ライフサイエンスコーパス: non-receptor tyrosine kinase

1 ions between the Na,K-ATPase and Src kinase (non-receptor tyrosine kinase).

2 al membrane 34) and SRC (SRC proto-oncogene, non-receptor tyrosine kinase).

3 chanism for the regulation of this important non-receptor tyrosine kinase.

4 that currently appears to be unique for this non-receptor tyrosine kinase.

5 bodies and require the function of the dBtk non-receptor tyrosine kinase.

6 s III phosphatidylinositol-3-kinase, and Src non-receptor tyrosine kinase.

7 3 is able to repress the activity of the Brk non-receptor tyrosine kinase.

8 um-dependent, focal adhesion kinase-related, non-receptor tyrosine kinase.

9 rged as a negative regulator of receptor and non-receptor tyrosine kinases.

10 ith a vertebrate signaling pathway involving non-receptor tyrosine kinases.

11 y ErbB-2 requires the participation of other non-receptor tyrosine kinases.

12 n signaling between these two highly related non-receptor tyrosine kinases.

13 le docking protein downstream of receptor or non-receptor tyrosine kinases.

14 s a novel negative regulator of receptor and non-receptor tyrosine kinases.

15 ways triggered by activation of receptor and non-receptor tyrosine kinases.

16 The isolated catalytic domain of the non-receptor tyrosine kinase Abl does not show a prefere

17 main containing proteins, including specific non-receptor tyrosine kinases-Abl via pY251 and C-termin

18 Deregulation of the non-receptor tyrosine kinase ACK1 (Activated Cdc42-assoc

19 We show here that the non-receptor tyrosine kinase Ack1, previously implicated

20 The non-receptor tyrosine kinase, ACK1 (also known as TNK2),

21 tudy, we have identified SAM domain-carrying non-receptor tyrosine kinase, activated Cdc42-associated

22 We have previously shown that the Arg/Abl2 non-receptor tyrosine kinase acts downstream of the EGF

23 Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein that

24 ein kinase IIdelta2 (CaMKIIdelta2) activates non-receptor tyrosine kinases and EGF receptor, with a S

25 receptor tyrosine kinases, the Src family of non-receptor tyrosine kinases and the Eph receptor tyros

26 members of the Janus kinase (Jak) family of non-receptor tyrosine kinases and the signal transducers

27 d p160(v-Abl) are plasma membrane-associated non-receptor tyrosine kinases and the transforming activ

28 ilar co-structures may be relevant for other non-receptor tyrosine kinases and their receptors.

29 Recent work has shown that non-receptor tyrosine kinases and tyrosine phosphorylati

30 ts with the SH3 domain of Fyn, an Src family non-receptor tyrosine kinase, and is tyrosine-phosphoryl

31 nsistent with genetic studies placing Abl, a non-receptor tyrosine kinase, and the Drosophila ortholo

32 kinase Itk is a member of the Tec family of non-receptor tyrosine kinases, and is required for signa

33 exposure of CD3 ITAMs to phosphorylation by non-receptor tyrosine kinases, and phase separation of s

34 Abelson non-receptor tyrosine kinases are also found in mature s

35 The activities of Src-family non-receptor tyrosine kinases are regulated by structura

36 substrate of all the three major classes of non-receptor tyrosine kinases associated with the IL-2R,

37 ted conformations that provide access to the non-receptor tyrosine kinases, BCR-ABL and Src, which ph

38 nism by which an adaptor protein activates a non-receptor tyrosine kinase by SH2 domain displacement.

39 Caspase-9 phosphorylation by the non-receptor tyrosine kinase c-Abl at Tyr-153 reportedly

40 The non-receptor tyrosine kinase c-Abl is activated in respo

41 The non-receptor tyrosine kinase c-Abl is also activated by

42 ronal morphogenesis, we demonstrate that the non-receptor tyrosine kinase c-Abl is an intermediary fo

43 Here, we show that the stress-signaling non-receptor tyrosine kinase c-Abl links parkin to spora

44 receptor tyrosine kinase and the downstream non-receptor tyrosine kinase c-Abl.

45 phosphorylation can also be catalyzed by the non-receptor tyrosine kinase c-Abl.

46 n by primary sperm cells was mediated by the non-receptor tyrosine kinase c-Abl.

47 pe-selective small molecule inhibitor of the non-receptor tyrosine kinase c-Src (IC(50) = 64 nM).

48 determined that tTG forms a complex with the non-receptor tyrosine kinase c-Src and PI3-kinase, and t

49 e G proteins through a pathway involving the non-receptor tyrosine kinase c-Src and the G protein Ras

50 macrophage colony-stimulating factor and the non-receptor tyrosine kinase c-Src play critical roles i

51 ubiquitination of another protooncogene, the non-receptor tyrosine kinase c-Src, as well as of itself

52 The non-receptor tyrosine kinase c-Src, hereafter referred t

53 The non-receptor-tyrosine kinase c-Src is overexpressed in >

54 ent or not dependent on ABL proto-oncogene 1 non-receptor tyrosine kinase (c-Abl).

55 t of the vesicular regulator, dynamin 2, the non-receptor tyrosine kinase, c-Abl, and the NADPH oxida

56 ough members from three distinct families of non-receptor tyrosine kinases can phosphorylate PLCgamma

57 Herein we demonstrate that activity of the non-receptor tyrosine kinase dBtk protein is required wi

58 Despite high level of homology among non-receptor tyrosine kinases, different kinase families

59 Breast tumor kinase (Brk) is a non-receptor tyrosine kinase distantly related to the Sr

60 Pyk2 is a Ca(2+)-activated non-receptor tyrosine kinase enriched in the forebrain,

61 reviously showed that targeted expression of non-receptor tyrosine kinase Etk/BMX in mouse prostate i

62 Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase expressed in epithelial can

63 The non-receptor tyrosine kinase FAK plays a key role at sit

64 Three non-receptor tyrosine kinase families (Src, ZAP-70 and T

65 tyrosine kinase (BTK) is a member of the Tec non-receptor tyrosine kinase family that is involved in

66 ffectors for Tec and Bmx, members of the Tec non-receptor tyrosine kinase family.

67 nase-1 (FRK-1), an ortholog of the mammalian non-receptor tyrosine kinase Fer, is necessary for embry

68 The c-fes proto-oncogene encodes a non-receptor tyrosine kinase (Fes) that has been implica

69 The non-receptor tyrosine kinase focal adhesion kinase (FAK)

70 The non-receptor tyrosine kinase focal adhesion kinase (FAK)

71 long cytoskeletal filaments and activate the non-receptor tyrosine kinase focal adhesion kinase, whic

72 ignaling protein, the ubiquitously expressed non-receptor tyrosine kinase focal adhesion kinase.

73 Recently a number of non-receptor tyrosine kinases (for example src and abl)

74 Herein, we identified a novel role for the non-receptor tyrosine kinase Fyn in regulating neuroinfl

75 ngest interaction was between MAP-2c and the non-receptor tyrosine kinase Fyn; however, MAP-2b and MA

76 The p56 Src family non-receptor tyrosine kinase has been shown to be critic

77 The Abelson (Abl) family of non-receptor tyrosine kinases has an important role in c

78 Tec family non-receptor tyrosine kinases have been implicated in si

79 eptor tyrosine kinases and the Abl family of non-receptor tyrosine kinases have both been implicated

80 inases (SrcFKs), a multi-functional group of non-receptor tyrosine kinases highly expressed in vascul

81 , PF-4618433) reveals a distinct subclass of non-receptor tyrosine kinases identifiable by the gateke

82 h tyrosine kinase 2 (PYK2) is a cytoplasmic, non-receptor tyrosine kinase implicated in multiple sign

83 lopment and represents an emerging family of non-receptor tyrosine kinases implicated in signal trans

84 we provide evidence for a selective role of non-receptor tyrosine kinases in specific aspects of hip

85 resent study, we examined the role of Fyn, a non-receptor tyrosine kinase, in microglial activation a

86 Thus, these studies strongly suggest that non-receptor tyrosine kinases, in particular c-Src, may

87 The Abl family of mammalian non-receptor tyrosine kinases includes c-Abl and Arg.

88 The Janus tyrosine kinase (JAK) family of non-receptor tyrosine kinases includes four isoforms (JA

89 Imatinib (Gleevec), a non-receptor tyrosine kinase inhibitor (nRTKI), is one o

90 or TNK2, an ubiquitously expressed oncogenic non-receptor tyrosine kinase, integrates signals from li

91 The c-Abl protein is a non-receptor tyrosine kinase involved in many aspects of

92 en hMSH5 and c-Abl; the latter is a critical non-receptor tyrosine kinase involved in many critical c

93 c-Abl is a non-receptor tyrosine kinase involved in the regulation

94 inase (Lyn) is a member of the Src family of non-receptor tyrosine kinases involved in immune signali

95 for its proviral activity, and the family of non-receptor tyrosine kinases involved in this process,

96 stimulation of VGSC, engagement of these two non-receptor tyrosine kinases involves distinct signalin

97 The Ableson (Abl) non-receptor tyrosine kinase is also involved in the rem

98 The non-receptor tyrosine kinase is rapidly mobilized and ac

99 osine phosphorylation of GIV by receptor and non-receptor-tyrosine kinases is a key step that is requ

100 Bruton's tyrosine kinase (BTK), a non-receptor tyrosine kinase, is a member of the Tec fam

101 ABI-1, a downstream target of Abl non-receptor tyrosine kinase, is a member of the WAVE re

102 Syk, a non-receptor tyrosine kinase, is an important component

103 Etk/Bmx, a member of the Tec family of non-receptor tyrosine kinase, is characterized by an N-t

104 Fgr, a member of the Src family of non-receptor tyrosine kinases, is expressed in myeloid h

105 cYes, a member of the Src family of non-receptor tyrosine kinases, is highly expressed in mo

106 Tec family non-receptor tyrosine kinases (Itk, Btk, Tec, Rlk and Bm

107 motes signaling by causing activation of the non-receptor tyrosine kinase, JAK2, which associates wit

108 The V617F mutation in the JAK2 non-receptor tyrosine kinase (JAK2V617F) is present as a

109 ed receptors, results in the activation of a non-receptor tyrosine kinase known as focal adhesion kin

110 Janus kinase 3 (Jak3) is a non-receptor tyrosine kinase known to be expressed in he

111 blished that BCR is a substrate for c-FES, a non-receptor tyrosine kinase linked to myeloid growth an

112 Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, mediates integrin-based ce

113 e of signaling nodes Itk and Txk, Tec family non-receptor tyrosine kinases, mice exhibit a significan

114 The emergence of a non-receptor tyrosine kinase (non-RTK), ACK1 (also known

115 Pcs is predicted to be a novel regulator of non-receptor tyrosine kinase (NRTK) signaling.

116 orylated in vitro by representatives of many non-receptor tyrosine kinase (NRTK) sub-families, sugges

117 und heterozygous deleterious variants in the non-receptor tyrosine kinases (NRTKs) ACK1 and BRK.

118 belson family kinases (AFKs; Abl1, Abl2) are non-receptor tyrosine kinases (NRTKs) implicated in canc

119 s (RTKs), DIR identifies altered splicing in non-receptor tyrosine kinases (nRTKs).

120 residues within p27 to be phosphorylated by non-receptor tyrosine kinases (NRTKs).

121 p59(fyn) is a non-receptor tyrosine kinase of the Src family that has

122 to-oncogenes encode 60 000 and 62 000 Dalton non-receptor tyrosine kinases of the Src family, pp60c-s

123 SHP-1 antagonizes the action of receptor and non-receptor-tyrosine kinases on GIV and down-regulates

124 orylation of cellular proteins including the non-receptor tyrosine kinases p125fak and Src and the ad

125 ase (FAK) potently, we explored whether this non-receptor tyrosine kinase participates in the activat

126 by Src64B mutants, linking Akap200 with the non-receptor tyrosine kinase pathway.

127 canonical signaling mechanisms such as Src (non-receptor tyrosine kinase), PI3K, ERK, or MAPK pathwa

128 Members of the Src family of non-receptor tyrosine kinases play a critical role in me

129 e reported previously that Janus kinase 3, a non-receptor tyrosine kinase, plays a crucial role in AJ

130 Non-receptor tyrosine kinase proline-rich protein tyrosi

131 Non-receptor-tyrosine kinases (protein-tyrosine kinases)

132 n that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modu

133 increase in tyrosine phosphorylation of the non-receptor tyrosine kinase, PYK2, in A7r5 cells treate

134 Fes/Fer non-receptor tyrosine kinases regulate cell adhesion and

135 nsights into the mechanisms by which Abelson non-receptor tyrosine kinases relay information from axo

136 Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase required for signaling from

137 eelin activates members of the Src family of non-receptor tyrosine kinases (SFKs) and that this activ

138 ent focal adhesion kinase/Src proto-oncogene non-receptor tyrosine kinase signaling.

139 Here we show that Drosophila Shark, a non-receptor tyrosine kinase similar to mammalian Syk an

140 The non-receptor tyrosine kinase Src and receptor tyrosine k

141 The non-receptor tyrosine kinase Src is a major player in mu

142 d pharmacologic approaches identify that the non-receptor tyrosine kinase Src is required for FN tran

143 ownstream signalling mechanisms, such as the non-receptor tyrosine kinase Src or N-methyl-D-aspartate

144 The non-receptor tyrosine kinase Src regulates resensitizati

145 Activated EGFR induced non-receptor tyrosine kinase SRC to phosphorylate the m(

146 in (LRP) was found to be a substrate for the non-receptor tyrosine kinase Src, but the physiological

147 -Cbl also acts as a ubiquitin ligase for the non-receptor tyrosine kinase Src, thereby down-regulatin

148 as ligand-independent EGFR activation by the non-receptor tyrosine kinase Src.

149 and S-glutathionylation within EGFR and the non-receptor-tyrosine kinase Src.

150 hysically interacts with SRC proto-oncogene, non-receptor tyrosine kinase (SRC) protein to regulate F

151 However, we have reported that the non-receptor tyrosine kinase, Src, is activated by Tf to

152 relationship between Notch and either of the non-receptor tyrosine kinases Src42A and Src64B to promo

153 They are regulated by many non-receptor tyrosine kinases such as Src, Jak, Syk and

154 by a broad spectrum of cytokines, as well as non-receptor tyrosine kinases, such as Src.

155 ted that integrin-mediated activation of the non-receptor tyrosine kinase Syk in hematopoietic cells

156 h collagen induced a rapid activation of the non-receptor tyrosine kinase, Syk, as measured by an inc

157 vated Cdc42-associated kinase-2 (ACK-2) is a non-receptor tyrosine kinase that appears to be a highly

158 Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that has been extensively s

159 The brk gene encodes a non-receptor tyrosine kinase that has been found to be o

160 ACK1 is a non-receptor tyrosine kinase that has been shown to be i

161 ACK1 is a non-receptor tyrosine kinase that interacts with ubiquit

162 c-Abl is a non-receptor tyrosine kinase that is activated in human

163 ACK1 is a multidomain non-receptor tyrosine kinase that is an effector of the

164 c-Abl is a non-receptor tyrosine kinase that is involved in a varie

165 Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that is regulated by integr

166 Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that localizes to focal adh

167 uton's tyrosine kinase (Btk) is a Tec family non-receptor tyrosine kinase that plays a critical role

168 target of the enzymatic activity of c-Abl, a non-receptor tyrosine kinase that potently activated in

169 JAK2 is a non-receptor tyrosine kinase that regulates hematopoiesi

170 JAK2 is a non-receptor tyrosine kinase that regulates several cell

171 ivated Cdc42-associated kinase-2 (ACK2) is a non-receptor tyrosine kinase that serves as a specific e

172 Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase that signals downstream of

173 Janus kinases (JAKs) are non-receptor tyrosine kinases that are essential compone

174 kinase (FAK) and its close relative Pyk2 are non-receptor tyrosine kinases that mediate adhesion sign

175 d gene) protein belongs to the Abl family of non-receptor tyrosine kinases that regulate cell motilit

176 s a novel negative regulator of receptor and non-receptor tyrosine kinases through currently undefine

177 eration, we asked whether the recruitment of non-receptor tyrosine kinases to the cytoskeleton might

178 and a putative substrate of the transforming non-receptor tyrosine kinase v-Src.

179 fere with signaling by interleukin-6 and the non-receptor tyrosine kinase, v-Src.

180 Cytoskeletal binding of non-receptor tyrosine kinases was synchronous with tyros

181 protein Hck is a member of the Src family of non-receptor tyrosine kinases which is preferentially ex

182 he identification of cellular Src (c-Src), a non-receptor tyrosine kinase, which has since been impli

183 Btk family kinases represent new members of non-receptor tyrosine kinases, which include Btk/Atk, It

184 , encoded by the TNK2 gene, is a cytoplasmic non-receptor tyrosine kinase whose aberrant activation c

185 The c-Abl proto-oncogene is a non-receptor tyrosine kinase whose activity and localiza

186 c-Abl is a non-receptor tyrosine kinase whose activity is tightly c

187 TNK1 is a non-receptor tyrosine kinase with poorly understood biol