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1 and cytochrome c loss--whereas others appear nonapoptotic.
4 d with confocal microscopy and determined in nonapoptotic and apoptotic cardiocytes by indirect immun
5 ults in loss of viability, but is apparently nonapoptotic and further differs from cellular death def
7 staglandin J(2) (15d-PGJ2), induced a novel, nonapoptotic and microtubule-associated protein 1 light
10 ate that T-oligos stimulate the induction of nonapoptotic autophagic also known as type II programmed
12 he pathways by which ceramide acts to induce nonapoptotic autophagic cell death in malignant gliomas.
13 as either apoptotic, partially apoptotic, or nonapoptotic based on infected HEp-2 cell morphologies,
16 opulation that is relatively nondividing and nonapoptotic but chemotherapy resistant and chemotactic.
17 is a critical event in caspase-independent, nonapoptotic (but not caspase-dependent, apoptotic) deat
19 highest in the body cells and lowest in the nonapoptotic cap cells, implying that their expression i
25 ochondrial-associated molecular link between nonapoptotic caspase function and autophagy regulation i
26 ce suggests a mitochondrial pathway of local nonapoptotic caspase signaling in mediating spine prunin
27 udies in C. elegans also unearthed conserved nonapoptotic caspase-independent cell death programs tha
28 this set, which acts via a nonmembranolytic, nonapoptotic caspase-independent mechanism, is more effe
30 D4(+) T cells, two minor pathways leading to nonapoptotic, caspase-independent AICD were identified,
32 ted a striking increase in the percentage of nonapoptotic CD11b+ VLA-4-negative macrophages/monocytes
33 by infiltration of the tumor with activated, nonapoptotic CD8+ effector T lymphocytes on day 7 postth
35 alternative response closely correlated with nonapoptotic cell death and characterized by proteolysis
36 malignant glioma cells through induction of nonapoptotic cell death and mitochondria hyperpolarizati
38 Ferroptosis is an iron-dependent form of nonapoptotic cell death associated with oxidized polyuns
39 le for the RB tumor suppressor in preventing nonapoptotic cell death by limiting the extent of BNIP3
41 s is pharmacologically blocked, SAHA-induced nonapoptotic cell death can also be potentiated by autop
43 grammed necrosis or necroptosis is a form of nonapoptotic cell death driven by the receptor interacti
44 that ferroptosis, an iron-dependent form of nonapoptotic cell death driven by unrestricted lipid per
45 proteolysis is also linked to apoptotic and nonapoptotic cell death following excessive glutamate ex
47 of this class, lanperisone, acts by inducing nonapoptotic cell death in a cell cycle- and translation
48 previously been shown that hyperoxia induces nonapoptotic cell death in cultured lung epithelial cell
50 e provide molecular inroads to understanding nonapoptotic cell death in metazoan development and dise
51 l trials, can activate a unique mechanism of nonapoptotic cell death in sarcomas and other cancer cel
52 he Rb tumor suppressor in protecting against nonapoptotic cell death in the developing mouse fetal li
53 ollowing vaccination and suggests a role for nonapoptotic cell death in the regulation of CD4 T cell
54 To identify additional factors that regulate nonapoptotic cell death in yeast, a collection of gene k
55 and azole-class antifungal drugs can induce nonapoptotic cell death in yeasts that can be blocked by
58 in that was not found following apoptotic or nonapoptotic cell death induced by stimuli other than me
59 anism of tumor necrosis factor (TNF)-induced nonapoptotic cell death is largely unknown, although the
63 his issue, Overholtzer et al. describe a new nonapoptotic cell death pathway termed "entosis" in mamm
64 otein kinase (RIP) 3-mediated necroptosis, a nonapoptotic cell death pathway, is implicated in a vari
71 aspases) mediate apoptosis, the mediators of nonapoptotic cell death programs are much less well char
73 ss responses, such as autophagy, and control nonapoptotic cell death routines, such as regulated necr
81 anism to mitigate SAHA-induced apoptotic and nonapoptotic cell death, suggesting that targeting autop
82 cellular proliferation and high doses caused nonapoptotic cell death, which was not mediated through
99 optosis, but it is also constitutive on some nonapoptotic cell populations where it plays a role in c
102 oliferative effects followed by significant, nonapoptotic, cell death within 72 hours occurred in 24
103 Bax is predominantly found in the cytosol of nonapoptotic cells and is commonly thought to translocat
105 ative analysis revealed aggresomes in 60% of nonapoptotic cells but only in 10% of apoptotic cells.
106 by approximately 75%, reduced the density of nonapoptotic cells by approximately 70% in residual tumo
110 s had low Bcl-2 and high Bax levels, whereas nonapoptotic cells had high Bcl-2 and low Bax levels.
111 nstitutively targeted to mitochondria but in nonapoptotic cells is constantly translocated back to th
112 uring wound closure promote the extrusion of nonapoptotic cells via mechanically regulated stretch-ac
114 bility to discriminate between apoptotic and nonapoptotic cells, an ability restored by exogenous ANX
115 dditional 9-fold reduction of the density of nonapoptotic cells, and an additional 30% increase in th
116 a is found predominantly in the cytoplasm of nonapoptotic cells, and the apoptotic signal that activa
119 lation has been reported to occur at G2-M in nonapoptotic cells, raising the possibility that this an
120 ls of NUC70 expression between apoptotic and nonapoptotic cells, suggesting that activation of NUC70
121 cells induced by photodynamic treatment and nonapoptotic cells, we successfully detected caspase-9 a
126 pase-8 can also promote cell migration among nonapoptotic cells; here, we show that caspase-8 can pro
127 fined two distinct groups: those that induce nonapoptotic (Class I) and apoptotic (Class II) parasite
133 y responses of cells dying an apoptotic or a nonapoptotic death as a result of adenoviral infection.
134 also protected cells from ceramide-induced, nonapoptotic death consistent with the idea that severe
135 oinflammatory stimuli, whereas cells dying a nonapoptotic death from infection with E1B 19K-competent
137 flammatory reactions, but cells that undergo nonapoptotic death in response to such stimuli lack this
140 under pathological conditions, apoptosis and nonapoptotic death paradigms are often interwined, which
141 understand how FAP-alpha is involved in this nonapoptotic death pathway, we performed immunoblotting
142 A related Fas- and caspase-independent, nonapoptotic death process is revealed in wild-type (WT)
143 data indicate that TCR ligation can activate nonapoptotic death programs in WT CD8(+) and CD8(+) T bl
144 totic, involving activation of caspases, but nonapoptotic death responses also have been described.
145 ggering NF-kappaB activation, apoptosis, and nonapoptotic death signals through separate and competin
146 t protein (Q97) undergo a protracted form of nonapoptotic death that is insensitive to Bax deletion o
147 tic death requires caspases; and (4) delayed nonapoptotic death that occurs in the presence of caspas
148 biquitinated proteins; (2) enhanced baseline nonapoptotic death; (3) marked accumulation of autophagi
149 nk between Ca(2+) dysregulation and primary, nonapoptotic degeneration of photoreceptors and a role f
150 Viruses d2-3, d3-4, d4-5, d5-6, and d6-7 are nonapoptotic, demonstrating that ICP27 contains a large
151 us, activation of ferroptosis results in the nonapoptotic destruction of certain cancer cells, wherea
152 Here, we demonstrate that the large-scale nonapoptotic developmental PCD in the Drosophila ovary o
155 PH oxidase-dependent mechanism of cytolytic, nonapoptotic eosinophil death initiates nuclear chromato
156 y, active NF-kappaB localized exclusively to nonapoptotic epithelial cells both in vivo and in the ma
157 Diverse cell fusions are accompanied by the nonapoptotic exposure of phosphatidylserine at the surfa
158 onversion of naive T cells was mediated by a nonapoptotic Fas signal, resulting in Akt-driven cellula
159 and may therefore be more likely to initiate nonapoptotic Fas signaling due to less RIP1 in the recep
166 Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in an
167 s are known killers, being responsible for a nonapoptotic form of cell death with features similar to
168 reveals that ferroptosis, an iron-dependent, nonapoptotic form of cell death, represents a new regula
169 on injury, we discovered that necroptosis, a nonapoptotic form of cell death, triggers the recruitmen
172 vive therapy or a mechanism for initiating a nonapoptotic form of programmed cell death remains contr
175 ts the signaling of the IFN-gamma-activated, nonapoptotic form of TNF receptor superfamily member 6 (
179 This finding sheds new light on the CD95 nonapoptotic function and provides a novel mechanism for
181 utes to cell migration and adhesion, a novel nonapoptotic function of an established apoptotic factor
184 ontrol of synaptic vesicle pools, and a new, nonapoptotic function of the BAD-BAX-caspase-3 pathway i
185 ing that caspase-8 possesses an alternative, nonapoptotic function that may contribute to tumor progr
187 mediates not only apoptosis but also diverse nonapoptotic functions depending on the tissue and the c
190 from NHEJ deficiency is highly restricted by nonapoptotic functions of p53, such as the G1/S checkpoi
192 it is mainly caspase-8 in its apoptotic and nonapoptotic functions that has been an intense research
196 the mammalian Bcl-2 gene in cis restored the nonapoptotic, immunorepressive cell death activity of vi
198 sis of both apoptotic (high PS exposure) and nonapoptotic (intermediate PS exposure) activated T cell
201 flammatory disorders, histiocytes can engulf nonapoptotic leukocytes and nonsenescent erythrocytes an
202 no nuclear NF-kappaB activity, and LY-ar, a nonapoptotic line with constitutive p50 homodimer activi
203 antitation indicated that there was an early nonapoptotic loss of cortical neurons followed by a prog
204 e to M. avium-infected apoptotic, but not to nonapoptotic M. avium-infected Mphi, suggesting a specif
209 growth factors did eventually die through a nonapoptotic mechanism associated with loss of DeltaPsi.
211 e beta-cell cytotoxicity primarily through a nonapoptotic mechanism linked to a decline in ATP levels
212 of rat beta-cells occurs predominantly by a nonapoptotic mechanism, including the following: 1) A ra
216 ls vulnerable to weaver die by apoptotic and nonapoptotic mechanisms and indicate that weaver-induced
217 human carcinoma cells by both apoptotic and nonapoptotic mechanisms and potentiates the effects of c
218 inje cells, highlighting a possible role for nonapoptotic mechanisms in the death of these neurons.
219 is and tumor cells engineered to die through nonapoptotic mechanisms, resulting in secretion of eithe
222 cell body, DIP expression induced excessive nonapoptotic membrane blebbing, a physiological process
223 tructures resemble, and may be identical to, nonapoptotic membrane blebs, a feature of the amoeboid f
224 ervention, and lend support to the idea that nonapoptotic modes of cell death may play a crucial role
225 els, the caspase-deficient neurons exhibit a nonapoptotic morphology in which nuclear changes such as
229 ed polarized intestinal Caco-2 cells undergo nonapoptotic necrotic cell death triggered by inositol 1
231 these domains elicits axon degeneration and nonapoptotic neuronal death even in the absence of injur
232 ss exon 1 of mutant huntingtin, showed dark, nonapoptotic neurons and degenerated mitochondria associ
233 at Bax also lies upstream of ROS produced in nonapoptotic neurons and present evidence that caspases
235 partially involved in O(2)(.-) production in nonapoptotic neurons, and that other caspases may also b
238 inflammatory responses to avoid exaggerated nonapoptotic neutrophil death, leading to tissue damage.
240 Drosophila ovary is an intriguing example of nonapoptotic, nonautonomous PCD, providing insight on th
241 s in PrP functional activity induce a novel, nonapoptotic, nonautophagic form of neuronal death whose
242 expressing cells had a higher frequency of a nonapoptotic, nonnecrotic type of cell death termed para
248 h can be executed by regulated apoptotic and nonapoptotic pathways, including the iron-dependent proc
251 e for NADPH oxidase-derived ROS in mediating nonapoptotic PCD evoked by mAbs in B-cell malignancies.
252 ered Fc regions are type II mAb that trigger nonapoptotic PCD in a range of B-lymphoma cell lines and
254 MEK2, and ERK2 is essential for this form of nonapoptotic pcd, leading to the phosphorylation of the
257 at the rear of the invading cell as well as nonapoptotic plasma membrane (PM) blebbing in this cellu
258 bly overexpressed by fusion to an unrelated, nonapoptotic polypeptide, the N-terminal 37 amino acids
259 tant mice, the accumulation of a sub-G1, but nonapoptotic, population was observed that we believe ma
260 rolling synaptic vesicle pools, and a novel, nonapoptotic, presynaptic function of the BAD-BAX-caspas
261 with DNA damage resulting from a variety of nonapoptotic processes (necrosis, in vitro autolysis, pe
262 anding of the roles of IAPs in apoptotic and nonapoptotic processes and explore the notion that the l
263 ction in apoptosis, but are also crucial for nonapoptotic processes such as NMDA receptor-dependent l
264 with resveratrol's ability to kill cells via nonapoptotic processes, cells transfected to express hig
271 opathicity and replication of human CMV by a nonapoptotic, reversible process that requires nuclear f
273 that extracellular GzmB plays an unexpected, nonapoptotic role in regulating Treg suppression and sug
274 apoptosis, recently has been implicated in a nonapoptotic role in the regulation of the cell cycle, c
277 cent developments have focused on uncovering nonapoptotic roles of caspases ranging from immune regul
282 ptor complex and also mediate RIP1-dependent nonapoptotic signaling events, thus reducing caspase act
285 the dual roles of Fas in both apoptotic and nonapoptotic signaling, the aim of the present study was
287 gers apoptosis by driving DU145 cells from a nonapoptotic status (c-FLIP(short)(high), CD95(low), CD9
289 (phosphate-buffered saline)-pretreated mice, nonapoptotic superficial cell death from 2 to 6 hours an
290 Our results identify a role for caspase 3 in nonapoptotic T cells and support that caspase 3-dependen
291 target genes such as BAX and PUMA while the nonapoptotic targets p21 and hMDM2 remain unaffected.
293 nges were associated with markedly increased nonapoptotic thyroid cell death, suggesting direct toxic
294 y phosphorylated tyrosine peptides after the nonapoptotic treatments, which we used to distinguish be
295 , by interacting directly with CD28 on live (nonapoptotic) tumor plasma cells, bone marrow mDCs downr
296 Cytokine-primed neutrophils can undergo a nonapoptotic type of cell death using components of the
298 (+) cells were classified morphologically as nonapoptotic (Type I) or apoptotic (Type II) to verify t
300 of culture with anti-mu, the remaining live, nonapoptotic xid cells were enlarged, viable, and primed