ライフサイエンスコーパス: nociception

1 ated peptide expression and basal trigeminal nociception.

2 s via caudal brainstem structures to control nociception.

3 modality- and sex-specific role for PMCA2 in nociception.

4 e diverse processes including blood flow and nociception.

5 and mediate protease-evoked inflammation and nociception.

6 orylation has the opposite effect on thermal nociception.

7 e directly involved in acute corneal mechano-nociception.

8 l the role of the AWC(OFF) neuron in thermal nociception.

9 cted role for TMCs in alkaline sensation and nociception.

10 ene functioning antagonistically to modulate nociception.

11 d thereby contributes to enhanced mechanical nociception.

12 ower of Drosophila for genetic dissection of nociception.

13 g genetic validation of their involvement in nociception.

14 ovel form of sensation that we term auditory nociception.

15 compounds that completely blocked persistent nociception.

16 cal mechanisms that drive distinct stages of nociception.

17 cations for sensory neuron transcription and nociception.

18 istinct pairs of sensory neurons to modulate nociception.

19 ration of autonomic nerves and modulation of nociception.

20 in primary sensory neurons where it mediates nociception.

21 nderstanding evolutionary roots of mammalian nociception.

22 e neural development, complex behaviours and nociception.

23 ted through behavioral studies to mechanical nociception.

24 lar cortex (RAIC) is a relevant structure in nociception.

25 tors while targeting receptors involved with nociception.

26 n and inhibits nociceptors, thereby reducing nociception.

27 d in drug addiction, movement disorders, and nociception.

28 he tail-withdrawal test, a measure of spinal nociception.

29 naling participates in the process of dental nociception.

30 ting precise spatial and temporal control of nociception.

31 ential physiological processes, most notably nociception.

32 de and TRPV1 suggestive of a role for NMB in nociception.

33 limbic areas involved with interoception and nociception.

34 unds, making it a crucial player in chemical nociception.

35 ity, vascular smooth muscle contraction, and nociception.

36 suppression of neuronal hypersensitivity and nociception.

37 this behavior could be used to measure tooth nociception.

38 of neuromodulation for processing of bladder nociception.

39 he crisis: vaso-occlusion, inflammation, and nociception.

40 ables rapid and selective optical control of nociception.

41 es such as affective regulation, reward, and nociception.

42 g a role of Piezo proteins in mechanosensory nociception.

43 unexpected contribution of ASIC1 channels to nociception.

44 potential vanilloid 1 (TRPV1) and sensitizes nociception.

45 V1 is the principal transduction channel for nociception.

46 which has not previously been implicated in nociception.

47 a brainstem region involved in modulation of nociception.

48 critical for survival and depends on thermal nociception.

49 y of colonic afferents and suppress visceral nociception.

50 ive pain-sensing neurons, but sparing normal nociception.

51 aluated these agonists in models relevant to nociception.

52 o pain and is involved in sex differences in nociception.

53 ion, but they play a minimal role in cardiac nociception.

54 reas to test the effects of CSD on meningeal nociception.

55 whereas photoinhibition potentiates thermal nociception.

56 ial learning, impaired gait, and supraspinal nociception.

57 sights of how alternative splicing regulates nociception.

58 signaling pathways that regulate mechanical nociception.

59 mouse showed an increased latency to thermal nociception.

60 rozygous NGF(R100W/wt) mice display impaired nociception.

61 d VEGFR-2 signaling in regulating mechanical nociception.

62 f colonic afferent excitability and visceral nociception.

63 ophila TrpA1 mediates heat and UVC-triggered nociception.

64 C-nociception, whereas TrpA1-D mediates heat-nociception.

65 in has traditionally been considered sensory nociception.

66 be the role of TRESK channel in migraine and nociception.

67 riggered or exacerbated peripherally induced nociception.

68 naling pathways that have been linked to pro-nociception.

69 mouse DRG neurons selectively abolished heat nociception.

70 ptibility, suggesting a link between for and nociception.

71 superficial dorsal horn, an area involved in nociception.

72 enetic silencing specifically reduced facial nociception.

73 ed paradigm for functional MRI of trigeminal nociception.

74 y relies on neural processes engaged by self-nociception.

75 irrors the interaction between attention and nociception.

76 duced acute and chronic peripherally induced nociception.

77 We found that, during capsaicin-induced nociception, 5,6-EET levels increased in dorsal root gan

78 rve growth factor (NGF) is a key mediator of nociception, acting during the development and different

79 in this context, we revisit the concepts for nociception, acute and chronic pain, and negative moods

80 iologic and pathologic conditions, including nociception, addiction, and fragile X syndrome.

81 gn and evaluate therapeutic efficacy of anti-nociception agent Capsaicin (Cap) and anti-TNFalpha siRN

82 ession of many genes known to be involved in nociception, analgesia, and antidepressant drug actions.

83 otrigeminal pathway is a potent modulator of nociception and a potential target for interventions to

84 cific knockdown of Magi-1 attenuated thermal nociception and acute inflammatory pain and produced def

85 matically reduced acute peripherally induced nociception and alleviated neuropathic and inflammatory

86 Girk-dependent signaling contributes to nociception and analgesia, reward-related behavior, mood

87 nervous system, where they have key roles in nociception and analgesia.

88 ystem that make it attractive for studies of nociception and anesthesiology and plasticity of primary

89 y contribute to cognition, reward, mood, and nociception and are implicated in a range of neurologica

90 c-like conditions may dually regulate muscle nociception and cardiovascular reflexes.

91 , for the first time, the optical control of nociception and central sensitization in behaving mammal

92 , TSP4 antibodies or genetic ablation blocks nociception and changes in synaptic transmission in mice

93 s efficacious in the mouse formalin model of nociception and Chung model of neuropathic pain, without

94 hese two players in a feedback cycle linking nociception and cytoskeletal remodeling.

95 ately been associated with regulating muscle nociception and exercise pressor reflexes (EPRs), and P2

96 down Dmpiezo in sensory neurons that mediate nociception and express the DEG/ENaC ion channel pickpoc

97 2-AG or AEA inhibit nociception and feeding through a pathway requiring the

98 , synaptic, neuropeptide release to modulate nociception and highlight the similarities between the t

99 tinal pathology, thereby modulating visceral nociception and IBS symptomatology, and might provide an

100 In particular, TRPA1 channel is involved in nociception and in sensory perception of many pungent ch

101 avalpha2delta1 knockdown blocks TSP4 induced nociception and its pathological correlates.

102 Cannabinoids also modulate nociception and locomotion through an NPR-19-independent

103 investigation of the role of the channel in nociception and migraine.

104 irect measures of specific brain function of nociception and new insights into preoperative evaluatio

105 re believed to be key signaling molecules in nociception and nociceptive sensitization.

106 s (Pvfs 2 and 3) are required for mechanical nociception and normal dendritic branching.

107 the understanding of the neurodevelopment of nociception and of the wide array of factors that may im

108 om nociceptive, inflammatory and neuropathic nociception and offers a much-needed non-opioid treatmen

109 Sexually dimorphic nociception and opioid antinociception is very pervasive

110 ibility of functional, endogenous MOP-CB1 in nociception and other pharmacologic effects has been rai

111 dorsal root ganglia (DRG) neurons mediating nociception and other sensory modalities express many ty

112 re known to exert powerful control of spinal nociception and pain behaviours in adult mammals.

113 assium channel, TRESK has been implicated in nociception and pain disorders.

114 ate the Nav1.1 subtype, the role of which in nociception and pain has not been elucidated.

115 Currently there are no objective measures of nociception and pain in the perioperative period.

116 s point to ZBTB20 as a critical regulator of nociception and pain sensation by modulating TRP channel

117 ecifically in nociceptors showed a defect in nociception and pain sensation in response to thermal, m

118 Thus progress on studies of nociception and pain-like responses in animal models dep

119 ently inhibited acute thermal and mechanical nociception and persistent inflammatory pain in control

120 e basolateral amygdala of mice with resolved nociception and persisting behavioral effects.

121 ch D1-like receptors (D1LRs) modulate spinal nociception and plasticity by regulating activation of t

122 within the PFC in the modulation of visceral nociception and point to TLR4 as a potential therapeutic

123 OT release from these OT neurons suppresses nociception and promotes analgesia in an animal model of

124 f regulated endogenous nucleotide release in nociception and provide a detailed mechanism of a pain-i

125 ple genes and the environment that influence nociception and regulate the consciousness of pain.

126 found suggestive evidence of involvement of nociception and renin-angiotensin systems in this effect

127 entral and peripheral nerves responsible for nociception and sensitization of the defensive behavior

128 kably, Avil-cre;Sptan1(f/f) mice have intact nociception and small-diameter axons, but severe ataxia

129 feeding and metabolism, learning and memory, nociception and spinal reflexes, and anxiety and related

130 entifies a mechanism underlying corneal cold nociception and suggests a potential target for the trea

131 y, therefore, play an important dual role in nociception and sympathetic reflexes and could provide a

132 ning in meal duration is a response to tooth nociception and that this nociception can be measured fo

133 to opioid-induced responses, including anti-nociception and the development of tolerance and depende

134 muscle afferents can dually regulate muscle nociception and the exercise pressor reflex.

135 role for Tachykinin signaling in regulating nociception and the power of Drosophila for genetic diss

136 rstanding of the physiological mechanisms of nociception and thermosensation, the molecular mechanics

137 neuronal activity that underlie the onset of nociception and touch discrimination in the preterm infa

138 for reward effects, the tail flick test for nociception, and a measure of locomotor activity for gen

139 ases and ion channels involved in olfaction, nociception, and blood coagulation.

140 ed by a reduction in neutrophil recruitment, nociception, and cartilage degradation.

141 processes, including synaptic transmission, nociception, and fear.

142 delta-1 is involved in various modalities of nociception, and for the development of behavioral hyper

143 Stress modifies nociception, and humans with post-traumatic stress disor

144 in cardiovascular homeostasis, hypertension, nociception, and insulin sensitivity through the metabol

145 including thermoreception, mechanoreception, nociception, and itch.

146 processing affective/pleasure/motivational, nociception, and mating-specific (such as for erection a

147 re likely to have distinct roles in visceral nociception, and that (2) the chronic stress-induced enh

148 aV1.7), a channel reported to be involved in nociception, and thus it might have potential as a pain

149 behavioral changes as shown by anxiety-like, nociception, and touch-sensitivity tests.

150 tributes to the regulation of vascular tone, nociception, angiogenesis and the inflammatory response.

151 However, cerebral contributions beyond nociception are not yet well characterized, leading to a

152 the brain creates a painful experience from nociception are still unknown.

153 he molecular and genetic bases of mechanical nociception are unclear.

154 We redefine nociception as the mechanism protecting the organism fro

155 wild-type mice in any model of inflammatory nociception assessed.

156 rojections have an impact on CeA stress- and nociception-associated maladaptive responses, which can

157 Finally, optogenetically triggered nociception behavior is unaffected by pickpocket RNAi, w

158 mpairment without causing defects in thermal nociception behavior.

159 e range of physiological processes including nociception, behavior, cognitive function, appetite, met

160 requirement for Balboa and PPK in mechanical nociception behaviors and their specific expression in l

161 e mutant for pickpocket show greatly reduced nociception behaviors in response to harsh mechanical st

162 ogenetics to activate larval nociceptors and nociception behaviors in the third-larval instar.

163 ng ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mecha

164 the hypothalamus and has been implicated in nociception, but the circuit mechanisms remain unexplore

165 eceptor (MC4R) ligands are known to modulate nociception, but the site of action of MC4R signaling on

166 nels are important for thermal sensation and nociception, but their gating mechanisms have remained e

167 gest that Hsp90 promotes opioid-induced anti-nociception by an ERK mechanism in mouse brain and that

168 ate that the ectonucleotidase NT5E regulates nociception by hydrolyzing AMP to adenosine in nocicepti

169 a high-FODMAP (HFM) diet increases visceral nociception by inducing dysbiosis and that the FODMAP-al

170 factors that act on nearby nerves to augment nociception by producing neuronal sensitization or spont

171 response to tooth nociception and that this nociception can be measured for over a week.

172 The evidence that nociception can be regulated at the level of mRNA transl

173 hototransduction, smooth muscle contraction, nociception, cell proliferation and control of neuronal

174 ion; consequently, an interaction modulating nociception could exist between oxytocin and GABA at RAI

175 namely on perineural cells, and in line with nociception defects of the JAM-C SC KO animals, on finel

176 ence support the adaptive value of immediate nociception during injury, no direct evidence exists for

177 cessary for discrimination between touch and nociception emerge from 35-37 weeks gestation in the hum

178 V, a rare disease characterized by impaired nociception, even in apparently clinically silent hetero

179 splice variant ASIC1a has been implicated in nociception, fear memory, mood disorders and ischemia.

180 proton-gated cation channels associated with nociception, fear, depression, seizure, and neuronal deg

181 Despite the importance of nociception for survival, the in vivo significance of ex

182 , our results indicate a critical mechanical nociception function for heteromeric PPK and Balboa chan

183 nce abuse, emesis, inflammatory pain, spinal nociception, gastrointestinal function, and cardiovascul

184 , and how such varying effects may impact on nociception given the role of this channel in sensory ac

185 le of each subtype in modulating anxiety and nociception have been inconsistent.

186 ances in our understanding of the process of nociception have led to insight into gene-based pain the

187 et in nociceptors phenocopies the mechanical nociception impairment without causing defects in therma

188 ropathic pain but only slightly blocked anti-nociception in a naive tail-flick model, while enhancing

189 ncanonical signaling in spinal processing of nociception in a number of pathologic pain disorders.

190 new population of OT neurons that modulates nociception in a two tier process: (1) directly by relea

191 id agonist and NK1R antagonist in inhibiting nociception in an animal model of acute pain while lacki

192 th its ability to attenuate formalin induced nociception in an animal model of pain.

193 he tyraminergic/octopaminergic inhibition of nociception in C. elegans and the noradrenergic inhibiti

194 se results demonstrate that opiates modulate nociception in Caenorhabditis elegans through a complex

195 er development or maintenance of neuropathic nociception in either neuropathic pain model.

196 naling pathway regulates baseline mechanical nociception in flies and rats.SIGNIFICANCE STATEMENT Hyp

197 signaling pathway that regulates mechanical nociception in flies.

198 e and neuropeptide signaling acts to inhibit nociception in food-poor environments.

199 tion highlights the need to evaluate pain or nociception in IVD degeneration models to better underst

200 elegans and the noradrenergic inhibition of nociception in mammals that also involves inhibitory pep

201 y network to the noradrenergic inhibition of nociception in mammals, where norepinephrine suppresses

202 ed in controlling mechanical and temperature nociception in mice.

203 a2AARs using the tail flick assay of thermal nociception in mice.

204 excitability leads to augmented ocular cold nociception in mice.

205 hin the LH glutamatergic circuitry, modulate nociception in mice.

206 ition strongly blocked morphine-induced anti-nociception in models of post-surgical and HIV neuropath

207 lower nociceptor excitability and attenuate nociception in peripheral tissues.

208 2 (VEGFR-2) signaling attenuated mechanical nociception in rats, suggesting a conserved role for PDG

209 from TRPM8(+) cold-sensing neurons to signal nociception in response to cold.

210 n pathway and not associated with changes in nociception in the absence of injury or with changes in

211 nd to be concordant with previous studies of nociception in the anaesthetised rat brain, supporting t

212 l networks that directly influence meningeal nociception in the brainstem trigeminocervical complex (

213 molecular characteristics that differentiate nociception in the trigeminal system from that in the so

214 ar, facial or lingual injection, Lgmn evoked nociception in wild-type (WT) female mice but not in fem

215 6% acetic acid and the inflammatory phase of nociception induced by 2.5% formalin, indicating that th

216 With the exception of nociception induced by direct TRPA1 activation, we have

217 ver, the ruthenium complexes inhibited overt nociception induced by formalin, acetic acid, capsaicin,

218 could account for all of the changes in anti-nociception induced by Hsp90 inhibition.

219 nvolved in the biologic pathways relevant to nociception, inflammation, and mood.

220 s in ppk-positive cells, and that mechanical nociception is abolished in the absence of both channels

221 Nociception is an evolutionarily conserved mechanism to

222 Nociception is essential for survival whereas pathologic

223 provide novel support to the view that self-nociception is involved during empathy for pain, and dem

224 The current knowledge about heat nociception is mainly confined to the thermosensors, inc

225 Nociception is protective and prevents tissue damage but

226 sed that central sensitization associated to nociception (maladaptive plasticity) and plasticity rela

227 valuated, using thermal stimulation to evoke nociception, measuring changes in paw withdrawal latenci

228 tch) and additionally in a capsaicin-induced nociception model of pain without any confounding effect

229 tal gray (PAG) is a brain region involved in nociception modulation, and an important relay center fo

230 onism, serotonin and norepinephrine mediated nociception modulation, and N-methyl-D-aspartate recepto

231 the hot-plate test, a measure of supraspinal nociception, morphine antinociception was increased, and

232 Although capsaicin-induced nociception, neuropeptide release, and ionic currents ar

233 hypothesis that cryolipolysis can attenuate nociception of a range of sensory stimuli, including sti

234 psaicin, and has been extensively studied in nociception of sensory neurons.

235 TRPV1 receptors feature prominently in nociception of spinal primary afferents but are also exp

236 but is not essential for heat or mechanical nociception or hypersensitivity in the adult mouse.

237 ological processes that indirectly influence nociception, or alleviate pain arising from the overload

238 ry is not attributed to sensory deprivation, nociception, or generalized inflammatory responses.

239 ivated current (I(h)) has been implicated in nociception/pain, but its expression levels in nocicepto

240 TRP ion channels participate in nociception, presumably via Ca(2+) influx, in most anima

241 e was enhanced in the presence of persistent nociception, producing a phenomenon of analgesia-enhance

242 e shown that ischemic injury can induce both nociception-related behaviors and exacerbated EPRs in th

243 pr1 expression and increased sensitivity to nociception relative to sitters.

244 molecular mechanisms by which mTOR regulates nociception remain unclear.

245 but the site of action of MC4R signaling on nociception remains to be elucidated.

246 heteromers, and, consequently, their role in nociception remains unknown.

247 gle TrpA1 isoform in vivo and that polymodal nociception requires co-expression of TrpA1 isoforms, pr

248 and is functionally required for mechanical nociception responses.

249 f complex physiological functions, including nociception, reward processing, and motivation.

250 e a specific effect of the R100W mutation on nociception.SIGNIFICANCE STATEMENT The R100W mutation in

251 ved in forebrain circuits related to memory, nociception, social fear, and auditory sensory integrati

252 ed into four categories: those that modulate nociception, stabilize or unload painful structures, inf

253 TRPV1-microtubule interaction in transducing nociception stimuli to cells by cytoskeletal rearrangeme

254 of thermosensors only partially impairs heat nociception, suggesting the existence of undiscovered me

255 n diverse physiological processes, including nociception, synaptic plasticity, learning, and memory.

256 ivated by external protons and play roles in nociception, synaptic transmission, and the physiopathol

257 uate the effect of blocking TLR4 on visceral nociception, TAK-242, a selective TLR4 antagonist, was a

258 In a tail flick assay of nociception, TAL increased response latency by 65 and 70

259 Neuropathic pain is a form of pathological nociception that occurs in a significant portion of trau

260 Nociception, the sensory mechanism that allows animals t

261 from the brain, and is commonly a result of nociception; the physiological process initiated by acti

262 d cold sensitivity, but no change in thermal nociception threshold.

263 genetic inhibition of mechanical and thermal nociception thresholds.

264 EREG-mediated activation of EGFR enhanced nociception through a mechanism involving the PI3K/AKT/m

265 d producing supraspinal inhibition of spinal nociception through activation of serotonergic and norad

266 hannel (TRPA1), an ion channel that mediates nociception through calcium influx of sensory neurons.

267 esults indicate that feeding state modulates nociception through the interaction of monoamine and neu

268 ctly implicates LH(PV) neurons in modulating nociception, thus expanding the repertoire of survival b

269 ons in thermosensation, thermoregulation and nociception, thus significantly extending the concept of

270 hotostimulation of LH(PV) neurons suppresses nociception to an acute, noxious thermal stimulus, where

271 we develop a Drosophila model of mechanical nociception to investigate the ion channels and signalin

272 diverse physiological processes ranging from nociception to taste.

273 sential pathways for transmission of cardiac nociception to the central nervous system during myocard

274 sensitivity but not those mediating thermal nociception under naive conditions.

275 rons to downstream targets in the context of nociception, using novel transgenic lines, optogenetics,

276 suggest that maternal loss of Ube3a affects nociception via a central, but not peripheral mechanism,

277 indings indicate that S1P evokes significant nociception via G-protein-dependent activation of an exc

278 This reduction in nociception was comparable to an intra-TMJ injection of

279 Nociception was determined by electronic Von Frey test.

280 nd tumor necrosis factor alpha (TNFalpha) in nociception was evaluated through behavioral and enzyme-

281 voltage-gated sodium channel 1.7 (Nav1.7) in nociception was revealed by remarkable human clinical an

282 into the genetic and neural basis of thermal nociception, we developed assays that quantify noxious h

283 ing a refined Drosophila model of mechanical nociception, we discovered a conserved VEGF-related rece

284 the noradrenergic/peptidergic modulation of nociception, we examined the octopaminergic inhibition o

285 ion channel subunits required for mechanical nociception, we identify a gene that we name balboa (als

286 To directly test the importance of PIP(2) in nociception, we intrathecally injected PIP(2) into mice.

287 e monoarthritis as a condition of persistent nociception, we showed that analgesia induced by either

288 nderlying regional differences in processing nociception, we sparsely traced non-peptidergic nocicept

289 mulations, namely, proprioception, touch and nociception were delivered to the limb and the electrone

290 acterized, leading to a predominant focus on nociception when studying pain and developing interventi

291 ss the impact of GABA signalling on visceral nociception, where test compounds were applied directly

292 functional specificity; TrpA1-C mediates UVC-nociception, whereas TrpA1-D mediates heat-nociception.

293 utants display impaired responses to thermal nociception, which are rescued by restoring for expressi

294 teers to characterize perceptual learning in nociception, which has been rarely studied.

295 identify a similar region as fundamental to nociception, which suggests the dpIns is its human homol

296 SC) module produced robust, lateralised anti-nociception while activation of LC(:PFC) produced aversi

297 , but noradrenergic signalling promotes anti-nociception, with alpha(2)-adrenergic agonists used clin

298 The induction of sustained sensitivity and nociception without joint damage may explain the clinica

299 a critical role for scaffolding proteins in nociception, yet few studies have investigated scaffoldi

300 s ligand, lysophosphatidylinositol (LPI), in nociception, yet their role in central pain processing h