ライフサイエンスコーパス: nonfunctional

1 icking likely explains why TLR9(471-1032) is nonfunctional.

2 This renders the centrosome nonfunctional.

3 five of which are fragmented and presumably nonfunctional.

4 shing the interaction renders the polymerase nonfunctional.

5 are found in POLE and POLD1 and appear to be nonfunctional.

6 STAT3 gene which renders most of the protein nonfunctional.

7 ion of smbT, which makes the ABC transporter nonfunctional.

8 in five fragmented genes that are presumably nonfunctional.

9 hromosomal deletions and are predicted to be nonfunctional.

10 ds between 81 and 96, rendering the molecule nonfunctional.

11 pulation of MC4R at the cell surface becomes nonfunctional.

12 he genome is noncoding and was thought to be nonfunctional.

13 hat NAGNAG splicing is purely stochastic and nonfunctional.

14 nic inflammation, endogenous CD8(+) TCs were nonfunctional.

15 ersity, suggesting that some recently became nonfunctional.

16 e-sensing domain, whereas the pore domain is nonfunctional.

17 reociliary bundles were absent, or small and nonfunctional.

18 tems in low- and middle-income countries are nonfunctional.

19 otype" control under which most targeting is nonfunctional.

20 ulfoxide (MetSO), rendering several proteins nonfunctional.

21 nant in tumor-derived cells in which ICP0 is nonfunctional.

22 Using sub-genomic replicons incorporating nonfunctional 3Bs and 3B fusion products in competition

23 classification of benign adrenal tumors as "nonfunctional" adequately reflects the continuum of horm

24 Objective: To evaluate the hypothesis that nonfunctional adrenal tumors (NFATs) increase risk for c

25 ween NP monomers, promoting the formation of nonfunctional aggregates.

26 Nonfunctional AGO5 from k1 alleles leads to altered dist

27 Comparison of Bs4C with a nonfunctional allele that is unable to recognize AvrBs4

28 e shift and a premature stop codon, led to a nonfunctional allele, tan1-a.

29 ense or deletion mutations in Mx1 and thus a nonfunctional allele, whereas wild-derived mouse strains

30 tained one functional allele (A-2) and three nonfunctional alleles (a-3, a-4, and a-5) each containin

31 n, we assessed germination of functional and nonfunctional alleles of these genes and measured their

32 etic analyses in M. tuberculosis showed that nonfunctional alleles were produced either by deletion o

33 pecies I of S. enterica and often present in nonfunctional allelic forms in organisms lacking the ide

34 Using a mouse model with a mutant, nonfunctional alpha2delta2 protein, we showed that the a

35 corresponding chNHE1 residues converted the nonfunctional ALV-J receptor huNHE1 to a functional one.

36 ound that their survival of treatment with a nonfunctional amino acid analog negatively correlates wi

37 hich contained functional NMDA receptors and nonfunctional AMPA receptors only in GFP-positive neuron

38 enerate a population of CD8 T cells that are nonfunctional and apoptotic; thus, our data support a mo

39 Most are classified as nonfunctional and are considered to pose no health risk,

40 L2 double point mutant renders the TM domain nonfunctional and blocks HPV16 infection by preventing e

41 but gB-Tet(-) CD8(+) T cells remain largely nonfunctional and do not provide increased protection fr

42 Mutant subunits were nonfunctional and exerted dominant-negative effects on w

43 e somatic features but hair bundles appeared nonfunctional and short.

44 ochasticity and pathway interconnectivity is nonfunctional and that cellular decisions are likely muc

45 mentation indicated that LARS2 c.1077delT is nonfunctional and that LARS2 p.Thr522Asn is partially fu

46 ion strain verified that the mutant WciG was nonfunctional, and the serology of the mutant could be r

47 cted nuclear localization signals of HMR are nonfunctional, and therefore mature HMR is unable to acc

48 , with p110alpha inactivation giving rise to nonfunctional angiogenesis, which can stunt tumor growth

49 Mutations that render this system nonfunctional are slightly attenuated in the mouse model

50 Previously, it was assumed that they were nonfunctional artifacts associated with cellular stress.

51 rica, where handpumps are common, 10-67% are nonfunctional at any one time, and many never get repair

52 Nonfunctional AVF occurred in 21 (13.0%) patients, and t

53 oint may obstruct the B cell repertoire with nonfunctional B cell clones.

54 by skewing stator selection in favor of the nonfunctional, "bad" stators.

55 Here we show that NaV1.1-L1649Q is nonfunctional because of folding defects that are rescua

56 ntry site (IRES) RNA, which shows that it is nonfunctional because of the incorrect position of the m

57 Our analysis shows that when there are many nonfunctional binding sites and many indirect targets, n

58 in CLEC14A-KO mice had increased numbers of nonfunctional blood vessels and severe hemorrhaging.

59 Our data show that nonfunctional box motifs abolish IL-12- and IL-23-induce

60 RANK overexpression in tumor cells with nonfunctional BRCA1 enhances invasiveness in acinar cult

61 In S. italica, this gene was rendered nonfunctional by a retrotransposon insertion in the dome

62 cribe two primate Siglecs that were rendered nonfunctional by single genetic events during hominin ev

63 ated by Dicer, they are generally considered nonfunctional by-products.

64 nal in nature, this evidence might reflect a nonfunctional byproduct rather than having a causal role

65 d predicted the presence of an incomplete or nonfunctional cag pathogenicity island in 18/276 genomes

66 Marijuana is distinguished from hemp by a nonfunctional CBDA synthase that appears to have been po

67 ection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells.

68 This alteration generated a nonfunctional CD56(bright) NK cell subset characterized

69 While intercellular competition weeds out nonfunctional cells, it may also select for cells that d

70 ction caused genome-wide misincorporation of nonfunctional CenH3-containing nucleosomes that protect

71 5A), generating variants encoding truncated, nonfunctional channels that are trapped in the endoplasm

72 2) reduces protein expression and produces a nonfunctional chimeric channel (TRPV1-AD2).

73 Cystic fibrosis (CF) is caused by a nonfunctional chloride and bicarbonate ion channel (CF t

74 Here, we show that unstable, nonfunctional complexes assembled from even shorter 3'-t

75 as a clearing factor that releases RNAP from nonfunctional complexes with nucleic acids.

76 high light levels are abolished in mice with nonfunctional cones and when horizontal cells are revers

77 and could distinguish regulatory sites from nonfunctional conserved residues.

78 People who maternally inherit a deletion or nonfunctional copy of the UBE3A gene develop Angelman sy

79 Plants with a nonfunctional cruP accumulate substantially higher level

80 in two independent lines produced truncated, nonfunctional CRY2 proteins, resulting in the in vivo di

81 tacting surfaces of incisors and canines and nonfunctional cusps of posterior teeth.

82 riments with multiple pairs of complementary nonfunctional CXCR4 mutants.

83 ion is disrupted by increasing expression of nonfunctional CXCR4 mutants.

84 al mucus of cystic fibrosis (CF) mice with a nonfunctional cystic fibrosis transmembrane conductance

85 ansporters and/or activation of a previously nonfunctional d-Ser deaminase.

86 ast a few other SC-containing accessions are nonfunctional, despite SCRC encoding a functional full-l

87 ed capability to repair a massively injured, nonfunctional DG.

88 Comparative analysis of functional and nonfunctional diversity in this highly abundant and adap

89 populations, even the small cost incurred by nonfunctional DNA because of extra energy and time expen

90 The second, trlR, is a nonfunctional, dominant-negative mutant located in an op

91 The survival of patients with large nonfunctional DP-NETs is known to be poor, but the overa

92 The first one is nonfunctional due to chronic rejection, the second one i

93 nine (pT)-binding domain, and found it to be nonfunctional due to misfolding in the bacterial peripla

94 strain of Escherichia coli were found to be nonfunctional due to their incorrect assembly.

95 litates miRNA-mediated silencing is rendered nonfunctional during cellular stress, including virus in

96 itial infection, many become dysregulated or nonfunctional during the course of chronic infection.

97 fragmented virulence genes that probably are nonfunctional, e.g., F1L, B13R, C10L, K3L, and C3L.

98 Importantly, a nonfunctional E4-ORF3 mutant protein, L103A, forms a sta

99 ZO-1 prevented maturation of functional into nonfunctional/endocytic channels, rather than ZO-1 inter

100 T VLPs, consistent with selective removal of nonfunctional Env (i.e., "trimer VLPs").

101 to the difficulty of separating trimers from nonfunctional Env (uncleaved gp160 and gp41 stumps).

102 We previously showed that nonfunctional Env can be selectively cleared from virus-

103 o UNC VLPs, again consistent with removal of nonfunctional Env.

104 ult which is consistent with the presence of nonfunctional Env.

105 on of virions that carry both functional and nonfunctional Envs contributes little to HIV infection o

106 e stop in translation, yielding a truncated, nonfunctional enzyme.

107 His]) were identified, probably resulting in nonfunctional enzyme.

108 essing either active ns2 or VP3-CTD, but not nonfunctional equivalents, were able to protect ribosoma

109 human cell lines due to masked and therefore nonfunctional ER retrieval motif.

110 nae, M. senegalense, and M. peregrinum and a nonfunctional erm gene in M. abscessus subsp. massiliens

111 l DNA (mtDNA), further fueling the notion of nonfunctional ETC in cancer cells.

112 ions with the same intron polymorphisms, the nonfunctional exon 3-skip P5CS1 splice variant constitut

113 nd a new pathogenic splicing mutation in the nonfunctional exon of CHRNA1 has been reported.

114 x17b in sortilin mRNA generates a truncated, nonfunctional, extracellularly released protein that bin

115 oviding the rationale for the development of nonfunctional fHbps as vaccine candidates.

116 , and V3 fHbp(E313A), demonstrating that the nonfunctional fHbps retain their immunogenicity.

117 The immunogenicity of the nonfunctional fHbps was assessed in transgenic mice expr

118 l (Fix(+)) nodules on one plant genotype but nonfunctional (Fix(-)) nodules on another.

119 se diabetic model, which expresses a mutant, nonfunctional form of ins2 in testes and pancreas, was u

120 DNA constructs encoding functional and nonfunctional forms of bovine granzyme B were produced,

121 ons exclusively express either functional or nonfunctional forms of Env has important implications fo

122 bodies interact with HIV-1 primarily through nonfunctional forms of envelope glycoproteins (Env), inc

123 ion of RhCMV-uninfected rhesus macaques with nonfunctional forms of RhCMV vIL-10 greatly restricted p

124 In strains carrying nonfunctional frq alleles, circadian rhythms in asexual

125 le labile hydrazone linker and a potentially nonfunctional furazanopyrazine ring that we attempted to

126 , ODDD-linked Cx43 N-terminal mutants formed nonfunctional gap junction-like plaques and exhibited do

127 with W4, resulting in the G2V mutant forming nonfunctional gap junctions.

128 eral types of variation in SM gene clusters: nonfunctional gene polymorphisms; gene gain and loss pol

129 ut further recombination; (iii) mutants with nonfunctional genes (pseudogenes) have been circulating

130 tact genes and do not attempt to distinguish nonfunctional genes from genes missing annotation due to

131 viral DNA has been shown to be dominated by nonfunctional genomes.

132 Pseudogenes have long been considered as nonfunctional genomic sequences.

133 We compare thousands of functional and nonfunctional genotypes at a genomic location and identi

134 ) shows exacerbated hemichannel activity but nonfunctional GJCs; this also occurs for those Cx26 KID

135 Loss of ponzr1 results in a nonfunctional glomerulus but retention of a functional p

136 A nonfunctional GlyR subunit, truncated at the intracellul

137 Both humans and mice with nonfunctional GPR88 have been shown to present striatal

138 We tested whether Sir2 becomes nonfunctional gradually or precipitously during aging.

139 of which are part of structurally intact but nonfunctional hAT transposons (BvhAT), in a B. vulgaris

140 tact arterial program with overproduction of nonfunctional hematopoietic precursors and total absence

141 afferent drive only), resulting in a mostly nonfunctional hemisphere.

142 rs (GIRK2 and GIRK4) or heterotetramers with nonfunctional homomeric subunits (GIRK1 and GIRK3).

143 Our observation that nmrASIC3 forms nonfunctional homomers may reflect a further adaptation

144 ti-HIV-1 Ab responses can be directed toward nonfunctional host protein epitopes that do not impair h

145 ce and rhesus monkeys, rendering the cagT4SS nonfunctional; however, these models rarely develop gast

146 RAG-mediated recombination mechanism to edit nonfunctional IgH genes or IgH genes encoding self-react

147 ed 2C7 ineffective, nonetheless; (2) 2C7 was nonfunctional in C1q-/- mice, when C5 function was block

148 ter amino acids and are generally considered nonfunctional in cancer.

149 an be triggered by bacterial contact, and is nonfunctional in CF due to poor mucin unfolding.

150 A72P, like the dimer-promoting variants, is nonfunctional in fission, consistent with a model in whi

151 urthermore, these altered PPE37 proteins are nonfunctional in HIA.

152 of the red algae Cyanidioschyzon merolae are nonfunctional in isolation, but together form a thermost

153 how that both Mx1 and Mx2 have been rendered nonfunctional in Odontoceti cetaceans (toothed whales, i

154 se to the NLRP1b activator LT, whereas it is nonfunctional in response to the NLRP3 activator nigeric

155 rase WciG was functional in serotype 35C but nonfunctional in serotype 42 due to a deletion in wciG S

156 is fragmentation did not render mitochondria nonfunctional in terms of ion handling and respiration e

157 does not require RDR2 for activity, RDR2 is nonfunctional in the absence of associated Pol IV.

158 mic response, and also indicate that phyC is nonfunctional in the absence of other phytochromes.

159 TWIST-1 is however transcriptionally nonfunctional in these cells as it is precluded from bin

160 ptor corepressor (NCOR or SMRT) render HDAC3 nonfunctional in vivo.

161 thesis in grapevine (Vitis vinifera) and are nonfunctional in white grapevine cultivars.

162 ions may explain the abundance of apparently nonfunctional interactions among proteins observed in hi

163 Overall, the avoidance of nonfunctional interactions significantly influences the

164 tion factors drive extensive, low-occupancy, nonfunctional interactions within the accessible portion

165 Proper assembly involved a nonfunctional intermediate containing non-native disulfi

166 ve subunits for the protein, the PCS remains nonfunctional internally.

167 Unresolved infection can be attributed to nonfunctional intrahepatic CD8+ T-cell responses.

168 tion of membrane ion channels involves their nonfunctional isoforms generated by alternative splicing

169 ves rise to a large number of functional and nonfunctional isoforms.

170 nal tissue is a promising approach to repair nonfunctional kidney tissue.

171 ZED1 is a nonfunctional kinase that forms part of small genomic cl

172 that used cryptic splicing sites and encoded nonfunctional KLF6 proteins.

173 In p53-nonfunctional KRAS-mutant cells, MTH1 suppression does n

174 a switch from the functional Kv11.1a to the nonfunctional Kv11.1a-USO isoform in HEK293 cells and HL

175 ion of the functional Kv11.1a isoform to the nonfunctional Kv11.1a-USO isoform.

176 is caused by mutations in LAMA2 that lead to nonfunctional laminin-alpha2, which compromises the stab

177 nsufficient as a heterozygote with the fully nonfunctional LARS2 c.1077delT allele.

178 ing undesired coevolution and propagation of nonfunctional library members, as well as allowing posit

179 has been replaced with the corresponding but nonfunctional loop from the Musca channel.

180 This probably prevents overaccumulation of nonfunctional M proteins in the cytoplasm and nuclei of

181 nterallelic complementation between pairs of nonfunctional mcd1 alleles (mcd1-1 and mcd1-Q266) or smc

182 efore propose that SUMO serves as a mark for nonfunctional mitochondrial proteins, which only sporadi

183 ther functional sites are distinguished from nonfunctional motifs by local primary sequence features

184 nation cryptic axon, resulting in truncated, nonfunctional mRNA.

185 e the differences between a functional and a nonfunctional mutant W972A and W972R, respectively.

186 Nonfunctional mutants gained drug resistance without eve

187 he membrane-spanning parts of functional and nonfunctional mutants of MS-DesK incorporated in lipid b

188 onformation of the wild-type AAP, but not of nonfunctional mutants, with respect to the tunnel.

189 and indeed no double deletion of 6q21 and no nonfunctional mutations have been reported).

190 In contrast, nonfunctional mutations in SCN9A are known to underlie c

191 Expression of CNGC12 with a nonfunctional N-terminal CaMBD constitutively induced pr

192 variants that encode prematurely truncated, nonfunctional Na(+) channels.

193 ifying selection that efficiently eliminates nonfunctional, noncoding sequences.

194 MAVS and were absent in a mouse expressing a nonfunctional NS3/4A protease.

195 on of specific domains, and co-expression of nonfunctional NSs with intact NSs will result in the att

196 radual sequestration of actin in the form of nonfunctional oligomers.

197 lized in an off-pathway conformation that is nonfunctional on the virus.

198 challenging to separate causal variants from nonfunctional ones in large haplotype blocks.

199 are widely perceived as resulting in either nonfunctional or even deleterious protein products.

200 ains, ultimately preventing the formation of nonfunctional or potentially toxic protein aggregates.

201 xperiments on mouse strains with functional, nonfunctional, or degenerated rods and cones show that D

202 el crack patterns on functional, contact and nonfunctional, or noncontact areas using 3D SS-OCT.

203 actions compete with a much larger number of nonfunctional, or promiscuous, interactions.

204 ble for misfolded or aggregated proteins and nonfunctional organelle recycling, allowing cells to mai

205 During neuronal differentiation, nonfunctional ORs are expressed initially but then are s

206 for anticancer drugs that target cells with nonfunctional p53 or impaired reactive oxygen species (R

207 Patients with nonfunctional pancreatic neuroendocrine tumors (NF-PNETs

208 against hypoxia-mediated cell death, whereas nonfunctional Parkinson disease-associated mutants Parki

209 site that is thought to produce a shortened, nonfunctional peptide.

210 inhibitor of phospholipase C, but not by the nonfunctional phospholipase C inhibitor analog U73343.

211 ion mutations without visiting disordered or nonfunctional points in sequence space.

212 that produce triploid egg cells but largely nonfunctional pollen.

213 s or antimicrobial peptides are derived from nonfunctional precursor proteins.

214 Here, we focus on peptides derived from nonfunctional precursors, and we address several key que

215 ltaIDR exon followed by rapid degradation of nonfunctional prestin protein.

216 ambda4 through noncoding splice variants and nonfunctional protein isoforms.

217 holog of Nt-CPS2, but it appears to encode a nonfunctional protein.

218 r "cryptic" splice sites, often resulting in nonfunctional protein.

219 substitutions at some positions resulted in nonfunctional proteins, we used in vivo non-canonical am

220 4D in hexaploid wheat, predicted to create a nonfunctional pseudogene.

221 t/Cufflinks pipeline correspond to annotated nonfunctional pseudogenes.

222 ting a functional and the other predicting a nonfunctional rearrangement).

223 ection by inducing apoptosis in cells with a nonfunctional rearrangement.

224 al Reb1 motifs that are bound as compared to nonfunctional Reb1 motifs that are unbound.

225 The failure of the nonfunctional receptor P2XC to restore the regulatory vo

226 act that important mutations often result in nonfunctional receptors.

227 cells to discriminate between functional and nonfunctional receptors.

228 ry element supplied by the TE and erosion of nonfunctional regions.

229 UTE R2 maps displayed a nonfunctional relation with CT data.

230 und repair typically results in scarring and nonfunctional reparation.

231 h shed RhCMV in saliva, were vaccinated with nonfunctional RhCMV vIL-10, and shedding levels of RhCMV

232 sus macaques were immunized with engineered, nonfunctional rhcmvIL-10 variants, which were constructe

233 The ES7L-mutated ribosomes escaped nonfunctional rRNA Decay (NRD) and remained stable.

234 ogy was seen when RL2 was coexpressed with a nonfunctional RTNLB13.

235 es misidentified by TB&S as S. boydii due to nonfunctional S. flexneri O antigen biosynthesis genes.

236 Two nonfunctional, Saccharomyces cerevisiae Fis1 mutants (L8

237 rate lost RPE and neuroretinal cells or form nonfunctional scars.

238 d GPIIb/IIIa-specific scFv (targ-CD39) and a nonfunctional scFv (non-targ-CD39).

239 mido-4-trifluoromethylcoumarin compared with nonfunctional scFv control.

240 rved comparable targeting for functional and nonfunctional sequences, suggesting similar biological p

241 cel Technologies Inc.; n = 29), an identical nonfunctional (sham) device (n = 25), or fixed appliance

242 tionally, functional full length isoform and nonfunctional short form pore-less variant of TRPV2 prot

243 he alternate sigma factor, sigma(28), from a nonfunctional sigma(28)-FlgM complex, releasing free, fu

244 nal binding sites and many indirect targets, nonfunctional sites are expected to occur in the cis-reg

245 The presence of a nonfunctional SOT1 allele in black poplar (Populus nigra

246 tive immunization with either wild-type or a nonfunctional SpeA mutant, protects mice from nasopharyn

247 Nonfunctional SSD mutants allowed us to test the importa

248 This is consistent with the expectation that nonfunctional states will not have evolved efficient fol

249 important conformations but can also lead to nonfunctional structures.

250 can be reconstituted even from independent, nonfunctional subunit domains, as shown previously for G

251 stic factors of survival using 326 sporadic, nonfunctional, surgically resected PanNET patients who w

252 Forced expression of nonfunctional SVs conferred a survival advantage of andr

253 ) incidence, number, and expression level of nonfunctional SVs than either NPs (n = 22) or hormone-na

254 Nonfunctional systems addressed the fewest, but, if use

255 +) H. pylori or an isogenic cagE (-) mutant (nonfunctional T4SS).

256 hailandensis to that of a mutant harboring a nonfunctional T6SS-5.

257 However, individuals with nonfunctional TAP complexes or tumor or infected cells w

258 cell lines as a model, we discovered that a nonfunctional target site unable to base-pair extensivel

259 owing to the prevalence of large numbers of nonfunctional TF binding sites.

260 face expression of HFE and HFE:TFR1 complex (nonfunctional TFR1) in peritoneal macrophages from C57BL

261 construction methods often yield vastly more nonfunctional than functional variants and, despite adva

262 of HPC are negated when the A2B receptor is nonfunctional, the hypoxia-->adenosine-->A2B receptor pa

263 tor 4-deficient mice and in mice harboring a nonfunctional TLR4 variant in myeloid cells.

264 es maintain protein homeostasis by degrading nonfunctional toxic proteins and play regulatory roles b

265 nce and mediate miR-30e-3p oncogenic role in nonfunctional TP53 backgrounds.

266 ote alternative splicing and production of a nonfunctional transcript lacking exon 3 (exon 3-skip P5C

267 sion in temperature transitions by producing nonfunctional transcripts and/or inducing nonsense-media

268 he production of a mixture of functional and nonfunctional transcripts may provide a means to fine-tu

269 in FOXP3-deficient IPEX patients, who harbor nonfunctional Tregs.

270 r the model to reproduce reported effects of nonfunctional troponin C on myofilament force generation

271 IPMS3 allele found in IL8-1/8-1-1 encodes a nonfunctional truncated IPMS protein.

272 One nonfunctional truncated mutant (R316X) could be rescued

273 fsX554 mutations were predicted to generate nonfunctional truncated proteins.

274 RG2 transcript level and producing a stable, nonfunctional truncated subunit that had a dominant-nega

275 ografts in association with the formation of nonfunctional tumor blood vessels.

276 Nonfunctional unitary pseudogenes belonging to these pat

277 Furthermore, the nonfunctional V3 fHbps elicit serum bactericidal activit

278 Here, we characterized the two nonfunctional V3 fHbps, fHbp(T286A) and fHbp(E313A), whi

279 esign of next-generation vaccines containing nonfunctional V3 fHbps.

280 A72P also disrupts dimerization of nonfunctional variants, indicating a common structural b

281 oidism by diverting pathogenic TSHR Abs to a nonfunctional variety.

282 The A619 inbred contains a nonfunctional Ven1 allele, leading to a decrease in pola

283 n of our editase and guide RNA can correct a nonfunctional version of enhanced green fluorescent prot

284 repeatedly immunizing infected animals with nonfunctional versions of the rhesus cytomegalovirus-enc

285 Likewise, both functional and nonfunctional versions of YscO were exclusively intrabac

286 Functional and nonfunctional versions of YscO were, however, distinguis

287 allowed us to determine the water volumes in nonfunctional vessels as a function of stress level.

288 aled the presence of both sugars and ions in nonfunctional vessels at elevated levels in comparison w

289 e osmotic potential of liquid collected from nonfunctional vessels increased while its volume decreas

290 ptomatic leaves presented significantly more nonfunctional vessels resulting from the presence of non

291 rom nonembolized (functional) and embolized (nonfunctional) vessels.

292 the probability of generating a mutated and nonfunctional virus in addition to cytosine deamination.

293 A small class of transcripts from apparently nonfunctional Vkappa genes was found, as were occasional

294 pyrosequencing to assess the functional and nonfunctional Vkappa repertoire.

295 been shown that the NaV1.1-L1649Q mutant is nonfunctional when expressed in a human cell line becaus

296 ASD-linked human Taok2 mutations rendered it nonfunctional, whereas its WT form could restore neurona

297 oncluded that the V60L and G353R mutants are nonfunctional, whereas the D273Y mutant has yet to be st

298 pite a 5.4-kb deletion in MSH5B rendering it nonfunctional, which occurred early in the evolution of

299 ITRs are classified as likely functional and nonfunctional with high confidence, respectively.

300 Both functional and nonfunctional YscO mutant proteins interacted with SycD,