ライフサイエンスコーパス: non-catalytic

1 s catalytic and the C-terminal Pol module is non-catalytic.

2 ty de novo on scaffolds that were previously non-catalytic.

3 whereas the N-terminal domain is considered non-catalytic.

4 , each of relative molecular mass 26K, and a non-catalytic 45K beta-subunit, a homologue of the beta-

5 Importantly, non-catalytic AAT2 mutants retained polysome association

6 ed of one catalytic domain associated with a non-catalytic accessory domain.

7 dney-specific isoform of ATP6N1A, the 116-kD non-catalytic accessory subunit of the proton pump.

8 We show here that a non-catalytic action of TET3 is essentially required for

9 Here, using EFR as a model, we describe a non-catalytic activation mechanism for LRR-RKs with non-

10 ounded-amoeboid cells use both catalytic and non-catalytic activities of MMPs for invasion.

11 ights an interplay between the catalytic and non-catalytic activities of TET1 that is essential for n

12 We discuss the catalytic and non-catalytic activities of TETs, and their roles as epi

13 g that the enzyme likely has uncharacterized non-catalytic activities.

14 ylating substrates and by means of regulated non-catalytic activities.

15 Here we demonstrate that this non-catalytic activity of LepB is to promote the associa

16 Thus, PDE7A1 possesses a non-catalytic activity that can contribute to the termin

17 mal DNA from the histone octamer, which is a non-catalytic activity.

18 In turn, non-catalytic ADAMTS-4 domains were critical for hydroly

19 unit to form the interface that contains the non-catalytic adenine nucleotide-binding site.

20 dy identifies a novel inhibitor of PKA and a non-catalytic affect of a cyclic nucleotide phosphodiest

21 stalk with F1-c10 implies that it binds to a non-catalytic alpha-beta interface in F1 and its inclina

22 These genes are believed to encode non-catalytic alpha-type subunits of 26S proteasomes and

23 results show the b dimer to be located at a non-catalytic alpha/beta cleft, with bI close to subunit

24 MPT51 may in fact represent a new family of non-catalytic alpha/beta hydrolases.

25 ency for two enzymes that differ by a single non-catalytic amino acid residue.

26 The non-catalytic amino terminus of DNMT1 binds to HDAC2 and

27 e interaction motif (KIM) located within the non-catalytic amino terminus of DUSP2.

28 tic/hydrophobic groove conformed between the non-catalytic and catalytic domains.

29 Our findings reveal a non-catalytic and PRC2-independent function for EZH2 in

30 Here, we show that EZH2 has a non-catalytic and PRC2-independent role in stabilizing D

31 Catalytic and non-catalytic antibodies are studied in this context of

32 ve marginally higher active site burial than non-catalytic antibodies, these values are generally sma

33 We show that both the catalytic and non-catalytic APC/C-Fzr1/Cdh1-mediated activities of PTE

34 We report here the remarkable and non-catalytic beneficial effects of a Ni(II) ion binding

35 The non-catalytic beta subunit of glucosidase II (GIIbeta) i

36 ort the cloning of full-length cDNAs for the non-catalytic beta- and gamma-subunits.

37 A non-catalytic binding cleft, proximal to the site of the

38 ysical barrier effects demonstrated here and non-catalytic binding of enzymes to cell walls limits th

39 autophosphorylation is promoted by specific non-catalytic binding proteins.

40 Palphabeta has high affinity, cGMP-specific, non-catalytic binding sites and that Pgamma stimulates c

41 and dissociation from various catalytic and non-catalytic binding sites on protein surfaces.

42 ibitory effect of genistein is due to direct non-catalytic blockade of the channels.

43 in embryonic ectoderm development (EED) is a non-catalytic but an essential component of PRC2 and its

44 sical and biochemical studies indicates that non-catalytic but conserved residues directly regulate t

45 variant leucine in a conserved domain of the non-catalytic C terminus restored viability to cells exp

46 2 FYVE-type domain and the N-terminal kinase non-catalytic C-lobe domain (KIND) that could not be det

47 to the active site and activated by the Nek9 non-catalytic C-terminal domain (CTD).

48 A conserved non-catalytic C-terminal domain of WRN was sufficient fo

49 blocks, ATR(Mec1) phosphorylates Chk1 on the non-catalytic C-terminal domain.

50 proper DNA-binding subsite is located on the non-catalytic C-terminal domain.

51 phorylation and is markedly inhibited by its non-catalytic C-terminal region.

52 Its non-catalytic, C-terminal half contains several proliner

53 We demonstrate that the non-catalytic C2 domain of PTEN specifically binds PI(3)

54 the I-CvuI DNA structures in the presence of non-catalytic (Ca(2+)) and catalytic ions (Mg(2+)).

55 The C-terminal non-catalytic carbohydrate binding module could not be o

56 LPMOs can contain non-catalytic carbohydrate binding modules (CBMs), but t

57 catalytic modules and, frequently, multiple non-catalytic carbohydrate binding modules (CBMs).

58 cell wall polysaccharides generally contain non-catalytic, carbohydrate-binding modules (CBMs) that

59 The molecular basis of how the N-terminal non-catalytic CD1 regulates the catalytic activity and c

60 ic triggering by the ca. 50 mM background of non-catalytic cellular monothiols.

61 and in vivo functional characterization of a non-catalytic CHI-fold family from plants.

62 Our work suggests a non-catalytic chromatin-stabilizing role of CPC in maint

63 mode of non-heme iron binding trapped by the non-catalytic Co(2+), which, we postulate, may be transi

64 Here we used affinity chromatography with non-catalytic Coa and vWbp to identify the ligands for t

65 eparate genes encoding the catalytic and the non-catalytic collagenic tail (ColQ) subunits, respectiv

66 atalytic acyltransferase, while CsSCPL5 is a non-catalytic companion paralog (NCCP).

67 etal muscle and found that the level of this non-catalytic component by itself was sufficient to chan

68 t cell line lacks expression of IKK gamma, a non-catalytic component of the IKK complex.

69 OST48 is a non-catalytic component of the oligosaccharyltransferase

70 in, but does not alter the expression of the non-catalytic components of the Set1 complexes.

71 ately 450 kDa complex that contains all five non-catalytic components of the Set1A complex, including

72 honate reacts with 2-aminoaryl ketones under non-catalytic conditions with formation of 4-substituted

73 ectroscopic methods under potentiometric but non-catalytic conditions.

74 When the PML/RAR alpha cleaving but not the non-catalytic control ribozyme is introduced into the NB

75 Introduction of a non-catalytic, control ribozyme into NB4 cells caused no

76 the non-catalytic core; contacts between the non-catalytic core and Rrp44, which inhibit exoribonucle

77 The nuclear RNA exosome includes a 9-subunit non-catalytic core that binds Rrp44 (Dis3) and Rrp6 subu

78 ed RNA path to Rrp6 that penetrates into the non-catalytic core; contacts between the non-catalytic c

79 lly how Tolloid activity is regulated by its non-catalytic CUB domains in the Drosophila embryo.

80 llowing S-nitrosylation of Trx proteins at a non-catalytic cysteine (Cys) residue.

81 nd UbcM2 form a complex upon alkylation of a non-catalytic cysteine in UbcM2, Cys-136.

82 -binding pocket and that can be mutated to a non-catalytic cysteine residue.

83 ellular ligands and possess highly conserved non-catalytic cytoplasmic domains.

84 ered that the tumorigenic role of AKR1C3 was non-catalytic dependent and the NRF2/MAFG-AKR1C3-PARP1 a

85 of VAV1 catalytic-dependent (MAPK, JNK) and non-catalytic-dependent (nuclear factor of activated T c

86 By broadening the non-catalytic displacement to p27 and CDK6 containing co

87 dues, we show that Ero1alpha is regulated by non-catalytic disulphides.

88 ation modulates the biological activities of non-catalytic DNA binding proteins.

89 are known to assemble by sequence-divergent non-catalytic dockerin domains (NCDDs)(4).

90 The kinase-like non-catalytic domain (KIND) of Spire directly interacts

91 f engineered motors, we demonstrate that the non-catalytic domain has a key role in the motility mech

92 A non-catalytic domain in A3G binds strongly to RNA, an in

93 Our results highlight the role of the non-catalytic domain in fine-tuning substrate specificit

94 Thus, one role of this non-catalytic domain may be to prevent transposition in

95 are consistent with a role of the conserved non-catalytic domain of a human RecQ helicase in DNA rep

96 degradation machinery targets the C-terminal non-catalytic domain of ACS6, which is sufficient to con

97 In this study, we show that the non-catalytic domain of GAP is required for its recruitm

98 Here we report that the N-terminal non-catalytic domain of separase binds to the C-terminal

99 tion motif located within the amino-terminal non-catalytic domain of the protein.

100 equence containing five PXXP motifs from the non-catalytic domain of the PTP is sufficient for intera

101 ally significant subdomains within the large non-catalytic domain of these proteins.

102 An N-terminal non-catalytic domain of YopH binds p130Cas in a phosphot

103 The amino-terminal, non-catalytic domain of YopH is bifunctional; it is esse

104 Expression of POLE1 non-catalytic domain rescued this defect resulting in sl

105 ly conserved catalytic domain and a variable non-catalytic domain that functions as the structural sc

106 in a large protein complex and requires its non-catalytic domain to localize to the cell periphery a

107 rmined by sequences within an amino-terminal non-catalytic domain whereas MAPK binding often leads to

108 We find that a non-catalytic domain within Cas9, REC3, recognizes targe

109 of two regions of homology in the C-terminal non-catalytic domain, termed polo-box 1 (PB1) and polo-b

110 on-independent and mediated via binding to a non-catalytic domain, we highlight how receptor PTPs cou

111 g within the region of the mRNA encoding its non-catalytic domain.

112 talyzes hydrolysis of GTP on ARF1 but also a non-catalytic domain.

113 using an aromatic/hydrophobic pocket in the non-catalytic domain.

114 However, both the N- and C-terminal non-catalytic domains from all mammalian tolloids bind c

115 rapeutics, underscoring the critical role of non-catalytic domains in deubiquitinase regulation and o

116 molecular interactions between catalytic and non-catalytic domains of BAP1, which generate a composit

117 es and the functional role of the C-terminal non-catalytic domains of Chk1.

118 is canonically activated by binding of these non-catalytic domains to phosphoproteins, which destabil

119 Having ascribed functions to the Tolloid non-catalytic domains, we recapitulate embryonic BMP gra

120 transcriptional activity also depends on its non-catalytic domains, which facilitate its recruitment

121 y two oligomerization interfaces mediated by non-catalytic domains.

122 Its non-catalytic donut-shaped core includes 9 subunits that

123 subunit is dispensable for survival, and its non-catalytic essential function is linked with replicat

124 th loss of factor IX-binding exosites on the non-catalytic factor XI heavy chain.

125 nded RNA binding proteins (DRBs), a group of non-catalytic factors containing one or more double-stra

126 and stimulates GSK3 enzymatic activity in a non-catalytic fashion.

127 ed by the EWSR1-exon 8 G-rich sequences in a non-catalytic fashion.

128 next generation of BoNT vaccines, utilizing non-catalytic full-length BoNT or a subunit vaccine comp

129 n, enzyme specificity, and strikingly, c-Src non-catalytic function as a substrate.

130 hile it is widely believed that Rev1 plays a non-catalytic function in translesion synthesis, the rol

131 the Rev1 dCMP transferase activity from its non-catalytic function in yeast.

132 Thus, we define an additional, non-catalytic function of OTULIN in the regulation of SN

133 However, it is not well understood about the non-catalytic function of Rev1 in translesion synthesis.

134 In addition to its dCMP transferase, a non-catalytic function of Rev1 is suspected in cellular

135 those of UV lesions, which only require the non-catalytic function of Rev1.

136 These findings identify an essential, non-catalytic function of the C2 domain of Psd2p and rai

137 then closely aligned, which requires XLF, a non-catalytic function of XRCC4-LIG4, and DNA-PK activit

138 its catalytic function was abolished but its non-catalytic function remained intact.

139 Recently, a non-catalytic function was reported for the leucine-rich

140 tion of its deacetylase domain, indicating a non-catalytic function.

141 Such non-catalytic functions have been ascribed to many kinas

142 dy we demonstrate that biotin has additional non-catalytic functions in regulating gene expression in

143 CKIdelta/epsilon and DBT may have divergent non-catalytic functions in the clockwork as well.

144 mination of endothelial lipase catalytic and non-catalytic functions in vitro, and from human genetic

145 rmational disruptors" to inhibit or modulate non-catalytic functions of pseudokinases deregulated in

146 Both catalytic and non-catalytic functions of tankyrase depend on its filam

147 ecent progress relating to the catalytic and non-catalytic functions of the Trithorax-COMPASS complex

148 lly, many histone-modifying proteins possess non-catalytic functions that overshadow their enzymatic

149 odifying proteins that resemble enzymes have non-catalytic functions that regulate the assembly of ep

150 containing SECIS elements and be adapted for non-catalytic functions.

151 a scaffold to promote tumorigenesis through non-catalytic functions.

152 a, each contain one catalytic domain and two non-catalytic GAF domains, whereas two small inhibitory

153 Mutational study reveals that several non-catalytic glycan-interacting residues, structurally

154 Histone chaperones are a non-catalytic group of proteins that are central to the

155 ke Moesin and engagement of effectors of its non-catalytic growth-promoting activity.

156 tains the ATPase motor protein SNF2h and the non-catalytic hACF1 subunit.

157 dies of this class of receptors as well as a non-catalytic homolog, the clearance receptor.

158 sition state) closely resembles that seen in non-catalytic hydrogen bonds, with distances and angles

159 shows that CDK4/6 inhibitors have two roles: non-catalytic inhibition of CDK2 via p21 displacement fr

160 lated by the binding of bicarbonate ion to a non-catalytic (inhibitory) site that controls the ligati

161 DNA ends for catalysis while another pair of non-catalytic integrase dimers bridge between the two vi

162 t CAIX augments MCT1 transport activity by a non-catalytic interaction.

163 ity of assaying relevant activity and by the non-catalytic interactions of KDACs with cellular protei

164 Disrupting either catalytic or non-catalytic interactions through mutagenesis hampers A

165 fferent positions of the two b subunits at a non-catalytic interface and imply that each b subunit ha

166 Specifically, in the non-catalytic interface, the B subunit seems to be incap

167 first molecular insight at the catalytic and non-catalytic interfaces, which was not possible in the

168 owever, it remains poorly understood how the non-catalytic ISWI subunits BAZ1A and BAZ1B might contac

169 e three protein domains suggests a potential non-catalytic ligand-binding role.

170 Dockerin modules located within a non-catalytic macromolecular scaffold, whose primary rol

171 osed that E.coli RNase III can function in a non-catalytic manner, by binding RNA without cleaving ph

172 ain how OTUB1 inhibits other E2 enzymes in a non-catalytic manner.

173 of Numb-TS4D in a non-apoptotic and possibly non-catalytic manner.

174 eases the enzymatic activity of TMPRSS2 in a non-catalytic manner.

175 gistically prevent inflammatory disease in a non-catalytic manner.

176 tion and/or protect it from degradation in a non-catalytic manner.

177 cineurin suppresses this futile cycling by a non-catalytic mechanism involving the masking of nuclear

178 Furthermore, using a non-catalytic mechanism, MMP-9 promotes rounded-amoeboid

179 g that 14-3-3 inhibits the complex through a non-catalytic mechanism.

180 on of TRAF6 to cytosolic p62 aggregates by a non-catalytic mechanism.

181 ecause of similarities between catalytic and non-catalytic metal binding sites, finding physicochemic

182 Substitutions of residues anchoring this non-catalytic metal ion severely impair DNA binding and

183 ere we studied the ancestral role of a model non-catalytic modulatory subunit.

184 nding of type I cohesin modules located in a non-catalytic molecular scaffold to type I dockerin modu

185 would lead to the loss or dislocation of two non-catalytic MuA subunits positioned in the transpososo

186 We show that the non-catalytic N terminus of Doa4 mediates its recruitmen

187 How mutations in the non-catalytic N-domain cause disease is unknown.

188 A3G consists of a non-catalytic N-terminal domain (NTD) and a catalytic C-

189 at complex formation is mediated through the non-catalytic N-terminal domain of DNA ligase I and the

190 Our data highlight the important role of the non-catalytic N-terminal domain of Twinkle.

191 fotransferase catalytic domains, alongside a non-catalytic N-terminal domain.

192 Instead, the non-catalytic N-terminus of PDK1 mediates the formation

193 Furthermore, we show that the non-catalytic new domains (UNE-T and TGS) of ThrRS are b

194 The non-catalytic nine-subunit exosome core (Exo9) features

195 id substitutions and a large deletion of the non-catalytic P450 reductase domain, which chemoselectiv

196 interacting with the thumb subdomain of its non-catalytic p51 subunit.

197 inhibitor 'bridges' the DNA and a transient non-catalytic pocket on the two-fold axis at the GyrA di

198 to identify and characterize less conserved non-catalytic pockets capable of interfering with the ki

199 s to reiterated cohesin domains located in a non-catalytic primary scaffoldin.

200 ts HIV-1 viral replication via catalytic and non-catalytic processes.

201 ide detailed insights into the catalytic and non-catalytic processing of small molecules by hCE1, and

202 smooth muscle MLCK (smMLCK), as well as the non-catalytic product telokin.

203 Recently, a small non-catalytic protein, PEA-15, has also been demonstrate

204 feature of bacterial cellulosomes is a large non-catalytic protein, the scaffoldin, which contains mu

205 wever, recent studies provide evidence for a non-catalytic protein-binding role for choline kinase al

206 The non-catalytic proteins encoded by PUL1,6-beta-glucan tar

207 druggable allosteric cysteine present in the non-catalytic pseudokinase domain of JAK1 (C817) and TYK

208 lysis at moderate and high temperature and a non-catalytic pyrolysis process are presented.

209 lack the catalytic non-conserved (conserved non-catalytic/Ras exchange motif/structurally conserved

210 t on both kinase activity and the C-terminal non-catalytic RCC1 domain.

211 REC insertion and succeeds in enlarging the non-catalytic REC domain of Streptococcus pyogenes Cas9.

212 We have demonstrated that this non-catalytic receptor can inhibit NT-3 signaling when c

213 rchical activation of downstream pathways in non-catalytic receptors.

214 ing yeast, Mps1 phosphorylation of a central non-catalytic region of Bub1 promotes its association wi

215 mutagenesis, we have mapped an exosite to a non-catalytic region of LF.

216 e results suggest a novel model in which the non-catalytic region of PKCmu acts as a scaffold for ass

217 tyrosine phosphorylations in the N-terminal non-catalytic region of the molecule, which contains an

218 -interactive site was mapped to a C-terminal non-catalytic region that is conserved in the PP1(C)2 is

219 have one or two highly conserved C-terminal non-catalytic regions, termed polo boxes.

220 ters and contains one degenerate site with a non-catalytic residue next to the Walker B motif.

221 performed to determine how mutations of this non-catalytic residue play a role in increasing 50% inhi

222 Substitution of key non-catalytic residues at the Dnmt3a-Dnmt3L interface or

223 ple effect", whereby mutations in peripheral non-catalytic residues can cause subtle allosteric chang

224 Each TNFAIP3 allele encoded substitutions at non-catalytic residues of the ubiquitin protease OTU dom

225 Expression of the catalytic or non-catalytic ribozymes in control cells lacking PML/RAR

226 l genomics" annotated proteins and catalytic/non-catalytic RNAs are studied in this context.

227 e mechanistic level, and whether CPC has any non-catalytic role at centromere remain open questions.

228 ketide biosynthetic landscape and identify a non-catalytic role for ABM superfamily proteins in type

229 These results define a novel non-catalytic role for Poleta in promoting PCNA monoubiq

230 may bind to the carboxyl terminus to serve a non-catalytic role in assembly and/or stabilization of a

231 strong support for REV1 playing an important non-catalytic role in coordinating translesion synthesis

232 een unsuccessful, suggesting that Rtr1 has a non-catalytic role in CTD dephosphorylation.

233 suggesting that CKIdelta/epsilon may have a non-catalytic role in stabilizing PER.

234 In contrast, Polkappa has a non-catalytic role in the extension step of cisplatin IC

235 A consequence of the non-catalytic role of domain 1 is that its active site r

236 nt cancer cells are primarily dependent on a non-catalytic role of EZH2 in the stabilization of the P

237 However, non-catalytic roles for REV1 have been suggested by the

238 TTL14 has a degenerate active site and plays non-catalytic roles in maintaining complex integrity and

239 ease apart what is known about catalytic and non-catalytic roles of RIPK1 and discuss the successes a

240 atalytic function is well-characterized, its non-catalytic roles remain unclear.

241 owed that the overexpression effects include non-catalytic roles.

242 A secondary, non-catalytic, rubredoxin-like iron site is conserved in

243 RIPK1 is required to trigger cell death, its non-catalytic scaffold function mediates strong pro-surv

244 The core non-catalytic scaffoldin subunit, CipA, bears nine type

245 repeated cohesin (Coh) modules located in a non-catalytic scaffoldin.

246 one of several type I cohesin modules in the non-catalytic scaffolding protein.

247 family, provide insight into the function of non-catalytic SDR residues, and illustrate that limited

248 the opportunity to analyze for functions of non-catalytic SDR residues.

249 ver, how new Sec residues evolve and whether non-catalytic Sec residues exist in proteins is not know

250 of these instances the domain functions as a non-catalytic sensor of ligands.

251 rheumatoid fibroblast-like synoviocytes that non-catalytic signaling is associated with rapid interna

252 Non-catalytic signaling mechanisms of protein kinase dom

253 to use the canonical ATP-binding motifs for non-catalytic signaling through allostery.

254 ed for both efficient catalytic activity and non-catalytic signaling.

255 ved in the binding of bicarbonate ion in the non-catalytic site and an active-site variant (D44N) tha

256 l molecule compound, 1E7-03, that targeted a non-catalytic site of PP1 and increased VP30 dephosphory

257 , pyridoxine 5'-phosphate oxidase contains a non-catalytic site that binds pyridoxal 5'-phosphate tig

258 ormed at the active site may transfer to the non-catalytic site without passing though the solvent.

259 tic of dual specificity phosphatases or to a non-catalytic site, respectively.

260 s stabilized by bicarbonate ion binding to a non-catalytic site.

261 Extent, timing, and role of non-catalytic-site movements are unknown.

262 n binding of hydrophobic peptides to several non-catalytic sites.

263 In heterodimeric GPPSs, a non-catalytic small subunit (GPPS-SSU) interacts with a

264 supporting in vitro evidence for additional, non-catalytic Spastin functions.

265 ce of an autophosphorylation site within the non-catalytic Src homology 3 (SH3) domain.

266 between transcription and translation of the non-catalytic subunit from its assembly into ColQ-AChE.

267 by the overexpression of an AMPK-activating non-catalytic subunit mutant (AMPK-gamma1-R70Q) dramatic

268 subunits, the catalytic subunit Sas3 and the non-catalytic subunit Nto1.

269 homologue with 5 WD40 repeats, Trm82, is the non-catalytic subunit of a tRNA methylase.

270 Here we show that alpha4, a non-catalytic subunit of the protein phosphatase 2A, pla

271 diverse approaches to elucidate how the PP1 non-catalytic subunit PPP1R15B (R15B) captures its full

272 However, the non-catalytic subunit, hACF1, altered the remodeling pro

273 Our data suggest roles for non-catalytic subunits (Nop56 and Nop58) in rRNA binding

274 The non-catalytic subunits are assumed to be redundant adapt

275 To elucidate the roles of the non-catalytic subunits in determining the specificity of

276 arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgam

277 omposed of a catalytic alpha-subunit and two non-catalytic subunits, beta and gamma.

278 nsists of a catalytic subunit (PP1c) and two non-catalytic subunits, M130 and M20.

279 alytic p110gamma subunit, which binds to two non-catalytic subunits, p87 or p101, and controls a plet

280 that the EF-Tu switch I region binds to the non-catalytic surface of AbDsbA.

281 These data point to the possibility that the non-catalytic surface of DsbA is a potential substrate o

282 NCP and its paralog RCB are non-catalytic thioredoxin-like proteins that diverged in

283 APDH), an important glycolytic enzyme, has a non-catalytic (thus a non-canonical) role in inducing mi

284 ated creating "defect-free" graphene that is non-catalytic towards electrolyte decomposition, simulta

285 was superior to Williamson in prediction of non-catalytic transient complex interfaces.

286 cobacter gastric pathogens utilizes a unique non-catalytic triad for catalysis, which could be exploi

287 d a BDNF survival response, co-expression of non-catalytic TrkB substantially reduced this response.

288 ated by the relative levels of catalytic and non-catalytic TrkB.

289 ic subunits TSEN2 and TSEN34, as well as the non-catalytic TSEN54 and TSEN15.

290 Modular cellulases contain non-catalytic type A carbohydrate-binding modules (CBMs)

291 ) of the topo II isoforms and by a conserved non-catalytic tyrosine, Y640 in topo IIalpha and Y656 in

292 These non-catalytic tyrosine-phosphorylated receptors (NTRs) s

293 they are found, including both catalytic and non-catalytic versions.

294 the vestigial 3' exonuclease subdomain and a non-catalytic water-bridged magnesium complex at the pro

295 enoyl-coenzyme A (CoA) hydratases, EchA6 is non-catalytic yet essential and binds long-chain acyl-Co

296 h aspartic acid has been shown to coordinate non-catalytic zinc in matrix metalloproteinases.

297 ss II aldolase has an active site zinc and a non-catalytic zinc nearby.

298 lass II aldolase FbaA through binding to the non-catalytic zinc site.

299 FbaA mutants (D144A and E174A) affecting the non-catalytic zinc were resistant to nickel inhibition.

300 A non-catalytic Zn(2+) site in the A. aeolicus GatB stabil