ライフサイエンスコーパス: nonenveloped

1 is that the ancestors of hepadnaviruses were nonenveloped.

2 es were considered to be either enveloped or nonenveloped.

3 Rotaviruses (RVs) are nonenveloped, 11-segmented, double-stranded RNA viruses

4 We examine virus maturation of selected nonenveloped and enveloped single-stranded RNA viruses,

5 ensitivity to inactivating agents.IMPORTANCE Nonenveloped and enveloped viruses are exposed to the en

6 Regulated structural transitions within nonenveloped and enveloped viruses are necessary for acc

7 mportant receptors that have been usurped by nonenveloped and enveloped viruses for attachment and/or

8 Cellular entry of nonenveloped and enveloped viruses is often accompanied

9 PaV particles are isometric, nonenveloped, and about 30 nm in diameter.

10 ronic infections, and that are nonsegmented, nonenveloped, and, most importantly, not transmitted by

11 the capsid of a cytoplasmically replicating nonenveloped animal virus despite the normally reducing

12 ring cell entry by this structurally complex nonenveloped animal virus.

13 sion, is not well characterized for any such nonenveloped animal virus.

14 r details of membrane penetration by a large nonenveloped animal virus.

15 Nonenveloped animal viruses must disrupt or perforate a

16 Several nonenveloped animal viruses possess an autolytic capsid

17 Cell entry by nonenveloped animal viruses requires membrane penetratio

18 The mechanisms employed by nonenveloped animal viruses to penetrate the membranes o

19 ration pathway, which may be shared by other nonenveloped animal viruses.

20 mbrane penetration shared by several diverse nonenveloped animal viruses.

21 model system for the Reoviridae family, is a nonenveloped arbovirus that causes hemorrhagic disease i

22 structural and genomic analyses suggest that nonenveloped archaeal viruses have evolved from envelope

23 The nonenveloped astroviruses and noroviruses similarly show

24 enveloped viruses (MHV and varphi6) and two nonenveloped bacteriophages (MS2 and T3) in raw wastewat

25 sful manipulation of a segmented genome of a nonenveloped capsid virus by the introduction of tags th

26 lumen, HSV-bearing organelles also displayed nonenveloped capsids attached to their cytoplasmic surfa

27 In the "separate" model, nonenveloped capsids travel from the cell body into and

28 Extracellularly, the interaction of nonenveloped capsids with several host cell proteins, af

29 f HBV virions, but not subviral particles or nonenveloped capsids, through the induction of tetherin

30 the secretion of HBV subviral particles and nonenveloped capsids.

31 Papillomaviruses are epitheliotropic, nonenveloped, circular, double-stranded DNA viruses with

32 ential for transferable application to other nonenveloped complex viruses.

33 on DNA; and (iii) a significant reduction of nonenveloped core particles in the medium.

34 uninfected or adenovirus serotype 5 (Ad5) (a nonenveloped cytolytic virus)-infected Huh7.5.1 cells by

35 Papillomaviruses are a family of nonenveloped DNA tumor viruses.

36 BKPyV is a nonenveloped DNA virus that must traffic through the end

37 lomaviruses (PVs) comprise a large family of nonenveloped DNA viruses that include HPV16, among other

38 llomaviruses (PV) comprise a large family of nonenveloped DNA viruses that include the oncogenic PV t

39 risk human papillomaviruses (HPVs) are small nonenveloped DNA viruses with a strict tropism for squam

40 AdVs, which have the largest genome of nonenveloped DNA viruses, are being extensively explored

41 rus infection have not been defined for this nonenveloped double-stranded DNA (dsDNA) virus.

42 Human papillomaviruses (HPVs) are nonenveloped double-stranded DNA viruses that utilize he

43 Bluetongue virus (BTV), a nonenveloped double-stranded RNA virus, is a potent indu

44 Mammalian orthoreoviruses (reoviruses) are nonenveloped double-stranded RNA viruses that infect mos

45 rototype members of the Reoviridae family of nonenveloped double-stranded RNA viruses, use at least t

46 Papillomaviruses are nonenveloped, double-stranded DNA viruses that are assoc

47 Adenovirus is one of the largest nonenveloped, double-stranded DNA viruses.

48 BTV is a nonenveloped, double-stranded RNA (dsRNA) virus with two

49 sensitive to polyamine depletion but that a nonenveloped enterovirus is not.

50 forming mechanism similar to that of certain nonenveloped eukaryotic viruses.

51 Hepatovirus, existing in both enveloped and nonenveloped forms, and with a capsid structure intermed

52 uses have been classified into enveloped and nonenveloped forms: Enveloped viruses exploit cellular m

53 ciation was observed between the presence of nonenveloped HEV and viral load, gender, or age at infec

54 tion in rabbits when it is preincubated with nonenveloped HEV particles.

55 ury markers contained a higher proportion of nonenveloped HEV than samples with HEV-negative serology

56 been described in circulating blood, whereas nonenveloped HEV virions have only been found in feces;

57 We found that compared to nonenveloped HEV virions, eHEV attachment to the cell wa

58 Unlike nonenveloped HEV virions, eHEV entry requires Rab5 and R

59 Nonenveloped HEV was detected in 8 of 23 plasma samples,

60 HEV-contaminated blood products may contain nonenveloped HEV, which may pose an additional risk to b

61 his study, we showed that quasi-enveloped or nonenveloped HEV-1, HEV-3, or HEV-4 virions do not readi

62 We found that both quasi-enveloped and nonenveloped HEVs can similarly cross the BBB and that a

63 igs and showed that both quasi-enveloped and nonenveloped HEVs invade the central nervous system (CNS

64 The nonenveloped, hollow, cylindrical virion is formed from

65 ue virus type 2, herpes simplex virus 1, and nonenveloped human adenovirus 5.

66 icking.IMPORTANCE After internalization, the nonenveloped human papillomavirus virion uncoats in the

67 ersistence of adenovirus type 5, a prevalent nonenveloped human virus, are dependent upon the intrace

68 es, and that the virus genome decay rates of nonenveloped (i.e., naked) viruses are similar to inacti

69 Poliovirus virions are nonenveloped icosahedral 30-nm particles with 60 copies

70 Circoviruses are small, nonenveloped icosahedral animal viruses characterized by

71 with linear single-stranded DNA genomes and nonenveloped icosahedral capsids.

72 Reovirus virions are nonenveloped icosahedral particles consisting of two con

73 The papillomavirus capsid is a nonenveloped icosahedral shell formed by the viral major

74 Iflaviruses have nonenveloped icosahedral virions containing single-stran

75 nimal viruses, this is the first report of a nonenveloped icosahedral virus CP inhibiting classical p

76 Porcine circovirus 2 (PCV2) is a T=1 nonenveloped icosahedral virus that has had severe impac

77 , of infectious pancreatic necrosis virus, a nonenveloped icosahedral virus, contains six N-glycosyla

78 ession.IMPORTANCE The Parvovirinae are small nonenveloped icosahedral viruses that are important path

79 licing.IMPORTANCE The Parvovirinae are small nonenveloped icosahedral viruses that are important path

80 The Parvovirinae are small nonenveloped icosahedral viruses that are important path

81 jor causes of childhood gastroenteritis, are nonenveloped, icosahedral particles with double-strand R

82 eno-associated viruses (AAV) are composed of nonenveloped, icosahedral protein shells that can be ada

83 astroviruses (HAstVs) belong to a family of nonenveloped, icosahedral RNA viruses that cause noninfl

84 Noroviruses are nonenveloped, icosahedral viruses of global importance t

85 ncapsidated dsRNA viruses, most of which are nonenveloped, infect a wide variety of hosts, from bacte

86 The outer capsid of the nonenveloped mammalian reovirus contains 200 trimers of

87 Membrane penetration by the nonenveloped mammalian reoviruses is believed to deliver

88 cteriophages as pathogenic virus surrogates: nonenveloped MS2 and Qbeta and enveloped Phi6.

89 5.6% (+/-16.7%) and 85.5% (+/-24.5%) for the nonenveloped MS2 and T3, respectively.

90 Giardia lamblia virus (GLV) is a small, nonenveloped, nonsegmented double-stranded RNA (dsRNA) v

91 Mammalian reoviruses are nonenveloped particles containing a genome of 10 double-

92 other members of the family, BTV virions are nonenveloped particles containing two architecturally co

93 Picornaviruses are nonenveloped particles with a single-stranded RNA genome

94 The nonenveloped parvovirus capsid carries determinants of h

95 itis virus, and dengue virus but not for the nonenveloped poliovirus.

96 The nonenveloped polyomavirus (Py) traffics from the plasma

97 The nonenveloped polyomavirus (PyV) simian virus 40 (SV40) t

98 The nonenveloped polyomavirus simian virus 40 (SV40) is take

99 The nonenveloped polyomavirus simian virus 40 (SV40) must pe

100 In the case of the nonenveloped polyomavirus simian virus 40 (SV40), the vi

101 ring ER-to-cytosol membrane transport of the nonenveloped polyomavirus SV40, a decisive infection ste

102 In the case of the nonenveloped polyomavirus SV40, penetration of the ER me

103 In the case of nonenveloped positive-sense RNA viruses, forming such co

104 d results were compared with those for other nonenveloped positive-stranded viruses (astroviruses and

105 LVs) are a diverse group of single-stranded, nonenveloped, positive-polarity RNA viruses and are the

106 Human astroviruses are nonenveloped, positive-sense single-strand RNA viruses a

107 Astroviruses are nonenveloped, positive-sense single-stranded RNA viruses

108 Human astroviruses (HAstVs) are nonenveloped, positive-sense, single-stranded RNA viruse

109 Parvoviruses are small, rugged, nonenveloped protein particles containing a linear, nonp

110 Classically considered "nonenveloped," recent studies show that some picornaviru

111 Membrane penetration by nonenveloped reoviruses is mediated by the outer-capsid

112 Hepatitis E virus is a nonenveloped RNA virus.

113 The picornavirus family of small nonenveloped RNA viruses includes significant human and

114 We conclude that the genetic content of nonenveloped RNA viruses is variable, not just by genome

115 Noroviruses are a diverse group of nonenveloped RNA viruses that are continuously evolving.

116 For many nonenveloped RNA viruses the requirements for this criti

117 In the picornavirus family of nonenveloped RNA viruses, the requirements for genome pa

118 The nonenveloped, rod-shaped virus SIRV2 (Sulfolobus islandi

119 roteins composing the outermost layer of the nonenveloped RV triple-layered icosahedral particle (TLP

120 Mammalian orthoreovirus (reovirus) is a nonenveloped, segmented, double-stranded RNA virus in th

121 The nonenveloped simian polyomavirus (PyV) simian virus 40 (

122 The nonenveloped simian virus 40 (SV40) hijacks the three en

123 Adeno-associated virus (AAV) is a nonenveloped single-stranded DNA (ssDNA) icosahedral T=1

124 Adeno-associated viruses (AAVs) are small nonenveloped single-stranded DNA (ssDNA) viruses that ar

125 Canine parvovirus (CPV) is a small nonenveloped single-stranded DNA virus that causes serio

126 Members of the genus Parvovirus are small, nonenveloped single-stranded DNA viruses that are nonpat

127 e investigated the RNA content of a purified nonenveloped single-stranded RNA virus, flock house viru

128 pe member of the Bocaparvovirus genus of the nonenveloped, single-stranded DNA (ssDNA) Parvoviridae f

129 and maturation of the coat protein of a T=4, nonenveloped, single-stranded RNA virus, Nudaurelia cape

130 Astroviruses are small, nonenveloped, single-stranded RNA viruses that cause dia

131 ridae family, which consists of icosahedral, nonenveloped, single-stranded RNA viruses.

132 uced in tissue culture cells by rotavirus, a nonenveloped, triple-protein-layered member of the Reovi

133 Merkel cell polyomavirus (MCPyV) is a small, nonenveloped tumor virus associated with an aggressive f

134 BK virus (BKV) is a nonenveloped, ubiquitous human polyomavirus that establi

135 re what appears to be the first example of a nonenveloped viral capsid that appears to have a role in

136 Nonenveloped viral capsids are metastable structures tha

137 ly investigate the innate immune response to nonenveloped viral infection in vivo.

138 Nonenveloped virions accumulate in the cytoplasm of cell

139 ential for assembly of infectious virus, and nonenveloped virions accumulate in the cytoplasm of cell

140 hepatitis E virus (HEV) sheds into feces as nonenveloped virions but circulates in the blood in a me

141 ating dissemination within the host, whereas nonenveloped virions shed in feces are stable in the env

142 e human pathogens are shed in feces as naked nonenveloped virions, recent studies indicate that both

143 ions, although it produces normal amounts of nonenveloped virions.

144 ons are more permissible to the BBB than the nonenveloped virions.

145 (Phi6 and murine hepatitis virus, MHV) and a nonenveloped virus (MS2) over time in clear water with s

146 characterized direct interactions of a whole nonenveloped virus (simian virus 40), as well as those o

147 while no inhibition was observed against the nonenveloped virus adeno-associated virus.

148 reveal a novel mechanism of cell entry for a nonenveloped virus and highlight mechanisms which may al

149 f the ESCRT machinery in the life cycle of a nonenveloped virus and highlights the complex mechanism

150 vidence that IFITM3 restricts infection by a nonenveloped virus and suggest that IFITM3 targets an in

151 ctor that mediates membrane penetration of a nonenveloped virus and suggest that PDI family members a

152 genome of bluetongue virus (BTV), a complex nonenveloped virus belonging to the Reoviridae family.

153 results provide a detailed analysis of how a nonenveloped virus can enter its host cell.

154 ultiple copies of the same protein form many nonenveloped virus capsids, it is unclear if lytic pepti

155 hus providing insight into the regulation of nonenveloped virus disassembly.

156 ane fusion and to reveal novel mechanisms of nonenveloped virus dissemination that contribute to viru

157 sults suggest a well-orchestrated process of nonenveloped virus entry involving autocleavage of the p

158 of reovirus host cell attachment.IMPORTANCE Nonenveloped virus entry is an incompletely understood p

159 ions for understanding membrane lysis during nonenveloped virus entry.

160 nteraction in which membranes can facilitate nonenveloped virus entry.

161 rther clarify the molecular basis by which a nonenveloped virus escapes a host membrane during infect

162 ane during infectious entry.IMPORTANCE How a nonenveloped virus escapes from a host membrane to promo

163 Although concentrated nonenveloped virus failed to activate freshly isolated h

164 entral helical bundle, observed in different nonenveloped virus families, are a specialized lytic mot

165 cern, eight enveloped virus families and one nonenveloped virus family, for which vaccine generation

166 viously unrecognized enzymatic mechanism for nonenveloped virus penetration.

167 irst demonstration of a functional ITAM in a nonenveloped virus presents a new mechanism for viral IT

168 two enveloped viruses decay faster than the nonenveloped virus studied, and k are significantly impa

169 icated in the intracellular trafficking of a nonenveloped virus such as HPV.

170 mbrane penetration apparatus of rotavirus, a nonenveloped virus that causes childhood gastroenteritis

171 Mammalian orthoreovirus (reovirus) is a nonenveloped virus that establishes primary infection in

172 Canine parvovirus (CPV) is a small, nonenveloped virus that is a host range variant of a vir

173 Adeno-associated virus (AAV) is a small, nonenveloped virus that was adapted 30 years ago for use

174 th membranes can function as a trigger for a nonenveloped virus to gain entry into host cells.

175 link the activity of a cellular factor on a nonenveloped virus to the membrane perforation event and

176 TA in controlling this step.IMPORTANCE How a nonenveloped virus transports across a biological membra

177 y of GP for inactivating MS2 bacteriophage-a nonenveloped virus widely used as a surrogate for SARS-C

178 IMPORTANCE Reovirus is a nonenveloped virus with a segmented double-stranded RNA

179 HAstV is a nonenveloped virus with a T=3 capsid and a positive-sens

180 (Gram-positive bacteria), MS2 bacteriophage (nonenveloped virus), and Phi6 (enveloped virus)) and for

181 As a nonenveloped virus, HAstV exhibits an intriguing feature

182 As a nonenveloped virus, HPV enters cells by interacting with

183 A nonenveloped virus, simian virus 40, was not affected by

184 Despite being a nonenveloped virus, the putative VP5 membrane penetratio

185 ut not by reovirus, a structurally unrelated nonenveloped virus.

186 sulting in fecal shedding of abundant naked, nonenveloped virus.

187 mes entry barriers faced by this multicapsid nonenveloped virus.IMPORTANCE Virus entry into a suscept

188 ed in our understanding of cellular entry by nonenveloped viruses (NEVs).

189 It is likely that other nonenveloped viruses also use this pathway for nonlytic

190 l spread of cytoplasmic constituents such as nonenveloped viruses and aggregated proteins is usually

191 in mammalian cells, including the release of nonenveloped viruses and apoptosis.

192 ategy to modulate the biological function of nonenveloped viruses and may have implications broader t

193 se replicative fitness.IMPORTANCE Capsids of nonenveloped viruses are composed of protein complexes t

194 chanisms involved in membrane penetration by nonenveloped viruses are not as well understood.

195 Nonenveloped viruses are, by their very nature, denied t

196 pathogen within the family Picornaviridae of nonenveloped viruses because of its rapid evolution and

197 ese results indicate that capsid proteins of nonenveloped viruses can interact among themselves withi

198 this work illustrates a novel strategy that nonenveloped viruses can use to gain access into cells a

199 The process by which nonenveloped viruses cross cell membranes during host ce

200 Consequently, nonenveloped viruses do not encode membrane fusion prote

201 l-characterized system for understanding how nonenveloped viruses enter and infect cells.

202 Many nonenveloped viruses have evolved an infectious cycle th

203 th no limiting membrane surrounding virions, nonenveloped viruses have no need for membrane fusion to

204 In order to complete infectious entry, nonenveloped viruses have to pass cellular membranes.

205 Mammalian orthoreoviruses (reoviruses) are nonenveloped viruses implicated in human disease that se

206 antiviral action for alpha-defensins against nonenveloped viruses in which HD5 directly interferes wi

207 The Picornaviridae family of small, nonenveloped viruses includes major pathogens of humans

208 Membrane penetration of nonenveloped viruses is a poorly understood process.

209 ped viruses, a roadmap for their use against nonenveloped viruses is lacking.

210 es in the assembly pathways of enveloped and nonenveloped viruses may be far simpler than previously

211 nfect vertebrates but also a sister group of nonenveloped viruses more recently discovered in fish an

212 ansmit their genetic material to a new host, nonenveloped viruses must protect their genomes by packa

213 To achieve cell entry, many nonenveloped viruses must transform from a dormant to a

214 Nonenveloped viruses often invade membranes by exposing

215 was stimulated after infection by DNA or RNA nonenveloped viruses or intracellular bacteria.

216 Nonenveloped viruses protect their genomes by packaging

217 eterminants of reovirus stability.IMPORTANCE Nonenveloped viruses rely on protein-protein interaction

218 Membrane penetration by nonenveloped viruses remains enigmatic.

219 We focus here on small nonenveloped viruses such as adeno-associated viruses, w

220 ons may reflect a general mechanism by which nonenveloped viruses such as poliovirus and other viruse

221 Nonenveloped viruses such as Simian Virus 40 (SV40) expl

222 For nonenveloped viruses such as Simian Virus 40, the mechan

223 Mammalian orthoreoviruses (reoviruses) are nonenveloped viruses that replicate in cytoplasmic membr

224 , a situation that may be relevant for other nonenveloped viruses that use microtubule-dependent tran

225 ition, we used cNDs to visualize how simple, nonenveloped viruses translocate their genomes across me

226 Some nonenveloped viruses use retrograde trafficking for entr

227 whereas ricin and Shiga-like toxins and some nonenveloped viruses use the retrograde pathway for cell

228 cell entry and infection, many enveloped and nonenveloped viruses utilize cell surface receptors that

229 Recent studies have established that several nonenveloped viruses utilize virus-encoded lytic peptide

230 Mammalian reoviruses are nonenveloped viruses with a long, filamentous attachment

231 s to poultry and aquaculture, is composed of nonenveloped viruses with a segmented double-stranded RN

232 Polyomaviruses are nonenveloped viruses with capsids composed primarily of

233 ing to its host cell, poliovirus (like other nonenveloped viruses) faces the challenge of translocati

234 % accuracy for differentiating enveloped and nonenveloped viruses, and 99% accuracy for differentiati

235 egress while maintaining cell integrity, and nonenveloped viruses, i.e., those lacking a membrane aro

236 orphogenic step that is exceedingly rare for nonenveloped viruses, immature rotavirus particles assem

237 A number of nonenveloped viruses, including AAV, carry proteases tha

238 erum are demonstrated for both enveloped and nonenveloped viruses, making the sensor generally applic

239 f membrane penetration for Py, and for other nonenveloped viruses, remains poorly characterized.

240 possible activity of these peptides against nonenveloped viruses, such as HPVs.

241 Reoviruses, a model system for entry of nonenveloped viruses, undergo a series of disassembly st

242 system for studying the entry mechanisms of nonenveloped viruses, undergoes a series of regulated st

243 cies and are more likely to be zoonotic than nonenveloped viruses, while other viral traits such as g

244 The enzymes encoded by nonenveloped viruses-a group of viruses that lack any li

245 driven process of antibody neutralization of nonenveloped viruses.

246 e compound had no effect on the infection of nonenveloped viruses.

247 ng and internalization of both enveloped and nonenveloped viruses.

248 eptors in the infectious pathways of several nonenveloped viruses.

249 e statistically significantly greater k than nonenveloped viruses.

250 ch are potent antiviral agents against other nonenveloped viruses.

251 ols in our pandemic-preparedness toolbox for nonenveloped viruses.

252 We identified 457 k-values, with 356 for nonenveloped viruses.

253 son, less is known about antibody binding to nonenveloped viruses.

254 nzymes and autocatalytic activity encoded by nonenveloped viruses.

255 tion of wastewater compared to 6% of the two nonenveloped viruses.

256 lexibility described for other enveloped and nonenveloped viruses.

257 ced with capsid proteins from two unrelated, nonenveloped viruses: simian virus 40 and satellite toba