ライフサイエンスコーパス: non-receptor

1 1 (ACK1; also known as Tnk2, tyrosine kinase non-receptor 2) as a novel binding partner of SLP-76.

2 monstrated that protein tyrosine phosphatase non-receptor 22 (PTPN22), variants in which are associat

3 we report that protein tyrosine phosphatase non-receptor 3 (PTPN3) profoundly potentiates TGF-beta s

4 ow that inositol hexakisphosphate (IP6) is a non-receptor activator of arrestin-3 and report the stru

5 Although several non-receptor activators of heterotrimeric G proteins hav

6 view has been challenged by the discovery of non-receptor activators of trimeric G proteins.

7 Non-receptor and receptor tyrosine kinases, such as Src

8 A non-receptor assisted toxin, melittin, was selected for

9 oteins as well as by receptor-associated and non-receptor-associated tyrosine kinases.

10 nce that G proteins can also be activated by non-receptor binding partners, and they can signal from

11 IgE-Fc mutant that is trapped in the closed, non-receptor binding state via an engineered disulfide a

12 A non-receptor-binding mutant of EtxB failed to prevent di

13 , an octamer capped peptide derived from the non-receptor-binding region of urokinase plasminogen act

14 Thus, multiple residues on the non-receptor-binding side of arrestin-3 are crucial for

15 We and others have recently cloned a non-receptor, calcium-dependent tyrosine kinase (CADTK;

16 oth receptor (light-activated rhodopsin) and non-receptor (casein and phosvitin) substrates.

17 (TPA) transforms cells that overexpress the non-receptor class tyrosine kinase c-Src.

18 in-tyrosine phosphatases (RPTPs), like their non-receptor counterparts, regulate the level of phospho

19 The third describes the function of a non-receptor, cytoplasmic activator of G protein signali

20 ing AP-driven Ca(2+) influx in receptor- and non-receptor-depolarized cells.

21 proteins can bind these motifs, and they are non-receptor factors.

22 anism of G-protein activation by a family of non-receptor GEFs containing a Galpha-binding and -activ

23 ing vesicle-associated protein) is the first non-receptor guanine nucleotide exchange factor (GEF) th

24 Mechanistically, GIV serves as a non-receptor guanine nucleotide exchange factor (GEF) th

25 The non-receptor guanine nucleotide exchange factor Ric-8A c

26 We have previously demonstrated that the non-receptor guanine nucleotide exchange factor RIC8 act

27 More specifically, we found that GIV is a non-receptor guanine nucleotide exchange factor that act

28 s on members of a newly identified family of non-receptor guanine nucleotide exchange factors (GEFs),

29 i is activated in the Golgi by GIV/Girdin, a non-receptor guanine-nucleotide exchange factor (GEF).

30 out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs)

31 -2 receptor contrasts with CAM-1 action as a non-receptor in other C. elegans Wnt pathways.

32 The non-receptor isoform of protein-tyrosine phosphatase (cy

33 Aberrant activation of the non-receptor kinase c-Abl is implicated in the developme

34 rectly stimulates the activity of a purified non-receptor kinase, Bruton's tyrosine kinase (Btk), whe

35 on and subsequent putative activation of the non-receptor kinase, focal adhesion kinase (FAK).

36 ns play key regulatory roles in receptor and non-receptor kinase-initiated signaling pathways.

37 Moreover, HECL is the first non-receptor-like C-type lectin to map near the natural

38 member of a large family of sperm-expressed non-receptor-like protein-tyrosine kinases.

39 PGHS-2 gene expression through activation of non-receptor-linked protein tyrosine kinase in MC.

40 PTEN also sensitized cells to non-receptor mediated apoptosis induced by a kinase inhi

41 vation of feedback mechanisms resulting from non-receptor mediated displacement of intraneuronal dopa

42 In mammalian cells, non receptor-mediated apoptosis occurs via the cytochrom

43 in the two xenografts are consistent with a non-receptor-mediated distribution.

44 stimulus and provides a framework for other non-receptor-mediated pathways of MAPK activation.

45 s are taken up by both receptor-mediated and non-receptor-mediated pathways.

46 gests that, at least in the intestine, other non-receptor-mediated uptake systems exist.

47 endovesiculation can be achieved by simple (non-receptor-mediated) mechanical perturbation of the er

48 ors coupled to membrane receptors or through non-receptor pathways by stimuli such as heat shock, UV

49 BRK is a recently described non receptor protein tyrosine kinase whose mRNA was foun

50 GIV (a.k.a Girdin) was the first non-receptor protein for which the GEF activity was ascr

51 The c-fes locus encodes a 93-kDa non-receptor protein tyrosine kinase (Fes) that regulate

52 (interleukin-2 inducible T cell kinase) is a non-receptor protein tyrosine kinase expressed primarily

53 Tnk1/Kos1 is a non-receptor protein tyrosine kinase found to be a tumor

54 Tnk1/Kos1 is a non-receptor protein tyrosine kinase implicated in negat

55 Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase localized at focal

56 LCK is a non-receptor protein tyrosine kinase required for signal

57 The brk gene encodes a non-receptor protein tyrosine kinase that consists of si

58 ton's tyrosine kinase (Btk), a hematopoietic non-receptor protein tyrosine kinase that is critical fo

59 Etk/BMX is a non-receptor protein tyrosine kinase that requires a fun

60 Src is a non-receptor protein tyrosine kinase, the expression and

61 CR cross-linking activates three families of non-receptor protein tyrosine kinases (PTKs) and these a

62 addition, the activity of both receptor and non-receptor protein tyrosine kinases along with numerou

63 timulating Factor (G-CSF) receptor activates non-receptor protein tyrosine kinases Lyn and Jak2.

64 dermal growth factor receptor (EGFR) and the non-receptor protein tyrosine kinases Src and Pyk2 have

65 ll antigen receptor (TCR) activates a set of non-receptor protein tyrosine kinases that assist in del

66 otein Dab1, Src and Fyn of the Src-family of non-receptor protein tyrosine kinases, and CrkL) are loc

67 The non-receptor protein tyrosine phosphatase (PTP) SHP2, en

68 osine phosphatase (HePTP) is a 38kDa class I non-receptor protein tyrosine phosphatase (PTP) that is

69 in physically associates with and degrades a non-receptor protein tyrosine phosphatase (PTPN13), and

70 Shp2 is a non-receptor protein tyrosine phosphatase containing two

71 of Corkscrew, the drosophila ortholog of the non-receptor protein tyrosine phosphatase type II (SHP2)

72 The focal adhesion (FAK) non-receptor protein-tyrosine kinase (PTK) links both ex

73 The human c-fes locus encodes a non-receptor protein-tyrosine kinase implicated in myelo

74 c-Abl is a non-receptor protein-tyrosine kinase lacking a clear phy

75 rtners and suggest a general role for BCR in non-receptor protein-tyrosine kinase regulation and sign

76 osine kinases suggests a novel mechanism for non-receptor protein-tyrosine kinase regulation.

77 gene encoding a member of the Csk family of non-receptor protein-tyrosine kinases (PTKs) in the earl

78 monstrate here that US28 signals through the non-receptor protein-tyrosine kinases Src and focal adhe

79 sion kinase (FAK) is a member of a family of non-receptor protein-tyrosine kinases that regulates int

80 an be activated by a variety of receptor and non-receptor protein-tyrosine kinases.

81 PTPN22 (Lyp), a non-receptor protein-tyrosine phosphatase, is expressed

82 decrease in the activity of the receptor and non-receptor protein-tyrosine phosphatases that down-reg

83 However, some non-receptor proteins are also GEFs.

84 ted Akt stimulation is regulated by multiple non-receptor PTK families which regulate Akt both proxim

85 ns, whose boundaries are distinct from other non-receptor PTK family members, again indicating a stru

86 differences that place it on its own amongst non-receptor PTKs.

87 e different subfamilies of both receptor and non-receptor PTPs.

88 le proteins, while the fusion of receptor or non-receptor sequences upstream of 537-673 afforded stab

89 s that a WW domain-mediated process, such as non-receptor signaling, protein degradation or pre-mRNA

90 , we employed pharmacological inhibitors for non-receptor Src homology-2 domain-containing protein ty

91 we identified buckyballs as a novel class of non-receptor Src kinases inhibitors.

92 Here we report that non-receptor Src tyrosine kinase and the membrane protei

93 nal palmitoylation motif of proteins such as non-receptor Src-related tyrosine kinases.

94 The molecular initiators of MAPKs by non-receptor stimuli have not been described.

95 ad wild type activity in phosphorylating the non-receptor substrate tubulin.

96 by, a wide variety of nuclear receptors and non-receptor transcription factors.

97 s in the protein tyrosine phosphatase (PTP), non-receptor type 11 (PTPN11) gene that encodes the SH2

98 per was from a protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) mutated allele encoding Sh

99 : a pathogenic protein tyrosine phosphatase, non-receptor type 11 (PTPN11) variant and variants of un

100 e reported that tyrosine-protein phosphatase non-receptor type 11 (SHP-2) and phosphatidylinositol 3-

101 Here, we demonstrate that PTP non-receptor type 12 (PTPN12) protects cells against abe

102 n expression of tyrosine-protein phosphatase non-receptor type 13 or FAS associated phosphatase 1 (FA

103 ing of PTPN14 (protein tyrosine phosphatase, non-receptor type 14) which, in turn, regulated the Hipp

104 locus encoding protein-tyrosine phosphatase non-receptor type 2 (PTPN2) has been associated with inf

105 Protein tyrosine phosphatase non-receptor type 2 (PTPN2) protects the IEC barrier fro

106 nase FYN (FYN), protein tyrosine phosphatase non-receptor type 2 (PTPN2), and adenylate cyclase-assoc

107 stablished that protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a key regulator of T ce

108 A variant in protein tyrosine phosphatase non-receptor type 22 (PTPN22) is associated with reduced

109 tor (IL23R) and protein tyrosine phosphatase non-receptor type 22 (PTPN22) pathways.

110 holipase D, and protein tyrosine phosphatase non-receptor type 22.

111 The human protein tyrosine phosphatase non-receptor type 4 (PTPN4) prevents cell death inductio

112 Protein tyrosine phosphatase non-receptor type 5 (PTPN5, STEP) is a brain specific ph

113 entified in the protein tyrosine phosphatase non-receptor type 6 (PTPN6) gene, also known as SHP-1, a

114 he Ptpn6 gene (protein tyrosine phosphatase, non-receptor type 6; also known as Shp-1).

115 In this study, we demonstrate that the non-receptor type protein tyrosine phosphatase 14 (PTPN1

116 These three genes encode a non-receptor type protein tyrosine phosphatase, a serine

117 e c-Yes proto-oncogene (pp62c-Yes) encodes a non-receptor-type protein tyrosine kinase (NRPTK) of the

118 t mutations in PTPN11, the gene encoding the non-receptor-type protein tyrosine phosphatase SHP-2 (sr

119 brary screening and identified Fer kinase, a non-receptor-type tyrosine kinase, as a key regulator of

120 ed receptor may initiate the cross-talk with non-receptor-type tyrosine kinases, thereby activating p

121 ion, among those the catalytically inactive, non-receptor-type tyrosine phosphatase PTPN23/HD-PTP.

122 ent or not dependent on ABL proto-oncogene 1 non-receptor tyrosine kinase (c-Abl).

123 The c-fes proto-oncogene encodes a non-receptor tyrosine kinase (Fes) that has been implica

124 The V617F mutation in the JAK2 non-receptor tyrosine kinase (JAK2V617F) is present as a

125 The emergence of a non-receptor tyrosine kinase (non-RTK), ACK1 (also known

126 Pcs is predicted to be a novel regulator of non-receptor tyrosine kinase (NRTK) signaling.

127 orylated in vitro by representatives of many non-receptor tyrosine kinase (NRTK) sub-families, sugges

128 The isolated catalytic domain of the non-receptor tyrosine kinase Abl does not show a prefere

129 Deregulation of the non-receptor tyrosine kinase ACK1 (Activated Cdc42-assoc

130 We show here that the non-receptor tyrosine kinase Ack1, previously implicated

131 We have previously shown that the Arg/Abl2 non-receptor tyrosine kinase acts downstream of the EGF

132 nism by which an adaptor protein activates a non-receptor tyrosine kinase by SH2 domain displacement.

133 Caspase-9 phosphorylation by the non-receptor tyrosine kinase c-Abl at Tyr-153 reportedly

134 The non-receptor tyrosine kinase c-Abl is activated in respo

135 The non-receptor tyrosine kinase c-Abl is also activated by

136 ronal morphogenesis, we demonstrate that the non-receptor tyrosine kinase c-Abl is an intermediary fo

137 Here, we show that the stress-signaling non-receptor tyrosine kinase c-Abl links parkin to spora

138 n by primary sperm cells was mediated by the non-receptor tyrosine kinase c-Abl.

139 receptor tyrosine kinase and the downstream non-receptor tyrosine kinase c-Abl.

140 phosphorylation can also be catalyzed by the non-receptor tyrosine kinase c-Abl.

141 pe-selective small molecule inhibitor of the non-receptor tyrosine kinase c-Src (IC(50) = 64 nM).

142 determined that tTG forms a complex with the non-receptor tyrosine kinase c-Src and PI3-kinase, and t

143 e G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras

144 macrophage colony-stimulating factor and the non-receptor tyrosine kinase c-Src play critical roles i

145 ubiquitination of another protooncogene, the non-receptor tyrosine kinase c-Src, as well as of itself

146 The non-receptor tyrosine kinase c-Src, hereafter referred t

147 Herein we demonstrate that activity of the non-receptor tyrosine kinase dBtk protein is required wi

148 Breast tumor kinase (Brk) is a non-receptor tyrosine kinase distantly related to the Sr

149 reviously showed that targeted expression of non-receptor tyrosine kinase Etk/BMX in mouse prostate i

150 Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase expressed in epithelial can

151 The non-receptor tyrosine kinase FAK plays a key role at sit

152 Three non-receptor tyrosine kinase families (Src, ZAP-70 and T

153 tyrosine kinase (BTK) is a member of the Tec non-receptor tyrosine kinase family that is involved in

154 ffectors for Tec and Bmx, members of the Tec non-receptor tyrosine kinase family.

155 nase-1 (FRK-1), an ortholog of the mammalian non-receptor tyrosine kinase Fer, is necessary for embry

156 The non-receptor tyrosine kinase focal adhesion kinase (FAK)

157 The non-receptor tyrosine kinase focal adhesion kinase (FAK)

158 long cytoskeletal filaments and activate the non-receptor tyrosine kinase focal adhesion kinase, whic

159 ignaling protein, the ubiquitously expressed non-receptor tyrosine kinase focal adhesion kinase.

160 Herein, we identified a novel role for the non-receptor tyrosine kinase Fyn in regulating neuroinfl

161 ngest interaction was between MAP-2c and the non-receptor tyrosine kinase Fyn; however, MAP-2b and MA

162 The p56 Src family non-receptor tyrosine kinase has been shown to be critic

163 h tyrosine kinase 2 (PYK2) is a cytoplasmic, non-receptor tyrosine kinase implicated in multiple sign

164 Imatinib (Gleevec), a non-receptor tyrosine kinase inhibitor (nRTKI), is one o

165 The c-Abl protein is a non-receptor tyrosine kinase involved in many aspects of

166 en hMSH5 and c-Abl; the latter is a critical non-receptor tyrosine kinase involved in many critical c

167 The Ableson (Abl) non-receptor tyrosine kinase is also involved in the rem

168 The non-receptor tyrosine kinase is rapidly mobilized and ac

169 ed receptors, results in the activation of a non-receptor tyrosine kinase known as focal adhesion kin

170 Janus kinase 3 (Jak3) is a non-receptor tyrosine kinase known to be expressed in he

171 blished that BCR is a substrate for c-FES, a non-receptor tyrosine kinase linked to myeloid growth an

172 p59(fyn) is a non-receptor tyrosine kinase of the Src family that has

173 ase (FAK) potently, we explored whether this non-receptor tyrosine kinase participates in the activat

174 by Src64B mutants, linking Akap200 with the non-receptor tyrosine kinase pathway.

175 Non-receptor tyrosine kinase proline-rich protein tyrosi

176 n that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modu

177 Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase required for signaling from

178 ent focal adhesion kinase/Src proto-oncogene non-receptor tyrosine kinase signaling.

179 Here we show that Drosophila Shark, a non-receptor tyrosine kinase similar to mammalian Syk an

180 The non-receptor tyrosine kinase Src and receptor tyrosine k

181 The non-receptor tyrosine kinase Src is a major player in mu

182 d pharmacologic approaches identify that the non-receptor tyrosine kinase Src is required for FN tran

183 ownstream signalling mechanisms, such as the non-receptor tyrosine kinase Src or N-methyl-D-aspartate

184 The non-receptor tyrosine kinase Src regulates resensitizati

185 Activated EGFR induced non-receptor tyrosine kinase SRC to phosphorylate the m(

186 in (LRP) was found to be a substrate for the non-receptor tyrosine kinase Src, but the physiological

187 -Cbl also acts as a ubiquitin ligase for the non-receptor tyrosine kinase Src, thereby down-regulatin

188 as ligand-independent EGFR activation by the non-receptor tyrosine kinase Src.

189 ted that integrin-mediated activation of the non-receptor tyrosine kinase Syk in hematopoietic cells

190 vated Cdc42-associated kinase-2 (ACK-2) is a non-receptor tyrosine kinase that appears to be a highly

191 Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that has been extensively s

192 The brk gene encodes a non-receptor tyrosine kinase that has been found to be o

193 ACK1 is a non-receptor tyrosine kinase that has been shown to be i

194 ACK1 is a non-receptor tyrosine kinase that interacts with ubiquit

195 c-Abl is a non-receptor tyrosine kinase that is activated in human

196 ACK1 is a multidomain non-receptor tyrosine kinase that is an effector of the

197 c-Abl is a non-receptor tyrosine kinase that is involved in a varie

198 Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that is regulated by integr

199 Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that localizes to focal adh

200 uton's tyrosine kinase (Btk) is a Tec family non-receptor tyrosine kinase that plays a critical role

201 target of the enzymatic activity of c-Abl, a non-receptor tyrosine kinase that potently activated in

202 JAK2 is a non-receptor tyrosine kinase that regulates several cell

203 ivated Cdc42-associated kinase-2 (ACK2) is a non-receptor tyrosine kinase that serves as a specific e

204 Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase that signals downstream of

205 and a putative substrate of the transforming non-receptor tyrosine kinase v-Src.

206 , encoded by the TNK2 gene, is a cytoplasmic non-receptor tyrosine kinase whose aberrant activation c

207 The c-Abl proto-oncogene is a non-receptor tyrosine kinase whose activity and localiza

208 c-Abl is a non-receptor tyrosine kinase whose activity is tightly c

209 canonical signaling mechanisms such as Src (non-receptor tyrosine kinase), PI3K, ERK, or MAPK pathwa

210 ions between the Na,K-ATPase and Src kinase (non-receptor tyrosine kinase).

211 al membrane 34) and SRC (SRC proto-oncogene, non-receptor tyrosine kinase).

212 The non-receptor tyrosine kinase, ACK1 (also known as TNK2),

213 tudy, we have identified SAM domain-carrying non-receptor tyrosine kinase, activated Cdc42-associated

214 ts with the SH3 domain of Fyn, an Src family non-receptor tyrosine kinase, and is tyrosine-phosphoryl

215 nsistent with genetic studies placing Abl, a non-receptor tyrosine kinase, and the Drosophila ortholo

216 t of the vesicular regulator, dynamin 2, the non-receptor tyrosine kinase, c-Abl, and the NADPH oxida

217 resent study, we examined the role of Fyn, a non-receptor tyrosine kinase, in microglial activation a

218 or TNK2, an ubiquitously expressed oncogenic non-receptor tyrosine kinase, integrates signals from li

219 Bruton's tyrosine kinase (BTK), a non-receptor tyrosine kinase, is a member of the Tec fam

220 ABI-1, a downstream target of Abl non-receptor tyrosine kinase, is a member of the WAVE re

221 Syk, a non-receptor tyrosine kinase, is an important component

222 Etk/Bmx, a member of the Tec family of non-receptor tyrosine kinase, is characterized by an N-t

223 motes signaling by causing activation of the non-receptor tyrosine kinase, JAK2, which associates wit

224 Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, mediates integrin-based ce

225 e reported previously that Janus kinase 3, a non-receptor tyrosine kinase, plays a crucial role in AJ

226 increase in tyrosine phosphorylation of the non-receptor tyrosine kinase, PYK2, in A7r5 cells treate

227 However, we have reported that the non-receptor tyrosine kinase, Src, is activated by Tf to

228 h collagen induced a rapid activation of the non-receptor tyrosine kinase, Syk, as measured by an inc

229 fere with signaling by interleukin-6 and the non-receptor tyrosine kinase, v-Src.

230 he identification of cellular Src (c-Src), a non-receptor tyrosine kinase, which has since been impli

231 s III phosphatidylinositol-3-kinase, and Src non-receptor tyrosine kinase.

232 bodies and require the function of the dBtk non-receptor tyrosine kinase.

233 3 is able to repress the activity of the Brk non-receptor tyrosine kinase.

234 um-dependent, focal adhesion kinase-related, non-receptor tyrosine kinase.

235 chanism for the regulation of this important non-receptor tyrosine kinase.

236 Recently a number of non-receptor tyrosine kinases (for example src and abl)

237 Tec family non-receptor tyrosine kinases (Itk, Btk, Tec, Rlk and Bm

238 belson family kinases (AFKs; Abl1, Abl2) are non-receptor tyrosine kinases (NRTKs) implicated in canc

239 residues within p27 to be phosphorylated by non-receptor tyrosine kinases (NRTKs).

240 eelin activates members of the Src family of non-receptor tyrosine kinases (SFKs) and that this activ

241 ein kinase IIdelta2 (CaMKIIdelta2) activates non-receptor tyrosine kinases and EGF receptor, with a S

242 receptor tyrosine kinases, the Src family of non-receptor tyrosine kinases and the Eph receptor tyros

243 members of the Janus kinase (Jak) family of non-receptor tyrosine kinases and the signal transducers

244 d p160(v-Abl) are plasma membrane-associated non-receptor tyrosine kinases and the transforming activ

245 Recent work has shown that non-receptor tyrosine kinases and tyrosine phosphorylati

246 Abelson non-receptor tyrosine kinases are also found in mature s

247 The activities of Src-family non-receptor tyrosine kinases are regulated by structura

248 substrate of all the three major classes of non-receptor tyrosine kinases associated with the IL-2R,

249 ough members from three distinct families of non-receptor tyrosine kinases can phosphorylate PLCgamma

250 The Abelson (Abl) family of non-receptor tyrosine kinases has an important role in c

251 Tec family non-receptor tyrosine kinases have been implicated in si

252 eptor tyrosine kinases and the Abl family of non-receptor tyrosine kinases have both been implicated

253 inases (SrcFKs), a multi-functional group of non-receptor tyrosine kinases highly expressed in vascul

254 , PF-4618433) reveals a distinct subclass of non-receptor tyrosine kinases identifiable by the gateke

255 lopment and represents an emerging family of non-receptor tyrosine kinases implicated in signal trans

256 The Abl family of mammalian non-receptor tyrosine kinases includes c-Abl and Arg.

257 stimulation of VGSC, engagement of these two non-receptor tyrosine kinases involves distinct signalin

258 to-oncogenes encode 60 000 and 62 000 Dalton non-receptor tyrosine kinases of the Src family, pp60c-s

259 orylation of cellular proteins including the non-receptor tyrosine kinases p125fak and Src and the ad

260 Members of the Src family of non-receptor tyrosine kinases play a critical role in me

261 Fes/Fer non-receptor tyrosine kinases regulate cell adhesion and

262 nsights into the mechanisms by which Abelson non-receptor tyrosine kinases relay information from axo

263 relationship between Notch and either of the non-receptor tyrosine kinases Src42A and Src64B to promo

264 They are regulated by many non-receptor tyrosine kinases such as Src, Jak, Syk and

265 Janus kinases (JAKs) are non-receptor tyrosine kinases that are essential compone

266 kinase (FAK) and its close relative Pyk2 are non-receptor tyrosine kinases that mediate adhesion sign

267 d gene) protein belongs to the Abl family of non-receptor tyrosine kinases that regulate cell motilit

268 s a novel negative regulator of receptor and non-receptor tyrosine kinases through currently undefine

269 eration, we asked whether the recruitment of non-receptor tyrosine kinases to the cytoskeleton might

270 Cytoskeletal binding of non-receptor tyrosine kinases was synchronous with tyros

271 protein Hck is a member of the Src family of non-receptor tyrosine kinases which is preferentially ex

272 kinase Itk is a member of the Tec family of non-receptor tyrosine kinases, and is required for signa

273 ted conformations that provide access to the non-receptor tyrosine kinases, BCR-ABL and Src, which ph

274 Despite high level of homology among non-receptor tyrosine kinases, different kinase families

275 Thus, these studies strongly suggest that non-receptor tyrosine kinases, in particular c-Src, may

276 cYes, a member of the Src family of non-receptor tyrosine kinases, is highly expressed in mo

277 e of signaling nodes Itk and Txk, Tec family non-receptor tyrosine kinases, mice exhibit a significan

278 by a broad spectrum of cytokines, as well as non-receptor tyrosine kinases, such as Src.

279 Btk family kinases represent new members of non-receptor tyrosine kinases, which include Btk/Atk, It

280 main containing proteins, including specific non-receptor tyrosine kinases-Abl via pY251 and C-termin

281 rged as a negative regulator of receptor and non-receptor tyrosine kinases.

282 ith a vertebrate signaling pathway involving non-receptor tyrosine kinases.

283 y ErbB-2 requires the participation of other non-receptor tyrosine kinases.

284 n signaling between these two highly related non-receptor tyrosine kinases.

285 le docking protein downstream of receptor or non-receptor tyrosine kinases.

286 s a novel negative regulator of receptor and non-receptor tyrosine kinases.

287 ways triggered by activation of receptor and non-receptor tyrosine kinases.

288 Here we report that non-receptor tyrosine phosphatase 14 (PTPN14) interacts

289 cogenic function via direct interaction with non-receptor tyrosine phosphatase 14 (PTPN14) through th

290 The non-receptor tyrosine phosphatase Ptpn11 (Shp2) is an im

291 RNA interference (RNAi) screening identified non-receptor tyrosine phosphatases (PTPNs) required for

292 osine kinases (protein-tyrosine kinases) and non-receptor tyrosine phosphatases (PTPs) have been impl

293 Bmx/Etk non-receptor tyrosine protein kinase has been implicated

294 Members of the Src family of non-receptor tyrosine protein kinases are known to be in

295 In this work we describe the profiling of a non-receptor tyrosine-protein kinase (TYK2) inhibitor wh

296 The non-receptor-tyrosine kinase c-Src is overexpressed in >

297 and S-glutathionylation within EGFR and the non-receptor-tyrosine kinase Src.

298 Non-receptor-tyrosine kinases (protein-tyrosine kinases)

299 osine phosphorylation of GIV by receptor and non-receptor-tyrosine kinases is a key step that is requ

300 SHP-1 antagonizes the action of receptor and non-receptor-tyrosine kinases on GIV and down-regulates