ライフサイエンスコーパス: nodes of Ranvier

1 tween three and ten myelinated segments (2-9 nodes of Ranvier).

2 yelin sheath and clustered Na(+) channels at nodes of Ranvier.

3 e also displayed severe abnormalities at the nodes of Ranvier.

4 source(s) and targeting of components to PNS nodes of Ranvier.

5 n comparison to the extensive injury seen at nodes of Ranvier.

6 pitalized" on this property and clustered at nodes of Ranvier.

7 that play a crucial role in the formation of nodes of Ranvier.

8 motif is sufficient for protein targeting to nodes of Ranvier.

9 n vertebrates are differentially targeted to nodes of Ranvier.

10 for the myelination and organization of the nodes of Ranvier.

11 at the edges of each myelin segment to form nodes of Ranvier.

12 d loss of Nfasc186 from the AIS but not from nodes of Ranvier.

13 ion and altered distribution of ezrin in the nodes of Ranvier.

14 ence of endogenous and exogenous NG2 at some nodes of Ranvier.

15 ient in the clustering of neurofascin at the nodes of Ranvier.

16 ons, restricting its activity to the AIS and nodes of Ranvier.

17 local acceleration of neurofilaments within nodes of Ranvier.

18 tected in its usual site of concentration at nodes of Ranvier.

19 ntration of voltage-gated sodium channels at nodes of Ranvier.

20 hed adjacent to paranodal loops of myelin in nodes of Ranvier.

21 channels at axon initial segments (AIS) and nodes of Ranvier.

22 yelin instability and disorganization of the nodes of Ranvier.

23 membrane protein diffusion barriers flanking nodes of Ranvier.

24 known about the mechanisms that organize the nodes of Ranvier.

25 ge-gated potassium channels (K(v)1.1) at the nodes of Ranvier.

26 s at specialized regions of the axon, termed nodes of Ranvier.

27 appropriate signaling for the maturation of nodes of Ranvier.

28 n localization of sodium channel proteins at nodes of Ranvier.

29 elinated bipolar cell body and at subsequent nodes of Ranvier.

30 nt endings, ganglionic initial segments, and nodes of Ranvier.

31 axons that have internodes and well-defined nodes of Ranvier.

32 ll (SC) differentiation and formation of the nodes of Ranvier.

33 normally occur only at initial segments and nodes of Ranvier.

34 ries of polarized domains that center around nodes of Ranvier.

35 tion potentials are thought to arise, and at nodes of Ranvier.

36 ay contribute to sodium channel placement at nodes of Ranvier.

37 Myelinated axons are constricted at nodes of Ranvier.

38 concentration of sodium channel complexes at nodes of Ranvier.

39 is the main sodium channel isoform at adult nodes of Ranvier.

40 n some but not all basal laminae, and (3) at nodes of Ranvier.

41 shed NG2, which subsequently associates with nodes of Ranvier.

42 y play a role in sodium channel placement at nodes of Ranvier.

43 ation of paranodal axoglial junctions at the nodes of Ranvier.

44 ule that plays a key role in the assembly of nodes of Ranvier.

45 associated with Caspr, is present in central nodes of Ranvier.

46 l-adhesion molecules at initial segments and nodes of Ranvier.

47 n(G) 480/270-kD at axon initial segments and nodes of Ranvier.

48 ck appears directed against the axolemma and nodes of Ranvier.

49 l and 79% of disease-associated IgM positive nodes of Ranvier.

50 immunoreactivity was absent at newly forming nodes of Ranvier.

51 mains at axon proximal segments and possibly nodes of Ranvier.

52 analysis of glial cell insertions at central nodes of Ranvier.

53 plasmamembrane of axon initial segments and nodes of Ranvier.

54 o regularly spaced gaps in the myelin called nodes of Ranvier.

55 of ankyrinG and O-GlcNAc immunoreactivity at nodes of Ranvier.

56 paranodal axon-glia junctions that flank the nodes of Ranvier.

57 ominant VGSC in the axon initial segment and nodes of Ranvier.

58 ting neuronal excitability at and around the nodes of Ranvier.

59 ths retract, which results in lengthening of nodes of Ranvier.

60 protein present in axon initial segments and nodes of Ranvier.

61 teins that are collectively required to form nodes of Ranvier.

62 nnel clustering at axon initial segments and nodes of Ranvier.

63 neurite growth, and shortened the length of nodes of Ranvier.

64 s such as the axon initial segment (AIS) and nodes of Ranvier.

65 m channel that was recently localized to the nodes of Ranvier.

66 correct spatial and temporal assembly of PNS nodes of Ranvier.

67 tients presenting IgG reactivity against the nodes of Ranvier.

68 lustering at axon initial segments (AIS) and nodes of Ranvier.

69 discrete subcellular locations, such as the nodes of Ranvier.

70 concentrated in the axon initial segment and nodes of Ranvier.

71 n be remyelinated and reassemble new AIS and nodes of Ranvier.

72 lustering at axon initial segments (AIS) and nodes of Ranvier.

73 ansiently elevates axoplasmic [C(2+)] around nodes of Ranvier.

74 ustering of voltage-gated sodium channels at nodes of Ranvier.

75 enriched at axon initial segments (AIS) and nodes of Ranvier.

76 n requires accumulation of Na(+) channels at nodes of Ranvier.

77 concentration of those channels at AISs and nodes of Ranvier.

78 l nerves, important for the formation of the nodes of Ranvier.

79 r strategies but different molecules to form nodes of Ranvier.

80 elin thickness, and molecular disruptions at nodes of Ranvier.

81 did not wrap axons tightly and had expanded nodes of Ranvier.

82 velocity by influencing the spacing between nodes of Ranvier.

83 e long-term maintenance of Na(+) channels at nodes of Ranvier.

84 ansport before anchoring them to the AIS and nodes of Ranvier.

85 ) channels in the axonal initial segment and nodes of Ranvier.

86 yelinated axons to cluster Na(+) channels at nodes of Ranvier.

87 nerates a substantial fraction of APs in its nodes of Ranvier.

88 d axons requires Na(+) channel clustering at nodes of Ranvier.

89 chwann cells with high concentrations at the nodes of Ranvier.

90 myelin sheath from Na(+) channels located at nodes of Ranvier.

91 Enrichment of sodium channels at nodes of Ranvier, a hallmark of myelinated axons, underl

92 d axons, the myelinated compartments between nodes of Ranvier act as a "reservoir" to slow Na(+) accu

93 embly of the AIS and normal morphogenesis of nodes of Ranvier all require a heretofore uncharacterize

94 Na(v)1.6 is heavily expressed at the nodes of Ranvier along adult CNS and PNS axons and along

95 fibres and associated changes in diameter of nodes of ranvier along an axon.

96 onstrate that betaIV spectrin recruitment to nodes of Ranvier also depends on binding to ankG.

97 However, axon diameter and distances between Nodes of Ranvier also influence signal propagation times

98 ealed submembranous localization of Ank-G at nodes of Ranvier and AIS.

99 e - the perinodal ECM - surrounds the axonal nodes of Ranvier and appears as myelination is completed

100 nkyrinGs of 270 and 480 kDa are localized at nodes of Ranvier and are candidates to couple the voltag

101 found to be coexpressed with neurofascin at nodes of Ranvier and at axon initial segments.

102 These domains include nodes of Ranvier and axon initial segments.

103 other functional domains of axons (e.g. the nodes of Ranvier and axon terminals) whose development d

104 ompact myelin around host axons and restored nodes of Ranvier and conduction velocity as efficiently

105 d to be present within the axolemma at early nodes of Ranvier and deleterious mutations of the alpha(

106 can diffuse into a desheathed nerve, bind to nodes of Ranvier and fix complement in vitro without res

107 calize with SMIT1 and SMIT2 at sciatic nerve nodes of Ranvier and in axon initial segments, and form

108 play a crucial role in the formation of the nodes of Ranvier and in the rapid propagation of the ner

109 ted Na(+) and K(+) channels are clustered at nodes of Ranvier and mediate the transmembrane currents

110 rt of fluorescently tagged components of the nodes of Ranvier and other myelinated axonal domains in

111 tes in vivo, and progressive accumulation at nodes of Ranvier and paranodes during postnatal mouse de

112 at paranodes and incisures of control mice, nodes of Ranvier and paranodes were unaffected in Pals1-

113 oskeleton with betaIV and betaII spectrin at nodes of Ranvier and paranodes, respectively, but that l

114 the lateral organization of proteins at the nodes of Ranvier and pave the way for deeper investigati

115 re interposed between sodium channels at the nodes of Ranvier and potassium channels in the juxtapara

116 KChs at the initial segment, and near/within nodes of Ranvier and presynaptic terminals, dendritic KC

117 ellular matrix (ECM) protein surrounding CNS nodes of Ranvier and proposed to function as (1) an inhi

118 The paranodal junctions flank mature nodes of Ranvier and provide a barrier between ion chann

119 by structural and biochemical alterations at nodes of Ranvier and reduced somatosensory-evoked potent

120 These patterns highlight nodes of Ranvier and Schmidt-Lanterman incisures and can

121 and TfR1 are predominantly localized at the nodes of Ranvier and Schmidt-Lanterman incisures, axonal

122 own, but their processes are in contact with nodes of Ranvier and synapses, suggesting a regulatory r

123 ent for the clustering of sodium channels at nodes of Ranvier and the AIS.

124 At the nodes of Ranvier and the axon hillocks of central neuron

125 7.2 or Kv7.3, which are instead localized to nodes of Ranvier and the cell bodies of large sensory ne

126 These domains include the nodes of Ranvier and the flanking paranodal regions wher

127 t supports the development and maturation of nodes of Ranvier and the restoration of impulse conducti

128 ing architectural rearrangements such as the nodes of Ranvier and their associated molecular domains.

129 chemistry, we show that AOE elongates the AN nodes of Ranvier and triggers notable perinodal morpholo

130 AnkG is required for assembly of the AIS and nodes of Ranvier and was a transformative innovation in

131 , are involved in axo-glial communication at nodes of Ranvier, and are required for normal action pot

132 set of neurons, a ring-like structure at the nodes of Ranvier, and diffuse staining in the interstiti

133 ochondria at Schmidt-Lanterman incisures and nodes of Ranvier, and impaired sciatic nerve regeneratio

134 protein concentrated in myelinated fibers at nodes of Ranvier, and NF155, the oligodendrocyte-specifi

135 l protein ankyrinG at axon initial segments, nodes of Ranvier, and postsynaptic folds of the mammalia

136 a+ channels are clustered at high density at nodes of Ranvier, and Shaker-type K+ channels are seques

137 The axon initial segment (AIS), nodes of Ranvier, and the oligodendrocyte-derived myelin

138 contrast, we observed minimal AGAb uptake at nodes of Ranvier, and this structure thus remained vulne

139 e overlapping mechanisms, to explain how the nodes of Ranvier are assembled in both the peripheral an

140 Clustered ion channels at nodes of Ranvier are critical for fast action potential

141 of PNS and CNS nodes.SIGNIFICANCE STATEMENT Nodes of Ranvier are essential for effective saltatory c

142 voltage-gated ion channel clustering at the nodes of Ranvier are essential for the rapid saltatory c

143 The nodes of Ranvier are essential regions for action potent

144 Nodes of Ranvier are excitable regions of axonal membran

145 y as postnatal day 5, during the period that nodes of Ranvier are forming.

146 Axonal initial segments (IS) and nodes of Ranvier are functionally important membrane sub

147 Nodes of Ranvier are regularly placed, nonmyelinated axo

148 channels at axon initial segments (AISs) and nodes of Ranvier are required for initiation, propagatio

149 Axon initial segments (AISs) and nodes of Ranvier are sites of action potential generatio

150 Axon initial segments (AISs) and nodes of Ranvier are sites of clustering of voltage-gate

151 Nodes of Ranvier are specialized, highly polarized axona

152 time-dependent manner.SIGNIFICANCE STATEMENT Nodes of Ranvier are the myelin-free gaps along myelinat

153 The axon initial segment (AIS) and nodes of Ranvier are the sites of action potential initi

154 .1B is implicated in the organization of the nodes of Ranvier as a linker between paranodal and juxta

155 pha-subunits in the juxtaparanodal region of nodes of Ranvier as well as in the axons and terminals o

156 g protein of the extracellular matrix at the nodes of Ranvier, as an age-dependent aggregating protei

157 al dendritic tree-like arbors with excitable nodes of Ranvier at peripheral and branching nodes and e

158 are localized to the paranodal region of the nodes of Ranvier, between axons and Schwann cells.

159 not affect sodium channel clustering at the nodes of Ranvier but alters the location of the Shaker-t

160 c nerve from WAVE1-/- mice, there were fewer nodes of Ranvier but nodal morphology was normal, implic

161 ssed first and becomes clustered at immature nodes of Ranvier, but as myelination proceeds, Na(v)1.6

162 the mobile population do not accumulate near Nodes of Ranvier, but continue to travel anterogradely.

163 as associated with the presence of malformed nodes of Ranvier characterized by an accumulation of axo

164 onal components of axon initial segments and nodes of Ranvier, colocalizing with ankyrin-G and voltag

165 ight be helpful for high-frequency firing at nodes of Ranvier compared to Nav1.2.

166 We speculate on why nodes of Ranvier contain a mechanosensitive K(+) channel

167 zed to cochlear nerve fibers, near the first nodes of Ranvier (D2) and in the inner spiral bundle reg

168 -spectrin, Nav1.6, and the Kv7.3 channels in nodes of Ranvier either dissolved or extended into the p

169 The evolution of ion channel clustering at nodes of Ranvier enabled the development of complex vert

170 nd paranodal junctional components, immature nodes of Ranvier form normally, but rapidly destabilize

171 ation of contactin and Na(+) channels at new nodes of Ranvier forming during remyelination.

172 ease in IgM (immunoglobulin M) deposition at nodes of Ranvier from 5.3+/-3.1% to 28.7+/-8.4% (mean+/-

173 s, i.e., continuous myelinated axons between nodes of Ranvier, from Xenopus laevis sciatic nerves and

174 The nodes of Ranvier have clustered Na(+) and K(+) channels

175 rning and segregation of ion channels at the nodes of Ranvier have not been elucidated.

176 rlie and are associated closely with nascent nodes of Ranvier, identified by clusters of ankyrin G.

177 formation disrupts the targeting of beta2 to nodes of Ranvier in a myelinating co-culture system and

178 ng of voltage-gated sodium channels (Nav) at nodes of Ranvier in a nodal complex.

179 at the distal axon initial segment (AIS) and nodes of Ranvier in a ratio of approximately 40 to 1.

180 re broad and may include dysfunctions at the nodes of Ranvier in a subgroup of patients.

181 soforms, Nav 1.6 is selectively expressed at nodes of Ranvier in both the CNS and the PNS.

182 linated axons in MS, with Nav1.6 confined to nodes of Ranvier in controls but with diffuse distributi

183 fluxes, Na pumps, mitochondrial motility) at nodes of Ranvier in frog during normal nerve activity.

184 oked PAD is produced by GABA(A) receptors at nodes of Ranvier in Ia afferents, rather than at presyna

185 Here we show both in vivo and ex vivo, that nodes of Ranvier in intramuscular motor nerve bundles ar

186 (Na(+)) channels are highly concentrated at nodes of Ranvier in myelinated axons and play a key role

187 av1.6 is the major sodium channel isoform at nodes of Ranvier in myelinated axons and, additionally,

188 cities are sensitive to the distance between nodes of Ranvier in myelinated axons have implications f

189 at high density in axon initial segments and nodes of Ranvier in myelinated axons.

190 inated axons, but are highly concentrated at nodes of Ranvier in myelinated axons.

191 in-actin network found at axonal segments of nodes of Ranvier in myelinated axons.

192 Axoglial junctions flank the nodes of Ranvier in myelinated nerves.

193 6, clusters voltage-gated sodium channels at nodes of Ranvier in myelinated nerves: here, we investig

194 -pore domain K(+) (K2P) channel localized to nodes of Ranvier in myelinated neurons.

195 rons and colocalizes with Na(v)1.6 at mature nodes of Ranvier in myelinated sensory fibers in the dor

196 dapter proteins to axon initial segments and nodes of Ranvier in neurons, and betaIV-spectrin dysfunc

197 axons and more myelinated axons with intact nodes of Ranvier in oestrogen receptor beta ligand-treat

198 In this study, developmental analysis of nodes of Ranvier in optic nerve axons reveals that early

199 (NF) and Nr-CAM are localized at developing nodes of Ranvier in peripheral myelinated axons prior to

200 Nodes of Ranvier in peripheral nerve and in the spinal c

201 m and potassium (Kv1.1, 1.5) channels at the nodes of Ranvier in peripheral nerves from human, rat an

202 opment and/or maintenance of myelination and nodes of Ranvier in sciatic nerve.

203 dium currents that have been reported at the nodes of Ranvier in sensory versus motor axons.

204 Nodes of Ranvier in the axons of myelinated neurons are

205 The absence of FHFs from Navs at nodes of Ranvier in the central nervous system suggests

206 The mechanisms of channel localization at nodes of Ranvier in the CNS during development in both n

207 Here, we show that the assembly of nodes of Ranvier in the CNS involves three mechanisms: a

208 onstrate that Kv3.1b subunits are present at nodes of Ranvier in the CNS of both rats and mice.

209 OLs that express myelin proteins and reform nodes of Ranvier in the context of chronic demyelination

210 Na(+) channel clustering at nodes of Ranvier in the developing rat optic nerve was a

211 ctly influences Na(+) channel distributions, nodes of Ranvier in the hypomyelinating mouse Shiverer w

212 Nerve impulses are propagated at nodes of Ranvier in the myelinated nerves of vertebrates

213 Changes to the structure of nodes of Ranvier in the normal-appearing white matter (N

214 ciation of NG2 cells and astrocytes with the nodes of Ranvier in the optic nerve, corpus callosum, an

215 we examined the development of heminodes and nodes of Ranvier in the peripheral axons of type I ANFs

216 These results demonstrate that nodes of Ranvier in the peripheral nervous system form i

217 aracterized by high-frequency firing, and at nodes of Ranvier in the PNS and some nodes in the CNS.

218 wise, betaIV spectrin is concentrated at the nodes of Ranvier in the rat sciatic nerve.

219 lination and that the number and location of nodes of Ranvier in the sciatic nerve are determined by

220 ptic vesicle fusion, in the formation of the nodes of Ranvier in the vertebrate nervous system.

221 Sixty-two percent of all nodes of Ranvier in this region were flanked by at least

222 ccount for the low level of Na(v)1.6-S21P at nodes of Ranvier in vivo and at the surface of transfect

223 Although NG2(+) cells form associations with nodes of Ranvier in white matter, measurements of conduc

224 annel subtypes are sequentially expressed at nodes of Ranvier, indicating an unexpected regulation in

225 Clustering of Na(+) channels at the nodes of Ranvier is coordinated by myelinating glia.

226 annels at the axon initial segment (AIS) and nodes of Ranvier is essential for the initiation and pro

227 mbrane barrier important for assembly of the nodes of Ranvier is found at the paranodal junction.

228 The assembly of myelinated fibres and nodes of Ranvier is mediated by a number of cell adhesio

229 A high density of Na(+) channels at nodes of Ranvier is necessary for rapid and efficient ac

230 of voltage-gated sodium (Na(v)) channels at nodes of Ranvier is paramount for action potential propa

231 otential are slowed and the number of mature nodes of Ranvier is reduced, but Na(v)1.6, contactin, ca

232 lear whether continued axon-glial contact at nodes of Ranvier is required to maintain these channels

233 ies, but their association with pathology of nodes of Ranvier is unclear.

234 n and promote the reestablishment of AIS and nodes of Ranvier is unknown.

235 assembly of axon initial segments (AISs) and nodes of Ranvier, it is difficult to uncouple their role

236 While staining was observed at the nodes of Ranvier, it was not restricted to these locatio

237 re myelinated but show structural defects at nodes of Ranvier, leading to delayed propagation of acti

238 At nodes of Ranvier, Na+ channel clustering occurred very e

239 and reassemble the axon initial segments and nodes of Ranvier necessary for rapid and efficient actio

240 altatory conduction and abnormalities at the nodes of Ranvier (NOR) interface where myelin and axons

241 nkyrin-G at axon initial segments (AISs) and nodes of Ranvier (NR).

242 s on action potential (AP) leaps through the nodes of Ranvier (NRs) along myelinated nerves.

243 elinated axons, and thus on the integrity of nodes of Ranvier (NRs) and their environment.

244 Ion channels at the nodes of Ranvier (NRs) are believed to play essential ro

245 find that Na(v)1.6 is highly concentrated at nodes of Ranvier of both sensory and motor axons in the

246 soma membrane, axon, axon terminals, and the nodes of Ranvier of induced pluripotent stem cell (iPSC)

247 is a component of axon initial segments and nodes of Ranvier of mature axons in peripheral and centr

248 s directed against axon initial segments and nodes of Ranvier of myelinated axons, including the axon

249 d at high density at juxtaparanodes flanking nodes of Ranvier of myelinated axons.

250 icated as the predominant isoform present at nodes of Ranvier of myelinated fibres.

251 ation, and organization of microvilli in the nodes of Ranvier of peripheral nerves.

252 n the cortex or cerebellum or at optic nerve nodes of Ranvier of Scn1b(W/W) mice.

253 GABA(A) receptors located at or near nodes of Ranvier of sensory axons cause this facilitatio

254 ation of 12 glial and axonal proteins at the nodes of Ranvier of teased sciatic nerve fibers.

255 egenerated peripheral nerve fibers, and that nodes of Ranvier of these axons display proper sodium ch

256 ous Schwann cells can establish and maintain nodes of Ranvier on central axons for over one year, and

257 irth and then persists almost exclusively at nodes of Ranvier on myelinated axons.

258 outgrowth, synaptogenesis, and formation of nodes of Ranvier on myelinated axons.

259 in high density at axon initial segments and nodes of Ranvier or in regulating the activity of immobi

260 of MBOs to discrete axonal subdomains (i.e. nodes of Ranvier or presynaptic terminals) are poorly un

261 These include nodes of Ranvier, paranodal axoglial junctions and juxta

262 High densities of sodium channels at nodes of Ranvier permit action potential conduction and

263 t with neuronal neurofascin; however, Nav at nodes of Ranvier persist, albeit with approximately 40%

264 that TTX-sensitive sodium channels at axonal nodes of Ranvier play a significant role in the secondar

265 ntenance of voltage-gated sodium channels at nodes of Ranvier, possibly by mediating trans interactio

266 sence of CK2 at the axon initial segment and nodes of Ranvier provides a mechanism to regulate the sp

267 TATEMENT Myelinated axons are constricted at nodes of Ranvier, resulting in a marked local decrease i

268 tibodies to neurofascin selectively targeted nodes of Ranvier, resulting in deposition of complement,

269 oskeletons are also required for assembly of nodes of Ranvier.SIGNIFICANCE STATEMENT A periodic axona

270 Of particular importance are the nodes of Ranvier, sites of voltage-gated sodium channel

271 edJ mice, resulting in delayed maturation of nodes of Ranvier, slowed nerve conduction velocity, redu

272 in the eighth nerve root and in neighboring nodes of Ranvier stained for unmasked glucuronic acid 3-

273 and Caspr2 also resulted in widening of the nodes of Ranvier, suggesting that Caspr2 (which is prese

274 aracteristics between human, rat, and bovine nodes of Ranvier suggests an essential role for this def

275 for mitochondrial function is high, such as nodes of Ranvier, synapses, and active growth cones.

276 that P0 is also important for organizing the nodes of Ranvier that occupy the gaps in the insulation.

277 show that TRAAK is localized exclusively to nodes of Ranvier, the action potential propagating eleme

278 rations in myelin organization affecting the nodes of Ranvier, the Schmidt-Lanterman incisures, and C

279 of myelinating Schwann cells project to the nodes of Ranvier; their composition and physiologic func

280 ed essential for Na(+) channel clustering at nodes of Ranvier to facilitate fast and efficient action

281 ions, which may explain the vulnerability of nodes of Ranvier to neurofilament accumulations in anima

282 nnels cluster in macromolecular complexes at nodes of Ranvier to promote rapid nerve impulse conducti

283 estores SC proliferation, myelin volume, and nodes of Ranvier to wildtype levels.

284 r axonal NF in clustering of Na+ channels at nodes of Ranvier via interactions with receptors on Schw

285 g excess paranodal loops, and the density of nodes of Ranvier was reduced, relative to control mice.

286 were myelinated by the transplanted OECs and nodes of Ranvier were formed.

287 1l3 affecting the structures at and near the nodes of Ranvier were significantly downregulated during

288 fic localization of Na(v)1.6 channels in the nodes of Ranvier were unchanged.

289 Neurofilament transport is accelerated at nodes of Ranvier, where axons are locally constricted.

290 At the axon initial segment and nodes of Ranvier, where nerve impulses are generated and

291 sodium channels within the axon membrane at nodes of Ranvier, where their presence supports saltator

292 enriched at axon initial segments (AISs) and nodes of Ranvier, where they are necessary for generatio

293 are restricted to axon initial segments and nodes of Ranvier, where they are responsible for initiat

294 high density of Na(v)1.6 at the newly formed nodes of Ranvier which were flanked by paranodal Caspr s

295 to normalization of the organization of the nodes of Ranvier, which is typically deficient in CMT4C

296 channels are clustered in high densities at nodes of Ranvier, while K(+) channels are found in juxta

297 at axon initial segments and colocalized at nodes of Ranvier with ankyrinG and the voltage-dependent

298 beta1 subunits localize to nodes of Ranvier with neurofascin in sciatic nerve axons

299 on, the AP depolarizing wave invades initial nodes of Ranvier within a fraction of a millisecond and

300 (3) and that NG2-positive processes contact nodes of Ranvier within the nodal gap at the location of