コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 st report of Sirt2 and Sirt6 inhibition by S-nitrosation.
2 of which have been reported as targets of S-nitrosation.
3 ion has been used as an index for endogenous nitrosation.
4 ly be applied for the detection of protein S-nitrosation.
5 ion of free NO as the primary mechanism of S-nitrosation.
6 onine requirements arising from homocysteine nitrosation.
7 sms, and obtained evidence of critical thiol nitrosation.
8 link dG-to-dG is an important product of DNA nitrosation.
9 and to which extent this effect depends on S-nitrosation.
10 to the N-nitrosoamidinium ion and reversible nitrosation.
11 ited slower reaction pathways required for S-nitrosation.
12 y, and this effect was also potentiated by S-nitrosation.
13 ttranslational modification of proteins by S-nitrosation.
14 reas electron-withdrawing ones decelerated N-nitrosation.
15 ing NO, an effect that is not prevented by S-nitrosation.
16 bly via reaction(s) of intracellular trans-S-nitrosation.
17 ometry were used to quantify the degree of S-nitrosation.
18 y regulate the direction of reversible S-(de)nitrosation.
19 on nitrosylation and S-nitrosation but not N-nitrosation.
20 DNA-binding by Cmr was severely impaired by nitrosation.
21 free thiols and site-specific analysis of S-nitrosation.
24 like GSNO, NO does not elicit homocysteine S nitrosation and compensatory increases in methionine bio
27 their activity, it has been suggested that S-nitrosation and denitrosation of cellular thiols are fun
28 sulted in a marked decrease in intracellular nitrosation and diminished NO-induced posttranslational
30 at neutral pH could be attributed to abiotic nitrosation and if N2O was consumed during N2 formation.
31 sociated with a drastic decrease in global S-nitrosation and in levels of SNO-Trx1 in the KI mice.
32 or and acute exercise reduced iNOS-induced S-nitrosation and increased insulin sensitivity in the mus
34 es with mtH(2)O(2) production through KGDH S-nitrosation and may be useful in alleviating nonalcoholi
37 rculating pool of NO metabolites (oxidation, nitrosation and nitrosylation products) were measured in
39 lational modifications of p21ras including S-nitrosation and S-glutathiolation have been demonstrated
41 proteomic analysis demonstrates that both S-nitrosation and S-sulfination are widespread, yet exhibi
44 s posttranslational protein modifications, S-nitrosation, and genome-wide epigenetic modifications th
45 oute for NO bioactivity occurs via protein S-nitrosation, and involves the addition of a NO moiety to
48 d liver modifications involved both S- and N-nitrosation, and RBC S-nitrosothiol formation emerged as
50 Dietary N-nitroso compounds and endogenous nitrosation are important carcinogenic factors, but huma
53 ciated from cSrc because of increased Cav1 S-nitrosation at Cys(156), leading to cSrc activation, con
56 the selectivity and redox dependence of Trx nitrosation at physiologically relevant concentrations a
58 t, MitoSNO, to determine how mitochondrial S-nitrosation at the reperfusion phase of myocardial infar
59 ditions could be a favourable medium for Tau nitrosation, attention should be paid to potential situa
61 r activity that increases with the degree of nitrosation, but S-nitroso derivatives show the greatest
62 , these effects are further potentiated by S-nitrosation, but this posttranslational modification is
63 Our results indicate that, in addition to nitrosation by the .NO derivative dinitrogen trioxide (N
64 tion (by measuring carbonyl groups), protein nitrosation (by measuring nitrosamines), and proteolysis
65 ather than NO autoxidation, explaining why S-nitrosation can compete effectively with nitrosylation.
68 are presented of a theoretical study of the nitrosation chemistry of pyrroline 1 (X = CH(2)), imidaz
71 ential tests revealed that even under strong nitrosation conditions, polyDADEPC and related lower-ord
73 lational modification of Sirt1 by cysteine S-nitrosation correlates with increased acetylation of Sir
77 ion of this residue, precluding hemoglobin S-nitrosation, did not change total red blood cell S-nitro
78 t not to NO2(-), combined with the lack of S-nitrosation during anoxia alone or by NO2(-) during norm
80 isothermal titration calorimetry as well as nitrosation experiments using S-nitrosocysteine demonstr
83 the reported oxygen-dependent promotion of S-nitrosation from SNO-Hb involves biochemical mechanisms
85 seudo-first-order rate constants for amidine nitrosation in aqueous acetic acid with excess nitrite a
92 t2, are modified and inhibited by cysteine S-nitrosation in response to exposure to both free nitric
95 ne in the formation of N-nitrosamines during nitrosation in the presence of carbonyl compounds, espec
96 ults indicate that ONOO- may contribute to S-nitrosation in vivo and that direct nitrosation of thiol
97 -nitrosylation are indeed as ubiquitous as S-nitrosation in vivo and that the products of these react
99 binding assays were consistent with Sirt1 S-nitrosation inhibiting binding of both the NAD(+) and ac
103 also raise the intriguing possibility that N-nitrosation is directly involved in the modulation of pr
106 itionally, pharmacologic agents disrupting S-nitrosation markedly increased cisplatin toxicity, where
107 dings suggest that the functional effects of nitrosation may be organized to occur within discrete do
108 ed and fully characterized, suggesting the S-nitrosation may proceed through the intermediary of anal
110 s mutagenic, in the present article tyramine nitrosation mechanisms have been characterized in order
111 igma-complex, whereas this Wheland adduct in nitrosation merely represents a high energy (transition-
112 toward elucidating the mechanism by which S-nitrosation modulates a protein's function is identifica
113 dation peaks and only glyphosate is prone to nitrosation, n-nitroso glyphosate and glufosinate were u
118 during normoxia places constraints on how S-nitrosation occurs in vivo and on its mechanisms of card
120 el of NO in the media was also observed, and nitrosation of 2,3-diaminonapthalene was increased great
123 o-4-nitroisoxazoles has been developed using nitrosation of 4-nitroisoxazole-based enamines with tert
124 benzoxazinone-3-sulfonamide was prepared by nitrosation of a beta-ketosulfonamide followed by intram
129 our-membered ring lactones, resulting in the nitrosation of amino carboxylic acids, the fraction of E
131 c-oxide synthase (NOS) inhibitors regulate S-nitrosation of an initiator caspase, procaspase-9, in a
133 steric mechanisms for hemoglobin, based on S-nitrosation of beta-chain cysteine 93, raise the possibi
134 a-chain (betaCys93) and, specifically, for S-nitrosation of betaCys93 to form S-nitrosohemoglobin (SN
135 hypothesis is that red meat facilitates the nitrosation of bile acid conjugates and amino acids, whi
142 isplatin treatment, resulting in augmented S-nitrosation of caspase-3 and prolyl-hydroxylase-2, the e
144 demonstrate that modulation of NO-mediated S-nitrosation of cellular proteins is strongly associated
147 of complex I is afforded by the selective S-nitrosation of Cys39 on the ND3 subunit, which becomes s
149 competes for DAF-2, whereas AA decreases the nitrosation of DAF-2 to a larger extent, possibly becaus
150 Quenching of DHR oxidation by azide and nitrosation of diaminonaphthalene were exclusively obser
151 modifluoromethyl)trimethylsilane followed by nitrosation of difluorinated organozinc species with an
154 nes with a biotin tag enabled us to reveal S-nitrosation of endogenous procaspase-9 that was immunopr
155 ploying a synthetic strategy that involves C-nitrosation of enoldiazoacetates, while the diazo functi
156 osation reactions, a systematic study of the nitrosation of ethylbenzene, phenethylamine, and tyramin
157 tional model of ceruloplasmin in mediating S-nitrosation of external thiols, with implications for bi
159 pounds in the formation of N-nitrosamines by nitrosation of five secondary amines via different pathw
160 processes and are inversely linked to the S-nitrosation of GAPDH and (ii) that the NO sensitivity of
166 ity and R-state character that result from S-nitrosation of Hb S would be expected to decrease its po
170 phosphate pathway and NRF2 pathway through S-nitrosation of Keap1, thereby preserving myocardial oxid
174 We found that protection is due to the S-nitrosation of mitochondrial complex I, which is the ent
175 oxide by cardiac myoglobin and subsequent S-nitrosation of mitochondrial membrane proteins reduced m
176 f mitochondrial respiration as a result of S-nitrosation of NADH: ubiquinone oxidoreductase (complex
177 When comparing the rate of DEANO-mediated nitrosation of Ng with other sulfhydryl-containing compo
178 -1-(3-pyridyl)-1-butanone (NNK) is formed by nitrosation of nicotine and has been identified as the m
179 -1-(3-pyridyl)-1-butanone (NNK) is formed by nitrosation of nicotine and has been identified as the m
183 propose a cationic chain mechanism in which nitrosation of nitrosothiol produces a nitrosated cation
184 elective, and convenient method for the ipso-nitrosation of organotrifluoroborates using nitrosonium
186 conjunction with ischemia led to extensive S-nitrosation of protein thiols across all cellular compar
188 rly neurodegeneration identified increased S-nitrosation of proteins important for synapse function,
189 ucible nitric oxide synthase (iNOS) in the S-nitrosation of proteins involved in the early steps of t
190 ccumulating evidence has demonstrated that S-nitrosation of proteins plays a critical role in several
191 to quantify the extent of NO2(-)-dependent S-nitrosation of proteins thiols in vivo Using this approa
195 is bimolecular attack by N(2)O(3); (iii) the nitrosation of taurine affords ethanesultone (ES), which
197 sation pathway is general and results in the nitrosation of the amine Ph2NH and alcohol (t)BuOH to gi
198 benzothiazolines (2) were synthesized by the nitrosation of the corresponding 2-iminobenzothiazolines
199 ations of FL(5) versus FL(5)-NO reveal how N-nitrosation of the fluorophore ligand brings about the f
200 The nitrosothiol 2 was prepared via direct S-nitrosation of the hydrochloride of L-cysteine ethyl est
201 d medium to nitrous acid, which leads to the nitrosation of the indole that is generated by tryptopha
202 ctivation, we show that NO activates TACE by nitrosation of the inhibitory motif of the TACE prodomai
206 in the presence of Zn(2+), consistent with S-nitrosation of the Zn(2+)-tetrathiolate as the primary s
207 ge DNA by deamination of DNA bases following nitrosation of their primary amine functionalities.
209 Although the nitric oxide (.NO)-mediated nitrosation of thiol-containing molecules is increasingl
210 ; 2b), which is extensively used for trans-S-nitrosation of thiol-containing proteins, has a limited
212 ute to S-nitrosation in vivo and that direct nitrosation of thiols or other nucleophilic substrates b
213 ced apoptosis to a degree similar to hTrx, S-nitrosation of this protein, which lacks Cys-69, failed
214 nsecticide) to photoinduce the nitration and nitrosation of three aromatic probes (phenol, resorcinol
215 roduced in a residue specific manner via the nitrosation of tryptophan, which enables an easily trigg
216 ogy studies have shown that the product of C-nitrosation of tyramine is mutagenic, in the present art
219 ctivities, and inhibition capacity against N-nitrosation) of seven neglected and underutilized specie
221 t the hypothesis that the reaction occurs by nitrosation on the imino nitrogen, followed by the addit
222 lobin), and Tyr-130 (beta-globin) as well as nitrosation on Tyr-24 (alpha-globin) were identified.
223 a significant factor in the advent of either nitrosation or oxidation chemistry in biological systems
225 veral of these phytochemicals either inhibit nitrosation or the formation of DNA adducts or stimulate
226 tivities of these enzymes are inhibited by S-nitrosation, our data thus indicate that modulation of i
231 on of NO(3)(-)/NO(2)(-) to the nitration and nitrosation processes was found to be minor under our ex
234 2), this result suggesting that the yield of nitrosation products in the human stomach would increase
236 types of DNA were lower than the morpholine nitrosation rate constant by a factor of approximately 1
237 ) yields close to unity, validating the slow nitrosation rates hypothesized for tertiary amines.
240 ts into identifying the protein targets of S-nitrosation reactions and their potential role in cell f
242 analysis and spectroscopic studies show that nitrosation reactions are sustained at sulfur, oxygen, n
243 Recent work has illuminated enzymatic N-nitrosation reactions in microbial natural product biosy
244 ic study with UV-visible spectroscopy of the nitrosation reactions of both molecules, as well as of L
248 cell-surface PDI reacts with NO, catalyzes S-nitrosation reactions, and facilitates NO transfer from
253 rts have studied thermodynamic end points of nitrosation reactions; however, the kinetics of Trx nitr
258 ns suggested that Zn(2+) loss due to Sirt1 S-nitrosation results in repositioning of the tetrathiolat
259 Although GSNO inactivated hBCATm, neither S-nitrosation, S-glutathionylation, nor dimerization could
260 ide (NO) modification, which can result in S-nitrosation, S-thiolation, or disulfide bond formation.
262 s occurs, and the functional importance of S-nitrosation sites across the mammalian proteome, remain
263 Here we define two specific non-heme iNOS nitrosation sites discovered by combining UV-visible spe
265 function in a cGMP-independent manner, via S-nitrosation (SNO), a redox-based modification of cystein
269 actions (amination, amidation, nitration and nitrosation) that involve the use of boronic acids and s
270 nd inhibits complex I by posttranslational S-nitrosation; this dampens electron transfer and effectiv
271 with (Ph,Me) TpZn(SNO) turns on competing S-nitrosation to form (Ph,Me) TpZn-SH and RSNO, the latter
272 te in [Cu(II)](kappa(2)-O2N) that leads to S-nitrosation to give the S-nitrosothiol RSNO and copper(I
276 Renin-angiotensin system-induced Cav1 S-nitrosation was associated with increased Cav1-endotheli
285 trations of IgG modified by chlorination and nitrosation were measured in synovial fluids from inflam
287 ased, such that there was a 95% reduction in nitrosation when the fluxes of NO and O-2 were nearly eq
288 cysteine residues that can be subjected to S-nitrosation, whereby this process often acts as an activ
290 d in hyperoxia-exposed GGT(enu1) mice except nitrosation, which showed a diminished decrease compared
291 rimental results suggest a mechanism for the nitrosation, whose rate-limiting step is bimolecular att
292 ituted methylamines, followed by their alpha-nitrosation with sodium nitrite and subsequent base medi
293 their R-state conformations in response to S-nitrosation, with increased oxygen affinity and decrease