ライフサイエンスコーパス: non-covalently

1 opies of peripheral enzymes bind tightly but non-covalently.

2 alose glycolipids that associate with the MM non-covalently.

3 ins are only known to bind to host receptors non-covalently.

4 ipheral enzymes (E1 and E3) bind tightly but non-covalently.

5 ly demonstrated that surface-associated InlB non-covalently adheres to both WTA and LTA, mediating it

6 ific dipole relaxation of PPSU assemblies to non-covalently anchor the proteins without disrupting th

7 rranged in cage-like particles, are found to non-covalently anchor to the vertices of the Matrix-M an

8 emokine-encapsulating nanoparticles that are non-covalently anchored onto the surface of injected ery

9 sitive surface proteins can be covalently or non-covalently anchored to the cell wall and can impart

10 The present work aims to separate vacuolar, non-covalently and covalently bonded tannins fractions.

11 quids (ILs) capable of complexing with siRNA non-covalently and delivering it effectively.

12 PUFAs activate TRPA1 non-covalently and independently of known ligand binding

13 lography, we show that imipridones bind ClpP non-covalently and induce proteolysis by diverse structu

14 nts of the gastric gland secretome associate non-covalently and show increased expression upon H. pyl

15 serum albumin was found to bind NO2-CLA both non-covalently and to form covalent adducts at Cys-34, s

16 ghout nature: seven beta-barrel subunits are non-covalently assembled through beta-strand pairings in

17 Cellular LRP consists of a non-covalently associated 515-kDa extracellular alpha-ch

18 The non-covalently associated B-subunit moieties of AB5 toxi

19 here, including in the alpha3 domain and the non-covalently associated beta2-microglobulin molecule,

20 inant human stem cell factor (rhSCF) forms a non-covalently associated dimer.

21 led receptors can exist as both monomers and non-covalently associated dimers/oligomers, the steady-s

22 c gp160 envelope (Env) protein consisting of non-covalently associated gp120 and gp41 subunits to med

23 envelope glycoprotein (Env) is comprised of non-covalently associated gp120/gp41 subunits that form

24 TLF2 also uniquely contains non-covalently associated immunoglobin M (IgM) antibodie

25 These invariant dimers are non-covalently associated on the T cell plasma membrane

26 to homogeneity and shown to consist of two, non-covalently associated polypeptide chains of molecula

27 ranslational autoproteolysis to generate two non-covalently associated polypeptide chains.

28 proprotein convertases (PPCs) resulting in a non-covalently associated prodomain-growth factor (PD-GF

29 cent to the ligand domain, which generates a non-covalently associated prodomain/ligand complex that

30 synthesized and secreted as pro-complexes of non-covalently associated prodomains and growth factors

31 ed that m3' receptors were also able to form non-covalently associated receptor dimers and that m3' r

32 polypeptides (epsilon, gamma, and delta) are non-covalently associated signaling subunits of the T ce

33 umed that the sequence of DSB formation from non-covalently associated tetramers to fully bonded tetr

34 zation with two covalently linked A subunits non-covalently associated to a pentameric B subunit.

35 s expressed as a latent complex (L-TGF-beta) non-covalently associated with its prodomain and present

36 typic alphabeta heterodimeric structure (Ti) non-covalently associated with the monomorphic CD3 signa

37 f the receptor during processing but remains non-covalently associated with the seven-transmembrane r

38 rane collagen by the GPVI receptor, which is non-covalently associated with the signal-transducing Fc

39 slationally into gp120 and gp41 which remain non-covalently associated.

40 tion motif (ITAM) in its cytoplasmic domain, non-covalently associates with membrane glycoproteins of

41 ules bind co-operatively to this enzyme, one non-covalently at the S-pocket and one covalently at the

42 lt with all of the MVP N termini interacting non-covalently at the vault midsection and 48 copies of

43 erminal and C-terminal fragments-that remain non-covalently attached after receptors reach the cell s

44 yme into alpha and beta subunits that remain non-covalently attached and are anchored to the inner me

45 strongly localized heating adequate to melt non-covalently attached double-stranded oligonucleotides

46 Eap and Emp are secreted proteins which are non-covalently attached to the S. aureus cell surface an

47 of peroxisomal location and that the FAD is non-covalently attached.

48 SA2, a small-molecule agonist that dimerizes non-covalently before binding to STING, we showed that i

49 polymer-peptide surface coating platform to non-covalently bind hyaluronic acid (HA), a natural lubr

50 t BfUbb lyses certain B. fragilis strains by non-covalently binding and inactivating an essential pep

51 G1/G0-specific masking of the site, owing to non-covalently binding factors.

52 We show that NalC non-covalently binds chlorinated phenols and chemicals c

53 iple stereochemical states within individual non-covalently bonded chirality-transfer complexes on a

54 ion at room temperature was able to separate non-covalently bonded compounds.

55 within the first few minutes of working with non-covalently bonded NAD(+)).

56 The CW EPR spectra of non-covalently bound 5- and 16-DOXYL stearic acid (5/16-

57 Non-covalently bound aromatic systems are ubiquitous and

58 of dihydrolipoamide, hE3 uses two molecules: non-covalently bound FAD and a transiently bound substra

59 The purified protein contains a non-covalently bound FAD but no detectable redox active

60 Four of them also led to the loss of the non-covalently bound FAD cofactor.

61 accepts electrons from dihydrolipoate, and a non-covalently bound FAD moiety, which transfers electro

62 protein surface to the active site, where a non-covalently bound flavin adenine dinucleotide (FAD) s

63 Purified NDH-2 contains a non-covalently bound flavin adenine dinucleotide cofacto

64 Blue-light absorption by the non-covalently bound flavin chromophore triggers sequent

65 length isolated flavodoxin, which contains a non-covalently bound flavin mononucleotide (FMN) as cofa

66 nzyme that contains 45 different subunits, a non-covalently bound flavin mononucleotide, and eight ir

67 stimated molecular mass of 23,050 Da and one non-covalently bound FMN as co-factor.

68 x-ray crystallography demonstrate a tightly, non-covalently bound FMN in the active site of the enzym

69 a homodimer of 80 kDa, containing a mole of non-covalently bound FMN per mole of subunit, and is dev

70 sponse to a specific protein and release its non-covalently bound guest molecules.

71 covalently, add to evidence that retinal is non-covalently bound in these intermediate states.

72 This is particularly so for the non-covalently bound lipids, whose natural distribution

73 ric prodomains forming a ring encircling the non-covalently bound mature TGF-beta homodimer.

74 n by equipping the channel with an internal, non-covalently bound molecular 'adapter' which mediates

75 nt challenge due to the exchange dynamics of non-covalently bound monomers and hence requires fine mi

76 ss spectrometry was used to analyse free and non-covalently bound polyphenols (ligands) in mixtures w

77 FOs to their targets nor enhances removal of non-covalently bound psoTFOs.

78 e cleavage-religation equilibrium toward the non-covalently bound state; this was caused by slowing o

79 nic GPCRs, CIRL consists of two heterologous non-covalently bound subunits, p120 and p85, due to endo

80 Structural characterization of chemokines non-covalently bound to GAGs provides physiologically me

81 levant antibodies (rituximab, anti-CD20) are non-covalently bound to the albumin scaffold of nab-pacl

82 w that the Fab2 arm in the 1HZH structure is non-covalently bound to the Fc region via long-lived hyd

83 of choline-binding proteins (CBPs) that are non-covalently bound to the phosphorylcholine of the tei

84 mprised fatty acid binding protein 1, FABP1, non-covalently bound to the small molecule therapeutic b

85 In addition, diallyl disulfide was non-covalently bound.

86 ted that the amphiphilic S10 shuttle peptide non-covalently combined with CRISPR-associated (Cas) rib

87 These shuttle peptides, non-covalently combined with GFP protein or CRISPR-assoc

88 la-peptidase of Streptomyces sp. strain R61, non-covalently complexed with a highly specific fragment

89 Additionally, AftD is non-covalently complexed with an acyl carrier protein (A

90 philic poly(ethylene glycol) (PEG) tail were non-covalently complexed with two lipids, 1,2-dioleoyl-s

91 ress this issue, nanoparticles consisting of non-covalently coupled polyethyleneimine (PEI) and folic

92 S3) are evolutionary conserved proteins that non-covalently crosslink actin filaments into tight bund

93 ell paper, Samwer et al. (2017) show that by non-covalently crosslinking DNA, BAF promotes chromosome

94 betaRII, coupled with its reduced ability to non-covalently dimerize and its inability to bind and re

95 in a high affinity for the target enzyme and non-covalently firm anchoring of the azobenzene-modified

96 graphene field-effect transistor (gFET) was non-covalently functionalised with 1-pyrenebutyric acid

97 idase enzyme from Clostridium perfringens is non-covalently immobilized in a thermally tunable nanoge

98 uantities of oriented biotinylated VHHs were non-covalently immobilized.

99 ulting waveshapes indicate that CcP is bound non-covalently in a highly active configuration.

100 durations of action in vivo despite binding non-covalently in vitro and having only moderately high

101 rs are either covalently (in the GO case) or non-covalently (in the RGO case) attached to the transdu

102 e a tractable chemotype that selectively and non-covalently inhibits RGS14 GTPase-accelerating protei

103 Additionally, we found that PPPA non-covalently interacts with ACAT2 apparently without a

104 is for the control of thermal transport, are non-covalently interfaced with polymeric networks, yield

105 enzyme to elongate DNA chains and weave them non-covalently into a hydrogel.

106 HIV-1 integrase (IN) non-covalently juxtaposes two viral DNA termini forming

107 fVIII is activated by thrombin to form a non-covalently linked A1/A2/A3-C1-C2 heterotrimer.

108 Meanwhile, the IR with non-covalently linked alphaCTs predominantly adopts an a

109 of a single pore-forming alpha subunit, one non-covalently linked beta subunit (beta1 or beta3), and

110 to sever tethered fragments originating from non-covalently linked compact structures and makes activ

111 ll organic electronics applications in which non-covalently linked fullerenes in van der Waals contac

112 tence, under non-denaturing conditions, as a non-covalently linked oligomer, and a sensitivity of the

113 These subunits form non-covalently linked oligomers on the surface of infect

114 SDS-PAGE analysis of non-covalently linked proteins of the cell wall of the m

115 e (EC ) exists as a homotetramer composed of non-covalently linked subunits of M(r) approximately 33,

116 ass polymers with ligand end groups that are non-covalently linked through metal-ion binding.

117 plex consisting of cationic granule proteins non-covalently linked to the chondroitin-sulfate proteog

118 ed by dimerization of two matured C peptides non-covalently linked with the N terminal pro-peptide.

119 vity could be reconstituted in vivo from two non-covalently linked, complementary polypeptides that r

120 n turn, sequestered, serum-borne heparin can non-covalently localize growth factors at the cell-mater

121 ence of FIB, shark corneal strips interacted non-covalently more substantively than those of rabbits,

122 ssembly(5-8) cover a broad spectrum(9-11) of non-covalently orchestrated phenomena between molecules.

123 structure in which the two chains interacted non-covalently over a wide surface.

124 l phosphate, DMNP) compared to MOFs that are non-covalently, physically entrapped in nylon, thus high

125 thermal curing process, both covalently and non-covalently, promoting RTP emission of holocellulose

126 ces presenting a heparin-binding peptide can non-covalently sequester heparin from culture supplement

127 Here, we report chemical dispersants that non-covalently solvate proteins within fluorous liquids

128 a results in the formation of covalently and non-covalently stabilized Vn multimers.

129 Furthermore, by studying non-covalently surface-bound proteins we discovered that

130 al studies reveal that GNE-6640 and GNE-6776 non-covalently target USP7 12 A distant from the catalyt

131 hat SodCI is dimeric, protease resistant and non-covalently tethered within the periplasm.

132 DNA dodecamer, [d(CGCGAATTCGCG)] (DDD)-bound non-covalently to a platinum(II) complex, [{Pt(NH)}-micr

133 to one Ubc9p's catalytic cysteine also binds non-covalently to another molecule of Ubc9p.

134 n contrast, whereas the Im3lexitropsin bound non-covalently to GC-rich sequences, the triimidazole-BA

135 -based coating was applied homogeneously and non-covalently to hospital curtains.

136 We find that ubiquitin binds non-covalently to Kog1, prevents Kog1 from degradation a

137 larly prior to secretion, and TGF-beta binds non-covalently to LAP.

138 perimental data suggest that dispersin binds non-covalently to lipopolysaccharide on the surface of t

139 The structure shows that the peptide binds non-covalently to the active site CXXC motif, the cis-Pr

140 by the protein backbone (far connection) and non-covalently to the PD of the next subunit (near conne

141 led that the tripyrrole- BAM conjugate bound non-covalently to the same AT-rich sites as distamycin.

142 a-Syn Y39W variant suggests that DOPAC binds non-covalently to the same N-terminal region of alpha-Sy

143 By binding non-covalently to two distinct sites on an enzyme, the S

144 A variety of protein domains that bind non-covalently to ubiquitin have been described and func

145 ociated with DNA oligonucleotide tags either non-covalently using a DNA-linked antibody or covalently

146 These attach non-covalently via a conserved N-terminus to the cell wa

147 inimide ester group, interacts with graphene non-covalently via pi-stacking.

148 two types of nanotubes, each functionalized non-covalently with a distinct DNA linker molecule.

149 ds at the polymerase active site interacting non-covalently with both the polymerase and the DNA dupl

150 common cell milieu and allowed to associate non-covalently with each other via a pair of leucine zip

151 2.5-fold more abundant than rom1, interacts non-covalently with itself and rom1 via the D2 loop, and

152 , formed covalent homodimers, and interacted non-covalently with itself, rds, and rom1.

153 ntation processes, anthocyanins can interact non-covalently with other molecules to enhance their sta

154 yde, 2-octanone and hexyl acetate interacted non-covalently with PPIs, whereas octanal bound PPIs via

155 Phenolic compounds are known to bind non-covalently with starch, but the impact of this inter

156 We show that these micelles associate non-covalently with the bacterial outer-membrane and tha

157 In addition, VP35 can also interact non-covalently with ubiquitin (Ub); however, the functio

158 tween both reactive intermediates associated non-covalently within the catalyst framework.