ライフサイエンスコーパス: non-covalent

1 hat the nature of nfGNPs-VLPs interaction is non-covalent.

2 indicating that the dominant interaction is non-covalent.

3 s diverse field with a focus on covalent and non-covalent 2D polymers and frameworks, and self-assemb

4 horesis studies demonstrate the formation of non-covalent adducts with natural plasmids.

5 rmal properties, low chemical reactivity and non-covalent affinity to graphene enable transfer of wri

6 gonists, did not affect sensitisation by the non-covalent agonist carvacrol, which activates by bindi

7 Here, we report the discovery of a non-covalent agonist, GNE551, and determine a cryo-EM st

8 How non-covalent agonists activate the channel and whether c

9 ctivate the channel and whether covalent and non-covalent agonists elicit the same physiological resp

10 action of the agonist, because covalent and non-covalent agonists were equally effective, and is lon

11 77 nM, which places it among the most potent non-covalent AmpC inhibitors known.

12 Supramolecular copolymers, non-covalent analogues of synthetic copolymers, constitu

13 In particular, this review analyzes various non-covalent and covalent interactions and chemistry app

14 This review is focused on non-covalent and covalent interactions that are employed

15 The interaction is non-covalent and extraction with octanol completely remo

16 meditope peptides could be used as specific non-covalent and paratope-independent handles in targete

17 d from a non-expert perspective, to identify non-covalent and pre-associative nucleic acid recognitio

18 Here, a non-covalent approach was used to conjugate PEG bearing

19 The use of ionic self-assembly, a facile non-covalent approach, to access non-conventional block

20 he supramolecular complexation behaviour and non-covalent approaches rather than on the proposed appl

21 e chemically modified, by either covalent or non-covalent approaches, in order to interface them with

22 ce of electronic properties not evidenced in non-covalent assemblies.

23 at a temperature (371 K) where the pristine, non-covalent assembly exists exclusively in a molecularl

24 nergy when compared to that recorded for the non-covalent assembly.

25 By non-covalent association after proteolytic cleavage, the

26 -specific chemisorption of MTFP and multiple non-covalent attractive interactions between the carbony

27 petition between electrostatic repulsion and non-covalent attractive interactions.

28 Interestingly, when non-covalent backside ubiquitin binding cannot occur, th

29 caffold for molecular transport based on its non-covalent base pairing to assemble both stationary an

30 ompared to native beta-Lactoglobulin and the non-covalent beta-lactoglobulin/caffeic complex (betaLg/

31 Also, due to the ability of the non-covalent beta-sheet cross-links to reassemble, the h

32 antibodies and DNA, which undergo important non-covalent binding interactions, with the formation of

33 strategies to fortify their capsids, such as non-covalent binding of auxiliary 'decoration' (Dec) pro

34 Non-covalent binding of K63-Ubn to 2CARD induces its tet

35 The biological implications of non-covalent binding of polyphenols to BLG were investig

36 o design ADCs that self-assemble through the non-covalent binding of the antibody to a payload that w

37 ing sites for allicin, whereas the number of non-covalent binding sites increased for diallyl disulfi

38 d gas diffusion electrodes (GDEs) by using a non-covalent binding strategy.

39 terized by two key molecular properties: (1) non-covalent binding to an antibody-based therapeutic, a

40 However, the effect of non-covalent binding to Nedd8 remains unknown.

41 1p and E3 components to the E2p core through non-covalent binding.

42 s a consequence of blocking the stimulatory, non-covalent, binding of ubiquitin to the backside of Ub

43 Thus, bPoNAs can serve as tools for both non-covalent bioconjugation and structure-function nucle

44 em prime candidates for in vitro and in vivo non-covalent bioconjugation, for imaging and delivery ap

45 tibody and the intermediate affinity of this non-covalent bond, fully assembled probes do not aggrega

46 achieved in dynamic reversible covalent and non-covalent bonding chemistries for self-healing polyme

47 Waals radii) and its ability to form strong non-covalent bonding interactions with pi-electron-rich

48 ployed to elucidate thermodynamic behaviors, non-covalent bonding of coacervates, and microstructure

49 the hydrophobicity of the protein such that non-covalent bonding within network was modified.

50 This tutorial review summarizes non-covalent bonding, reversible reactions and responsiv

51 The non-covalent bonds allow the extrusion of the inks into

52 rate shear forces that exceed the ability of non-covalent bonds to remain attached.

53 Non-covalent bonds, more likely salt bridge and ionic in

54 We also demonstrate how strong non-covalent bonds, which are versatile for controlled p

55 The non-covalent capture of olive pheromones inside the beta

56 s has been performed under both covalent and non-covalent catalysis, with diaryl prolinols, imidazoli

57 at phenolics may complex with starch through non-covalent CH-pai bonds along alpha-(1 -> 4) glycosidi

58 interactions contribute to the formation of non-covalent chainmail in BPP-1, unlike covalent inter-p

59 The idea I advocate here is that the non-covalent change in protein conformation itself might

60 ry and the emergence of dynamic covalent and non-covalent chemistries, novel perspectives have been o

61 While, initial recruiters have utilized non-covalent chemistry for protein binding, very recentl

62 However, the contribution of non-covalent chromatin structure to the poised state is

63 tion in mesostructured soft solids involving non-covalent co-assembly has received little attention.

64 olution on how the monomer structure affects non-covalent COF layer stacking.

65 The straightforward non-covalent combination of MSN and gold-protein cluster

66 , the intracellular delivery of avidin, as a non-covalent complex with a biotinylated Tat vector, is

67 ivery capabilities and function by forming a non-covalent complex with cargo, protecting it from nucl

68 and finally dynamic molecular motion within non-covalent complexes as unravelled by hydrogen-deuteri

69 that CB[7]6 is among the tightest monovalent non-covalent complexes ever reported in water with Ka =7

70 The non-covalent complexes formed between the peptide and ca

71 Several new structures of non-covalent complexes of PGA with different substrates,

72 sociation and formation of covalent bonds in non-covalent complexes through the reactivity in the res

73 Moreover, the non-covalent complexes were optimally detected at wavele

74 heir ability to specifically target and form non-covalent complexes with other proteins.

75 The array is fabricated using non-covalent conjugation of an aptamer-anchor polynucleo

76 tunable biohybrid hydrogels by covalent and non-covalent conjugation schemes, including both theory-

77 Here we show that non-covalent contacts between the active molecular compo

78 tructures, we uncover a conserved network of non-covalent contacts that defines the GPCR fold.

79 ages as well as challenges relative to their non-covalent counterpart.

80 differences: the chains are kinked, enabling non-covalent cross-linking of fibrils and disfavoring fo

81 lf-assembling beta-sheet peptides to provide non-covalent cross-linking through beta-sheet assembly,

82 s with mucin forming a network structure via non-covalent cross-links between mucin chains.

83 d with a small-amount dynamic CB[8]-mediated non-covalent crosslinking (2.5 mol%), yields extremely s

84 These non-covalent crosslinking moieties are able to undergo a

85 oducing chemical moieties to promote dynamic non-covalent crosslinking of the conjugated polymers.

86 Specific non-covalent crosslinks involving domains/motifs lead to

87 s and / or domains that can form reversible, non-covalent crosslinks with one another.

88 However, the non-covalent Cu(II) coordination approach is vulnerable

89 main cysteines, retained the ability to form non-covalent dimers, and all of the BST-2 variants were

90 oluble and membrane-bound proteins exists as non-covalent dimers, trimers, and higher-order oligomers

91 The formation of non-covalent directional interactions, such as hydrogen

92 (AH78 TriplatinNC) and 7 (AH78H), are potent non-covalent DNA binding agents where nucleic acid recog

93 There is a wide range of applications for non-covalent DNA binding ligands, and optimization of su

94 chanisms, we have successfully constructed a non-covalent DNA catalysis network that resembles an all

95 ctive is provided along with descriptions of non-covalent DNA recognition focusing on intercalation,

96 (b) Some non-covalent drug-protein complexes rely on rather affin

97 In the present communication, a non-covalent fenarimol-imprinted polymer was synthesized

98 e interactions by docking, both covalent and non-covalent, for 38 lipases with a large number of stru

99 to use supramolecular design to leverage the non-covalent forces between COF monomers and sheets to i

100 ecular polymers depending on the cooperative non-covalent forces driving their formation, with partic

101 ulsive steric and stabilizing intermolecular non-covalent forces in the stereodetermining hydride tra

102 of n-->pi* interactions in the inventory of non-covalent forces that contribute to protein stability

103 oups that may interact either by covalent or non-covalent forces with other molecules present in the

104 whereas octanal bound PPIs via covalent and non-covalent forces.

105 onds which are then stacked together through non-covalent forces.

106 t inhibitors through merging of covalent and non-covalent fragment hits; one series of low-reactivity

107 med a large-scale screen of electrophile and non-covalent fragments through a combined mass spectrome

108 nt synthetic approaches for the covalent and non-covalent functionalization and characterization of G

109 The non-covalent functionalization through pi-pi stacking in

110 Non-covalent functionalization with phospholipid-polyeth

111 into organophilic material via covalent and non-covalent grafting strategies.

112 rovide new insights into the role of unusual non-covalent halogen bonding interactions involved in th

113 Contrary to the non-covalent heterogeneous dispersion of pure (unmodifie

114 The resulting non-covalent heterotrimer was exported in a Tat-dependen

115 that the molecular self-assembly in water by non-covalent host-guest molecular recognition is suffici

116 successful supramolecular polymerization by non-covalent host-guest molecular recognition was confir

117 thylene glycol interact with heparin to form non-covalent hydrogels.

118 associations are stabilized and mediated by non-covalent hydrogen bonds that arise on the backbone o

119 chains into a short polymer block leading to non-covalent, hydrophobic interactions with the lipid bi

120 such selectivity is partially retained upon non-covalent (i.e. intercalation) mixture formed by nati

121 tion interface was fabricated via simple and non-covalent immobilization of antibody using lectin-med

122 The method of non-covalent immobilization of DNA probes on an uncharge

123 /Au/GO nanocomposite was synthesized through non-covalent imprinting process in the presence of IMQ,

124 enetic or chemical modification, we report a non-covalent infusion technique that facilitates efficie

125 K27 is a potent, non-covalent inhibitor of nucleotide exchange, showing c

126 ailed interactions between first generation, non-covalent inhibitors and GlgE, a variant Streptomyces

127 o generate potent, class-specific, bioactive non-covalent inhibitors for these enzymes are still limi

128 to advance the development of high affinity, non-covalent inhibitors of K-Ras oncogenic mutants.

129 ve cells using either covalent attachment or non-covalent insertion, while maintaining high cell viab

130 lographically observed structural motifs and non-covalent interaction acceptor-donor pairings.

131 We found an unexpected non-covalent interaction between AbDsbA and the highly c

132 ELF domain of FANCL is required to mediate a non-covalent interaction between FANCL and ubiquitin.

133 vity and/or selectivity have been imputed to non-covalent interaction between the reaction partners.

134 ting evidence points to the emerging role of non-covalent interaction between ubiquitin and the targe

135 as been a growing interest in exploring this non-covalent interaction in nanoscale drug delivery syst

136 driver for assembly, the contribution of the non-covalent interaction is to direct the molecular-leve

137 nidine and arginine formed both covalent and non-covalent interaction products.

138 s occurs via an initial metal ion-dependent, non-covalent, interaction between TSG-6 and HCs that als

139 The pretargeting approach utilises specific non-covalent interactions (e.g. strept(avidin)/biotin) o

140 n of the major enantiomer through attractive non-covalent interactions (NCIs) rather than retarding t

141 ondary orbital interactions, are overcome by non-covalent interactions affording to the unusual exo a

142 In natural systems, highly synergistic non-covalent interactions among biomolecular components

143 d crystalline molecules are organized due to non-covalent interactions and due to delicate nature of

144 achieved a predictable control over various non-covalent interactions and have used these weak inter

145 r the rational manipulation of these complex non-covalent interactions and their direct incorporation

146 ly of low-molecular weight compounds by weak non-covalent interactions and thus, they may be easily d

147 Non-covalent interactions are thought to be involved in

148 Nature uses the power of non-covalent interactions as the basis for many kinds of

149 s tools for the qualitative understanding of non-covalent interactions as well as energy decompositio

150 or two diverse catalytic systems with unique non-covalent interactions at the heart of each process.

151 adhesive materials that rely on a number of non-covalent interactions at the interfaces.

152 fers enormous potential, in which attractive non-covalent interactions between a chiral catalyst and

153 the channel protein through a combination of non-covalent interactions between adjacent helices and c

154 vantage of the cumulative effect of multiple non-covalent interactions between adjacent molecules.

155 Non-covalent interactions between beta-lactoglobulin (BL

156 The theoretical analysis of the non-covalent interactions between host and guest confirm

157 s that are loaded onto nanoparticles through non-covalent interactions between polyhistidine tags and

158 In this work, substituent effects tune non-covalent interactions between side-chain fluorinated

159 hat the amide E:Z equilibrium is affected by non-covalent interactions between the amide oxygen and a

160 of viral capsid self-assembly require weak, non-covalent interactions between the capsid subunits to

161 Non-covalent interactions between the cellulose crystals

162 be dedicated to catalytic systems for which non-covalent interactions between the partners of the re

163 standing of the synergy between covalent and non-covalent interactions can form the basis for any pre

164 ssembly of binary systems driven by specific non-covalent interactions can greatly expand the structu

165 ous assembly driven by coordination multiple non-covalent interactions can help explain the well-orde

166 and consolidated by the recruitment of other non-covalent interactions contributed by subsurface moie

167 nt proteins provide striking examples of how non-covalent interactions could be exploited for tuning

168 logy is validated by directly connecting the non-covalent interactions defined through empirical data

169 Stronger non-covalent interactions delayed pepsin and pancreatin

170 rotein analysis due to its ability to retain non-covalent interactions during measurements, making it

171 The utilization of non-covalent interactions for the design of adhesives wi

172 w molecular weight gelators (LMWGs) based on non-covalent interactions has been proven to be a useful

173 In this way, many types of non-covalent interactions have been characterized, from

174 re designed to interact with one another via non-covalent interactions in order to create function.

175 ative enzymes and their models, the roles of non-covalent interactions in promoting this activity are

176 s this, the significantly higher strength of non-covalent interactions in the absence of competing so

177 The role of non-covalent interactions in the formation of visco-elas

178 n-biotin interaction is one of the strongest non-covalent interactions in the nature.

179 results more from stabilizing intramolecular non-covalent interactions in the secondary coordination

180 These results indicate that manipulating non-covalent interactions in zein can alter and in some

181 Commonly used non-covalent interactions include hydrogen bonding, pai-

182 unfolding interest in integrating unorthodox non-covalent interactions into functional systems.

183 racteristics underlying the most significant non-covalent interactions involved in fibrin polymerizat

184 binding and catalysis are often mediated by non-covalent interactions involving aromatic functional

185 lecular chemistry is overwhelmingly based on non-covalent interactions involving organic architecture

186 plasmon resonance (SPR) phenomenon to study non-covalent interactions not just between plasmonic par

187 ells can metabolize aroma compounds and that non-covalent interactions occur between aroma compounds

188 rb on graphitic nanomaterials (GNMs) through non-covalent interactions occurring at their interfaces.

189 Non-covalent interactions of EGCG with proteins contribu

190 Next, non-covalent interactions of peptides with other peptide

191 tuitive to use it to study the structure and non-covalent interactions of proteins that form in solut

192 pecific, directional, tunable and reversible non-covalent interactions offer unprecedented advantages

193 They can be as labile as non-covalent interactions or as permanent as covalent bo

194 to their dynamic, stimuli-responsive nature, non-covalent interactions represent versatile design ele

195 terplay between polyvalent electrostatic and non-covalent interactions that work in unison to disrupt

196 iew eminent examples which take advantage of non-covalent interactions to achieve regiocontrol.

197 ry have previously been synthesized by using non-covalent interactions to assemble and entangle molec

198 Supramolecular chemistry uses non-covalent interactions to coax molecules into forming

199 ts a combination of attractive and repulsive non-covalent interactions to direct the enantio-determin

200 This strategy takes advantage of non-covalent interactions to template a topochemical pho

201 ms make simultaneous use of several types of non-covalent interactions together, one would expect the

202 esidue offset is lucrative, as it leaves the non-covalent interactions unsatisfied at the termini and

203 d subsequently quantify the strengths of the non-covalent interactions using Kohn-Sham density functi

204 By establishing conditions that preserve non-covalent interactions we exploit the surface to capt

205 ysis was performed on the complex network of non-covalent interactions which stabilize each cluster.

206 a viral RNA sensor, RIG-I, both covalent and non-covalent interactions with K63-linked ubiquitin chai

207 Non-covalent interactions with the -CF(3) groups, and hy

208 olated guest molecules demonstrates that the non-covalent interactions with the host hardly affect th

209 les are assembled into regular structures by non-covalent interactions, attract tremendous interests

210 re the nature of the covalent chemical bond, non-covalent interactions, bond formation, and exotic 3-

211 By using specific, dynamic, and tunable non-covalent interactions, engineered approaches to drug

212 c receptors which bind carbohydrates through non-covalent interactions, mimicking the strategies used

213 Furthermore, non-covalent interactions, such as electrostatics, pi-st

214 Non-covalent interactions, such as self-interaction and

215 ssociate with the resulting Np complexes via non-covalent interactions, which together decrease the e

216 We found that the structure is stabilized by non-covalent interactions, with dominant contributions f

217 n-2D materials that adhere primarily through non-covalent interactions.

218 ave renewed their interest in water-mediated non-covalent interactions.

219 eine was enclosed within the gel network via non-covalent interactions.

220 ucts and at the same time exhibiting various non-covalent interactions.

221 ing that protein network was mostly based on non-covalent interactions.

222 IP3 R1 remain associated, presumably through non-covalent interactions.

223 ng nanomaterial whose assembly is driven via non-covalent interactions.

224 action partners that can be held together by non-covalent interactions.

225 stic properties of zein arise as a result of non-covalent interactions.

226 plex transformations exploiting covalent and non-covalent interactions.

227 e excited state by employing confinement and non-covalent interactions.

228 nition phenomena are a direct consequence of non-covalent interactions.

229 Self-assembly occurs via non-covalent interactions.

230 eric structures from small molecules through non-covalent interactions.

231 dapt to cell behavior as a result of dynamic non-covalent interactions.

232 e correlations is introduced for postulating non-covalent interactions.

233 Here we systematically investigated non-covalent interchain interactions for CH3 domains in

234 Specifically, the weak non-covalent intermolecular interactions induced by the

235 trameric complex exhibits the involvement of non-covalent intermolecular interactions that are locali

236 otein nanostructures have been assembled via non-covalent intramolecular and intermolecular interacti

237 l of photo-activation, enabling the study of non-covalent kinetic intermediates and heterogeneous mix

238 es, the activities of which are regulated by non-covalent ligand binding, and that may provide a temp

239 xes and allows selections in the presence of non-covalent ligands.

240 The p75(NTR) DD forms non-covalent, low-affinity symmetric dimers in solution.

241 The kinetic stability of non-covalent macromolecular complexes controls many biol

242 ential benefit of using a serum protein in a non-covalent manner in conjunction with paclitaxel nanoc

243 s can coat the surfaces of Ad particles in a non-covalent manner to modify their transduction propert

244 stabilized by serum protein transferrin in a non-covalent manner.

245 e synthetic biology, nanodisc-technology and non-covalent mass spectrometry provides excellent synerg

246 e not held together by covalent bonds but by non-covalent mechanical interactions.

247 t NAAA in a potent and selective manner by a non-covalent mechanism are described.

248 Microtubules are non-covalent mesoscale polymers central to the eukaryoti

249 ausible approach to the development of novel non-covalent methods of binding, retention, and release

250 These data demonstrated that our non-covalent modification was able to alter Ad's interac

251 were immobilized to the graphene surface via non-covalent modification.

252 actor governing recognition, particularly in non-covalent molecularly imprinted polymers.

253 compound exemplifies a second generation of non-covalent NAAA inhibitors that may be useful in the t

254 of dynamic features as a consequence of the non-covalent nature of their core interactions, but also

255 inically relevant setting, likely due to the non-covalent nature of their interaction with collagen m

256 both Smurf1 and its homologue Smurf2 carry a non-covalent Nedd8-binding site within its catalytic HEC

257 Responsive graphene oxide sheets form non-covalent networks with optimum rheological propertie

258 If a fusion protein assembles into a non-covalent oligomeric complex, exciting their GFP moie

259 k using pyrene carboxylic acid (PCA) through non-covalent pai-pai stacking interaction between PCA an

260 We describe seven kinds of non-covalent-pai interactions between c-di-AMP and its r

261 This is the first demonstration of non-covalent PEGylation of acylated peptides, an importa

262 , phospholipids (dithranol, THAP, HABA), and non-covalent peptide-peptide and protein-peptide complex

263 advance for future structure-based design of non-covalent peptidomimetic inhibitors.

264 Non-covalent pi-pi interactions are central to chemical

265 ustering by enabling reversible, cooperative non-covalent (pi-pi, solvophobic, and hydrogen bonding)

266 MO-interacting motif favors formation of the non covalent PIAS1.SUMO.UBC9 ternary complex.

267 A non-covalent polymerization reaction between macromolecu

268 In this study, non-covalent polymers from self-assembled boric acid wer

269 Surface coating using non-covalent polymers from self-assembled boric acid wil

270 Non-covalent polymers have remarkable advantages over sy

271 l properties of formally substitution-inert "non-covalent" polynuclear platinum complexes (PPCs).

272 e of the polysaccharides by the formation of non-covalent polysaccharides-OE complexes.

273 We introduce a non-covalent pore engineering approach to achieve except

274 uctural proteomics under the assumption that non-covalent protein complexes being transferred into th

275 moieties in these polymeric mimics improves non-covalent protein delivery, providing crucial design

276 Rationally designed non-covalent protein nanocapsules incorporating copper-f

277 In this tutorial review the non-covalent recognition of CWAs is considered from firs

278 shed a mechanism-of-action involving initial non-covalent recognition of inhibitors at the IspD bindi

279 for mediating targeted cell penetration and non-covalent self-assembly with therapeutic cargo, formi

280 Numerous non-covalent small-molecule Keap1-Nrf2 PPI inhibitors ha

281 ierarchical functional nanomaterials through non-covalent soft-chemical routes.

282 , supramolecular structures held together by non-covalent solvophobic and coordination interactions a

283 cond conformational change associated with a non-covalent step not previously reported for Pol beta.

284 The second part introduces various non-covalent strategies for achieving desired doping in

285 analysis suggested covalent (ester bond) and non-covalent (strong hydrogen-bonding, mostly) interacti

286 exity of the extracellular matrix (ECM) to a non-covalent structure with minimal chemically defined c

287 "strands"-connected together via covalent or non-covalent/supramolecular interactions, are arguably t

288 essing challenges in the prospering field of non-covalent surface functionalization.

289 The overall approach offers an efficient, non-covalent synthesis method for the solution-phase fab

290 des an attractive bottom-up approach for the non-covalent synthesis of nascent axial organic heterost

291 ning self-assembled structure in biology and non-covalent synthesis.

292 her differentiation in terms of covalent and non-covalent systems.

293 Finally, our results also indicate that the non-covalent ternary complex is required for the known t

294 as assembled into a previously unidentified non-covalent ternary complex with SUMO as evidenced by b

295 This non-covalent three-helix bundle domain is homologous in

296 either covalent arabinogalactan mycolates or non-covalent trehalose mycolates in live mycobacteria.

297 mology domain (THD) of human (h)4-1BBL forms non-covalent trimers, we found that m4-1BBL formed a cov

298 Non-covalent Ub binding to the backside of certain E2s p

299 nexpected synergism between the covalent and non-covalent ubiquitin interaction modes.

300 Non-covalent vdW interactions, however, are ubiquitous i