ライフサイエンスコーパス: non-neoplastic

1 eater population of wider fibers compared to non-neoplastic and adenoma samples.

2 Dystrophin is expressed in the non-neoplastic and benign counterparts of GIST, RMS and

3 and formalin-fixed paraffin-embedded healthy non-neoplastic and diabetic nephropathy kidney tissues.

4 ion of CNAs at the single-cell level in both non-neoplastic and neoplastic cells.

5 ricular signs and symptoms are the result of non-neoplastic and neoplastic space-occupying lesions.

6 r to many multicellular organisms, including non-neoplastic and neoplastic tissue.

7 rent descriptors between two colonic polyps: non-neoplastic and neoplastic.

8 We found that the average elastic moduli of non-neoplastic and tumor-bearing optic nerves were appro

9 We identified a high frequency of ERG+ non-neoplastic-appearing glands in these cases, includin

10 m cell-associated Sox2 but nevertheless were non-neoplastic as they coexpressed Rb and/or retained tw

11 diagnoses, encompassing both neoplastic and non-neoplastic as well as pigmented and nonpigmented ski

12 m/initiating cells, but hardly detectable in non-neoplastic astrocytes, neural stem cells or normal b

13 a higher level in glioblastoma cells than in non-neoplastic astrocytes.

14 reased in malignant astrocytomas, but not in non-neoplastic astrocytes.

15 essing CLL B cells that do not use VH1-69 or non-neoplastic B cells that express VH1-69.

16 ling of wild-type cultured mouse astrocytes, non-neoplastic B8 astrocytes, B8 astrocytoma cultures, a

17 We conclude that acid exposure in non-neoplastic BAR-T cells causes early antiproliferativ

18 e effects on proliferation in neoplastic and non-neoplastic BAR-T cells.

19 the G(1)-S cell cycle checkpoint, we exposed non-neoplastic Barrett's cells to acidic media (pH 4.0)

20 In non-neoplastic Barrett's epithelial (BAR-T) cells, in co

21 sed significantly in CCA cells compared with non-neoplastic biliary epithelial cells.

22 atic and 8 extrahepatic CCs in comparison to non-neoplastic biliary tissue specimens, using methyl-Cp

23 idate how radiotherapy-induced senescence of non-neoplastic brain cells promotes tumor growth.

24 infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neuron

25 ote GBM recurrence by inducing senescence in non-neoplastic brain cells, suggesting that senolytic th

26 en specific subpopulations of neoplastic and non-neoplastic brain cells.

27 invading human glioblastoma cells present in non-neoplastic brain parenchyma secrete high levels of T

28 osome profiling of human proneural tumor and non-neoplastic brain tissue with computational deconvolu

29 ession in tumors, mainly in GBM, compared to non-neoplastic brain tissue.

30 y increased in human glioma as compared with non-neoplastic brain tissue.

31 ion was elevated in GBM tumors compared with non-neoplastic brain tissues, portended a worse prognosi

32 in a subset of human GBMs compared with the non-neoplastic brain.

33 y is elevated in glioblastomas compared with non-neoplastic brain.

34 n ATRTs compared with other brain tumors and non-neoplastic brain.

35 ly KLF5 mRNA was expressed at high levels in non-neoplastic breast epithelial cells and in normal hum

36 ive histological subtypes of lung cancer and non-neoplastic bronchial mucosa as in vitro models repre

37 se of balance can generally be attributed to non-neoplastic causes, such as otitis media, otosclerosi

38 sis using T51B rat liver epithelial cells, a non-neoplastic cell line previously developed for carcin

39 loid cells were the predominant infiltrating non-neoplastic cell population.

40 composed of numerous distinct neoplastic and non-neoplastic cell populations, which could each influe

41 ymbiotic relationship between neoplastic and non-neoplastic cell types dictate where and when cancers

42 One of the most prevalent non-neoplastic cell types in the GBM TME are myeloid cel

43 e distinct and impressionable neoplastic and non-neoplastic cell types that form the unique brain tum

44 novel therapies targeting the properties of non-neoplastic cell-types within the tumour such as tumo

45 been developed to understand the effects of non-neoplastic cells and extracellular matrix (ECM) on d

46 3D human model demonstrated the influence of non-neoplastic cells and matrix on chemoresistance of GB

47 -causing genetic changes, contributions from non-neoplastic cells and signals in the tumor microenvir

48 tter understanding of how shammah transforms non-neoplastic cells and warrants additional studies tha

49 The majority of the non-neoplastic cells are tumor-associated macrophages (T

50 solution using scRNA-seq of 59,915 tumor and non-neoplastic cells from 8 primary and 3 metastatic sam

51 applied to the comparison of neoplastic and non-neoplastic cells from a human glioblastoma dataset,

52 fixation methods to separate neoplastic from non-neoplastic cells in primary colorectal cancers and m

53 e to killing by methotrexate (MTX) than were non-neoplastic cells in the same culture.

54 Non-neoplastic cells in the TME form reciprocal interact

55 interactions with neoplastic cells and other non-neoplastic cells in the TME.

56 origin, deregulated intracellular signaling, non-neoplastic cells in the tumor microenvironment and g

57 en transcriptomic groups and suggesting that non-neoplastic cells in the tumor microenvironment can m

58 revealed critical roles for the NF1 gene in non-neoplastic cells in the tumor microenvironment, the

59 cancer cells can influence the phenotype of non-neoplastic cells in the tumor microenvironment.

60 lism is also hypothesized to be a feature of non-neoplastic cells in the tumour microenvironment.

61 the preferential killing of neoplastic over non-neoplastic cells of the same derivation.

62 Conversely, the glia were distinct from the non-neoplastic cells that strongly expressed the stem ce

63 Leptin sensitizes non-neoplastic cells to proliferative stimuli, causes mi

64 ated that calpain 3 moves from the nuclei of non-neoplastic cells to the cytoplasm of malignant cells

65 Neither neoplastic nor non-neoplastic cells were killed once they had stopped m

66 st of cone-like neoplastic cells and diverse non-neoplastic cells whose roles in tumorigenesis have n

67 nt research has revealed a critical role for non-neoplastic cells within the tumor microenvironment i

68 , which constitute a large proportion of the non-neoplastic cells within the tumor microenvironment,

69 GBM cells coexist with normal non-neoplastic cells, including endothelial cells, astro

70 unoreactivity was detected in neoplastic and non-neoplastic cells, including in intestinal metaplasti

71 omposed of a mixture of neoplastic cells and non-neoplastic cells, including tumour-associated macrop

72 re complex tumors composed of neoplastic and non-neoplastic cells, which each individually contribute

73 ultiple cell types, including neoplastic and non-neoplastic cells.

74 e exacerbated by Nf1 heterozygosity in other non-neoplastic cells.

75 ty of solid tumor lines but had no effect on non-neoplastic cells.

76 come neoplastic as well as heterozygosity in non-neoplastic cells.

77 erg (H/RS) cells in a reactive background of non-neoplastic cells.

78 gical malignancies but are largely absent on non-neoplastic cells.

79 dysfunction and aneuploidy in neoplastic and non-neoplastic cells.

80 t-offs for differentiation of neoplastic and non-neoplastic cells.

81 ed for the differentiation of neoplastic and non-neoplastic cells.

82 cer clones from one another, or from admixed non-neoplastic cells.

83 cancer cells and smMLCK highly expressed in non-neoplastic cells.

84 ty in both the pre-neoplastic/neoplastic and non-neoplastic cellular compartments contribute to gliom

85 ls in papillomas were elevated over those in non-neoplastic choroid plexus.

86 f cytoskeletal associated tyrosine kinase in non-neoplastic, circulating, hematopoietic cells.

87 We found that HCC and adjacent non-neoplastic cirrhotic tissue have considerable overla

88 perinsulinism of infancy display a dramatic, non-neoplastic clonal expansion of beta cells that have

89 arcinomas, respectively, but not in adjacent non-neoplastic colon biopsy samples from the same patien

90 al copies is present in cancer cells than in non-neoplastic colon cells, and sequence microheterogene

91 g for differentiation between neoplastic and non-neoplastic colonic lesions.

92 e risk of developing a second malignancy and non-neoplastic complications, most notably cardiac disea

93 increasing recognition of the importance of non-neoplastic components, the ability to breakdown the

94 amples and age/gender/smoking-status-matched non-neoplastic controls from the Lung Cancer in Central

95 provides trophic support to the tumor cells' non-neoplastic counterparts.

96 fluids of 18 patients with benign tumors or non-neoplastic cysts.

97 classified into groups containing those with non-neoplastic disease and those with high-grade dysplas

98 the interplay between somatic mutations and non-neoplastic disease grows, opportunities for the join

99 ns in serum that distinguish neoplastic from non-neoplastic disease within the ovary.

100 cancer who had undergone cholecystectomy for non-neoplastic disease.

101 estigation in both other tumour types and in non-neoplastic disease.

102 d risks of cytotoxic therapy when treating a non-neoplastic disease.

103 eneficially directed toward the treatment of non-neoplastic diseases in which autoimmune mechanisms w

104 fore, MPE concept and paradigm can extend to non-neoplastic diseases including diabetes mellitus, car

105 eriampullary neoplasms, and 51 patients with non-neoplastic diseases who underwent pancreatic resecti

106 e may also contribute to the pathogenesis of non-neoplastic diseases.

107 ions are hypothesized to play a role in many non-neoplastic diseases.

108 ncommon and sometimes fatal, neoplastic, and non-neoplastic diseases.

109 s, and ovarian metastases than in those from non-neoplastic diseases; (3) CMV and EBV have been detec

110 several cancers and is also associated with non-neoplastic diseases; although the underlying mechani

111 cer treatments, labile nature of HTN, use of non-neoplastic drugs such as steroids and erythropoietin

112 east cancer tissues whereas not expressed in non-neoplastic ducts.

113 ce Advice Statements BEST PRACTICE ADVICE 1: Non-neoplastic duodenal lesions (eg, metaplastic foveola

114 BV-PTLD and subclassifying as neoplastic and non-neoplastic EBV-PTLD were 0.73 (95% CI: 0.54-0.93) an

115 lse negatives) and two biopsied lesions were non-neoplastic entities on pathological review (false po

116 the superficial cells of preneoplastic over non-neoplastic epithelia (P<0.0001), consistent with a r

117 l of expression in normal hepatocytes and in non-neoplastic epithelial cells.

118 Vascular malformations are non-neoplastic expansions of blood vessels that arise du

119 sion: Estrogens stimulate IL-6 production in non-neoplastic female BECs and in neoplastic BECs expres

120 MKN1 gastric cancer and HFE-145 immortalized non-neoplastic gastric mucosa cell lines.

121 tatic lymph nodes (22 cases), microdissected non-neoplastic gastric mucosa of EBVaGC (five cases), an

122 inal-type gastric cancer compared to matched non-neoplastic gastric samples (P = 0.018).

123 n gastric cancer samples compared to matched non-neoplastic gastric samples (P = 0.019).

124 ssion in gastric tumors and in corresponding non-neoplastic gastric samples.

125 1.5-fold in 35% of tumors compared to paired non-neoplastic gastric tissue.

126 in 22 pairs of gastric tumors and in matched non-neoplastic gastric tissue.

127 17 pairs of gastric tumors and corresponding non-neoplastic gastric tissue.

128 tric tumors from CEA/Tag mice, compared with non-neoplastic gastric tissue.

129 stic transformation with 39 patients who had non-neoplastic GHPs.

130 ring in a seizure-like manner, but only when non-neoplastic glial cells were present.

131 Within the non-neoplastic group, aspirin users had lower EMF (p = 0

132 SOC), and from 60 women with other tumors or non-neoplastic gynecological diseases.

133 ith those of HCC (n = 40), and a spectrum of non-neoplastic hepatic lesions including normal liver an

134 ent is well established, its contribution in non-neoplastic hepatic pathologies has not been investig

135 ISG) in PH5CH8 cells, which are derived from non-neoplastic hepatocytes transformed with large T anti

136 (ATAC-seq) was performed in MFD-1, OE33, and non-neoplastic HET1A cells.

137 multicentric Castleman disease patients and non-neoplastic HHV8-associated syndromes.

138 We further examined a non-neoplastic human primary cell line (lung lymphatic e

139 in LNCaP, 22Rv1 and LAPC4 cells, but not in non-neoplastic human prostate epithelial PWR-1E cells.

140 300 RNA-Seq libraries covering 30 different non-neoplastic human tissues and cells as well as 15 mou

141 receptor agonist, isoproterenol, result in a non-neoplastic hypertrophy and hyperplasia of the rat pa

142 ly, crosstalk between neoplastic B cells and non-neoplastic immune and stromal cells in the microenvi

143 ue classifications of cancerous, healthy and non-neoplastic inflamed tissue samples with an accuracy

144 er types, lymphoma results in a reduction of non-neoplastic inflammatory cells and their characterist

145 in-like plasmin fragments are generated in a non-neoplastic inflammatory setting.

146 re variably detected in leukocyte DNA and/or non-neoplastic intestinal mucosa of these patients.

147 we found no evidence for mosaicism in APC in non-neoplastic intestinal mucosa.

148 H&E images improves the diagnosis of several non-neoplastic kidney diseases, sampled from 58 unique s

149 or proportion of subjects with resection of non-neoplastic lesions (26.0% in the CADe group vs 28.7%

150 98 of these polyps were adenomas and 80 were non-neoplastic lesions (of which 62 were hyperplastic).

151 thout a concomitant increase in resection of non-neoplastic lesions (THR).

152 ital vascular malformations are tumour-like, non-neoplastic lesions caused by disorders of vascular t

153 een groups (83 [23.31%] of 356 patients with non-neoplastic lesions in the MB-MMX vs 97 [29.75%] of 3

154 e MB-MMX vs 97 [29.75%] of 326 patients with non-neoplastic lesions in the placebo group).

155 P for noninferiority < .001; total number of non-neoplastic lesions, 284 vs 375).

156 h placebo, without increasing the removal of non-neoplastic lesions.

157 SOC) and 100 control patients with benign or non-neoplastic lesions.

158 nesis, although the potential role of YAP in non-neoplastic liver diseases remains largely unknown.

159 scade were determined in tumor and adjacent, non-neoplastic liver specimens by Western blot analysis

160 ion of Hippo pathway components in tumor and non-neoplastic liver tissue from 7 pediatric patients wi

161 Overall, surrounding non-neoplastic liver tissue was highly positive for GADD

162 antly decreased when compared to surrounding non-neoplastic liver tissue.

163 onstrated that HCC scored lower than matched non-neoplastic liver tissues consistently and significan

164 ants; the median contribution of B6 cells to non-neoplastic liver was 50%.

165 The overall contribution of each strain to non-neoplastic liver was determined using the PCR assay

166 ed intense cytoplasmic expression of MEG3 in non-neoplastic liver with absent or very weak expression

167 ssion in tumorigenic tissue versus adjacent, non-neoplastic liver.

168 an be objectively distinguished from HCC and non-neoplastic liver.

169 like structures and 8-OHdG expression in the non-neoplastic liver.

170 In contrast, most cells in non-neoplastic lung tissue appear not to express the gen

171 mited expression in both adenocarcinomas and non-neoplastic lungs.

172 neoplastic mammary gland samples compared to non-neoplastic mammary gland tissue.

173 markedly over-hydroxylated in comparison to non-neoplastic mammary tissue.

174 are heterogeneous cellular ecosystems, where non-neoplastic monocytic cells have emerged as key regul

175 nomas/dysplasias, and corresponding adjacent non-neoplastic mucosa.

176 ting Src phosphorylation, compared with HT22 non-neoplastic nerve cells.

177 edgehog, and Notch, which play a key role in non-neoplastic neural stem cells.

178 oxygenase and lipoxygenase (LOX) pathways in non-neoplastic, normal appearing mucosa from patients wi

179 s that characterize these tumors relative to non-neoplastic optic nerve tissue.

180 , in murine optic gliomas relative to normal non-neoplastic optic nerve.

181 , but a 13% decrease per year for all proven non-neoplastic or unresected polyps (p<0.0001).

182 5% of ovarian tumor samples as compared with non-neoplastic ovarian tissue samples.

183 ul as markers that can distinguish MCNs from non-neoplastic pancreatic cystic lesions.

184 emonstrated that SPARC mRNA was expressed in non-neoplastic pancreatic ductal epithelial cells, but w

185 s had higher levels of nuclear TRAIL-R2 than non-neoplastic pancreatic tissue, which correlated with

186 levels of TRAIL-R2 in sections of PDACs and non-neoplastic peritumoral ducts from patients.

187 There were significantly more non-neoplastic polyps detected with CAD (1.08 vs 0.57, p

188 Of 86 colon polyps, 52 neoplastic and 34 non-neoplastic polyps were observed in 56 patients (34.6

189 False-positive (resection rate for non-neoplastic polyps) and adverse events were assessed

190 samples and resection of all (neoplastic and non-neoplastic) polyps.

191 glia/macrophages (TAM) are the most numerous non-neoplastic populations in the tumour microenvironmen

192 lines of NIH 3T3 cells had the properties of non-neoplastic, preneoplastic, and neoplastic cells, res

193 activity nor showed any cytotoxicity against non-neoplastic prostate epithelial PWR-1E cells.

194 iling of laser capture microdissected normal non-neoplastic prostate epithelial tissue and compared i

195 er levels of IL-6 than their counterparts in non-neoplastic prostate.

196 Interestingly, expression of Aurora-A in non-neoplastic prostates correlated with seminal vesicle

197 man prostate cancers, but is a rare event in non-neoplastic prostatic epithelium suggesting a role fo

198 Clinically, they are often misdiagnosed as non-neoplastic pseudocysts leading to failed opportuniti

199 r probability of survival than patients with non-neoplastic PTLD and non-cases.

200 OX11+ and SOX11- primary nodal MCL cases and non-neoplastic reactive lymph nodes.

201 omes were adenomas detected per colonoscopy, non-neoplastic resection rate, and withdrawal time.

202 ession three-dimensional (3D) culture model, non-neoplastic S1 cells form a fully polarized epitheliu

203 Association analysis in panels of CC-RCC and non-neoplastic samples using the RFLPs generated by each

204 gths in 18,430 samples, including tumors and non-neoplastic samples, across 31 cancer types.

205 q (scATAC-seq) data sets spanning cancer and non-neoplastic samples, we show that SComatic detects mu

206 s and prostate tumors when compared with the non-neoplastic samples.

207 lters and statistical tests parameterized on non-neoplastic samples.

208 XTEND, using cell lines, cancer samples, and non-neoplastic samples.

209 n was significantly higher in tumors than in non-neoplastic samples.

210 cellular proliferation and a lower number of non-neoplastic Schwann-cell-like cells, while GPR139 is

211 ether angiostatin is generated in mice under non-neoplastic settings.

212 tein expression in gastric cancer and paired non-neoplastic specimens from 33 patients and also in ga

213 was markedly lower in tumors than in paired non-neoplastic specimens.

214 changes, including those associated with the non-neoplastic state in the B8 transgenic mouse, those a

215 Hypoxia promotes the expansion of non-neoplastic stem and precursor cell populations in th

216 I-N87) and primary human gastric tissues (31 non-neoplastic stomach (NS) and 25 gastric carcinomas (G

217 verging data have revealed the importance of non-neoplastic stromal cells in influencing tumor growth

218 ween epithelial cancer cells and surrounding non-neoplastic stromal cells.

219 hether epigenetic modifications occur in the non-neoplastic stromal cells.

220 thelial compartment, despite the presence of non-neoplastic stromal components that substantially con

221 ertebral endplate, leading to Modic changes (non-neoplastic subchondral vertebral bone marrow lesions

222 F-kappaB) pathway to apoptotic resistance in non-neoplastic, telomerase-immortalized esophageal squam

223 ed 21 cases of thyroid tumours, six cases of non-neoplastic thyroid pathology, 30 population controls

224 deregulation also occurs in the surrounding non-neoplastic tissue and contributes to the occurrence

225 intestinal cancer, and sarcoma from adjacent non-neoplastic tissue in mouse models.

226 adenoid cystic carcinoma (ACC), relative to non-neoplastic tissue of origin.

227 u between the neoplastic and the surrounding non-neoplastic tissue, which may have further influenced

228 core antigen (WHcAg) and WHxAg expression in non-neoplastic tissue.

229 short half-life, so it is rarely detected in non-neoplastic tissue.

230 liver and stomach as compared to background non-neoplastic tissue.

231 a low level of mutated DNA was identified in non-neoplastic tissue.

232 ncerous specimens compared to tumor-adjacent non-neoplastic tissues (P = 0.009).

233 Yet, many non-neoplastic tissues are more prolific compared with t

234 aGC cases, 8 of 10 metastatic carcinomas, 14 non-neoplastic tissues from 27 EBVaGC cases, and 12 of 2

235 We collected colorectal tumor and non-neoplastic tissues from 31 patients with IBD and col

236 nces were more common in both neoplastic and non-neoplastic tissues from different geographic areas t

237 for rapid distinction between cancerous and non-neoplastic tissues is an important goal in disease d

238 In non-neoplastic tissues, reactivity was highly selective

239 tion were observed in neoplastic vs adjacent non-neoplastic tissues, suggesting that targeted MSP amp

240 kidney, and lung carcinomas and in adjacent non-neoplastic tissues, using immunohistochemistry.

241 To study somatic mutations in non-neoplastic tissues, we developed a series of protoco

242 Within neurofibromas, PR was expressed by non-neoplastic tumor-associated cells and not by neoplas

243 ical stages of UC-associated carcinogenesis (non-neoplastic UC colon, dysplasia, and carcinoma).

244 In contrast, no non-neoplastic UC mucosa showed HPP1 methylation.

245 r II mRNA were up-regulated significantly in non-neoplastic WAP-CRD-BP mammary tissue.