ライフサイエンスコーパス: nitrosylation

1 /nitrogen species (peroxynitrite and protein nitrosylation).

2 ranslational modification of pp71, protein S-nitrosylation.

3 greatly enhanced in mice lacking betaCys93 S-nitrosylation.

4 leading to dysregulation of total cellular S-nitrosylation.

5 ed by nitric oxide on cysteine residues by S-nitrosylation.

6 mutating cysteine-150 of GAPDH, its site of nitrosylation.

7 force for experimentally observed reductive nitrosylation.

8 nction GSNOR1 mutant defective in protein de-nitrosylation.

9 inhibited auxin transport probably through S-nitrosylation.

10 ma transcriptional activity by NO-mediated S-nitrosylation.

11 ine residues in a chemical reaction called S-nitrosylation.

12 ing that Cys931 is the predominant site of S-nitrosylation.

13 -l-glutathione, a NO donor, triggered LKB1 S-nitrosylation.

14 and sufficient for iNOS-S100A8/A9-mediated S-nitrosylation.

15 EC insulin transport by enhancing protein S-nitrosylation.

16 assembly of the NLRP3 inflammasome via thiol nitrosylation.

17 receptor-dependent NO formation and GluA1 S-nitrosylation.

18 the posttranslational level by NO through S-nitrosylation.

19 SNOR(-/-)), a denitrosylase that regulates S-nitrosylation.

20 s of nitric oxide are mediated via protein S-nitrosylation.

21 one by focusing on the endogenous heme iron nitrosylation.

22 d perfusion-processes regulated by protein S-nitrosylation.

23 sialic acid intake reduced ROS and protein S-nitrosylation.

24 would be manifest in increased myocardial S-nitrosylation, a posttranslational modification increasi

25 toxic effects at least in part via protein S-nitrosylation, a reaction that covalently attaches NO to

26 ification of Cys residues by NO results in S-nitrosylation, a ubiquitous post-translational modificat

27 logical activity of NO is also mediated by S-nitrosylation, a well-known redox-based posttranslationa

28 osoglutahione reductase, Tyr-nitration and S-nitrosylation along with the expression of genes involve

29 Nitrosylation also significantly reduced subsequent CaMK

30 vestigate the extent of endogenous heme iron nitrosylation an experimental in vitro model that mimics

31 detection concept with cysteine modifying S-nitrosylation and ADP-ribosylation reactions using a che

32 w that deletion of ADH6 increases cellular S-nitrosylation and alters CoA metabolism.

33 sidue is governed by the equilibrium between nitrosylation and denitrosylation reactions.

34 l to investigate the molecular mechanisms of nitrosylation and denitrosylation using a combination of

35 In mice, GSNOR deficiency causes S-nitrosylation and depletion of the DNA repair protein O6

36 e residues undergo S-glutathionylation and S-nitrosylation and form non-native disulfide bonds.

37 which potently and selectively blocks GAPDH nitrosylation and GAPDH-Siah binding, prevents these act

38 GSNO was found to trigger both GAPDH nitrosylation and glutathionylation, although nitrosylat

39 Our results suggest that S-nitrosylation and GSNOR1-mediated de-nitrosylation contr

40 Increases in S-nitrosylation and inactivation of the neuroprotective ub

41 us small-molecule NO donors promote the AR S-nitrosylation and inhibit growth of castration-resistant

42 mutagenesis of IRE1alpha(Cys931) prevented S-nitrosylation and inhibition of its ribonuclease activit

43 lation, phosphorylation, methylthiolation, S-nitrosylation and nitration) in a natural microbial comm

44 ing in vitro and transgenic plants to show S-nitrosylation and other in vivo interactions with NO and

45 14), suggesting molecular cross-talk between nitrosylation and phosphorylation of RyR2.

46 reveal an elusive parallel between protein S-nitrosylation and phosphorylation, namely, stimulus-depe

47 ic oxide deficiency reduces neuronal calpain nitrosylation and results in enzyme activation, which, i

48 difications of Cys residues, in particular S-nitrosylation and S-oxidation.

49 subjected to two competing modifications: S-nitrosylation and S-sulfhydration, which are naturally o

50 ht-evoked NO production leads to extensive S-nitrosylation and that this process is a significant pos

51 over, mechanisms underlying site-selective S-nitrosylation and the potential role of specific sequenc

52 s acetoacetyl-CoA thiolase from inhibitory S-nitrosylation and thereby affects sterol biosynthesis.

53 Moreover, S-nitrosylation and ubiquitination of LKB1 were confirmed

54 hereby promoting the inhibition of PTEN by S-nitrosylation and ubiquitination.

55 NOs), formed by nitric oxide (NO)-mediated S-nitrosylation, and hydrogen peroxide (H2O2), a prominent

56 oring local NO production, nuclear protein S-nitrosylation, and induction of mitochondrial biogenesis

57 eased the levels of Nos2 expression, protein nitrosylation, and protein nitration, alleviating nitros

58 levated, as were lipid peroxidation, protein nitrosylation, and ROS.

59 s including the nitrite reductase, reductive nitrosylation, and still controversial nitrite anhydrase

60 lation, acetylation, methylation, nitration, nitrosylation, and sulfoxidation and consider their pote

61 at muscle proteins were highly modified by S-nitrosylation, and that oxidative stress-responsive gene

62 ; by the drug CGP3466B, which prevents GAPDH nitrosylation; and by mutating cysteine-150 of GAPDH, it

63 Total cellular levels of protein S-nitrosylation are controlled predominantly by S-nitrosog

64 Recent studies have pointed to protein S-nitrosylation as a critical regulator of cellular redox

65 In summary, this study discloses cysteine S-nitrosylation as a new factor responsible for increasing

66 Our study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regula

67 scope, a particular emphasis is placed on S-nitrosylation as the emerging physiologic mechanism for

68 d substrates for the three peptides in the S-nitrosylation assay, 5.8 in the NAD(+) hydrolysis assay,

69 ished autonomy, indicating that simultaneous nitrosylation at both sites was required.

70 NO induced S-nitrosylation at Cys-280/289, and mutation of either sit

71 described reduction of CaMKII activity by S-nitrosylation at Cys-6 was also observed here, but only

72 o endothelial cells is identified with TG2 S-nitrosylation at the endothelial cell-blood interface.

73 iew, we explore the functional features of S-nitrosylation at the proteome level and the structural d

74 ammation are normally regulated by protein S-nitrosylation but systemic assessments of nitric oxide b

75 ys-346 (Panx1(C40A/C346A)) prevented Panx1 S-nitrosylation by GSNO as well as the GSNO-mediated inhib

76 A role of S-nitrosylation by inducible nitric oxide (NO) synthase, a

77 00 nM, indicating that Hcr protects Hcp from nitrosylation by its substrate, NO.

78 Finally, inhibition of S-nitrosylation by knockdown of thioredoxin-interacting pr

79 Dexras1 is activated by S-nitrosylation by nitric oxide (NO) produced by either in

80 Under physiological conditions, S-nitrosylation can be an important modulator of signal tr

81 Although the S-nitrosylation catalysed by haem proteins is well known,

82 that S-nitrosylation and GSNOR1-mediated de-nitrosylation contribute to auxin physiology, and impair

83 Protein post-translational modification by S-nitrosylation conveys a ubiquitous influence of nitric o

84 pecific P2X4R overexpression had increased S-nitrosylation, cyclic GMP, NO formation, and were protec

85 that LKB1 is degraded by LPS treatment via S-nitrosylation-dependent proteasome pathways, and this ha

86 y is critical in initiating a nitric oxide/S-nitrosylation-dependent signal transduction pathway that

87 d as a tool for studying iron-sulfur protein nitrosylation despite the fact that there exists a wealt

88 fective enrichment of proteins modified by S-nitrosylation, disulfide formation, and Cys-sulfenic aci

89 paired beta(2) integrin function and actin S-nitrosylation do not occur in neutrophils from mice lack

90 AR S-nitrosylation does not impact its subcellular distributi

91 es not affect NO dioxygenase activity, and S-nitrosylation does not significantly consume NO.

92 Low nitrosylation due to nitrate initially present in meat a

93 oxide production is transient due to actin S-nitrosylation during exposure to hyperoxia.

94 duced significant vasodilation and increased nitrosylation during hypoxaemia that could not be revers

95 al nuclease assay to determine the role of S-nitrosylation during nuclear reprogramming to pluripoten

96 se, a denitrosylase that regulates protein S-nitrosylation, exhibited decreased adipogenesis and incr

97 also indicate that druggable regulators of S-nitrosylation, for example S-nitrosoglutathione (GSNO) r

98 nal class of enzymes that regulate protein S-nitrosylation from yeast to mammals and suggest that SNO

99 in the thiol-based transfer of NO groups (S-nitrosylation) has not been considered.

100 Most PTM events, except S-nitrosylations, have low fractional occupancy.

101 This post-translational modification, S-nitrosylation, impacts protein function, stability, and

102 the protective and mechanistic effects of S-nitrosylation in Akr1a1(-/-) mice, whereas Cys-mutant PK

103 tric oxide generation by the microbiota or S-nitrosylation in ALG-1, we reveal unforeseen effects on

104 approach to understand the broader role of S-nitrosylation in auxin physiology in Arabidopsis.

105 e newly identified determinants of protein S-nitrosylation in both yeast and mammals.

106 teins is well known, no direct evidence of S-nitrosylation in copper proteins has been reported.

107 s demonstrate that the consensus motifs of S-nitrosylation in cytoplasmically accessible sites are cr

108 identify a metabolic hallmark of aberrant S-nitrosylation in HCC and exploit it for therapeutic gain

109 a specific molecular signature of aberrant S-nitrosylation in HCC, a novel molecular target in SDH, a

110 ling and suggest a role for SCoR-regulated S-nitrosylation in multiple metabolic processes.

111 , and redox regulation exhibited increased S-nitrosylation in NE samples compared with IE plants upon

112 identify mechanisms for reversal of actin S-nitrosylation in neutrophils after exposure to high oxyg

113 and they highlight the importance of PTEN S-nitrosylation in supporting cell survival and proliferat

114 ivation alone is sufficient to induce PTEN S-nitrosylation in the absence of PARK2 depletion.

115 Thus, through a bird's-eye view of S-nitrosylation in the cardiovascular system, we provide a

116 Here we review mechanisms that regulate S-nitrosylation in the context of its essential role in "s

117 C155S), excluding an essential role of GAPC1 nitrosylation in the mechanism of nuclear relocalization

118 In this study, we investigated the role of S-nitrosylation in the NO regulation of high voltage-activ

119 Roussin's Red Ester is also favored on nitrosylation in the presence of the thiolate scavenging

120 sm and further highlight the importance of S-nitrosylation in the regulation of the immune response.

121 Here we describe protein S-nitrosylation in yeast (heretofore unknown) that is medi

122 difications (phosphorylation, oxidation, and nitrosylation) in SH-SY5Y neuroblastoma cells expressing

123 tion, we uncovered major roles for protein S-nitrosylation, in general, and for phospholamban and car

124 d for phospholamban and cardiac troponin C S-nitrosylation, in particular, in betaAR-dependent regula

125 to short filamentous actin in response to S-nitrosylation, including vasodilator-stimulated phosphop

126 The possibility that S-nitrosylation induces cAPX ubiquitination and degradatio

127 ide (NO) signaling is largely conducted by S-nitrosylation, involving >3000 proteins.

128 data indicate that obesity-induced protein S-nitrosylation is a key mechanism compromising the hepati

129 S-Nitrosylation is a redox-mediated posttranslational modi

130 Nitrosylation is a reversible post-translational modific

131 S-nitrosylation is a ubiquitous protein modification emerg

132 ide evidence that the mechanism of reductive nitrosylation is gated by a conformational change of the

133 S-nitrosylation is therefore revealed here as a nitric oxi

134 S-Nitrosylation is well established as an important post-t

135 PN, and CS resulted in cysteine and tyrosine nitrosylation leading to an altered three-dimensional st

136 Manipulation of the S-nitrosylation level may prove therapeutic in heart failu

137 t (-/-), S-nitrosothiol (SNO) condition at a nitrosylation level of 25.9 pmol mg(-1) and the statisti

138 xygen species (ROS) via the control of the S-nitrosylation level of ROS-metabolizing enzymes, thus mo

139 S-nitrosylation levels, however, were increased in DMD.

140 vel work supports a model in which protein S-nitrosylation may be an additional mechanism in which a

141 r results suggest a model in which protein S-nitrosylation may function as a host response to viral i

142 mammals and suggest that SNO-CoA-mediated S-nitrosylation may subserve metabolic regulation.

143 ide (NEM), indicating that NO acted via an S-nitrosylation mechanism.

144 Protein S-nitrosylation mediates a large part of nitric oxide's in

145 S-Nitrosylation mediates the feedback regulation of N-type

146 Accordingly, we hypothesized that S-nitrosylation might also have a role in nuclear reprogra

147 stimulation, global reductions in cellular S-nitrosylation mitigate hypertrophic signaling resulting

148 Protein S-nitrosylation modulates important cellular processes, in

149 as Cys-mutant PKM2, which is refractory to S-nitrosylation, negated SNO-CoA bioactivity.

150 oglutathione (GSNO), another NO source for S-nitrosylation, occurred in H2O2-treated cells, while a d

151 Nitrosylation of (NEt4)2[Fe2S2(SPh)4] (1) in the presenc

152 We identified protein S-nitrosylation of 13 viral proteins during infection of h

153 The extent of nitrosylation of a given cysteine residue is governed by

154 tric oxide synthase (iNOS) activity causes S-nitrosylation of a key UPR regulator, IRE1alpha, which l

155 that involves AR function inactivation by S-nitrosylation of a single C601 residue present in the DN

156 ric-oxide synthase (NOS-2) and resulted in S-nitrosylation of actin.

157 Here, we describe S-nitrosylation of additional ER pathways that affect the

158 ne and MG), which is most likely caused by S-nitrosylation of aldose reductase.

159 s synthesis of reactive species leading to S-nitrosylation of beta-actin, which causes temporary inhi

160 Mice harboring mutations that prevent S-nitrosylation of betaCys93 had higher rates of morbidity

161 We further show that microbiota-dependent S-nitrosylation of C. elegans Argonaute protein (ALG-1)-at

162 Here, we demonstrate that NO-induced S-nitrosylation of CaMKIIalpha also directly generated aut

163 vivo and in vitro experiments showed that S-nitrosylation of cAPX was responsible for the rapid decr

164 Coincident S-nitrosylation of cardiac troponin C decreases myocardial

165 s GAPDH activity was reversibly inhibited by nitrosylation of catalytic Cys-149 mediated either chemi

166 e-2 (COX-2), increased by atorvastatin via S-nitrosylation of COX-2 and reduced by COX-2 inhibitors.

167 only provide the first direct evidence of S-nitrosylation of Cu(II)-bound cysteine in metalloprotein

168 We find that this depends on the selective S-nitrosylation of Cys(501) in the mitochondrial chaperone

169 Specific nitrosylation of Cys-226 decreases NAB1 activity and cou

170 uctural elements that govern the selective S-nitrosylation of cysteine residues, and the potential ov

171 Exposure of bacteria to NO results in the nitrosylation of cysteine thiols in proteins and low mol

172 Reactive species cause S-nitrosylation of cytosolic actin that enhances actin pol

173 eNMDAR-mediated increase in NO can produce S-nitrosylation of Drp1 (dynamin-related protein 1) and Cd

174 The reductive nitrosylation of ferric (met)hemoglobin is of considerab

175 In hepatocytes, cholate promoted S-nitrosylation of GAPDH and its translocation to the nucl

176 Thus, we found that nitrosylation of GAPDH is not a step toward formation of

177 S-nitrosylation of GAPDH was assessed using a biotin-switc

178 , inhibition of nNOS resulted in a loss of S-nitrosylation of gephyrin and the formation of larger ge

179 In conclusion, S-nitrosylation of gephyrin is important for homeostatic a

180 Thus, S-nitrosylation of GluA1 at C875 enhances S831 phosphoryla

181 Also interesting, no nitrosylation of GSH/GSSG was oberved in the presence of

182 , to current understanding that centers on S-nitrosylation of Hb (ie, S-nitrosohemoglobin; SNO-Hb) as

183 mpal neuroplasticity mediated, in part, by S-nitrosylation of HDAC2 and histone acetylation, such pla

184 f nitrosylated GAPDH reduced cholate-induced nitrosylation of HDAC2 and SIRT1; this effect was accomp

185 d factor, is one of the genes regulated by S-nitrosylation of HDAC2.

186 JCI, Zhang and colleagues demonstrate that S-nitrosylation of hemoglobin at betaCys93 is important fo

187 (NO) as a signaling molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epige

188 anslocation to the nucleus, accompanied by S-nitrosylation of histone deacetylase 2 (HDAC2) and Sirtu

189 The S-nitrosylation of HopAI1 restores MAPK signaling and is r

190 The increase in NO results in S-nitrosylation of insulin-degrading enzyme (IDE) and dyna

191 While S-nitrosylation of IRE1alpha inhibited its ribonuclease ac

192 promise UPR function through iNOS-mediated S-nitrosylation of IRE1alpha, which contributes to defecti

193 164) gain of function decreased glomerular S-nitrosylation of laminin in eNOS(-/-) mice.

194 deposition of laminin and collagen IV and de-nitrosylation of laminin.

195 We demonstrate that obesity promotes S-nitrosylation of lysosomal proteins in the liver, thereb

196 nitric oxide (NO) production, NO-dependent S-nitrosylation of matrix metalloprotease 9 (MMP9) as well

197 represses the tumour suppressor gene p53 via nitrosylation of Mdm2.

198 vity of microglial caspase-3 and increased S-nitrosylation of mitochondria-associated caspase-3 throu

199 S-Nitrosylation of MTA3 is associated with decreased NuRD

200 Targeted S-nitrosylation of NMDARs by NitroMemantine is potentiated

201 S-nitrosylation of nuclear factor kappaB (NF-kappaB) on th

202 n DNA accessibility is mediated in part by S-nitrosylation of nuclear proteins, including MTA3 (Metas

203 ancer of activated B cells; NO generation; S-nitrosylation of nuclear proteins; and DNA accessibility

204 NO accumulation results in the S-nitrosylation of PAL and 4CL required for the synthesis

205 alpha inhibited its ribonuclease activity, S-nitrosylation of PERK activated its kinase activity and

206 For example, S-nitrosylation of peroxiredoxin-2 (Prx2), a peroxidase wi

207 Notably, S-nitrosylation of phospholamban consequent upon betaAR st

208 S-nitrosylation site and demonstrated that S-nitrosylation of PPARgamma inhibits its transcriptional

209 equivalent PPARgamma expression; however, S-nitrosylation of PPARgamma was elevated in S-nitrosoglut

210 oxide to form S-nitroso-CoA (SNO-CoA), and S-nitrosylation of proteins by SNO-CoA is governed by its

211 Endogenous S-nitrosylation of proteins, a principal mechanism of cell

212 d S-nitrosoglutathione readily induced the S-nitrosylation of Prx1, causing structural and functional

213 Importantly, S-nitrosylation of PTEN decreases its phosphatase activity

214 -CoA-SCoR system is mediated by inhibitory S-nitrosylation of pyruvate kinase M2 (PKM2) through a nov

215 The release of epigenetic repression by nitrosylation of RING1A is critical for effective transd

216 Nitrosylation of RING1A reduced its binding to chromatin

217 Nitrosylation of RING1A reduces its binding to chromatin

218 nel RyR1 can be enhanced by S-oxidation or S-nitrosylation of separate Cys residues, which are allost

219 S-Nitrosylation of SHP-2 inhibited its phosphatase activit

220 the local redox environment and influence S-nitrosylation of surface proteins on platelets and endot

221 nhibition of the sulfur transfer activity, S-nitrosylation of the active site residue Cys63 causes an

222 Deficient S-nitrosylation of the cardiac ryanodine receptor (RyR2) h

223 inducible nitric oxide synthase (iNOS) and S-nitrosylation of the endonuclease inositol-requiring pro

224 from resident bacteria promotes widespread S-nitrosylation of the host proteome.

225 g increased mitochondrial ROS emission and S-nitrosylation of the RyR, whereas hydrogen peroxide indu

226 sine and arginine residues, acetylation, and nitrosylation of thiol groups and tyrosine residues, hav

227 ed nitrosative/oxidative stress results in S-nitrosylation of transcription factor MEF2C in A53T hNs

228 ductase activity was potentiated following S-nitrosylation of Trx proteins at a non-catalytic cystein

229 ssion and NO were associated with reversible nitrosylation of tuberous sclerosis complex (TSC) 2, and

230 de dismutase (MnSOD) activity by causing the nitrosylation of tyrosine 34, thereby increasing ROS.

231 oso-N-acetylcysteine induced site-specific S-nitrosylation of VLCAD mutants at cysteine residue 237.

232 ocalization of iNOS, and its binding to, and nitrosylation of, the epigenetic modifier ring finger pr

233 translational modification of proteins via S-nitrosylation often impacts enzymatic activities, our da

234 owever, genetic evidence for the effect of S-nitrosylation on auxin physiology has been lacking.

235 implications for understanding the impact of nitrosylation on cellular redox homeostasis.

236 vates histidine kinase sensor VbrK through S-nitrosylation on cysteine 86, which results in downregul

237 enesis, we find that Cys106 is the site of S-nitrosylation on DJ-1 and that mutation of this site inh

238 We have investigated the effects of S-nitrosylation on the rhodanese domain of the Escherichia

239 sttranslational modification (PTM) protein S-nitrosylation on viral proteins to determine the biologi

240 NO reacts with cysteine residues (S-nitrosylation) on hyperpolarization-activated and nucleo

241 S-Nitrosylation operates in concert with phosphorylation t

242 ied previously as subject to physiological S-nitrosylation or S-oxidation.

243 atile mechanisms such as nutrient depletion, nitrosylation, or apoptosis.

244 ith N-ethylmaleimide (NEM), which occludes S-nitrosylation, or with 1-(2-trifluromethylphenyl)imidazo

245 to the pathophysiological role of aberrant S-nitrosylation pathways will enhance our understanding of

246 onditions only slight differences in their S-nitrosylation pattern, the in vivo S-nitroso-proteome of

247 sts that loss of the iron-sulfur cluster (by nitrosylation) permits positively charged residues in th

248 nitrosoglutathione Reductase 1 (GSNOR1) by S-nitrosylation, preventing scavenging of S-nitrosoglutath

249 (from meat or vegetables) on the endogenous nitrosylation process was also tested.

250 The nitrosylation products are similar to a pair of dinuclea

251 f NO metabolites (oxidation, nitrosation and nitrosylation products) were measured in plasma and eryt

252 In particular, nitrosylation promoted disulfide formation involving the

253 to reduce SCoR activity increased protein S-nitrosylation, protected against acute kidney injury and

254 , Adh6-regulated, SNO-CoA-mediated protein S-nitrosylation provides a regulatory mechanism parallelin

255 The fast, efficient and reversible S-nitrosylation reaction is used to demonstrate its abilit

256 The NsrR nitrosylation reaction was not significantly affected by

257 oxins that generate excessive NO, aberrant S-nitrosylation reactions can occur and affect protein mis

258 At steady state, cellular S-nitrosylation reflects dynamic equilibria between S-nitr

259 Here, we show that HDAC2 nitrosylation regulates neuronal radial migration during

260 S-nitrosylation regulates proteins in all functional class

261 Transfection of cells with a S-nitrosylation-resistant Ras mutant reduced iNOS protein

262 econstitution of IRE1alpha expression with a nitrosylation-resistant variant restored IRE1alpha-media

263 Furthermore, overexpression of S-nitrosylation-resistant variants of lysosomal enzymes en

264 trate in this issue of Molecular Cell that S-nitrosylation selectively modulates enzymatic activity o

265 S-palmitoylation, S-glutathionylation, and S-nitrosylation show little correlation with pKa values pr

266 llustrate a paradoxical inhibitory role of S-nitrosylation signaling in MSC vasculogenesis.

267 a mutant form of RING1A (C398A) lacking the nitrosylation site almost abrogated transdifferentiation

268 ther identified Cys 139 of PPARgamma as an S-nitrosylation site and demonstrated that S-nitrosylation

269 .2, and Cys-346 in the Cavbeta3 subunit were nitrosylation sites mediating NO sensitivity of N-type c

270 ifications, including disulfide formation, S-nitrosylation (SNO) and S-glutathionylation (SSG), have

271 n modifications (acetylations, methylations, nitrosylations, succinylation, and ubiquitinations), som

272 ion of GSNOR results in pathologic protein S-nitrosylation that is implicated in human hepatocellular

273 tem, and we highlight examples of aberrant S-nitrosylation that may lead to altered oxygen homeostasi

274 immunohistochemical evidence for extensive S-nitrosylation that takes place in the goldfish and mouse

275 evelopment and stress responses is through S-nitrosylation, that is, covalent attachment of NO to cys

276 oute for the transfer of NO bioactivity is S-nitrosylation, the addition of an NO moiety to a protein

277 and SNP significantly increased EC protein S-nitrosylation, the colocalization of S-nitrosothiol (S-N

278 S-Nitrosylation, the covalent addition of an nitric oxide

279 oute for the transfer of NO bioactivity is S-nitrosylation, the covalent attachment of an NO moiety t

280 Protein S-nitrosylation, the nitric oxide (NO(*))-mediated posttra

281 ignalling is generally mediated by protein S-nitrosylation, the oxidative modification of Cys residue

282 S-Nitrosylation therapy restored the microcirculation and

283 that signals predominantly through protein S-nitrosylation to form S-nitrosothiols (SNOs) in target p

284 ocytes was performed together with protein S-nitrosylation to investigate the effects of CO at the ce

285 2B6, which may act synergistically with heme nitrosylation to target the enzyme for degradation.

286 eine (C430S) in LKB1 prevented LPS-induced S-nitrosylation, ubiquitination, and degradation.

287 lowing for wide-ranging control of protein S-nitrosylation under both physiological and pathological

288 roarginine methyl ester [L-NAME]) or protein nitrosylation (via dithiothreitol) on bile salt homeosta

289 GAPDH nitrosylation was assessed in normal and cholestatic rat

290 Cysteine 237 S-nitrosylation was associated with an 8-17-fold increase

291 Nitrosylation was optimal under mildly acidic conditions

292 itrosylation and glutathionylation, although nitrosylation was widely prominent.

293 a(2+) currents are reduced by NO-activated S-nitrosylation, we tested whether CNs affect membrane cha

294 enic mice to titrate the levels of protein S-nitrosylation, we uncovered major roles for protein S-ni

295 Levels of protein S-nitrosylation were decreased in the brain 6 hours after

296 Furthermore, the consensus motifs of S-nitrosylation were much more abundant in Cav2.2 than in

297 rite (1 mM) considerably increased heme iron nitrosylation while a significant decrease was observed

298 hemically with a strong NO donor or by trans-nitrosylation with GSNO.

299 reductase (GSNOR), which exhibit enhanced S-nitrosylation, would have improved outcomes in a preclin

300 This work reveals that nitrosylation yields multiple products structurally rela