ライフサイエンスコーパス: nitroxyl

1 of nitric oxide as opposed to its redox form nitroxyl.

2 is to enable nNOS to generate NO instead of nitroxyl.

3 ONNOH), the adducts of nitric oxide (NO) and nitroxyl (3NO- and 1HNO), are revised.

4 rification pathway, including isolation of a nitroxyl adduct similar to that proposed in the P450nor

5 readily enable the continuous generation of nitroxyl, an antithrombotic species, from physiologicall

6 uction from the ferric catalase oxidation of nitroxyl and identify a catalase-mediated pathway as a p

7 nd related reactive nitrogen species such as nitroxyl and peroxynitrite, after up-regulation of expre

8 uding nitrogen dioxide, dinitrogen trioxide, nitroxyl, and peroxynitrite.

9 ydrolysis of this nitroso species to produce nitroxyl, and reductive nitrosylation of the ferric heme

10 ts a prompt turn-on response when exposed to nitroxyl, and this emission response is specific to HNO

11 de (NO) to its one-electron reduced species, nitroxyl anion (3NO-) has been determined by a combinati

12 Nitroxyl anion (HNONO(-)), the one-electron reduced form

13 Nitroxyl anion (NO(-)) is the one-electron reduction pro

14 dence indicates that the NO-related species, nitroxyl anion (NO), is produced in physiological system

15 the NADPH/O2 reaction is proposed to be the nitroxyl anion (NO-) based on the formation of a ferrous

16 The nitroxyl anion (NO-) formed from HNO (pKa 4.5) was trapp

17 The nitroxyl anion (NO-) is a highly reactive molecule that

18 In the absence of oxygen, nitroxyl anion (NO-) is liberated in a reaction producin

19 does not synthesize NO, but rather generates nitroxyl anion (NO-) that is subsequently converted to N

20 aNonoate], an S-nitrosothiol [GSNO], and the nitroxyl anion donor, Angelis salt).

21 2)(-), Angeli's anion) is used to generate a nitroxyl anion in its excited singlet state ((1)NO(-)).

22 The singlet state of nitroxyl anion, 1NO-, is physiologically inaccessible.

23 d (c) oxidized forms of nitrogen such as the nitroxyl anion, the nitric oxide free radical, and S-nit

24 on pathway, converting oximes to ketones and nitroxyl anions (NO(-) ).

25 on NO disappearance from heme groups to form nitroxyl anions or S-nitrosated Hb at low ratios of NO t

26 sults for evaluating the biological roles of nitroxyl are discussed.

27 cially noteworthy at high pH, where bicyclic nitroxyls are inhibited by formation of an oxoammonium h

28 le formation of a hydroxylamine N-oxide when nitroxyls are oxidized in alkaline media.

29 iven reactions, consistent with formation of nitroxyl as an immediate product.

30 intermediates, which upon hydrolysis release nitroxyl (azanone, HNO) in excellent yields.

31 with one nitroxyl bearing 15N and the other nitroxyl bearing 14N (14N-X-15N), were employed as probe

32 lly asymmetric nitroxyl biradicals, with one nitroxyl bearing 15N and the other nitroxyl bearing 14N

33 interaction of r# with the asymmetric ortho-nitroxyl biradical (14N-O-15N), which exists in a condit

34 The para-nitroxyl biradical (14N-P-15N) exists in weak spin excha

35 Both isotopically symmetric nitroxyl biradicals (14N-X-14N) and isotopically asymmet

36 cals (14N-X-14N) and isotopically asymmetric nitroxyl biradicals, with one nitroxyl bearing 15N and t

37 and chemical interactions between r and the nitroxyl biradicals.

38 Cu/nitroxyl catalysts have been identified that promote hig

39 comparisons of (a) NO(x)/oxoammonium and Cu/nitroxyl catalysts, (b) high-potential quinones and amin

40 Herein, we report a Cu/nitroxyl co-catalyzed method for direct conversion of cy

41 may be tuned by changing the identity of the nitroxyl cocatalyst.

42 st biomimetic water-soluble Fe(II)-porphyrin nitroxyl complexes were obtained and characterized by UV

43 roscopically by the sorption of paramagnetic nitroxyl compounds (spin probes) of different polarity,

44 The species resembles a nitroxyl coordinated to a highly distorted disulfide, an

45 useful synthetic intermediates and potential nitroxyl delivery agents.

46 Bicyclic nitroxyl derivatives, such as 2-azaadamantane N-oxyl (AZ

47 is the best choice for determination of iron-nitroxyl distances in the range of 15-30 A.

48 d that is consistent with the formation of a nitroxyl disulfide in the gas phase.

49 requirements and charge stabilization of the nitroxyl disulfide reaction intermediate are discussed.

50 Addition of Angeli's salt, a nitroxyl donor, to ferric catalase also produces the fer

51 ent study investigates the impact of several nitroxyl donors and the thiol-oxidizing agent diamide on

52 Nitroxyl donors have been shown to affect contractility

53 The formation of a heme-bound nitroxyl equivalent and its subsequent oxidation is a no

54 Thus, nitroxyl exists almost exclusively in its protonated for

55 etermination is the first for a nonheme iron nitroxyl {FeNO}(8) and has allowed to identify structura

56 d to determine the distance between iron and nitroxyl for spin-labeled metmyoglobin variants in low-s

57 rmal steric effect), while for the noncyclic nitroxyl fragment (except for one case), a leveled steri

58 r interest to the chemical activation of the nitroxyl fragment by oxidation/reduction of selected fun

59 nd colleagues showed that protonation of the nitroxyl fragment deactivated the alkoxyamine C-ON bond.

60 rmal steric effect also applies to noncyclic nitroxyl fragments and that for one case an enhanced ste

61 For all cyclic nitroxyl fragments, the steric effect is described as th

62 ydrogen bond (IHB) between the alkyl and the nitroxyl fragments, which leads to an 8-fold decrease in

63 The nitroxyl free radicals used were TEMPO, TEMPAMINE, and T

64 A series of stable nitroxyl free radicals, which are characterized by diffe

65 Nitroxyl, generated from Angeli's salt, reacts with ferr

66 rations between the unpaired electron of the nitroxyl group and isotopically identified nuclei.

67 an hydrogen bond with the oxygen atom of the nitroxyl group of Tempo, and that a single water molecul

68 distances from the unpaired electron of the nitroxyl group of the spin-label to the methylene and me

69 xidation reactions of five different organic nitroxyls have been performed across a wide pH range (0-

70 was shown previously to mimic the effect of nitroxyl (HN=O), the putative active metabolite of cyana

71 The thermodynamic properties of aqueous nitroxyl (HNO) and its anion (NO(-)) have been revised t

72 The redox siblings nitroxyl (HNO) and nitric oxide (NO) have often been ass

73 Angeli's salt produces both nitroxyl (HNO) and nitric oxide (NO), depending upon the

74 rosothiols can react with thiols to generate nitroxyl (HNO) and the corresponding disulfide.

75 The emergence of nitroxyl (HNO) as a biological signaling molecule is att

76 We show that Nmar_1354 selectively produces nitroxyl (HNO) by coupling the oxidation of the obligate

77 The most recent study suggests that nitroxyl (HNO) can react with free chlorine (HOCl) to fo

78 Despite its negative redox potential, nitroxyl (HNO) can trigger reactions of oxidation.

79 Nitroxyl (HNO) donated by Angeli's salt activates uptake

80 The nitroxyl (HNO) donor, Angeli's salt, exerts positive ino

81 acene derivative was prepared as a potential nitroxyl (HNO) donor.

82 Nitroxyl (HNO) exerts inotropic and lusitropic effects i

83 he biological and pharmacological effects of nitroxyl (HNO) from its oxidized/deprotonated product ni

84 Nitroxyl (HNO) has gained a considerable amount of atten

85 Nitroxyl (HNO) is a redox sibling of nitric oxide (NO) t

86 ws that hydroxylamine (NH(2)OH) oxidation to nitroxyl (HNO) is the most energetically efficient means

87 date the factors that impart selectivity for nitroxyl (HNO) over nitric oxide (NO), thiols, and H2S i

88 Despite the mechanisms for endogenous nitroxyl (HNO) production and action being incompletely

89 Nitroxyl (HNO) reacts with thiols, and this reactivity r

90 The fact that nitroxyl (HNO) reduces platelet aggregation, preconditio

91 gel chemistry were used to fabricate optical nitroxyl (HNO) sensors [corrected] Selective detection o

92 NOate Angeli's salt (Na(2)N(2)O(3)) releases nitroxyl (HNO) under physiological conditions and exhibi

93 cts the hydrolysis of the latter compound to nitroxyl (HNO) which dimerizes to cis-hyponitrous acid (

94 ic and mechanistic data for the reactions of nitroxyl (HNO) with biomolecules (k approximately 10(3)

95 enzene (PhNO) serves as a stable analogue of nitroxyl (HNO), a biologically relevant, redox-active ni

96 hiol reactivity to promote the generation of nitroxyl (HNO), a distinct signaling species often overs

97 The formation of nitroxyl (HNO), a product of the reaction of 5 with diet

98 Nitroxyl (HNO), a redox congener of nitric oxide (NO.),

99 (NO(2) (*)), dinitrogen trioxide (N(2)O(3)), nitroxyl (HNO), and peroxynitrite (ONOO(-)/ONOOH), as we

100 Protonation of 4 releases nitroxyl (HNO), as observed by ESI-MS and (31)P NMR trap

101 Due to its inherent reactivity, nitroxyl (HNO), must be generated in situ through the us

102 A potential alternative is nitroxyl (HNO), the 1-electron reduction product of nitr

103 orescent turn-on sensor for the detection of nitroxyl (HNO), the one-electron reduced form of nitric

104 reduced state with concomitant generation of nitroxyl (HNO), the one-electron reduction product of NO

105 Nitroxyl (HNO), the one-electron-reduced form of nitric

106 Nitroxyl (HNO), the protonated one-electron reduction pr

107 Donors of nitroxyl (HNO), the reduced congener of nitric oxide (NO

108 Detection of nitroxyl (HNO), the transient one-electron reduced form

109 One such pathway involves dimerization of nitroxyl (HNO), which can occur directly or enzymaticall

110 occur upon exposure of cysteine residues to nitroxyl (HNO), which has received recent attention as a

111 Selective detection of nitroxyl (HNO), which has recently been identified as a

112 and H2S can be ascribed to the generation of nitroxyl (HNO), which is a direct product of the reactio

113 s-nitrite (NO(2)(-)), nitric oxide (NO), and nitroxyl (HNO)-that are new to both nature and synthetic

114 discussed and may involve the intermediate, nitroxyl (HNO).

115 the PDH complex by using lipoate to generate nitroxyl (HNO).

116 quely advantageous prodrug form of bioactive nitroxyl (HNO).

117 ms of the bioeffectors nitric oxide (NO) and nitroxyl (HNO).

118 one-electron reduced analogue of NO, namely nitroxyl (HNO/NO(-)), has revealed distinguishing proper

119 Nitroxyl (HNO/NO(-)), the reduced form of nitric oxide,

120 Azanone (nitroxyl, HNO) is a highly reactive compound whose biolo

121 Nitroxyl, HNO/NO(-), the one-electron reduced form of NO

122 entical potentials and lifetimes for ferrous nitroxyl intermediate (Fe(II)-NO(-)) in CYP119 and Mb.

123 Iron-nitroxyl interspin distances in the range of 17-30 A wer

124 d herein show that the catalytic activity of nitroxyls is more strongly affected by the nitroxyl/oxoa

125 Azanone (HNO, nitroxyl) is a highly reactive and short-lived compound

126 d trapping experiments demonstrate that HNO (nitroxyl) is formed, at least when tppts is the reductan

127 Nitrosyl hydride, HNO, also commonly termed nitroxyl, is a transient species that has been implicate

128 Nitrosyl hydride, HNO or nitroxyl, is the one-electron reduced and protonated for

129 nd exhibits a nu(NO) vibration indicative of nitroxyl-like character.

130 alysis reveals the nitroso groups possess a "nitroxyl-like" bent configuration.

131 Metal-nitroxyl (M-HNO/M-NO(-)) coordination units are found in

132 ich suggests that the biological activity of nitroxyl may be mediated by its reactivity with ferrous

133 ia/reperfusion and suggest that formation of nitroxyl may contribute to postischemic myocardial injur

134 e mimicked by Angeli's salt, arguing against nitroxyl mediation.

135 ion of a hydroxyl group located close to the nitroxyl moiety successively into aldehyde, then acid, a

136 nd aqueous thermochemistry and reactivity of nitroxyl (nitrosyl hydride, HNO) were elucidated with mu

137 rmed during NHCl(2) decomposition, including nitroxyl/nitroxyl anion (HNO/NO(-)) and peroxynitrous ac

138 role of two reactive nitrogen oxide species, nitroxyl (NO(-)) and nitric oxide (NO(.)), in myocardial

139 Nitroxyl (NO(-)) may be produced by nitric-oxide synthas

140 The dihedral angle between the beta-H and nitroxyl O bonds is smaller in phosphorylated nitrones,

141 ntrol the binding and release of coordinated nitroxyl or its anion at these biological metal sites, w

142 Nitroxyl, or nitrosyl hydride, (HNO) is a pharmacologica

143 ise mechanism taking place through a side-on nitroxyl Os(VI) intermediate, OsO2 (eta(2) -NO)(-) .

144 itions was used to vary the potential of the nitroxyl/oxoammonium redox couple by 0.95 V.

145 f nitroxyls is more strongly affected by the nitroxyl/oxoammonium redox potential than by steric effe

146 Nitroxyl permeability in sensor films deposited in round

147 The nitroxyl radical 1-methyl-2-azaadamantane N-oxyl (Me-AZA

148 nown classes of "oxygen mimetic" agents: the nitroxyl radical 2,2,6, 6-tetramethylpiperidin-N-oxyl (4

149 is (1) fluorescent, (2) stable as opposed to nitroxyl radical adducts, (3) biologically relevant, and

150 activity of a diverse range of water-soluble nitroxyl radical compounds.

151 al and catalytic activity of a wide range of nitroxyl radical derivatives.

152 to modified bases in DNA containing oxidized nitroxyl radical EPR probes.

153 -methoxypiperidine-N-oxyl) were conducted by nitroxyl radical exchange experiments.

154 en-atom-transfer from a Cu(II)-alkoxide to a nitroxyl radical is higher in energy than hydrogen trans

155 er but continuous decay of dpph(*) because a nitroxyl radical is recovered from the TEMPOnium cation,

156 spin-label mimetic of PI(3)P that contains a nitroxyl radical near the threitol group of the lipid.

157 strate oxidation" mediated by Cu(II) and the nitroxyl radical of TEMPO via a Cu(II)-alkoxide intermed

158 This stable nitroxyl radical reacts rapidly with reducing radicals a

159 cally hindered aniline/anilide complexes and nitroxyl radical species.

160 reatly accelerated in the presence of stable nitroxyl radical TEMPO(*) (k(mix)(MeOH) = 1.4 x 10(3) M(

161 ssion results in the formation of the stable nitroxyl radical TEMPO(.) as well as a reactive carbocat

162 low-energy pathway involving addition of the nitroxyl radical to the double bond followed by H-atom a

163 tained by the reaction of 2 molar equiv of a nitroxyl radical with an unactivated alkene.

164 nsisting of an acridinium photooxidant and a nitroxyl radical, promotes site-selective amination of a

165 of the unmodified compounds with the stable nitroxyl radical, TEMPO (2,2,6,6-tetramethylpiperidin-1-

166 Stable nitroxyl radical-containing compounds, such as 2,2,6,6-t

167 g of the epoxide followed by trapping by the nitroxyl radical.

168 om the intermediate by another equivalent of nitroxyl radical.

169 generate the transient Cp2Ti(III)Cl and the nitroxyl radical.

170 achloroperoxybenzoic acid in the presence of nitroxyl radicals and detected with the use of rapid-mix

171 Titanium-oxygen bonds derived from stable nitroxyl radicals are remarkably weak and can be homolyz

172 tic resonance (EPR) imaging utilizing stable nitroxyl radicals is a promising technique for measuring

173 The nitroxyl radicals served as selective reductants of APO-

174 The decay of water-soluble nitroxyl radicals showed radicals are formed in the aque

175 The reaction of nitroxyl radicals TEMPO (2,2',6,6'-tetramethylpiperidiny

176 The reaction of stable sterically hindered nitroxyl radicals with benzylic and allylic substrates w

177 Nitroxides, also known as nitroxyl radicals, are long-lived or stable radicals wit

178 fer an electron and a proton to phenoxyl and nitroxyl radicals, indicating that e(-) and H(+) are cou

179 n atom transfer (HAT) from hydroxylamines to nitroxyl radicals, using the stable radicals TEMPO(*) (2

180 ylacetonate) pyridine-imidazole complexes to nitroxyl radicals.

181 , using the different optical spectra of the nitroxyl radicals.

182 s with itself to nitrous oxide (N(2)O), (ii) nitroxyl reaction with dissolved oxygen (DO) to peroxyni

183 iological and cardiovascular implications of nitroxyl reactions are discussed.

184 Nitroxyl reduction was confirmed using EPR and triphenyl

185 sfer from a Cu(II)-alkoxide to a coordinated nitroxyl species.

186 on the spin-lattice relaxation rates of the nitroxyl spin label using the modified Bloembergen equat

187 overy measurements of the enhancement of the nitroxyl spin lattice relaxation rates between approxima

188 with the fatty acid spin-label, [15N,2H12]-5-nitroxyl stearate, have been obtained at the two sample

189 activity observed between TEMPO and bicyclic nitroxyls, such as ABNO (ABNO = 9-azabicyclo[3.3.1]nonan

190 n this reaction, which provides evidence for nitroxyl, the one-electron reduced form of nitric oxide.

191 n of 17 produces nitrous oxide, evidence for nitroxyl, the one-electron-reduced form of nitric oxide.

192 leading to the ultimate liberation of NB or nitroxyl, thereby inhibiting AlDH.

193 rseradish peroxidase is capable of oxidizing nitroxyl to nitric oxide.

194 rosylation of the ferric heme of catalase by nitroxyl to yield the ferrous-NO catalase complex.

195 Similarly, pro-prodrug forms of nitroxyl were prepared by derivatization of the hydroxyl

196 formation by (i) dichloramine hydrolysis to nitroxyl which reacts with itself to nitrous oxide (N(2)