ライフサイエンスコーパス: non-coding

1 because most disease-associated variants are non-coding and functional characterization of these sign

2 However, ~ 98% of the genome is non-coding and includes regulatory elements whose normal

3 11265259 and rs181704186), both of which are non-coding and more common in individuals of African anc

4 istant nucleotide variants covary, including non-coding and ORF1ab sites covarying with the D614G spi

5 These variants were mainly non-coding and reached at least nominal significance in

6 association studies (GWAS) are predominantly non-coding and typically attributed to altered regulator

7 Overall, this work demonstrates that non-coding AR binding sites are frequently mutated in pr

8 acterial transcriptomic data commonly ignore non-coding but functional elements e.g. small RNAs, long

9 Disruption of this stem abolishes the non-coding, but not the coding, function of the endogeno

10 However, non-coding cancer driver mutations are less well-charact

11 These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strik

12 data reveal how expression variation through non-coding cis variation at FLC has enabled Arabidopsis

13 We find that a non-coding constraint mutation in the SEMA3C promoter re

14 Performing analysis on non-coding constraint mutations and their position relat

15 These results suggest that non-coding constraint mutations could play an essential

16 y genes, we find a significant enrichment of non-coding constraint mutations in the neighborhood of 7

17 also identify 1776 other genes enriched for non-coding constraint mutations with likely regulatory p

18 e than 98% of the human genome is made up of non-coding DNA, but techniques to ascertain its contribu

19 can support more and larger genes, far more non-coding DNA, greater regulatory complexity, and thous

20 genomic regions or de novo, from previously non-coding DNA.

21 patterns of weak selection in predominantly non-coding DNA.

22 ciations with specific mutational processes, non-coding driver genes and evolutionary features.

23 mapped many protein-coding drivers, yet few non-coding drivers are known because genome-wide discove

24 enome contains arrays of extremely conserved non-coding elements termed genomic regulatory blocks (GR

25 Enhancers are important non-coding elements, but they have traditionally been ha

26 ergo bidirectional transcription to generate non-coding enhancer RNAs (eRNAs).

27 tates downstream analysis of both coding and non-coding features.

28 Functional non-coding (fnc)RNAs are nucleotide sequences of varied

29 es isoform-resolved annotation of coding and non-coding functional domains, motifs, and sites, in com

30 iscovered recurrent SVs targeting coding and non-coding functional elements known to promote prostate

31 Efficient translational bypassing of a 50-nt non-coding gap in a phage T4 topoisomerase subunit gene

32 lls for targeted discovery and validation of non-coding gene variants affecting gene expression and d

33 iants that drive cancer are less frequent in non-coding genes and regulatory sequences than in protei

34 In particular AD-associated non-coding-genes play an important, as yet largely unexp

35 sed INFERence of the molecular mechanisms of NOn-coding genetic variants (SparkINFERNO), a scalable b

36 entify novel therapeutic targets in the vast non-coding genome to enhance radiation therapy.

37 e vast majority of these variants lie in the non-coding genome, where they likely function through in

38 lable bioinformatics pipeline characterizing non-coding genome-wide association study (GWAS) associat

39 dscape of infrequent driver mutations in the non-coding genome.

40 iologically relevant SVs altering coding and non-coding genome.

41 While few non-coding genomic elements are recurrently mutated in t

42 can be used for genome editing of coding and non-coding genomic regions effectively.

43 matic mutation enrichment in both coding and non-coding genomic regions from WGS data.

44 impact of single nucleotide polymorphisms in non-coding genomic regions.

45 ole in GBM, underscoring the need to connect non-coding genomic variation to biological function and

46 omerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR), which serves as a

47 Non-coding IPS1 RNA is highly expressed during Pi starva

48 g), in addition to four uncharacterized long non-coding (lnc) RNA genes and part of a novel protein-c

49 n of VINR, a Drosophila VSR-interacting long non-coding (lnc) RNA that activates non-canonical innate

50 w material for the evolution of diverse long non-coding (lnc) RNAs by non-adaptive mechanisms, such a

51 sed with transcription units specifying long non-coding (lnc) RNAs, there are many opportunities for

52 ormation about under-studied genes including non-coding lncRNAs, (ii) replying to requests for inform

53 These results suggest that a large number of non-coding loci affect the development and progression o

54 We explore the representative non-coding loci and their linked genes of each cluster a

55 ced rate of small changes in gene structure, non-coding loci show even much larger changes.

56 classes and the detection of novel expressed non-coding loci.

57 ances VEGFA expression by the targeting of a non-coding microRNA that regulates its expression.

58 DNA methylation, histone modifications, and non-coding miRNAs.

59 MicroRNAs (miRs) are small non-coding molecules that regulate post-transcriptional

60 microRNAs (miRs) are small non-coding molecules that regulate post-transcriptional

61 ulti-faceted pathway and network analyses of non-coding mutations across 2583 whole cancer genomes fr

62 however the true extent of how such somatic non-coding mutations affect RNA splicing are largely une

63 cer genes and mechanisms that are altered by non-coding mutations and offer insights into additional

64 r types, we integrated genes with coding and non-coding mutations and revealed frequently mutated pat

65 Non-coding mutations at the far end of a large gene dese

66 Non-coding mutations can create splice sites, however th

67 annotating the splicing impact of coding and non-coding mutations in future large-scale analyses.

68 The functional consequences of somatic non-coding mutations in ovarian cancer (OC) are unknown.

69 RNA splicing is primarily altered by non-coding mutations in this cohort, and samples contain

70 tions in this cohort, and samples containing non-coding mutations in well-known RNA splicing factors

71 ations suggests that splice sites created by non-coding mutations interact with pre-existing potentia

72 this cohort, we identify 93 genes harboring non-coding mutations that cluster into several modules o

73 nd 9494 cases with WES data, discovering 562 non-coding mutations that lead to splicing alterations.

74 al patterns of somatic mutations, especially non-coding mutations, and their roles in defining molecu

75 haracterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutatio

76 facilitate the identification of functional non-coding mutations, we present dbInDel, a database whe

77 esses had variable proportions of coding and non-coding mutations, with chromatin remodeling and prol

78 ly whole-genome sequencing (WGS) to identify non-coding mutations, with regulatory potential in GBM,

79 e buffered against the effects of disruptive non-coding mutations.

80 ng Wnt and Notch, altered by both coding and non-coding mutations.

81 Using both coding (beta-actin mRNA) and long non-coding (NEAT1) RNAs, we show that the Mango array do

82 This is especially true for the non-coding part of the genome which is enormous yet poor

83 is that most associated variants fall in the non-coding part of the human genome.

84 low for both the identification of candidate non-coding pathogenic variants and their functional vali

85 xbp-1 mRNA bifurcates it into a coding and a non-coding pathway; modulation of the two pathways may a

86 One way in which non-coding polymorphisms could cause disease is by affec

87 ease-associated risk loci are located in the non-coding region of the genome and therefore, their tar

88 r point mutations and structural variants in non-coding regions across 2,658 genomes from the Pan-Can

89 e proportion of risk variants are located in non-coding regions and remain unexplained by current exp

90 ied our MGW-prioritization approach to three non-coding regions associated with systemic lupus erythe

91 specific HLA peptides derived from annotated non-coding regions could elicit anti-tumor immune respon

92 ecent years have revealed essential roles of non-coding regions in gene regulation.

93 These results suggest that SVs within non-coding regions may play an important role in ADHD de

94 results uncover a function for ribosomes on non-coding regions of RNAs and reveal the mechanisms und

95 ore meaningful prediction in both coding and non-coding regions of the cancer genome.

96 ch 68.4% involved associations with flanking non-coding regions of the gene.

97 r understanding of the rules that govern the non-coding regions of the genome is less complete than o

98 ion factors, other protein coding genes, and non-coding regions of the genome with regulatory potenti

99 For somatic point mutations in coding and non-coding regions of the genome, we propose CScape-soma

100 nown aetiological variants in the coding and non-coding regions of the genome.

101 crucial role in the study of the effects of non-coding regions on the molecular classification of ca

102 graphical reports are offered for coding and non-coding regions that annotate the potential impact of

103 y and clinical covariates and detect loci in non-coding regions that are difficult to interpret.

104 ding those targeting intergenic and intronic non-coding regions that eluded previous exome focused st

105 Many disease-associated loci are found in non-coding regions that house regulatory elements.

106 eview a GRB-based approach to assign loci in non-coding regions to potential target genes, and apply

107 ut those somatic mutations that occur at the non-coding regions where AR binds DNA.

108 The majority of these are in non-coding regions, and are commonly assigned to the nea

109 of the identified associated variants are in non-coding regions, and presumably influence gene expres

110 To further characterize the burdening of non-coding regions, we used NIMBus to screen transcripti

111 lanced accuracy in coding regions and 69% in non-coding regions, whereas even higher accuracy may be

112 ften unclear, especially when they appear in non-coding regions.

113 vel variants and/or may be uninformative for non-coding regions.

114 139 microsatellites, of which 71 were in the non-coding regions.

115 ng need to understand the functional role of non-coding regulatory elements (REs).

116 t the majority of loci are thought to affect non-coding regulatory elements, the second question is o

117 ease have been performed, alterations in the non-coding regulatory regions of GBM have largely remain

118 tion in the CNS, elucidating the function of non-coding regulatory sequences in neurobiology and link

119 These experiments validated new non-coding regulatory sequences near induced and/or esse

120 Here, we investigate the non-coding regulatory space in the maize (Zea mays) geno

121 used as an indicator of the significance of non-coding regulatory variants.

122 and establishes a framework for identifying non-coding regulatory variation with phenotypic conseque

123 Non-coding repeat expansions in different genes have bee

124 We further identified a long-non coding RNA transcribed at CHPT1 enhancer (also known

125 egulated by the interaction between the long non-coding RNA (lncRNA) DIGIT and the bromodomain and ex

126 nt of these are located within BANCR, a long non-coding RNA (lncRNA) exclusively expressed in primate

127 Misregulation of long non-coding RNA (lncRNA) genes has been linked to a wide

128 While long non-coding RNA (lncRNA) genes have attracted a lot of at

129 Herein, based on long non-coding RNA (lncRNA) profiling induced by active AKT,

130 RNA myeloid-specific 1 (HOTAIRM1) is a long non-coding RNA (lncRNA) that plays a pivotal role in reg

131 ide Metabolism Regulator (lincNMR) is a long non-coding RNA (lncRNA) which is induced in hepatocellul

132 d GC, by targeting and downregulating a long non-coding RNA (lncRNA), LOC553103.

133 ctivity of the promoter of LOXL1-AS1, a long non-coding RNA (lncRNA).

134 ng, we systematically annotated multi-exonic non-coding RNA (mencRNA) genes transcribed from 1.5-Mb i

135 xbp-1 mRNA cleavage is a biologically active non-coding RNA (ncRNA) essential for axon regeneration i

136 A new concept is emerging in the non-coding RNA (ncRNA) field: an increasing number of nc

137 Research on non-coding RNA (ncRNA) is a rapidly expanding field.

138 es are sites for RNA biology including small non-coding RNA (ncRNA) mediated gene silencing.

139 CREs could be identified by context-specific non-coding RNA (ncRNA) profiling, based on the observati

140 r genes, virus-host interactions involved in non-coding RNA (ncRNA), target gene and microRNA express

141 om the screen, progenitor renewal associated non-coding RNA (PRANCR), using RNA interference-mediated

142 Recent studies have demonstrated sperm small non-coding RNA (sncRNA) populations vary in response to

143 We identify the IFN-stimulated non-coding RNA 1 (INCR1) as a long noncoding RNA (lncRNA

144 ntibodies interact with beta-amyloid, a long non-coding RNA AC099552.4 (p = 1.2 x 10(-7)), and a zinc

145 The extent of non-coding RNA alterations in patients with sepsis and t

146 C across hundreds of residues in rRNA, tRNA, non-coding RNA and mRNA from hyperthermophilic archaea.

147 analysis of leukocyte RNA we found that long non-coding RNA and, to a lesser extent, small non-coding

148 A long non-coding RNA called GRASLND is essential to help stem

149 ed UBE3A allele is silenced in cis by a long non-coding RNA called UBE3A-ATS.

150 Long non-coding RNA expression, but not small non-coding RNA,

151 xpressed genes NEXMIF, SLC16A2, and the long non-coding RNA gene FTX.

152 n of PPARalpha directly upregulates the long non-coding RNA gene Gm15441 through PPARalpha binding si

153 and global annotation of protein-coding and non-coding RNA genes in a manner orthogonal to gene expr

154 d across all cohorts was located in the long non-coding RNA growth arrest specific five gene (GAS5) (

155 presents a paradigm for the function of long non-coding RNA in epigenetic regulation, although how it

156 se H-mediated cleavage, splicing modulation, non-coding RNA inhibition, gene activation and programme

157 We hypothesized that U3 snoRNA, a non-coding RNA involved in ribosomal RNA maturation, is

158 sed modulation of a triple helix in the long non-coding RNA metastasis-associated lung adenocarcinoma

159 ional study of EV-mediated transfer of small non-coding RNA molecules at single-cell resolution.

160 The long non-coding RNA NEAT1 serves as a scaffold for the assemb

161 Mature microRNAs are short non-coding RNA sequences which upon incorporation into t

162 dependent tool evaluates pre-processed small non-coding RNA sequencing (sncRNA-seq) data, i.e. expres

163 A fast-growing number of non-coding RNA structures have been resolved and deposit

164 ato spindle tuber viroid (PSTVd), a circular non-coding RNA that replicates and spreads systemically

165 on-coding RNA and, to a lesser extent, small non-coding RNA were significantly altered in sepsis rela

166 The long non-coding RNA Xist establishes an intra-chromosomal com

167 h CIZ1, including interaction with XIST long-non-coding RNA, epigenetic maintenance and regulation of

168 A single P. aeruginosa non-coding RNA, P11, is both necessary and sufficient to

169 ong non-coding RNA expression, but not small non-coding RNA, was largely recapitulated in human endot

170 Long intergenic non-coding RNA-Nucleotide Metabolism Regulator (lincNMR)

171 he translational potential of XIST, a unique non-coding RNA.

172 ontains CpG-rich promoters for TERRA, a long non-coding RNA.

173 Our results suggest that this non-coding-RNA-dependent mechanism evolved to survey the

174 enes (2.94-fold), GWAS loci (1.52-fold), and non-coding RNAs (1.44-fold), compared with random distri

175 how that the mutation and regulation of long non-coding RNAs (lncRNAs) are associated with various hu

176 Long non-coding RNAs (lncRNAs) are components of epigenetic c

177 ein-coding genes, the majority of human long non-coding RNAs (lncRNAs) are considered non-conserved.

178 Long non-coding RNAs (lncRNAs) are defined as non-protein-cod

179 Long non-coding RNAs (lncRNAs) are emerging regulators of gen

180 Long non-coding RNAs (lncRNAs) are emerging regulators of pat

181 Long non-coding RNAs (lncRNAs) are important regulators of de

182 Long non-coding RNAs (lncRNAs) are of fundamental biological

183 Long non-coding RNAs (lncRNAs) are often aberrantly expressed

184 known ASD risk genes code for proteins, long non-coding RNAs (lncRNAs) as essential regulators of gen

185 Long non-coding RNAs (lncRNAs) constitute a significant fract

186 Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)p

187 Long non-coding RNAs (lncRNAs) exhibit highly cell type-speci

188 Long non-coding RNAs (lncRNAs) have emerged as essential infl

189 Despite our understanding of long non-coding RNAs (lncRNAs) in primary colon cancer, their

190 o identify binding proteins of specific long non-coding RNAs (lncRNAs) in the native cellular context

191 the targeting and spreading patterns of long non-coding RNAs (lncRNAs) on chromatin requires a techni

192 As ncRNAs such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) or circular RNAs (circRNAs) ca

193 Long non-coding RNAs (lncRNAs) play an important role in gene

194 Long non-coding RNAs (lncRNAs) play crucial roles in regulati

195 of multi-protein DNA complexes, so how long non-coding RNAs (lncRNAs) regulate DNA repair is less we

196 is transcribed and that there are more long non-coding RNAs (lncRNAs) than protein coding genes, sev

197 alian genome is transcribed, generating long non-coding RNAs (lncRNAs) that can undergo post-transcri

198 Long non-coding RNAs (lncRNAs) with a length of > 200 nucleot

199 Here, we report that long non-coding RNAs (lncRNAs), a recently discovered class o

200 expression of LRRK2 and two long intergenic non-coding RNAs (lncRNAs), LINC02555 and AC079630.4, in

201 oma (LUAD) based on multi-omics data of long non-coding RNAs (lncRNAs), microRNAs and mRNAs.

202 and predicting circular RNAs from other long non-coding RNAs (lncRNAs).

203 ts (TEs) comprise a large proportion of long non-coding RNAs (lncRNAs).

204 rates, while rRNA, tRNA, and other conserved non-coding RNAs (ncRNAs) are excluded from these bodies.

205 Small non-coding RNAs (ncRNAs) are short non-coding sequences

206 The functional importance of many non-coding RNAs (ncRNAs) generated by repetitive element

207 Non-coding RNAs (ncRNAs) have been reported to control f

208 (DMD) is a surveillance pathway for certain non-coding RNAs (ncRNAs) including ribosomal RNAs (rRNAs

209 Small non-coding RNAs (sncRNAs) play important roles in health

210 conserved between mouse and human XIST long non-coding RNAs and defined protein communities whose bi

211 gene transcripts, separating short and long non-coding RNAs and predicting circular RNAs from other

212 R, that automates the discovery of expressed non-coding RNAs and UTRs from RNA-seq reads mapped to a

213 Non-coding RNAs are fundamental to the competing endogen

214 Long non-coding RNAs are important regulators of biological p

215 teracting RNAs (piRNAs) are a class of small non-coding RNAs essential for fertility.

216 n be achieved in three steps: distinguishing non-coding RNAs from protein coding gene transcripts, se

217 Non-coding RNAs generated from heterochromatic regions a

218 Circular RNAs (circRNAs), a class of non-coding RNAs generated from non-canonical back-splici

219 Small non-coding RNAs have gained substantial attention due to

220 We find that alignments for several long non-coding RNAs previously shown to lack covariation sup

221 ing of EVs identifies diverse RBPs and small non-coding RNAs requiring the LC3-conjugation machinery

222 lasma contains > 40,000 different coding and non-coding RNAs that are potential biomarkers for human

223 MicroRNAs (miRs) are small non-coding RNAs that can have large impacts on oncogenic

224 MicroRNAs (miRNAs) are small non-coding RNAs that have been successfully identified t

225 MicroRNAs (miRNAs) are short, non-coding RNAs that modulate the translation-rate of me

226 Small RNAs are non-coding RNAs that play important roles in the lives o

227 MicroRNA are small non-coding RNAs that post-transcriptionally regulate the

228 However, the contribution of non-coding RNAs to complex traits is not clear.

229 Numerous differentially expressed non-coding RNAs were identified and quantified and poten

230 MicroRNA-27a/b are small non-coding RNAs which are reported to regulate inflammat

231 miRNAs are a large family of non-coding RNAs which play important roles in translatio

232 MiRNAs are small non-coding RNAs which post-transcriptionally regulate ge

233 chromosomes are active and express the long non-coding RNAs X active coating transcript (XACT) and X

234 m of m(6)A modifications (in both coding and non-coding RNAs) in cancer pathogenesis and drug respons

235 gth, mature tRNAs and other structured small non-coding RNAs, and less abundant tRNA fragments and ma

236 lysis of changes in genome methylation, long non-coding RNAs, circular RNAs, micro-RNAs and fruit met

237 most eukaryotic pre-messenger RNAs and long non-coding RNAs, introns are removed through the process

238 ch of these genes, either coding proteins or non-coding RNAs, is or are responsible for DFNA58 HL.

239 found not only in messenger RNAs but also in non-coding RNAs, m(6)A affects the fate of the modified

240 processed for EXO-NGS, we observed two long non-coding RNAs, malat-1 and CRNDE to be variably expres

241 ied three highly abundant HHV-6 encoded long non-coding RNAs, one of which generates a non-polyadenyl

242 sequence-divergent but structurally related non-coding RNAs, share RNP networks and that network hub

243 transcription factor binding motifs and long non-coding RNAs, that potentially contribute to organoge

244 modification and chromatin remodelling, and non-coding RNAs, the manipulation of these mechanisms is

245 Enhancer RNAs (eRNA) are unstable non-coding RNAs, transcribed bidirectionally from active

246 element family member, which generates long non-coding RNAs.

247 osine release and expression of certain long non-coding RNAs.

248 hers function broadly across both coding and non-coding RNAs.

249 nuclear RNA degradation, primarily targeting non-coding RNAs.

250 oteins, post-translational modifications and non-coding RNAs.

251 ying localization consistent with other long non-coding RNAs.

252 essing and/or degradation of both coding and non-coding RNAs.

253 ntially targeted by differentially expressed non-coding RNAs.

254 t addition to the ever-expanding pantheon of non-coding RNAs.

255 cations, and regulation of transcription via non-coding RNAs.

256 tified and characterized on mRNA and various non-coding RNAs.

257 to cis-regulatory elements (CREs), which are non-coding segments of DNA that spatially and temporally

258 isted by a Foxp3 enhancer known as conserved non-coding sequence 1 (CNS1)(2-4).

259 ed by genome-wide association studies map to non-coding sequence and their tissue-specific effects in

260 how emerging findings regarding the role of non-coding sequence variation offer opportunities for un

261 be driven in part by variation in conserved non-coding sequences (CNS).

262 Our results shed light on the importance of non-coding sequences in the evolution of the S-locus, an

263 Small non-coding RNAs (ncRNAs) are short non-coding sequences involved in gene regulation in many

264 llion people, with risk variants enriched in non-coding sequences near chondrocyte genes, loci that l

265 thin 3'UTRs that results in species-specific non-coding sequences that may contribute to bacterial di

266 and fails to distinguish between coding and non-coding sequences.

267 These data indicate that non-coding somatic mutations disrupt the PAX8 transcript

268 the other hand, allows for identification of non-coding somatic variation and expanded estimation of

269 U1 snRNP (U1), vertebrates' most abundant non-coding (spliceosomal) small nuclear RNA, silences pr

270 Most of these variants are non-coding, suggesting that regulatory effects may drive

271 We identified clustering of non-coding SVs around neuroactive ligand-receptor intera

272 t cis-sQTL for the alternative splicing of a non-coding transcript of EPB41L4A, called EPB41L4A-203.

273 In addition, the level of Per2AS, a novel non-coding transcript that is expressed at the Period 2

274 Non-coding transcriptional regulatory elements are criti

275 pe, Gr and r mutant fruits at the coding and non-coding transcriptomic, metabolomic and genome methyl

276 al surveillance whereby only a subset of the non-coding transcripts is allowed to attain sufficient s

277 In this work, we annotated viral mRNAs and non-coding transcripts, and a large number of transcript

278 notated 27 969 protein-coding genes and 6747 non-coding transcripts.

279 How mutations in the non-coding U8 snoRNA cause the neurological disorder leu

280 scale population sequencing data in studying non-coding variant classes.

281 g the distribution of the probability that a non-coding variant disrupts regulatory activities.

282 nd functionally validated a novel pathogenic non-coding variant in a small family with a previously u

283 ting eQTLs in the DGRP, including one common non-coding variant that lowers enteric infection suscept

284 Establishing causal links between non-coding variants and human phenotypes is an increasin

285 For one, non-coding variants are present at much higher number in

286 The odds ratio for qualifying non-coding variants considered independently from coding

287 Non-coding variants have been shown to be related to dis

288 (IRT), to predict the regulatory targets of non-coding variants identified in studies of eQTLs.

289 o the regulatory role of enhancer-associated non-coding variants in cancer epigenome, and to facilita

290 investigation of functional contributions of non-coding variants in cancer epigenome.

291 only, coding alteration only, or coding plus non-coding variants in experimentally predicted regulato

292 Predicting the regulatory effects of non-coding variants on candidate genes is a key step in

293 Non-coding variants present a unique challenge for such

294 We show that 71% of all rare non-coding variants previously proposed as causal lead t

295 Non-coding variants remain particularly difficult to int

296 Finally, we identified four novel non-coding variants that cause disease through the disru

297 Previous genome-wide scans found many non-coding variants under selection, suggesting a pressi

298 lements (RE) and genes perturbed by acquired non-coding variants, here we establish epigenomic and tr

299 nally, our study emphasizes the relevance of non-coding variation in genetic studies of complex disea

300 es (DEGs), including both protein-coding and non-coding, were detected in astrocytes, oligodendrocyte