ライフサイエンスコーパス: nociceptive neuron

1 stinct underlying mechanisms within a single nociceptive neuron.

2 ptive terminal tree determines the output of nociceptive neurons.

3 , regions that contain functionally distinct nociceptive neurons.

4 tissues but has not been directly studied in nociceptive neurons.

5 ar milieu to control excitability of primary nociceptive neurons.

6 ly, many of these agents activate peripheral nociceptive neurons.

7 ion channels and is expressed in a subset of nociceptive neurons.

8 ceptor TRPV1, a key ion channel expressed in nociceptive neurons.

9 ) family of ion channels and is expressed in nociceptive neurons.

10 tory Gs-coupled opioid receptor signaling in nociceptive neurons.

11 ay enhance the signaling of primary afferent nociceptive neurons.

12 el, Na(v)1.7, which is strongly expressed in nociceptive neurons.

13 ting on the histamine H1 receptor in C-fiber nociceptive neurons.

14 eased in situ to activate TRPV1 receptors on nociceptive neurons.

15 heat germ agglutinin (WGA) to nonpeptidergic nociceptive neurons.

16 d vanilloid receptor 1, a marker for primary nociceptive neurons.

17 s are therefore hypothesized to be polymodal nociceptive neurons.

18 with significantly larger N-type currents in nociceptive neurons.

19 oxious heat and inflammatory hyperalgesia in nociceptive neurons.

20 be the principal heat-responsive channel for nociceptive neurons.

21 ct membrane properties of these two types of nociceptive neurons.

22 he TRPV1 ion channel and selectively ablates nociceptive neurons.

23 important cation channel present on primary nociceptive neurons.

24 nhancing the descending inhibition of spinal nociceptive neurons.

25 tenance of mature dorsal root ganglion (DRG) nociceptive neurons.

26 ction mechanisms in this particular class of nociceptive neurons.

27 gulation of opioid excitability functions in nociceptive neurons.

28 led an upregulation of Nav1.3 in dorsal horn nociceptive neurons.

29 the electroresponsive properties of primary nociceptive neurons.

30 during the falling phase, characteristic of nociceptive neurons.

31 actions on chemokine receptors expressed by nociceptive neurons.

32 e employed to rapidly and selectively delete nociceptive neurons.

33 expected degree of molecular diversity among nociceptive neurons.

34 d for the proper development of pain-sensing nociceptive neurons.

35 elopment of pain therapies targeted at these nociceptive neurons.

36 by substance P or serotonin, in contrast to nociceptive neurons.

37 l root ganglion (DRG) neurons, which include nociceptive neurons.

38 in the function of C. elegans olfactory and nociceptive neurons.

39 id (NMDA) excited nociceptive as well as non-nociceptive neurons.

40 enous FST increased neuronal excitability in nociceptive neurons.

41 (DRG), where these immune cells are close to nociceptive neurons.

42 uced sensory hypersensitivity by sensitizing nociceptive neurons.

43 us accumbens shell that is innervated by BLA nociceptive neurons.

44 cytes and causes sensitisation of peripheral nociceptive neurons.

45 a critical role in enhancing excitability of nociceptive neurons.

46 mediates activation of HCN2 ion channels in nociceptive neurons.

47 cessary for a subset of responses in the ASH nociceptive neurons.

48 ated neurite outgrowth and the activation of nociceptive neurons.

49 ubtype predominantly expressed in peripheral nociceptive neurons.

50 brainstem to drive feedforward inhibition of nociceptive neurons.

51 between cranial sensory neurons and the PBL-nociceptive neurons.

52 ted cation channel acting as key receptor in nociceptive neurons.

53 cts the input-output relation of the primary nociceptive neurons.

54 by action potential activity in a subset of nociceptive neurons.

55 r mechanisms underlying such interactions in nociceptive neurons.

56 eveal that balboa is also highly enriched in nociceptive neurons.

57 s-sensitization between AITC and acidosis in nociceptive neurons.

58 that Kv7.5 provides the primary M current in nociceptive neurons.

59 receptor expression in small non-peptidergic nociceptive neurones.

60 These included 10/21 C-fibre nociceptive neurones.

61 ificant), and was similar to that of A-fibre nociceptive neurones.

62 r, and what is their downstream mechanism on nociceptive neurons?

63 lar single unit recordings were made from 61 nociceptive neurons (23 NS, 38 WDR) in the superficial a

64 ns (23 NS, 38 WDR) in the superficial and 37 nociceptive neurons (3 NS, 34 WDR) in the deeper dorsal

65 edge of the molecular composition of KARs in nociceptive neurons, a key piece in understanding the me

66 We report a signaling pathway of SP in nociceptive neurons: Acting predominantly through NK1 re

67 larly in the enhanced excitability of spinal nociceptive neurons after repeated noxious inputs, are l

68 rMrgD with rMrgE, which occurs in peripheral nociceptive neurons, allowed coimmunoprecipitation of th

69 o fully recapitulate the complexity of human nociceptive neuron and dorsal horn neuron biology, signi

70 the nociceptive neurones, was not limited to nociceptive neurones and apart from receptive properties

71 ctly with TRPV1, an ion channel expressed in nociceptive neurones and brain.

72 ry neurotransmitter phenotype in dorsal horn nociceptive neurons and a resulting increase in inhibito

73 n pathway for protease-induced activation of nociceptive neurons and an important new target for anti

74 iator that transmits the signal from AT2R to nociceptive neurons and causes activation of HCN2 ion ch

75 ibits the enhancement of responses of spinal nociceptive neurons and changes in exploratory behavior

76 g the biology and electrophysiology of human nociceptive neurons and dorsal horn interneurons in noci

77 gulate the physiological properties of other nociceptive neurons and drive central sensitization.

78 sed preferentially in most slowly conducting nociceptive neurons and in sympathetic neurons.

79 nkyrin 1 (TRPA1) ion channel is expressed in nociceptive neurons and its activation causes ongoing pa

80 (Mtb)-specific lipid, SL-1, stimulates human nociceptive neurons and makes guinea pigs cough.

81 maintain hyperresponsiveness of spinal cord nociceptive neurons and pain-related behaviors.

82 N2 modulates action potential firing rate in nociceptive neurons and plays a critical role in all mod

83 els as novel physiological JNK substrates in nociceptive neurons and propose JNK-dependent phosphoryl

84 ales acute noxious mechanical sensitivity in nociceptive neurons and suppresses neuropathic pain tran

85 ce high-frequency action potential firing in nociceptive neurons and that resurgent currents associat

86 The function of Mrgprd in nociceptive neurons and the physiologically relevant som

87 of ecto-5'-nucleotidase (CD73) in trigeminal nociceptive neurons and their axonal fibers, including t

88 identities and spinal terminations of TrkA+ nociceptive neurons and TrkC+ proprioceptive neurons.

89 However, how TrkA regulates the function of nociceptive neurons and whether its activity levels may

90 Induction of OIH increased cAMP in nociceptive neurons, and a consequent shift in the activ

91 (Nav1) transmit pain signals from peripheral nociceptive neurons, and blockers of these channels have

92 R) superfamily, is expressed specifically in nociceptive neurons, and is implicated in the modulation

93 aV2.3 calcium channels are both expressed in nociceptive neurons, and mice lacking either protein dis

94 eration and altered the branching pattern of nociceptive neurons, and reduced thermal nociceptive res

95 V4) in Xenopus laevis oocytes, HEK cells and nociceptive neurons, and stimulated neuronal hyperexcita

96 onism suppressed PAR(2) signaling to primary nociceptive neurons, and TRPV4 deletion attenuated PAR(2

97 tability of L3-L5 dorsal horn multireceptive nociceptive neurons, and when pain-related behaviors wer

98 osomes precede morphological degeneration of nociceptive neuron arbors, which could be prevented by i

99 Piezo2 levels in nociceptive neurons are higher in female than in male mi

100 MDA receptors (NMDARs) in spinal dorsal horn nociceptive neurons are key regulators of pain processin

101 Spinal nociceptive neurons are well known to undergo a process

102 um channel Nav1.9 is expressed in peripheral nociceptive neurons, as well as visceral afferents, and

103 Ablation of the nociceptive neurons ASH and ADL transforms social animal

104 e transmembrane protein ODR-4, acting in the nociceptive neurons ASH and ADL.

105 m imaging show that tyra-2 expression in the nociceptive neuron, ASH, is necessary and sufficient to

106 as hyperresponsiveness in lumbar dorsal horn nociceptive neurons associated with the aberrant express

107 In nociceptive neurons, Balboa::GFP proteins distribute uni

108 aled upregulation of Na(v)1.3 in dorsal horn nociceptive neurons but not in astrocytes or microglia,

109 by changes in the excitability of peripheral nociceptive neurons, but the precise mechanisms controll

110 lgesic lipid-derived mediators, which excite nociceptive neurons by activating selective G-protein-co

111 zed of these is the sensitization of primary nociceptive neurons by arachidonic acid metabolites such

112 o evidence for direct activation of isolated nociceptive neurons by AT2R agonists.

113 nhances Nav1.7-mediated hyperexcitability of nociceptive neurons by binding to IGF1R, making it a pot

114 ectly inhibit peripheral capsaicin-sensitive nociceptive neurons by dephosphorylating and desensitizi

115 modulation of presynaptic TRPV1 channels in nociceptive neurons by descending noradrenergic inputs m

116 PD-1 activation in DRG nociceptive neurons by PD-L1 induced phosphorylation of

117 review how non-neuronal cells interact with nociceptive neurons by secreting neuroactive signaling m

118 rkably, the sensing of protease allergens by nociceptive neurons can represent a primary step in the

119 G protein-coupled receptors of nociceptive neurons can sensitize transient receptor pot

120 Consistently, ablation of nociceptive neurons decreased the number of osteoclasts

121 show that the input-output properties of the nociceptive neurons depend on the length, the axial resi

122 In addition, nociceptive neurons did not exhibit windup in the SP-SAP

123 (e.g., lipopolysaccharides) activate primary nociceptive neurons directly through Toll-like receptors

124 ly challenged by studies showing that spinal nociceptive neurons do not target CeA-projecting PBN cel

125 rotrophin family, is crucial for survival of nociceptive neurons during development.

126 and its activator, p35, are up-regulated in nociceptive neurons during peripheral inflammation.

127 Previous studies identified atrophy in nociceptive neurons during SIV infection, which was asso

128 Our findings help to predict how nociceptive neurons encode noxious stimuli and how this

129 PD-L1 also potently suppressed nociceptive neuron excitability in human DRGs.

130 Our data highlight that sensory nociceptive neurons exert a significant host protective

131 Nociceptive neurons express a unique set of ion channels

132 dy, we tested the hypothesis that trigeminal nociceptive neurons express the TLR4 or CD14 receptors,

133 Most nociceptive neurons express the vanilloid receptor, TRPV

134 ed cytotoxicity and the specific deletion of nociceptive neurons expressing the wild-type vanilloid r

135 nables reversible optical silencing of mouse nociceptive neuron firing without exogenous gene express

136 al, functional and molecular similarities to nociceptive neurons from more complex organisms and can

137 epetitive action potential firing in primary nociceptive neurons from mouse dorsal root ganglia and a

138 is phenomenon may allow new insight into how nociceptive neuron function in response to a variety of

139 In small nociceptive neurons, genetic deletion of HCN2 abolished

140 eceptive (LTM) neurons showed Nav1.8-LI, and nociceptive neurons had significantly more intense immun

141 Nociceptive neurons have also been reported in the vicin

142 alleviated neuropathic pain and reduced the nociceptive neuron hyperexcitability induced by SNL.

143 RG neurons, a process that may contribute to nociceptive neuron hyperexcitability, which is associate

144 nels regulate action potential generation in nociceptive neurons, identifying them as putative analge

145 f-avoidance of sister dendrites from the PVD nociceptive neuron in Caenorhabditis elegans.

146 he firing of two important classes of spinal nociceptive neurons in a rat model of OA.

147 - and C-fiber-evoked responses of trigeminal nociceptive neurons in anesthetized rats.

148 uncated rod-like unbranched cilia of the ASH nociceptive neurons in animals carrying a microtubule-de

149 1), has been shown to be highly expressed by nociceptive neurons in dorsal root and trigeminal gangli

150 as located on peptidergic and nonpeptidergic nociceptive neurons in dorsal root ganglia (DRG) and on

151 P3 receptor at these sites did not sensitize nociceptive neurons in healthy animals.

152 tly related to functional distinctions among nociceptive neurons in maturity.

153 Selective targeting of sensory or nociceptive neurons in peripheral nerves remains a clini

154 Gly potently inhibited heat-evoked firing of nociceptive neurons in rat dorsal horn.

155 pid GM1 ganglioside plays a critical role in nociceptive neurons in regulating opioid receptor excita

156 ntaneous activities and hyperexcitability of nociceptive neurons in the adjacent uninjured L4 dorsal

157 ral responses, we chemogenetically activated nociceptive neurons in the amygdala, which further separ

158 late the HSC niche(3-6), the contribution of nociceptive neurons in the bone marrow remains unclear.

159 Recordings were made from 29 nociceptive neurons in the C2 dorsal horn of the rat tha

160 Pirt is expressed in most nociceptive neurons in the dorsal root ganglia (DRG) inc

161 NMDA-evoked responses of nociceptive and non-nociceptive neurons in the medullary dorsal horn.

162 Nociceptive neurons in the peripheral nervous system det

163 exclusively, expressed in smaller trigeminal nociceptive neurons in the rat.

164 dependent and modulates pain through the pro-nociceptive neurons in the rostral ventromedial medulla

165 tion of MOG results in aberrant sprouting of nociceptive neurons in the spinal cord.

166 ular changes that sensitize the responses of nociceptive neurons in the spinal dorsal horn.

167 entral branches of meningeal nociceptors and nociceptive neurons in the spinal trigeminal nucleus can

168 the A delta- and C-fiber-evoked responses of nociceptive neurons in the superficial and deeper dorsal

169 the A delta- and C-fiber-evoked responses of nociceptive neurons in the superficial and deeper dorsal

170 Chemical ablation of nociceptive neurons in the trigeminal ganglia achieved b

171 These signals are relayed by nociceptive neurons in the trigeminal ganglion, a struct

172 dan-1,5-dicarboxylic acid), were examined on nociceptive neurons in the ventroposterolateral (VPL) nu

173 s of the cannabinoid agonist WIN 55,212-2 on nociceptive neurons in the ventroposterolateral (VPL) nu

174 ed receptor 2 was expressed by virtually all nociceptive neurons in thoracic dorsal root ganglia.

175 e show that an Mtb organic extract activates nociceptive neurons in vitro and identify the Mtb glycol

176 ration prevented some CFA-induced changes in nociceptive neurons including: the increased fiber follo

177 itatory postsynaptic currents in spinal cord nociceptive neurons, increased CGRP release from sciatic

178 o show that Piezo2 conditional deletion from nociceptive neurons increases body weight growth, slows

179 ough which reactive prostanoids may activate nociceptive neurons independent of prostaglandin recepto

180 to more fully understand how the activity in nociceptive neurons individually and collectively is rel

181 Here we show that activation of nociceptive neurons induces shedding of L-selectin from

182 In nociceptive neurons, inhibition tended to be maximal at

183 Nociceptive neurons innervate the skin with complex dend

184 small subpopulations of pruriceptive and/or nociceptive neurons innervating the cheek project to tha

185 The cough reflex can be triggered by nociceptive neurons innervating the lungs, and some bact

186 Pulpitis and osteitis affected the nociceptive neurons innervating the orofacial region by

187 was observed in a subpopulation of putative nociceptive neurons innervating the site of inflammation

188 ecision required for chemotaxis, whereas ASH nociceptive neurons integrate noxious cues over several

189 multiple terminals; thus, the output of the nociceptive neuron is defined by the integration and com

190 lation of TRPV1 channels by noradrenaline in nociceptive neurons is a mechanism whereby noradrenaline

191 ain, crosstalk between the immune system and nociceptive neurons is central to inflammatory pain; the

192 s PKD, and the expression of PKD isoforms by nociceptive neurons is poorly characterized.

193 which is constitutively expressed by primary nociceptive neurons, is the link between peripheral infl

194 n et al. report that activation of cutaneous nociceptive neurons leads to a nerve-reflex action that

195 or contributions to the hyperexcitability of nociceptive neurons, likely leading to altered sensory p

196 m synaptic connections with the second-order nociceptive neurons located in the dorsal horn of the sp

197 rated transduction of cells positive for the nociceptive neuron marker vanilloid receptor subtype 1,

198 X in the regulation of [Ca(2+)]i in putative nociceptive neurons may be unique relative to other cell

199 modulation of TRPV1 channels by dopamine in nociceptive neurons may represent a way for dopamine to

200 eport provides a genetic analysis of primary nociceptive neuron mechanisms that promote sensitization

201 These results suggest that Piezo2 in nociceptive neurons mediates innocuous colonic mechanose

202 In the nociceptive neurons, ODR-3 may interact with OSM-9, a ch

203 is specifically expressed in small-diameter, nociceptive neurons of dorsal root ganglia (DRGs) and is

204 potential cation channel V1 expressed in the nociceptive neurons of dorsal root ganglion (DRG).

205 tic deletion of HCN2 ion channels in primary nociceptive neurons of male mice completely abolished OI

206 In HEK and KNRK cell lines and in nociceptive neurons of mouse dorsal root ganglia, Cat-S

207 lso known as the vanilloid receptor, VR1) in nociceptive neurons of the dorsal root and trigeminal ga

208 known as NaN) is preferentially expressed in nociceptive neurons of the dorsal root ganglia (DRG) and

209 potential ankyrin 1 (TRPA1) is expressed by nociceptive neurons of the dorsal root ganglia (DRGs) an

210 Although TRPV1 receptors are mainly found in nociceptive neurons of the peripheral nervous system, th

211 Here, we describe how nociceptive neurons of the spinal cord and thalamus proc

212 ivated ionophore preferentially expressed in nociceptive neurons of trigeminal and dorsal root gangli

213 The peripheral terminals of primary nociceptive neurons play an essential role in pain detec

214 ated sodium channel, expressed in peripheral nociceptive neurons, plays a role in transmitting nocice

215 opposing sensory inputs: aversive inputs to nociceptive neurons promote social feeding, whereas anta

216 Comparisons of data from nociceptive neurones recorded in CFA treated animals aft

217 signal kinase (ERK) signaling in spinal cord nociceptive neurons, reduces Nav1.7 surface expression a

218 physical properties of NMDARs in dorsal horn nociceptive neurons remain poorly understood.

219 arization drives sensitization of peripheral nociceptive neurons remains elusive.

220 ion of the presynaptic terminals of adjacent nociceptive neurons requires different levels of Trim9,

221 the differentiation and survival of sensory nociceptive neurons, requires Brn3a to maintain normal t

222 d predominantly in sensory neurons including nociceptive neurons responding to protons.

223 Defects in form3 function in nociceptive neurons result in severe impairment of noxio

224 dependent spike initiation zone (Nav-SIZ) in nociceptive neurons, showing its plasticity under inflam

225 Selective ablation of nociceptive neurons significantly increased bacterial bu

226 specifically in the Class IV multidendritic nociceptive neuron, significantly attenuated ultraviolet

227 i peppers that can trigger the activation of nociceptive neurons-significantly enhanced HSC mobilizat

228 The skin is densely innervated with nociceptive neurons specialized in detecting noxious and

229 We further found that nociceptive neuron-specific overexpression of integrins,

230 ve response, and that multidendritic sensory nociceptive neurons synapse onto pr1 neurons in the VNC.

231 al nociception by describing a population of nociceptive neurones that receive convergent input from

232 Sensory nociceptive neurons that can detect bacterial pathogens

233 show here that social feeding is induced by nociceptive neurons that detect adverse or stressful con

234 dorsal root ganglia (DRG) neurons, including nociceptive neurons that expressed TRPV1, PAR(2), and ne

235 sensitization of trigeminal primary afferent nociceptive neurons that innervate the cranial meninges.

236 this cascade in mechanical sensitization of nociceptive neurons that innervate the meninges, a proce

237 tained protease signaling to colonocytes and nociceptive neurons that naturally express PAR2 and medi

238 The neuronal loss is restricted to nociceptive neurons that normally depend on TrkA for neu

239 b extract, but not SL-1, also stimulates non-nociceptive neurons that participate in the cough reflex

240 identify a subpopulation of nonpeptidergic, nociceptive neurons that project exclusively to the skin

241 vous system senses peripheral damage through nociceptive neurons that transmit a pain signal.

242 hyperexcitability and spontaneous firing of nociceptive neurons that underlie pain.

243 n modulate the activity of TRPV1 channels in nociceptive neurons, the effects of dopamine and dopamin

244 sensory transmission in nociceptive and non-nociceptive neurons, thereby contributing to radicular p

245 d and released by peripheral damage-sensing (nociceptive) neurons; these neurons also express SP rece

246 G) E(2) and D(2), respectively, would excite nociceptive neurons through direct activation of TRPA1.

247 tering the sensitivity and/or selectivity of nociceptive neurons to aversive stimuli.

248 i.v.) it did not alter the responses of non-nociceptive neurons to brush stimulation.

249 ansient receptor potential (TRP) channels of nociceptive neurons to induce neurogenic inflammation an

250 asting increases in the responses of central nociceptive neurons to innocuous and noxious stimuli.

251 The responsiveness of spinal cord nociceptive neurons to innocuous mechanical stimuli can

252 argets the OCTR-1 octopamine receptor on ASH nociceptive neurons to modulate an aversive olfactory re

253 d reduced responses of peripheral and spinal nociceptive neurons to noxious stimuli but only when the

254 t that ubiquitination is a mechanism used in nociceptive neurons to regulate TrkA level and function.

255 functional complexes that allow craniofacial nociceptive neurons to respond synergistically to altere

256 its acute pain and alters the sensitivity of nociceptive neurons to subsequent stimuli.

257 somes, convey NGF signals from the target of nociceptive neurons to their cell bodies.

258 actor (NGF) is a neurotrophin that activates nociceptive neurons to transmit pain signals from the pe

259 athic pain models, dorsal root ganglia (DRG) nociceptive neurons transfer miR-21 packaged in extracel

260 Results suggest that nociceptive neurons use the BMP2/4 ligand, along with id

261 st time investigated TRESK function in human nociceptive neurons using induced pluripotent stem cell-

262 ide (iCGRP) release from capsaicin-sensitive nociceptive neurons via in vitro superfusion of bovine d

263 ediator in this condition, can also activate nociceptive neurons via the proteinase-activated recepto

264 TRPV1, a PGE2-regulated channel in nociceptive neurons was also increased in the DRG.

265 ending inhibitory mechanism acting on spinal nociceptive neurons was obtained by monitoring noxious s

266 RP expression was detected in under half the nociceptive neurones, was not limited to nociceptive neu

267 ether SFL is caused by spontaneous firing in nociceptive neurons, we studied the following groups of

268 th nasal or labial receptive fields, whereas nociceptive neurons were found in the adjacent portions

269 matic action potential (AP) configuration in nociceptive neurons were incomplete 24 hr after CFA.

270 Drosophila melanogaster larvae whose primary nociceptive neurons were reduced in levels of specific c

271 m clusters of selectively thermoreceptive or nociceptive neurons were used to guide precise microinje

272 TRPA1 channels are expressed in nociceptive neurons, where they detect noxious stimuli,

273 ate immune response, is regulated by primary nociceptive neurons, which are generally considered to h

274 are detected by terminal endings of primary nociceptive neurons, which are organized into morphologi

275 put from the peripheral terminals of primary nociceptive neurons, which detect and encode the informa

276 expression of Cdk5 and its activator p35 in nociceptive neurons, which is modulated during a periphe

277 Alkaline pH evokes an inward current in nociceptive neurons, which is primarily mediated by TMC-

278 Inhibition or removal of certain nociceptive neurons, while retaining all other sensory m

279 There was a tendency for nociceptive neurones with slower CVs and/or smaller cell

280 be attributed to a sensitization of central nociceptive neurons with an increased excitability to af

281 e, type C low-threshold mechanosensitive and nociceptive neurons with markedly different molecular an