NCl(3).

14 Thus, GSNO (a nitrosating agent) and NO have distinct cellular effects

15 rase (NA) reaction in which N2O3, a potent S-nitrosating agent, is produced through the reaction of N

16 Here we used a mitochondria-selective S-nitrosating agent, MitoSNO, to determine how mitochondri

17 roducing NO, also produces the highly potent nitrosating agent, nitrosyliodide.

18 of phosphate may be due to reaction with the nitrosating agent, nitrous anhydride (N2O3), formed by o

19 known to be up-regulated by nitric oxide and nitrosating agents (e.g. hmp and norVW) were unaffected.

20 satable drugs (NSDs) can, in the presence of nitrosating agents and highly acidic conditions, form N-

21 acid, while mitigating scavenging of *OH and nitrosating agents by oxidants, prolongs NCl(3)-NHCl(2)

22 Nitric oxide and nitrosating agents exert powerful antimicrobial effects

23 apsulated within the tube NO+ species act as nitrosating agents for secondary amides.

24 e added to a mixture of HOCl and HNO-derived nitrosating agents generated by chlorinating hydroxyurea

25 endent mechanism leading to formation of the nitrosating agents N(2)O(3) and/or N(2)O(4).

26 hile *OH facilitates micropollutant removal, nitrosating agents promote nitrosamine formation.

27 A wide variety of nitric oxide donors and S-nitrosating agents protect the ischemic myocardium from

28 oxide reacts with oxygen to form endogenous nitrosating agents such as N2O3.

29 alkaloids produced in tobacco can react with nitrosating agents such as nitrite to form tobacco-speci

30 f N-nitrosamines through reactions that form nitrosating agents.

31 curs in swimming pools and generates *OH and nitrosating agents.

32 structural gene hmp is upregulated by NO and nitrosating agents; (ii) purified Hmp binds NO avidly, b

33 Although S-nitrosated albumin has been considered the major species

34 exes in plasma previously considered to be S-nitrosated albumin were <10 nM after elimination of nitr

35 Moreover, oxidized and nitrosated amino acids are suspected to promote various

36 ined significantly greater concentrations of nitrosated and chlorinated IgG compared with ostearthrit

37 clusters (BGCs) encoding homologues of the N-nitrosating biosynthetic enzyme SznF, including the BGC

38 Nitric oxide nitrosates both precursor and mature forms of the chemoa

39 asorelaxation activity as that observed with nitrosated bovine serum albumin.

40 When hTrx was partially S-nitrosated by preincubation with S-nitrosoglutathione, i

41 a viable alternative to polyDADMAC to avoid nitrosated byproduct formation during chloramination.

42 ons drawn are as follows: (i) Nitrite showed nitrosating capacity on Tau.

43 The nitrosated carboxymethyl-bovine serum albumin exhibited

44 which nitrosation of nitrosothiol produces a nitrosated cation that, in turn, reacts with a second ni

45 Here we report on the presence of nitrosated compounds in plasma and erythrocytes of rats,

46 ursor protein processing and secretion are S-nitrosated, correlating with increased amyloid formation

47 d met forms of Hb A(0) and Hb S, and their S-nitrosated counterparts, is presented.

48 Labeling S-nitrosated cysteines with a biotin tag enabled us to rev

49 The nitrosated disulfide acts as a source of nitrosonium for

50 reacts with a second nitrosothiol to produce nitrosated disulfide and the NO dimer.

51 ethod is also applied to trace analysis of N-nitrosated drug impurities within their parent pharmaceu

52 ng enzyme (Tri28) and a nitrite-utilizing, N-nitrosating enzyme (Tri17).

53 ce of a 1-, 20-, 100-, or 200-fold excess of nitrosating equivalents removes 0.6 +/- 0.2, 3.2 +/- 0.4

54 pollen differentially trigger nitric oxide, nitrosate FER to suppress reactive oxygen species in SC

55 copper complex with NO indicated that the N-nitrosated fluorescein ligand (FL(5)-NO) is the species

56 Cu(I) with concomitant dissociation of the N-nitrosated fluorophore ligand from copper.

57 m the thiol, disulfide, sulfinic acid, and S-nitrosated forms of cysteine while displaying an accepta

58 d SNO-Hb, the oxygen binding properties of S-nitrosated forms of normal and sickle cell Hb were inves

59 No nitrosated forms of the enzyme were observed.

60 by inducible NOS (iNOS) causes buildup of S-nitrosated GAPDH (SNO-GAPDH) in cells, which then inhibi

61 Previously, we have shown that S-nitrosated GC1 (SNO-GC1) is desensitized to NO stimulati

62 Nitrosated Gly-Trp exhibited dose-dependent vasorelaxati

63 from 1,2-diarylcyclopropanes under suggested nitrosating-halogenating conditions.

64 rom heme groups to form nitroxyl anions or S-nitrosated Hb at low ratios of NO to Hb.

65 otein also produce an allosteric effect on S-nitrosated Hb.

66 S-Nitrosated hemoglobin (SNO-Hb) is of interest because of

67 S-Nitrosated hemoglobin is remarkably stable and can be cy

68 of GSNO supporting the hypothesis that GSNO nitrosates homocysteine, thereby withdrawing this interm

69 d for carbon capture, but amine solvents can nitrosate in the desorber, forming potentially carcinoge

70 Cys(101), in contrast, is S-nitrosated in a single step but is subject to negative c

71 ADAR1 was S-nitrosated in human endothelial cells, and the knockdown

72 Cys(47) of GSTP1-1 is S-nitrosated in two steps, with the chemical step limited

73 The nitrosated iNOS crystal structure revealed an unexpected

74 , recent evidence suggests that Hb that is S-nitrosated may act as an NO donor and vasodilator.

75 avenger compounds suggested that the salient nitrosating mechanism was the NO/O(2) reaction leading t

76 2.4-3:1) produced an intermediate capable of nitrosating N-chloro-alkylamines to N-nitrosamines at yi

77 Identification of the nitrosated non-cysteine residue(s) was studied using 16

78 sated selectively on Cys62, whereas oTrx was nitrosated only on Cys73.

79 econdary species, many of which can oxidize, nitrosate or nitrate biomolecules.

80 oth the disappearance of NO and formation of nitrosated product from DAF in aerobic aqueous buffer fo

81 P-based compounds formed oxygenated and not nitrosated products.

82 Cellular S-nitrosated protein abundance changed as expected, with c

83 The most abundant S-nitrosated protein in the resting endothelial cell is GA

84 Quantifying S-nitrosated protein thiols now allows determination of mo

85 of thioredoxin, providing three views of the nitrosated protein.

86 NO2(-) may act by S-nitrosating protein thiols, thereby altering protein act

87 Detection of nitrosated proteins (i.e., S-nitrosoalbumin) was also po

88 en we used this methodology, we found that S-nitrosated proteins can form within endothelial cells fr

89 r a dinitrosyl-iron (II) cysteine complex or nitrosated proteins including NOS.

90 sence of NO-containing factors (free SNOs or nitrosated proteins such as NOS), which promote NADPH-de

91 enrich and annotate hundreds of endogenous S-nitrosated proteins.

92 d p120 identified cysteine 579 as the main S-nitrosated residue in the region that putatively interac

93 deprotonates RS-H at the basic u-O site and nitrosates RS(-) at the u-NO site.

94 aster than oxidized Trx (oTrx), and rTrx was nitrosated selectively on Cys62, whereas oTrx was nitros

95 idation of NO (cyanometHb), and Hb that is S-nitrosated (SNO-Hb and SNO-cyanometHb) on HPV, expired N

96 n assessing the significance of formation of nitrosated species is the limited reliability of availab

97 n 8.8-fold increased affinity of MPO-derived nitrosating species for IQ.

98 The quintessential nitrosating species produced during NO autoxidation is N

99 boronate-based probes, nitric oxide-derived nitrosating species with 4,5-diaminofluorescein, and hyd

100 regulation by NO to one of adaptation during nitrosated stress.

101 y be stabilized by binding to hemoglobin, by nitrosating thiol-containing plasma molecules, or by con

102 sults in cleavage of the amine moiety, which nitrosates to give N-nitrosopyrrolidine.

103 -based method for the direct analysis of the nitrosated Trx.

104 the mitochondrial matrix were selectively S-nitrosated under these conditions, potentially contribut

105 mides (R = MeO, Me, H, CF(3), and NO(2)) was nitrosated using a standardized solution of N(2)O(4) in

106 Increased formation of S-nitrosated YC (YCysNO) was detected in the MPO/H(2)O(2)/