ライフサイエンスコーパス: noncovalent

1 structurally diverse, potent, and selective noncovalent AChE1 inhibitors were discovered.

2 ional organocatalysis combining covalent and noncovalent activation is presented.

3 ing (XB) has recently emerged as a promising noncovalent activation mode that can be employed in cata

4 e that a myo-inositol hexakisphosphate (IP6) noncovalent adduct can substantially enhance IRMPD for n

5 Noncovalent adsorption of DNA on nanoparticles has led t

6 We compared immobilization indirectly via noncovalent affinity capture using NeutrAvidin or concan

7 NAAA function and inhibition by covalent and noncovalent agents; and finally, the potential value of

8 rding whether pDA is a covalent polymer or a noncovalent aggregate of low molecular weight species.

9 influence of a covalent chemical process on noncovalent aggregates can be mediated, which holds grea

10 ly nonmetal cages, like fullerenes, and even noncovalent aggregates such as water clusters.

11 Whereas the noncovalent aggregation of various BODIPY dyes has been

12 f piperidine carboxamides (PIPCs) as potent, noncovalent agonists of human TRPA1.

13 hrough covalent modification or activated by noncovalent agonists through ligand binding.

14 tional mechanism of complement activation by noncovalent anchoring of C3 activation fragments, includ

15 lative to a common warhead scaffold, in both noncovalent and covalent binding states, and for two hig

16 ld parameters that are representative of the noncovalent and covalent complexes.

17 Both noncovalent and covalent hits emerge from such endeavors

18 enhanced selectivity toward BTK compared to noncovalent and irreversible covalent PROTACs.

19 ouse tumor necrosis factor ligands that form noncovalent and mostly trimeric assemblies, the m4-1BBL

20 rization of these interactions by preserving noncovalent assemblies for mass analysis, including prot

21 ays typically exploit reversible covalent or noncovalent assemblies that impart optical signals, comm

22 In addition, the noncovalent assembly enabled us to modify the sensor wit

23 er, a lectin-based nanoprobe was designed by noncovalent assembly of concanavalin A (ConA) on gold na

24 ra contains polypeptide domains designed for noncovalent assembly with anionic molecules and tumor ho

25 This cancer cell killing is due to noncovalent association between Fc regions of neighborin

26 ust balance the requirements to maintain the noncovalent association of gp120 with gp41 and to evade

27 rises a diverse alphabeta TCR heterodimer in noncovalent association with three invariant CD3 dimers.

28 lies in the catalyst development to maximize noncovalent attractive interactions through fine-tuning

29 f using reversible interactions (covalent or noncovalent) becomes challenging, especially when the ta

30 ads to channel opening and, importantly, how noncovalent binding activates TRPA1 are not well-underst

31 binding of the agonist, ATR, as well as the noncovalent binding of beta-ionone, an antagonist for G

32 Noncovalent binding of biopharmaceuticals to human serum

33 ty to monitor membrane protein complexes and noncovalent binding of ligands and lipids to membrane pr

34 Moreover, the noncovalent binding of SUMO-interacting motif (SIM) at t

35 calculations also revealed that covalent and noncovalent binding states of an inhibitor do not necess

36 also discuss the conditions under which the noncovalent binding step is no longer negligible and pro

37 he biotin-streptavidin bond is the strongest noncovalent bond in nature and is thus used extensively

38 alled expansins that nonenzymatically loosen noncovalent bonding between cellulose microfibrils.

39 ycol chain length has on the strength of the noncovalent bonding interactions taking place between cy

40 The noncovalent bonding patterns indicate higher fitness cos

41 s with axial ligands is a sensitive test for noncovalent bonding.

42 ibiotic spiramycin (SPI) were synthetized by noncovalent bulk polymerization technique.

43 couplings are indicative of the presence of noncovalent C-Hpi hydrogen-bond-like interactions involv

44 Noncovalent catalysis has the potential to be a powerful

45 lar technologies owing to the reversible and noncovalent chemical connectivities that define their pr

46 olution, surface/interface, solid state, and noncovalent chemistries have been developed for producin

47 a versatile strategy to promote an efficient noncovalent co-encapsulation of enzymes within a single

48 The results presented confirm that the noncovalent combination of supramolecular hosts with imi

49 otaxane was prepared by capping the end of a noncovalent complex composed of the tetralactam macrocyc

50 indicate that the reaction is catalyzed by a noncovalent complex formed between an iridium(III) photo

51 acid-PTX (ODDA-PTX) prodrug readily forms a noncovalent complex with human serum albumin (HSA).

52 ess to the enzyme's active site by forming a noncovalent complex with this host protease.

53 ion starts with the known coordinates of the noncovalent complex.

54 s optimized using docking approaches for the noncovalent complex.

55 rea serves as a strong denaturant to disrupt noncovalent complexes and release intact proteins for do

56 ore, using model systems, we show that these noncovalent complexes can also be fragmented by surface-

57 ge of the methods on two typical examples of noncovalent complexes drawn from a broad class of nuclei

58 meaningful information to be obtained on the noncovalent complexes formed by ACE2 and the receptor-bi

59 e applied to determine the stability of weak noncovalent complexes in their journey from bulk solutio

60 powerful activation method for the study of noncovalent complexes of biological significance.

61 ed unfolding (CIU) of protein ions and their noncovalent complexes offers relatively rapid access to

62 reserving fragile species, in particular the noncovalent complexes up to pentamers (332 kDa) destroye

63 were revealed by photofragmentation of their noncovalent complexes with aromatic molecules.

64 be gas-phase unfolding of proteins and their noncovalent complexes, notably for biotherapeutics.

65 ively to measure the equilibrium constant of noncovalent complexes.

66 ce is prone to formation of salt adducts and noncovalent compounds in samples enriched with inorganic

67 Noncovalent conformational locks are broadly employed to

68 isselenylvinylene (DESVS), with novel Se...O noncovalent conformational locks is designed and synthes

69 nd address the relative lack of stability of noncovalent constructs.

70 conformational changes and binding energy of noncovalent contacts at the FcRn binding interface.

71 eteroaryl phosphonate scaffold that exhibits noncovalent cross-class inhibition of representative car

72 e conformational ensemble of monomer tau and noncovalent cross-linking of multiple tau monomers.

73 chains are more effective at intermolecular, noncovalent cross-linking of tau.

74 ds, effectively repairing the intramolecular noncovalent cross-links.

75 r ATPase systems showing the presence of one noncovalent dimer and four monomer subunits.

76 version of the frontier orbital model for a noncovalent dimer is used to derive guidelines for dimer

77 re of the Kondo resonance also persists upon noncovalent dimerization of molecules.

78 s of melanins are influenced by covalent and noncovalent disorder.

79 By use of a noncovalent double mutant (T790M/L858R and T790M/del746-

80 probe can be used as a competitor to develop noncovalent drug candidates.

81 lycationic peptides forms a dense network of noncovalent, electrostatic linkages within the chromosom

82 The systematic shortening of the noncovalent element of a C8-linked pyrrolobenzodiazepine

83 The effects of shortening the noncovalent element of the molecule on transcription fac

84 bility similar to that of WT FrdA, contained noncovalent FAD, and displayed a reduced capacity to int

85 Herein we present a dynamic continuum of noncovalent filaments formed by the instructed assembly

86 ced properties of aza-glycine is a result of noncovalent forces (H-bonding) and backbone preorganizat

87 Proximal noncovalent forces are commonplace in natural systems an

88 erging these singular chemical structures by noncovalent forces has provided a large number of unprec

89 Understanding all the noncovalent forces involved has the potential to allow d

90 In contrast, soluble and noncovalent formats efficiently elicited anti-His tag an

91 es, such as homodimerization in covalent and noncovalent forms.

92 Noncovalent fragment hits revealed binding hotspots, whi

93 Towards this end, noncovalent functionalization offers a route to reversib

94 times more than that of SWCNT/GCE, SWCNT-Pc-noncovalent/GCE and SWCNT-Pc 3D/GCE in terms of peak hei

95 of pristine fullerenes (C(60/70)), with the noncovalent ground and excited state interactions that o

96 uronic acid (HA) hydrogels that form through noncovalent guest-host interactions, undergo disassembly

97 olate and characterize the smallest possible noncovalent H-type BODIPY aggregate, namely, an H-dimer.

98 anding on the nature, role, and potential of noncovalent halogen bonding.

99 Tubulin, the subunit of microtubules, is a noncovalent heterodimer composed of one alpha- and one b

100 e treatment of female infertility, but, as a noncovalent heterodimer, cumulin is difficult to produce

101 extensively to prepare several covalent and noncovalent heteroporphyrin-based multiporphyrin arrays.

102 udies, we demonstrate the presence of strong noncovalent hydrophobic interactions between ESAT-6 and

103 Enzymatic reactions and noncovalent (i.e., supramolecular) interactions are two

104 is described, which undergoes facile in situ noncovalent immobilization onto a carbon cloth electrode

105 gioselective ion pairing acts in effect as a noncovalent in situ protection mechanism, a concept that

106 rming the role of the K745 H-bond in potent, noncovalent inhibition of the C797S variant.

107 The reversible, noncovalent inhibitors described complement the covalent

108 Noncovalent inhibitors of AChE1, such as the ones presen

109 The compounds were found to be noncovalent inhibitors of DprE1, a subunit of decaprenyl

110 he side chains were synthesized as potential noncovalent inhibitors of PAD enzymes.

111 Noncovalent inhibitors of protein kinases have different

112 ydroxy-NQs (2-OH-NQs) act as highly specific noncovalent inhibitors of the essential bacterial thymid

113 hybrid stem replacement method practical for noncovalent installation of synthetic probes of RNA inte

114 This noncovalent interaction (Lys131-Tyr154) triggers nucleop

115 Noncovalent interaction (NCI) analysis showed that a ser

116 stereoselectivity is studied by means of the noncovalent interaction (NCI) analysis.

117 tational side, density functional theory and noncovalent interaction analysis reveal that torsional s

118 pported by quantum chemical calculations and noncovalent interaction analysis.

119 t hard to identify the contributions of each noncovalent interaction behind the remarkable rate accel

120 ion constraints of halogen bonding (XB), the noncovalent interaction between an electrophilic halogen

121 lanar geometry is realized through the F...H noncovalent interaction between CPDT and DFB for DF-PCIC

122 Furthermore, the noncovalent interaction between FAT10 and OTUB1 not only

123 efining the affinity of inhibitors through a noncovalent interaction called the halogen bond or X-bon

124 promotes conformational changes that improve noncovalent interaction energies and lead to enhancement

125 f drug action that relies on the reversible, noncovalent interaction of a ligand with its biological

126 BMS-806 strengthened the labile, noncovalent interaction of gp120 with the Env trimer, en

127 ed in its proteasomal degradation, whereas a noncovalent interaction stabilized OTUB1.

128 This noncovalent interaction strategy presents a solution tha

129 Halogen bonding is an excellent noncovalent interaction that forms halogen-halogen (X(2)

130 Although regarded as a strong noncovalent interaction, benchmark measurements of the h

131 Although recognized as a strong noncovalent interaction, driven by electrostatic charge-

132 e substrate, a ubiquitous type of attractive noncovalent interaction, is seldom accounted for in the

133 oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented

134 he C-H...pai, pai...pai, and lone pair...pai noncovalent interactions (NCIs) between the N-benzyl and

135 perimental results suggest possible roles of noncovalent interactions (NCIs) in directing the NT; com

136 ultivariate modeling allow identification of noncovalent interactions (NCIs) in monoaryloxy-pyrrolide

137 the differences in the number and nature of noncovalent interactions (NCIs) in the stereocontrolling

138 s the question of how many and what types of noncovalent interactions allow for binding site mapping

139 stinct properties, such as multiple combined noncovalent interactions and a diversity of stimuli-base

140 ach step, highlighting the key importance of noncovalent interactions and conformational flexibility

141 ansfer coupled with a multitude of transient noncovalent interactions and conformational fluctuations

142 ng the ability of the FT-ICR to maintain the noncovalent interactions and efficiently transmit labile

143 ractions through CF...S, CF...H, and CF...pi noncovalent interactions and enhance electron mobility,

144 ions was immobilized on carbon nanotubes via noncovalent interactions and further deposited on glassy

145 ecially for membrane proteins, is preserving noncovalent interactions and maintaining native-like str

146 and pentacene fragments on interchromophoric noncovalent interactions and photophysical properties, r

147 c hydroxo complexes, differentiated by their noncovalent interactions and reactivity, suggest that ne

148 The technique relies on the preservation of noncovalent interactions at energies that are sufficient

149 Furthermore, with reconfigurable, noncovalent interactions at nanomaterial interfaces, the

150 Recent experiments on noncovalent interactions at the nanoscale have challenge

151 The relative strength of noncovalent interactions between a thioether sulfur atom

152 Noncovalent interactions between biomolecules are critic

153 Use of attractive noncovalent interactions between ligand and substrate is

154 This strategy takes advantage of noncovalent interactions between long alkyl chains chemi

155 Noncovalent interactions between molecules are key for m

156 Based on noncovalent interactions between the capsule and the sub

157 ns, highlight the existence of a set of weak noncovalent interactions between the catalyst and substr

158 Noncovalent interactions between the neutral sulfonamidy

159 linkage isomers through controlled tuning of noncovalent interactions between the nitrosyl ligands an

160 of the active cofactors is mainly driven by noncovalent interactions between the protein scaffold an

161 ates is then controlled through a network of noncovalent interactions between the squaramide catalyst

162 esise molecules and our understanding of the noncovalent interactions between these molecules, the ch

163 e enzymatic reactions control intermolecular noncovalent interactions for spatial organization of hig

164 field heating is insufficient to disrupt the noncovalent interactions governing these assemblies.

165 nterplay between covalent bond formation and noncovalent interactions has become increasingly relevan

166 ving protein backbone bonds while preserving noncovalent interactions has made it especially suitable

167 er drug-surface interactions compared to the noncovalent interactions holding the antibody-drug conju

168 gy analogues, underscoring the importance of noncovalent interactions in enantio- and diastereocontro

169 s, a critical overview is given on essential noncovalent interactions in synthetic supramolecular com

170 eld important insights into the interplay of noncovalent interactions in the assembly of ordered chro

171 ng initially maintained their solution-phase noncovalent interactions intact.

172 Self-assembly of small molecules through noncovalent interactions into nanoscale architectures ha

173 self-assemble as a result of intermolecular noncovalent interactions into supramolecular gels in dee

174 ing pattern based on an intricate network of noncovalent interactions involving residues spaced apart

175 ection of literature which utilizes multiple noncovalent interactions like H-bonding, solvent bonding

176 nctionalized peptides, was used to study the noncovalent interactions of cell-penetrating peptides an

177 ception of the Oheteroarene interaction, all noncovalent interactions of sulfur with pi systems are f

178 ems, strategies based on self-assembly using noncovalent interactions offer the possibility to mimic

179 Our work demonstrates the important role of noncovalent interactions on the properties of metal comp

180 nd then systematically probed the effects of noncovalent interactions on their electronic, structural

181 cles covers QMC applications to systems with noncovalent interactions over the last three decades.

182 Finally, cooperative noncovalent interactions present between the APAQ ligand

183 e of additional hydrogen bonds such that the noncovalent interactions remain stronger than the covale

184 n states, which allows for analysis into the noncovalent interactions responsible for asymmetric indu

185 laced on identifying and quantifying the key noncovalent interactions responsible for the selectivity

186 functional theory calculations, the relevant noncovalent interactions stabilizing tri-, tetra-, hexa-

187 yer at the crude oil-brine interface through noncovalent interactions such as -O-H...O hydrogen bonds

188 as well as underexplored strong directional noncovalent interactions such as halogen-bonding and ani

189 cal pathways encompasses the coordination of noncovalent interactions that bring biomolecules to be c

190 tions is an ongoing challenge due to subtle, noncovalent interactions that drive selectivity.

191 The resulting control optimizes noncovalent interactions to differentiate the uptake and

192 lts offer further support for the ability of noncovalent interactions to enforce stereoselectivity in

193 design and synthesis are needed to optimize noncovalent interactions to improve target-selective bin

194 To advance their utility, we use noncovalent interactions to incorporate the biological c

195 to unambiguously assign binding energies of noncovalent interactions to physisorbed disulfides.

196 We show that noncovalent interactions with associated benzene rings (

197 ession analysis, we determined that multiple noncovalent interactions with the chiral environment of

198 e macrocycle cavity and engage in attractive noncovalent interactions with the macrocycle's NH residu

199 Although such assembly most commonly uses noncovalent interactions, a set of dynamic reactions inv

200 ocess with molecular self-assembly driven by noncovalent interactions, and dynamic assemblies are the

201 s of negative cooperativity, or "frustrated" noncovalent interactions, as a source of potential energ

202 ceptors with a specific focus on reversible, noncovalent interactions, in particular, hydrogen- and h

203 The crystal structures of all three display noncovalent interactions, including Watson-Crick base pa

204 that a series of more favorable cooperative noncovalent interactions, namely, hydrogen bond, pi-stac

205 lied to derive binding increments for single noncovalent interactions, start with the evaluation of c

206 Insights on how a series of noncovalent interactions, such as C-H...O, C-H...N, C-H.

207 Microenvironments are regulated by noncovalent interactions, such as hydrogen bonds (H-bond

208 We identified additional noncovalent interactions, which allowed us to develop me

209 in reactive structural adhesives, or through noncovalent interactions, which are nearly ubiquitous in

210 e microscopic and even macroscopic level via noncovalent interactions.

211 ions have also been used to evidence crucial noncovalent interactions.

212 lt in gas-phase protein unfolding or loss of noncovalent interactions.

213 ystems requires a comprehensive knowledge of noncovalent interactions.

214 ct selectivity can be achieved with few weak noncovalent interactions.

215 tate of a robust protein shell assembled via noncovalent interactions.

216 with anions through these different kinds of noncovalent interactions.

217 nding) has attracted notable attention among noncovalent interactions.

218 tructure and function is dependent on myriad noncovalent interactions.

219 components hierarchically organized through noncovalent interactions.

220 plish this at pH 7 using only collections of noncovalent interactions.

221 result of the strength of the intercomponent noncovalent interactions.

222 ctures and are incorporated into virions via noncovalent interactions.

223 acceptor (A) units presenting intramolecular noncovalent interactions.

224 l ketones triggered by Lewis base/Lewis acid noncovalent interactions.

225 ombine the computational design of physical (noncovalent) interactions with pathway-dependent, hierar

226 Although shortening the noncovalent interactive element of 13 had a less than ex

227 Weak noncovalent intermolecular interactions play a pivotal r

228 e determined the relative strengths of these noncovalent intramolecular sigma-sigma interactions via

229 del system, we show efficient degradation by noncovalent, irreversible covalent, and reversible coval

230 y of DprE1 inhibitors represents a promising noncovalent lead series for the discovery of novel antit

231 essed their potential use as halogen-bonding noncovalent Lewis acids.

232 Starting with a noncovalent ligand, we appended a chiral, conformational

233 esolution crystal structures of covalent and noncovalent ligand/Hsp90 complexes provide mechanistic i

234 Noncovalent ligands have been found to form only interac

235 cation-driven polymers to demonstrate a new noncovalent link based on receptor-stabilized anion-anio

236 tentially longer-term in vivo instability of noncovalent linkage of the trimers to the liposomes.

237 aptured HIV-1 Env glycoprotein trimers via a noncovalent linkage with improved efficacy over soluble

238 ble trimers and liposome-bearing trimers via noncovalent linkages.

239 ality of target proteins by interacting in a noncovalent manner.

240 ols such as single-molecule spectroscopy and noncovalent mass spectrometry allow unprecedented access

241 nanodiscs by combining cell-free expression, noncovalent mass spectrometry, and NMR spectroscopy.

242 ial light-driven sodium or proton pump, with noncovalent mass-spectrometric, electrophysiological, an

243 affinity of the overall cluster, providing a noncovalent method of tuning fullerene electronics.

244 Noncovalent modulation of the electron-accepting ability

245 We report the design of a noncovalent modulator of HbS, clinical candidate PF-0705

246 ion process, typically used to stabilize the noncovalent monolayer, can also be used to selectively d

247 to respond to external stimuli due to their noncovalent nature.

248 functional synthetic model for studying the noncovalent networks (NCNs) required for complex protein

249 rovide desirable therapeutic properties over noncovalent ones for treating challenging diseases.

250 nhibitors have many clinical advantages over noncovalent or irreversible covalent drugs.

251 These reagents effectively act as noncovalent, or traceless, chiral auxiliaries.

252 mation of hydrogen and coordinative bonds as noncovalent organizing principles for the assembly of el

253 ended pai-conjugated backbone and interlayer noncovalent pai-pai interactions endows TPAPC-COF with e

254 alyze chemical processes through stabilizing noncovalent pai-pai interactions resulting from shape co

255 To suppress noncovalent peptide formations, increasingly disruptive

256 Herein, we demonstrate the feasibility of noncovalent polymer adsorption to GQD surfaces, with a s

257 -fold in oxidation level, then investigating noncovalent polymer association to these substrates.

258 Implementing noncovalent polymers with multiple components can bring

259 re-activity relationship study of a class of noncovalent proteasome inhibitors with picomolar potenci

260 ting crystals of transient and heterogeneous noncovalent protein assemblies.

261 erent nanoparticles, an exemplary protein, a noncovalent protein complex, a virus-like particle, a po

262 The extent to which noncovalent protein complexes retain native structure in

263 SID provides structural information on noncovalent protein complexes that is complementary to o

264 te native top-down backbone fragmentation of noncovalent protein complexes, leading to comparable seq

265 ic capability unattainable with conventional noncovalent protein drugs.

266 ations to reveal the details of covalent and noncovalent protein interactions that link the outer mem

267 t by visualizing the spatial distribution of noncovalent protein interactions within tissue.

268 EC-nMS) platform for measuring affinities of noncovalent protein-small-molecule interactions on an Or

269 Using a second noncovalent reagent-commercially available 18-crown-6-fa

270 as components in cyclic host systems for the noncovalent recognition of fullerenes is unprecedented,

271 ce where suitable combinations of selective (noncovalent) recognition and transduction can be integra

272 ilizing a combination of chemical probes and noncovalent reconstructions, we draw new specific conclu

273 ine-based lead 7 has led to the discovery of noncovalent reversible and selective human factor D (FD)

274 for the generation of the first known potent noncovalent reversible Factor D inhibitors.

275 We show that it efficiently crosslinks noncovalent RNA complexes with mimimal sequence bias and

276 how different warhead chemistry, reversible noncovalent (RNC), reversible covalent (RC), and irrever

277 This study suggests that a relatively short noncovalent side chain at the C8 position of PBD is suff

278 ond formation, degenerate bond exchange, and noncovalent stacking processes.

279 accomplished using chiral lithium amides as noncovalent stereodirecting auxiliaries.

280 The assembly is directed by dynamic noncovalent sulfone-sulfone bonds that are susceptible t

281 cal modification is described that relies on noncovalent, supramolecular host-guest interactions to e

282 We investigated different covalent and noncovalent surface treatments (PEGMA, HEMA, BSA, O(2) p

283 Enzymatic noncovalent synthesis (ENS) refers to a process where en

284 Our results show that the noncovalent synthesis approach based on dipolar aggregat

285 researchers who are interested in exploring noncovalent synthesis for developing molecular science a

286 nd microscale dynamic molecular processes by noncovalent synthesis in the cellular environment have y

287 otubes constitute highly relevant targets in noncovalent synthesis.

288 g cooperative interactions in multicomponent noncovalent systems is crucial to design complex molecul

289 vature membranes in cellulo, implicating the noncovalent tetramer as a minimal unit of function.

290 y 0.3 kcal/mol stabilization compared to the noncovalent, tightly bound antagonist-GPCR complex of io

291 dimer activates UbcH5B~Ub and indicate that noncovalent Ub binding further stabilizes the cIAP1-UbcH

292 Noncovalent Ub binding to the backside of the E2 Ub-conj

293 We observed that the noncovalent Ub binds to the backside of UbcH5B and abuts

294 5B covalently linked to Ub (UbcH5B-Ub) and a noncovalent Ub to 1.7 angstrom resolution.

295 WP1 requires the presence of a low-affinity, noncovalent Ub-binding site within the HECT domain.

296 Noncovalent van der Waals (vdW) or dispersion forces are

297 Many such biosensors utilize noncovalent van der Waals force to attach proteins onto

298 ex with functional properties similar to the noncovalent wild-type complex.

299 kingly more potent antitumor effect over the noncovalent wild-type PD-1, attaining therapeutic effica

300 escribe the discovery of BI-4020, which is a noncovalent, wild-type EGFR sparing, macrocyclic TKI.