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1  or displacement loop (D-loop), in the major noncoding region.
2 poliovirus lacking the entire genomic RNA 3' noncoding region.
3 ance, incomplete penetrance, or mutations in noncoding regions.
4 le-nucleotide polymorphisms (SNPs) reside in noncoding regions.
5 ) specificity and overprediction of genes in noncoding regions.
6 of protein coding genes resides within these noncoding regions.
7 ity levels decrease near exons and conserved noncoding regions.
8 e nif structural genes and in the intergenic noncoding regions.
9 e complete genome, including both coding and noncoding regions.
10 he entire genome of HSV-1 in both coding and noncoding regions.
11 riminate and identify functional elements in noncoding regions.
12 es was significantly greater for coding than noncoding regions.
13 limited sequence conservation found in these noncoding regions.
14 itates identification of critical coding and noncoding regions.
15 e utilized to assess polymorphic variants in noncoding regions.
16 enerally similar to those for the other four noncoding regions.
17  with DNA repeats localized in 15 apparently noncoding regions.
18 ssion may be evolving differently from other noncoding regions.
19 nt than synonymous ones and substitutions in noncoding regions.
20 e defined, largely through comparison of the noncoding regions.
21 tein-coding regions and is rare or absent in noncoding regions.
22 atio tests for the detection of selection in noncoding regions.
23 e over time, some sequences are conserved in noncoding regions.
24 he synonymous sites of exons compared to the noncoding regions.
25 nsible for the compositional biases found in noncoding regions.
26 enetic variations in both protein-coding and noncoding regions.
27  21, combining the information of coding and noncoding regions.
28  expressed chimeric mRNAs containing the HCV noncoding regions.
29 utrality across the locus in both coding and noncoding regions.
30 ociated genes, a lot of risk variants lie in noncoding regions.
31 ousand years on de novo mutations, mainly in noncoding regions.
32 elevant editing events, many of which are in noncoding regions.
33 s and 10 to 21 short insertions/deletions in noncoding regions.
34 utionary changes in protein-coding genes and noncoding regions.
35 ent in frame-preserving events and events in noncoding regions.
36 ntified within the partial genomic region E2/noncoding region 2 (NCR2) will enable the simpler identi
37 within the partial E2 open reading frame and noncoding region 2.
38 he majority of these polymorphisms reside in noncoding regions, 241 SNPs and 10 indels alter the prot
39                            The poliovirus 3' noncoding region (3' NCR) is necessary for efficient vir
40                                       The 3' noncoding region (3' NCR) of flaviviruses contains secon
41  at nonstructural protein 5 (NS5) and the 3' noncoding region (3'NC) of DENV.
42 brain-expressed microRNAs (miRNAs) in the 3' noncoding region (3'NCR) of the flavivirus genome (chime
43  by comparing nucleotide sequences of the 3' noncoding region (3'NCR).
44                    There are two significant noncoding regions (377 and 294 bp), which are the best c
45 framework would reduce genotyping effort for noncoding regions 4-fold.
46                  The approximately 1.2-kb 5'-noncoding region (5'-NCR) of mRNA species encoding mouse
47 esses a selective binding element for the 5' noncoding region (5'NCR) of viral late mRNAs (known as t
48 or phylogenetic analysis by targeting the 5' noncoding region (5'NCR).
49 majority of the GWAS signals were located to noncoding regions, a consistent outcome of all GWAS to d
50 V genome included an atypical, presumptively noncoding region absent in previously described hepadnav
51 le some studies show that highly constrained noncoding regions act to enhance transcription, other st
52  a very high level of accuracy in coding and noncoding regions alike.
53                          Moreover, conserved noncoding regions among Brassicaceae species are enriche
54  the C2-V3 region of env of HIV-1 and the 5' noncoding region and a region of E1/E2 of HCV.
55 diated by an AU-rich element (ARE) in the 3' noncoding region and by interacting ARE-binding proteins
56  the combined effects of the viral 5' and 3' noncoding regions and 2a polymerase open reading frame.
57 The TGA triplet was also found more often in noncoding regions and as a stop codon, though the bias w
58 ments that control gene expression reside in noncoding regions and can be identified by mapping the b
59  identification of tissue-specific conserved noncoding regions and can simplify the analysis of ances
60 ranscripts, including rearrangements between noncoding regions and clinically relevant genes such as
61 ns a significant challenge, particularly for noncoding regions and distantly related species.
62 nucleotide sequence similarity in coding and noncoding regions and encode identical apoplastic protei
63  humans, 5'CCR5 was more diverse than 90% of noncoding regions and had an excess of common variants.
64                 However, most loci reside in noncoding regions and have unknown biological functions.
65 ion is strongest in regulatory and conserved noncoding regions and in the most conserved portion of p
66 m genome-wide association studies lie within noncoding regions and perturb transcription factor recog
67  for the functional annotation of regulatory noncoding regions and systematically benchmarking the re
68 t that ribosomes frequently enter downstream noncoding regions and that Dom34 carries out the importa
69 these GWAS susceptibility variants reside in noncoding regions and the causal genes underlying the as
70    However, pinpointing the risk variants in noncoding regions and underlying biological mechanisms r
71 panzees, 5'CCR5 was less diverse than 80% of noncoding regions and was characterized by an excess of
72 ortion, 10%, encode 2-8 genes), have minimal noncoding regions, and are differentially amplified to a
73 ructure, gene and repeat contents, conserved noncoding regions, and relative rates of sequence evolut
74 ited in long stem-loop structures located in noncoding regions, and thus contrast with previously ide
75 ecific DNA, exons, and conserved (coding and noncoding) regions, and to identify rodent evolutionary
76 onal annotations for enhanced discoveries in noncoding regions; and enable enrichment analyses using
77 ing both intergenic regions and, especially, noncoding regions antisense to known open reading frames
78                                              Noncoding regions are also associated with disease; howe
79 s genes in close proximity to the identified noncoding regions are involved in craniofacial embryo de
80 phrenia have demonstrated that variations in noncoding regions are responsible for most of the common
81                                              Noncoding regions are usually less subject to natural se
82 us RNA segments are located in the 5' and 3' noncoding regions as well as in the terminal regions of
83                    This identity encompasses noncoding regions as well as multiple mobilization seque
84 us RNAs (vRNAs) are located in the 5' and 3' noncoding regions, as well as in the terminal regions, o
85 anzee prolactin gene sequences suggests that noncoding regions associated with regulating expression
86 us analyses investigating the implication of noncoding regions at the EBOV gene borders for gene expr
87 ains three potential regulatory sites within noncoding regions at the gene's 3' end, where alternativ
88 cs approach to identify conserved coding and noncoding regions at these genes and resequenced them in
89 y, which was originally located in the HU-14 noncoding region between dnaG (DNA primase) and rpoD (si
90 SV-2 sequences from seven regions, including noncoding regions between UL19 and UL20, UL24 and UL25,
91 ntial to dissect the functional landscape of noncoding regions, but is highly susceptible to false di
92  Since a similar effect is also found in the noncoding regions, but is present for all adjacent nucle
93                   In contrast, expansions in noncoding regions cause RNA-mediated toxicity.
94 utside of the IG loci, predominantly targets noncoding regions causing numerous "passenger" mutations
95  Single nucleotide polymorphisms (SNPs) in a noncoding region close to the CDKN2a/b senescence genes
96  The PhiCD119 attachment site attP lies in a noncoding region close to the putative integrase (int) g
97 ggesting that these evolutionarily conserved noncoding regions (CNCs) are selectively constrained and
98 sequence analyses revealed several conserved noncoding regions (CNRs) upstream of beta4 and alpha5.
99 the introduction of four mutations in the 5' noncoding region compared to the present vaccine.
100 ine loses the attenuating mutation in the 5' noncoding region completely.
101    Sequencing of a 150-bp fragment of the 5' noncoding region confirmed EV-D68 in 16 of 506 respirato
102                                Many of these noncoding regions contain important regulatory sequences
103 binant mitochondrial genomes showed that the noncoding region, containing origins of replication, gov
104 e genome-wide significant loci in introns or noncoding regions could affect regulation of genes nearb
105                                              Noncoding regions could be further fractionated into pro
106 on-PCR (RT-PCR) assay targeting the viral 5' noncoding region defined by sequences obtained from all
107 uence-based approach to characterize a large noncoding region deleted in patients affected by Van Buc
108  that poliovirus RNA harboring a complete 3' noncoding region deletion mutation is infectious (not me
109 ot provide compensatory functions for the 3' noncoding region deletion mutation replication defect.
110 r analyze the consequences of the genomic 3' noncoding region deletion, we examined viral RNA replica
111 ted by copy number alterations, mutations in noncoding regions, dysregulation of microRNA, epigenetic
112 ng editing in exons, but also the editing in noncoding regions (e.g., Alu-repetitive elements and mic
113  sought to identify evolutionarily conserved noncoding regions (ECRs) and motifs shared among them, w
114  for the validity of the rules in coding and noncoding regions, especially for the CIImono rule.
115 ains of ENBA1, in addition to aberrations in noncoding regions, especially in BamHI A rightward trans
116                We find that over 5000 distal noncoding regions exhibit dynamic changes in chromatin a
117 ns, flanking intronic regions, and conserved noncoding regions for variations in COL1A1, COL1A2, COL2
118 dentify 1434 protein-coding genes and 39,806 noncoding regions for which molecular rates were signifi
119 rand RNA synthesis, we deleted the entire 3' noncoding regions from human rhinovirus and poliovirus g
120 isorders, expansion of repeated sequences in noncoding regions gives rise to RNA that produces a toxi
121                         Copy number gains of noncoding regions harboring super-enhancers near KLF5, U
122 romic repeat (CRISPR) mutagenesis screens of noncoding regions have emerged as a novel method for fin
123 ost tumor-associated sites, predominantly in noncoding regions, have unknown functional relevance.
124                             We identified 92 noncoding regions highly conserved (>70%) between human
125  of selection we sequenced the homologous 5' noncoding region in chimpanzees, bonobos, a gorilla, an
126 lymorphism at position 5 of the 3' conserved noncoding region in IDV and influenza C virus (ICV) resu
127 d we sequenced the coding exons and flanking noncoding regions in 450 asthmatic cases and 515 nonasth
128  and UTRs, emphasizing the importance of the noncoding regions in EBOV gene expression control.
129 clusters, in regulatory regions dispersed in noncoding regions in genomic DNA.
130 xplored the evolutionary pressures acting on noncoding regions in Mononegavirales genomes and observe
131 blem, we identified evolutionarily conserved noncoding regions in primate, mammalian, and more distan
132 published 5'CCR5 data from 112 humans and 50 noncoding regions in the human and chimpanzee genomes.
133 ribe a powerful method to identify important noncoding regions in the human genome, and emphasize the
134 ency), there is extensive transcription from noncoding regions, including both intergenic regions and
135     However, the addition of characters from noncoding regions increased the number of parsimony-info
136 icantly higher F(ST) estimates than those in noncoding regions, indicating adaptive evolution in the
137                             When a site in a noncoding region is evolving neutrally zeta = 1, while z
138 imiting in neuronal cells, the poliovirus 3' noncoding region is involved in positive-strand synthesi
139 expression due to cis-regulatory variants in noncoding regions is central to disease susceptibility.
140  C. difficile chromosome (attB) located in a noncoding region just upstream of gene gltP, which encod
141 enetic variants have been shown to reside in noncoding regions, leading to the hypothesis that regula
142 bstrate through which genetic differences in noncoding regions may affect cellular function and respo
143                                        These noncoding regions may be involved in directing neuronal
144  of mutations within the conserved 3' and 5' noncoding regions, most likely due to error-prone BMV RN
145 eals retention of three primers in the major noncoding region (NCR) and one at the prominent lagging-
146 e transcripts, a miRNA located within a long noncoding region (NCR) of the genome.
147                                 The terminal noncoding region (NCR) sequences of the eight gene segme
148 c GBV-B containing an HCV insert from the 5' noncoding region (NCR) that was adapted for efficient re
149 nting for approximately two-thirds of the 5' noncoding region (NCR).
150 specific packaging signals that include both noncoding regions (NCRs) and adjacent terminal coding re
151 inds to AU-rich elements, or AREs, in the 3' noncoding regions (NCRs) of mRNAs to affect the stabilit
152 gate the contributions of the long 5' and 3' noncoding regions (NCRs) of the S genomic segment to in
153 onfirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of
154 ls for type 2 diabetes risk are located in a noncoding region near CDKN2A.
155  alterations, including partial deletions of noncoding regions not typically captured or considered p
156  small noncoding RNA (BocaSR), within the 3' noncoding region (nucleotides [nt] 5199 to 5338) of the
157 xanucleotide (GGGGCC) repeat expansions in a noncoding region of C9ORF72 are the major genetic cause
158      The GGGGCC (G4C2) repeat expansion in a noncoding region of C9orf72 is the most common cause of
159 ave a hexanucleotide repeat expansion in the noncoding region of chromosome 9 open reading frame 72 (
160                                          The noncoding region of exon 2 of the p73 gene has two polym
161            A new mutation within an upstream noncoding region of FOXP3 results in a variant of IPEX s
162  internal ribosome entry site, within the 5' noncoding region of genomic RNAs, were presumed to reduc
163  consensus primer/probe set targeting the 5' noncoding region of HRV.
164 cy virus type 2 (HIV-2) is present in the 5' noncoding region of RNA and contains a 10-nucleotide pal
165 gh introduction of a kan-gfp cassette into a noncoding region of the 200-kb B. hermsii linear plasmid
166 s of a hexanucleotide repeat (GGGGCC) in the noncoding region of the C9orf72 gene are the most common
167 exanucleotide GGGGCC repeat expansion in the noncoding region of the C9ORF72 gene is the most common
168  luxAB reporter genes were integrated into a noncoding region of the CDC plague-diagnostic phage phiA
169 ant hexanucleotide (GGGGCC) expansion in the noncoding region of the chromosome 9 open reading frame
170 nt oncogenic transgene (targeted into the 3' noncoding region of the cytoplasmic beta-actin locus) th
171  specific three-dimensional structure in the noncoding region of the ferritin mRNA model that is reco
172              CGG repeat expansions in the 5' noncoding region of the fragile X mental retardation 1 g
173 d by inserting the Puro-EGFP cassette into a noncoding region of the FV3 genome (FV3-Puro/GFP).
174 lmost all risk variants are localized to the noncoding region of the genome; therefore, the role of t
175 ensive base-pairing interactions with the 5' noncoding region of the hepatitis C virus (HCV) RNA geno
176            We studied the DNA diversity of a noncoding region of the homologous genes DD44Y and DD44X
177 netic interaction between miR-122 and the 5' noncoding region of the viral genome was revealed by mut
178  designed to specifically target an 18-bp 5' noncoding region of the viral genome.
179 ified a novel HBoV1 gene that lies in the 3' noncoding region of the viral positive-sense genome and
180 al interpretation of the SNPs located in the noncoding region of these loci remains challenging.
181 cture within a CpG island in the 5'-flanking noncoding region of this gene.
182  to cytosine (C) at nucleotide 472 in the 5' noncoding region of type 3 OPV.
183 the LD analysis, we surveyed both coding and noncoding regions of 66 DNA fragments from 47 accessions
184 scent transcripts associated with coding and noncoding regions of Abd-B in developing embryos.
185                          All eight mapped to noncoding regions of BMV RNAs, and the positions of seve
186 ncing efforts should not ignore the study of noncoding regions of cancer patients.
187 tic switches has been found to reside within noncoding regions of certain bacterial mRNAs.
188 t the population level can be detected using noncoding regions of DNA.
189 ll help identify regulatory sequences in the noncoding regions of genes and contribute to our underst
190 otifs in putative enhancers found within the noncoding regions of genes having heart expression.
191       The identification of sequences within noncoding regions of genes that are conserved between se
192  biases (excess of G over C and T over A) in noncoding regions of genes.
193 r-type-specific indel hotspots targeting the noncoding regions of highly expressed genes defining cer
194  overwhelming, making it prudent to focus on noncoding regions of known function, for which the effec
195 ches are complex folded RNA domains found in noncoding regions of mRNA that regulate gene expression
196 tructured domains that usually reside in the noncoding regions of mRNAs, where they bind metabolites
197 karyotic genomes and is especially common in noncoding regions of plants.
198  addition, this study pinpoints thousands of noncoding regions of relevance to both Mendelian and com
199 ed by expansions of repeating nucleotides in noncoding regions of RNA.
200           For a subset of diseases, however, noncoding regions of RNAs assume a primary toxic gain-of
201  1 and type 2 strains in which the entire 5' noncoding regions of Sabin 1 and Sabin 2 were replaced e
202  specific sequences or structures present in noncoding regions of some EBV mRNAs.
203 ressivity of HOS, we screened the coding and noncoding regions of TBX5 and SALL4 for mutations in 55
204 e still unknown, and many possibly reside in noncoding regions of the ABCA4 locus.
205 e regions of significant conservation in the noncoding regions of the BAC.
206 prion protein expression by the promoter and noncoding regions of the bovine and murine Prnp genes.
207 a subgroup were up to several times those in noncoding regions of the Drosophila genome.
208                   Variation in the coding or noncoding regions of the gene could potentially affect t
209 genome-wide association studies are found in noncoding regions of the genome and are likely to involv
210 ied for neuropsychiatric disorders reside in noncoding regions of the genome and are therefore likely
211         These variants are located mainly in noncoding regions of the genome and likely include varia
212 egulatory roles played by noncoding RNAs and noncoding regions of the genome during cancer progressio
213            Interpreting genetic variation in noncoding regions of the genome is an important challeng
214                                The role that noncoding regions of the genome play in the etiology of
215 ity of the AF-associated variants lie within noncoding regions of the genome where causal variants af
216 he associated variants are overwhelmingly in noncoding regions of the genome where we have few guidin
217 in genome-wide association studies reside in noncoding regions of the genome with regulatory roles.
218       Genetic risk factors often localize to noncoding regions of the genome with unknown effects on
219 enome-wide association studies (GWAS) are in noncoding regions of the genome, a common polymorphism i
220 nsive sets of orthologous protein-coding and noncoding regions of the genome, and identified a basal
221 ation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehen
222 nals for type 2 diabetes risk are located in noncoding regions of the genome, hindering translation i
223  widespread transcription in both coding and noncoding regions of the genome, including differential
224 le nucleotide polymorphisms (SNPs) reside in noncoding regions of the genome, which hampers biologica
225 ered in the search and are located mainly in noncoding regions of the genome.
226  causal mutations for rare diseases, fall in noncoding regions of the genome.
227 e believed to be restricted to the 5' and 3' noncoding regions of the genome.
228 ting sites have unknown functions and are in noncoding regions of the genome.
229 the novel loci; the majority of which are in noncoding regions of the genome.
230 ever, the vast majority of these SNPs lie in noncoding regions of the genome.
231 nts included large deletions and variants in noncoding regions of the genome.
232  on novel regulatory functions of p53 within noncoding regions of the genome.
233   Nucleotide substitutions were found in the noncoding regions of the genomes as well as in all codin
234 ic workflow, we assessed both the coding and noncoding regions of the human genome, including the eva
235 tes (T1D) genetic association signals lie in noncoding regions of the human genome.
236  to single-nucleotide polymorphism data from noncoding regions of the human genome.
237 t, we demonstrated that DNA sequences in two noncoding regions of the Kaposi's sarcoma-associated her
238 alignments, we found one or more CNSs in the noncoding regions of the majority of genes studied.
239 ally mutate coding sequences and/or the vast noncoding regions of the mouse genome for large-scale fu
240 Still, more than half of the hotspots lie in noncoding regions of the mouse genome.
241 t natural patterns of molecular variation in noncoding regions of the nuclear genome accurately refle
242 ing regions and faster elongation within the noncoding regions of the operon.
243 at positive epistasis between the coding and noncoding regions of the viral genome combined to elicit
244                  The genetic stability of 5' noncoding regions of these viruses matched that of the t
245 n addition, 6 differences were identified in noncoding regions of transcribed mRNA, and 1 silent codo
246 ith high affinity to sites located in the 5' noncoding regions of two additional cp32 genes.
247  homozygous 221-kb and 338-kb deletions in a noncoding region on chromosome 8 with an approximately 2
248 ith initiation factor eIF4G and the viral 5' noncoding region on viral late mRNAs, known as the tripa
249 SNPs was one SNP per 46 bp across coding and noncoding regions on average.
250       Here we build on a continuing study of noncoding regions on the X chromosome in a panel of 41 g
251 s performed on IGH (~1650 nt) and nine other noncoding regions potentially targeted by AID (combined
252       Of particular interest are MCSs within noncoding regions previously shown to contain GDF6 regul
253           An AU rich element (ARE) in the 3' noncoding region promotes the rapid degradation of mamma
254                  The rate of substitution in noncoding regions relative to the rate of synonymous sub
255          We show that one of these conserved noncoding regions represents a transcriptional enhancer
256 creens to interrogate functional elements in noncoding regions requires generating sgRNA libraries th
257 n expanded data set of 50 unlinked autosomal noncoding regions, resequenced in samples of Hausa from
258 identified 30 and 5 insertions in coding and noncoding regions, respectively.
259 aled that deleting the poliovirus genomic 3' noncoding region resulted in a positive-strand RNA synth
260 eys of worldwide DNA variation in four 10-kb noncoding regions revealed many interesting but also som
261  evolution in human or chimp, as compared to noncoding regions showing accelerated evolution in mouse
262                                       Within noncoding regions, SNPs in regulatory elements are more
263 dentified 14 methylation peaks in coding and noncoding regions, splicing junctions and splicing regul
264 copies due to rapid divergence of coding and noncoding regions such that neither retains the complete
265 ity of shared disease-associated variants in noncoding regions suggests they contribute to risk of au
266 re, we analyzed how diverse gene borders and noncoding regions surrounding the gene borders influence
267 tential, A/T richness, insertion bias toward noncoding regions, terminal inverted repeats (TIRs), tar
268 s from published studies (in both coding and noncoding regions) than the recently proposed CADD score
269 ing blocks or host proteins and mutations in noncoding regions that accelerate virus replication, all
270 e genetic changes in both protein-coding and noncoding regions that affect brain development and evol
271 and other sources to systematically identify noncoding regions that are recurrently mutated in cancer
272 h the expansion of microsatellite repeats in noncoding regions that result in the synthesis of pathog
273 ination rates are increased around conserved noncoding regions that show accelerated evolution in hum
274 phylogenetic comparison identified conserved noncoding regions that stimulate transcriptional activit
275  contain AU-rich elements (AREs) in their 3' noncoding regions that target them for degradation.
276 o amplify cDNA originating from the viral 5' noncoding region, the amplified product mixture was trea
277 any AF-associated genetic variants reside in noncoding regions; this knowledge gap impairs efforts to
278 recently developed annotation frameworks for noncoding regions through enrichment analysis on genome-
279 e that germline mutations in both coding and noncoding regions throughout the BAP1 gene can impair pr
280 attern of nucleotide variation at DPS2002, a noncoding region tightly linked to a paracentric inversi
281 tes channel function in vivo, and identify a noncoding region underlying this regulation.
282 ation sites, open reading frames, regulatory noncoding regions, untranslated regions and transcriptio
283 ch occurred in ORF 10, ORF 21, ORF 62, and a noncoding region upstream of ORF 64.
284 eotide polymorphisms that occur in conserved noncoding regions upstream of genes and identifying CpG
285 pressure and detecting positive selection in noncoding regions using multiple aligned DNA sequences.
286                  Conservation of a number of noncoding regions was observed; one coincides with an el
287                    Combining three autosomal noncoding regions, we estimated the long-term effective
288 ne candidates containing deletions in the 3' noncoding region were prepared by passage in DBS-FRhL-2
289 ns within the open reading frames (ORFs) and noncoding regions were identified and compared with the
290       The polymorphism rates from coding and noncoding regions were significantly different (0.07% an
291                           We show that viral noncoding regions were sufficient to drive gene expressi
292 ciphering the functionality of coding versus noncoding regions when interpreting GWAS data.
293 ike common laboratory strains retains intact noncoding regions where several EBV miRs reside.
294                Here we studied another 10-kb noncoding region, which is in 6p22.
295 ative genomic analysis to identify conserved noncoding regions, which were resequenced for single nuc
296 mozygous deletion of the mouse ortholog of a noncoding region with candidate pacemaker-specific REs i
297 or the encoded protein, whereas most fall in noncoding regions with potential to regulate gene expres
298 ong the entire chromosome in both coding and noncoding regions, with an enrichment at the 5' end of g
299                  We analyzed both coding and noncoding regions, with the former corroborating the lat
300 nked color pattern variation to a handful of noncoding regions, yet the presumptive cis-regulatory el

 
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