ライフサイエンスコーパス: nongenetic

1 te-matter incoherence with age appears to be nongenetic.

2 erapy of multiple diseases, both genetic and nongenetic.

3 anticancer agent that works via genetic and nongenetic actions.

4 dosis, potentially explaining the origins of nongenetic amyloid subtypes.

5 the latest inconvenient findings indicating nongenetic and "imprecise" phenotype dynamics of tumors

6 Combining nongenetic and genetic cardiovascular risk factors provi

7 Nongenetic and genetic characteristics were included in

8 mall studies have investigated the effect of nongenetic and genetic factors on the dose response to V

9 For the model with all nongenetic and genetic factors, the respective C statist

10 and present models of the interplay between nongenetic and genetic processes that contribute to the

11 Combining the nongenetic and genetic risk models improved the AUC to 0

12 model was used to partition and account for nongenetic and genetic sources of variation, and quantit

13 Clinical evaluation and investigations (both nongenetic and genetic) can yield an aetiological diagno

14 alleles, and therefore all of the variation (nongenetic and genetic) in methylation patterns within a

15 in their overall survival, thus making this nongenetic and non-in vivo approach a new clinically rel

16 t, for a fictitious disease that is strictly nongenetic and nonenvironmental, lambdaS can be dramatic

17 re addicted to KRAS by illustrating adaptive nongenetic and nontranscriptional mechanisms of resistan

18 to activated KRAS, by illustrating adaptive nongenetic and nontranscriptional mechanisms of resistan

19 entiated cells can give rise to SPEM using a nongenetic approach in mice.

20 Here we describe a broadly applicable nongenetic approach that simultaneously addresses the mu

21 d multitargeted kinase inhibitor describes a nongenetic approach to tease out key kinases that promot

22 allele), and other factors, both genetic and nongenetic, are likely to be important contributors.

23 ylation changes and scedasticity depended on nongenetic as well as genetic factors.

24 research participants, we report genetic and nongenetic associations with testing positive for SARS-C

25 amolecular) interactions are two fundamental nongenetic attributes of life.

26 aches by identifying DLBCLs with genetic and nongenetic bases for BTKi sensitivity.

27 with multiorgan involvement and a genetic or nongenetic basis.

28 virus (HCMV) is one of the leading causes of nongenetic birth defects, and development of a prophylac

29 hildren in developed countries are born with nongenetic birth defects.

30 tic risk score was additive to the effect of nongenetic CAD risk factors, and did not change after ad

31 These results suggest that for most nongenetic cardiovascular epidemiology studies, SIR is s

32 alcohol is thought to be the most prevalent nongenetic cause of a wide range of neurodevelopmental d

33 0.5-2.0% of all live births and is the main nongenetic cause of congenital sensorineural hearing los

34 likely to advance the search for genetic and nongenetic causes of ASD.

35 providing mechanistic explanations for some nongenetic causes of CHD.

36 nic role of hepcidin, it is anticipated that nongenetic causes of hepcidin loss (eg, end-stage liver

37 investigate and disentangle the genetic and nongenetic causes of stability and change in lipids and

38 syndromes (LQTS) arise from many genetic and nongenetic causes with certain characteristic ECG featur

39 t-induced transcriptional programs governing nongenetic cell plasticity.

40 Such stochastic cell fate decisions generate nongenetic cellular diversity, which may be critical for

41 Nongenetic cellular heterogeneity is associated with agi

42 The basis for this nongenetic cellular memory, which records developmental

43 We found that knowing the fitness and nongenetic (cellular) memory associated with specific ge

44 Expanding on a validated and published nongenetic, CF-like sheep model, ewes inhaled CFTR(inh)1

45 ll cultures represents multistep genetic and nongenetic changes that develop during the neoplastic pr

46 onalized nutrition appears to depend more on nongenetic characteristics (eg, physical activity, abdom

47 osing strategies including genetic-based and nongenetic clinical-based, multiple-dose adjustment prot

48 printing, but it cannot evaluate the role of nongenetic cofactors like exposures.

49 Subunit vaccines consist of nongenetic components of the infectious agent or disease

50 se findings and to establish the genetic and nongenetic contributions to altered callosal morphology

51 n as an important source of both genetic and nongenetic contributions to phenotypic variation and, as

52 Path analysis estimated genetic and nongenetic contributions to variability in systolic bloo

53 The nongenetic conversion of human pancreatic exocrine cells

54 ng the detection of spurious hotspots due to nongenetic correlation induced by uncontrolled environme

55 0.53 for a baseline model that accounted for nongenetic covariates to AUCs of 0.58 (pedigree), 0.62 (

56 After adjusting for nongenetic covariates, the heritability of log-transform

57 Our methods allow adjustment for nongenetic covariates, which may be critical when analyz

58 Such nongenetic cryptic variation may provide a resource of a

59 Second, premating isolation may arise from nongenetic, cultural causes; isolation may be affected p

60 nd mediated by both Lamarckian induction and nongenetic Darwinian selection of drug-tolerant states.

61 popular approach to systematically analyzing nongenetic data sets and guarding against false positive

62 was reduced in genetic versus patients with nongenetic DCM (P=0.01).

63 data highlight and clarify the importance of nongenetic determinants in spontaneous recovery from HCV

64 Adjustment for the nongenetic determinants of ACR had no significant effect

65 enter, population-based study of genetic and nongenetic determinants of coronary heart disease (CHD),

66 worldwide and is among the most significant nongenetic determinants of immune system.

67 d in our ongoing research on the genetic and nongenetic determinants of major affective disorders.

68 llaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in indi

69 erns of leukocyte subset numbers, as well as nongenetic determinants that affect these patterns, ther

70 pose, is underpinned by specific genetic and nongenetic determinants that lead to a maladaptive macro

71 Such nongenetic differences are likely heritable between succ

72 , rigorous investigation of both genetic and nongenetic differences is important to identify the vari

73 comorbidity, senile systemic amyloidosis, a nongenetic disease associated with wild-type TTR misfold

74 d is applicable to virtually all genetic and nongenetic disease models of the pancreas.

75 opper metabolism associated with genetic and nongenetic diseases are summarized, including potential

76 , and recognition of the various genetic and nongenetic diseases in which it may develop has led to t

77 ment options for a wide range of genetic and nongenetic diseases.

78 and functional cures for diverse genetic and nongenetic diseases.

79 -system atrophy is widely considered to be a nongenetic disorder, we previously identified multiplex

80 llar ataxia results from various genetic and nongenetic disorders and is characterized by involuntary

81 his study demonstrates that excess RNS are a nongenetic driving force for Brca2-deficiency-induced pa

82 ounder alleles are treated as random and the nongenetic effects are treated as fixed.

83 deficiency, indicating that the genetic and nongenetic effects converge to common anxiety manifestat

84 thods for dimension reduction to account for nongenetic effects in estimates of expression levels, an

85 ent analysis was used to measure genetic and nongenetic effects on the associations.

86 determined by the magnitudes of genetic and nongenetic effects on the indexing (first) coronary hear

87 w measure of the influence of genetic versus nongenetic effects, and operations research and simulati

88 om contributions of genetic, epigenetic, and nongenetic (environmental) factors.

89 to estimate the contribution of genetic and nongenetic (environmental) influences to the variation a

90 hood exposures to tobacco smoke suggest that nongenetic, environmental exposures may have long-term i

91 ter insight to deconstruct their genetic and nongenetic etiologies.

92 d effects of genetic susceptibility factors, nongenetic experiences and exposures, and bad luck.

93 To distinguish between simple genetic and nongenetic explanations of sex-specific recombination di

94 Nongenetic explanations such as effects of ASD severity

95 of type 2 diabetes and obesity can highlight nongenetic exposures that drive development of these con

96 mmon polymorphisms in the absence of data on nongenetic exposures, and may explain the heterogeneity

97 ations in the gut are a good candidate for a nongenetic factor contributing substantively to brain tu

98 rtance of each genetic factor (QTL) and each nongenetic factor/covariate included in the function is

99 ence are likely a result of both genetic and nongenetic factors (eg, socioeconomic status, intake of

100 Statistical adjustments for nongenetic factors (gender, ethnicity, age, HIV-1 infect

101 We sought to determine which nongenetic factors affect the dynamics of innate leukocy

102 Thus, other genetic or nongenetic factors also contribute to sex differences in

103 n associates with sarcomeric gene mutations, nongenetic factors also contribute to the disease, leadi

104 In addition to the candidate QTL, nongenetic factors and covariates, such as age, gender,

105 ariate analysis the relative contribution of nongenetic factors and VKORC1/CYP2C9/CYP4F2 genotypes on

106 As such, nongenetic factors are increasingly seen as critical con

107 Nongenetic factors are still appreciable and account for

108 al explained compared with a model with only nongenetic factors at nearly every significance level.

109 plex etiology influenced both by genetic and nongenetic factors but disentangling these factors is di

110 Together these results indicate that nongenetic factors contribute to the development of SPs

111 Nongenetic factors explained 45.8% and 7.5% of MR-pro-AD

112 While several genetic and nongenetic factors have been linked to HSCR, the underly

113 We analyzed numerous genetic and nongenetic factors impacting short-term and long-term ex

114 Nongenetic factors include smoking, which has been shown

115 pecific areas of the intestine suggests that nongenetic factors may be important for their developmen

116 We hypothesized that nongenetic factors might contribute to disease developme

117 Genetic and nongenetic factors need to be considered in future AD re

118 ontaining 3 (PNPLA3) rs738409 genotypes, and nongenetic factors on the steatosis grade assessed 6-30

119 reased recognition of the dominant role that nongenetic factors play in disease, an effort to charact

120 gy of Graves disease is multifactorial, with nongenetic factors playing an important role.

121 recent reports support the idea that several nongenetic factors present in the tissue microenvironmen

122 ring involvement of nonleukemic elements and nongenetic factors promoting CLL cell growth, identifyin

123 Because nongenetic factors shape the human immune system, we her

124 hensive analysis including known genetic and nongenetic factors that determine MPV is still lacking.

125 t, even in well-studied populations in which nongenetic factors that influence adaptively important c

126 ations of sociocultural, economic, and other nongenetic factors that influence family sizes.

127 ations of sociocultural, economic, and other nongenetic factors that influence family sizes.

128 should be considered along with genetic and nongenetic factors to better explain the etiology of thi

129 elative contribution of genetic ancestry and nongenetic factors to HbA(1c) values and the effect of g

130 The contribution of host genetic and nongenetic factors to immunological differences in human

131 ne the relative contributions of genetic and nongenetic factors to the association between structural

132 f the contributions of genetic variation and nongenetic factors to the population differences in gene

133 ate the relative contribution of genetic and nongenetic factors to variation in folate, we have evalu

134 few common population-relevant, quantifiable nongenetic factors with strong associations may be the m

135 on of occupational status can be ascribed to nongenetic factors, and raises questions of how such kno

136 effects of variants in numerous genes, plus nongenetic factors, determine outcome.

137 al animal model of MS, is also influenced by nongenetic factors, including age and season at immuniza

138 .005 for both), after accounting for several nongenetic factors, including gender, age at estimated d

139 ese genetic associations were independent of nongenetic factors, including number of sex partners, ra

140 Nongenetic factors, including the stage of disease at th

141 Of the nongenetic factors, use of tacrolimus, sirolimus, and ol

142 grating clinical phenotypes with genetic and nongenetic factors.

143 y caused by multiple interacting genetic and nongenetic factors.

144 ment induced by a combination of genetic and nongenetic factors.

145 y to establish patterns mostly determined by nongenetic factors.

146 ultivariate models that included a number of nongenetic factors.

147 etermined by multiple additional genetic and nongenetic factors.

148 plex trait determined by various genetic and nongenetic factors.

149 action between multiple genetic variants and nongenetic factors.

150 of complex interactions between genetic and nongenetic factors.

151 e in female individuals, indicate a role for nongenetic factors.

152 in older CF patients is caused primarily by nongenetic factors.

153 ndrome in CF patients is caused primarily by nongenetic factors.

154 C level is influenced by several genetic and nongenetic factors.

155 e/dose and susceptibility due to genetic and nongenetic factors.

156 fected by genes, are determined primarily by nongenetic factors.

157 neity driven by the interplay of genetic and nongenetic factors.

158 ercentage AGA is correlated with genetic and nongenetic factors.

159 lt to measure, and known to be influenced by nongenetic factors.

160 population and are influenced by genetic and nongenetic factors.

161 indicate a contribution of other genetic or nongenetic factors.

162 s are known to be mediated by environmental (nongenetic) factors.

163 In this study, we established a nongenetic FECD animal model based on the physiologic ou

164 ngs support the notion that both genetic and nongenetic fibrogenic factors, particularly TGF-beta1 an

165 inflammatory diseases, including genetic and nongenetic forms of chronic obstructive pulmonary diseas

166 Nongenetic forms of DCM can result from different aetiol

167 II diabetic GK rats and certain genetic and nongenetic forms of obesity in rats, is associated with

168 the involvement of TRPC6 in the pathology of nongenetic forms of proteinuric disease.

169 Major cellular processes affected by nongenetic functions of the genome include establishment

170 the concept, mechanisms, and implications of nongenetic functions of the genome.

171 >1.6 per allele) and assuming the sum of all nongenetic hazard ratios was <10, bias was usually <10%

172 To address the contribution of nongenetic heritability and cell cycle in cell-to-cell v

173 Multicellular eukaryotes demonstrate nongenetic, heritable phenotypic versatility in their ad

174 namics can provide insight into the basis of nongenetic heterogeneities within cell populations, as w

175 from a physiological perspective, and their nongenetic heterogeneity is examined.

176 ment in a discussion of stochastic noise and nongenetic heterogeneity, we explore the hypothesis that

177 ise from complex interactions among genetic, nongenetic host susceptibility, and environmental factor

178 al development) or other factors (genetic or nongenetic) in the parents may contribute to autism.

179 dence is emerging that paternal effects, the nongenetic influence of fathers on their offspring, can

180 ss, we sought to investigate how genetic and nongenetic influences are balanced to create vascular tr

181 ere is preliminary evidence that genetic and nongenetic influences may modify risks.

182 an animal model for the study of genetic and nongenetic influences on craniofacial variation.

183 o-twins, suggesting a preferential impact of nongenetic influences on long-term memory systems.

184 nd sex effects and to dissociate genetic and nongenetic influences on morphology.

185 We tested for genetic and nongenetic influences on the association among these tra

186 These findings suggest that nongenetic influences play a role in brain volume/cognit

187 c factors and is also cumulatively shaped by nongenetic influences throughout human life; both can in

188 is a major hindrance for the transmission of nongenetic information between generations.

189 odel accounting for the germline transfer of nongenetic information from sire to offspring must inclu

190 progenitor cells cannot accurately transmit nongenetic information to their progeny; full epigenetic

191 apply this technology to examine the role of nongenetic inheritance in cell heterogeneity of yeast ph

192 ecular and cellular mechanisms through which nongenetic inheritance occurs.

193 novel DNA sequences, NT can also promote the nongenetic inheritance of traits during this conserved m

194 pective that includes group organization and nongenetic inheritance.

195 a plastidial response process that involves nongenetic inheritance.

196 e correlations across generations that imply nongenetic inheritance.

197 The outcomes of both models suggest that nongenetic instability, stress-induced adaptation, selec

198 Genetic and nongenetic instrumental variable approaches (eg, Mendeli

199 ci (QTL) responsible for complex genetic and nongenetic interactions.

200 ever, certain biological questions require a nongenetic labeling approach to purify a distinct cell p

201 Currently, there is a need for remote, nongenetic, light-induced control of cellular activity i

202 les from the selected populations exercise a nongenetic maternal effect on the development time of th

203 iation in host-associated fitness, ruled out nongenetic maternal effects, and discuss the maintenance

204 iPSCs relies on the development of efficient nongenetic means of factor delivery, and although a hand

205 es, the genome affects cellular functions by nongenetic means through its physical and structural pro

206 humans, but these effects can be modified by nongenetic mechanisms [2-4].

207 mutations, emerging evidence indicates that nongenetic mechanisms also play an important role.

208 iency can be transmitted by both genetic and nongenetic mechanisms in a population.

209 We also discuss the implications of nongenetic mechanisms of drug resistance recently report

210 epidemiologic studies are helping to define nongenetic mechanisms of embryopathy.

211 c disruption of NKX3.1 in mice leads to PIN, nongenetic mechanisms reduce NKX3.1 protein levels early

212 via genotoxic and nongenotoxic pathways, but nongenetic mechanisms remain poorly characterized.

213 egulated in many cancer types by genetic and nongenetic mechanisms, encodes a protein whose RhoGAP an

214 vive otherwise lethal doses of drugs through nongenetic mechanisms, which can lead to cancer regrowth

215 he development of ASD through genetic and/or nongenetic mechanisms.

216 in chromatin structure, potentially through nongenetic mechanisms.

217 However, it is unknown whether nongenetic methods of suppressing PTEN have similar effe

218 phenotypic variability, the heterogeneity of nongenetic, microenvironmental factors remains elusive.

219 Likewise, study of the mechanisms of nongenetic models of a common form of human epilepsy, co

220 rrents and membrane potential in genetic and nongenetic models of hypertension.

221 FE-null mouse and HJV-null mouse) and in two nongenetic models of iron overload (cytomegalovirus infe

222 ile experimentalists are eager to claim that nongenetic modes of inheritance characterized in this an

223 largely followed from the identification of nongenetic modifiable factors.

224 on was impeded in highly variable regimes by nongenetic modifications but was promoted in more stable

225 A better understanding of genetic and nongenetic modifiers in ZZ alpha1-antitrypsin deficiency

226 in USH2A, however, suggests that genetic or nongenetic modifiers may be involved in the disease expr

227 nd aggregate effects of putative genetic and nongenetic modifiers of AD risk.

228 ine the relative contribution of genetic and nongenetic modifiers to the development of this major co

229 , and demonstrations of optically controlled nongenetic modulation of cellular calcium dynamics, neur

230 To discover genetic versus nongenetic molecular pathways important to the pathogene

231 address this key challenge by introducing a nongenetic molecular platform for cell- and molecule-spe

232 nystagmus most often develops as a result of nongenetic neurologic disease, and it manifests in a var

233 Optically controlled nongenetic neuromodulation represents a promising approa

234 butions of NK cells to HIV-1 immune control, nongenetic NK cell parameters directly associated with s

235 remodeling was more common in patients with nongenetic or nonfamilial DCM than in patients with gene

236 f a major gene in the presence of additional nongenetic or polygenetic familial associations, by rela

237 facilitate genetic analysis in traditionally nongenetic organisms.

238 n identified in cancer genomes, suggesting a nongenetic origin of this phenomenon.

239 Finally, genetic and nongenetic origins common to major types of diabetes can

240 A nongenetic outcome of the CMAH mutation is human metabol

241 changing profile that implicates genetic and nongenetic patterns of deficits.

242 Nongenetic phenotypic variation can either speed up or s

243 breakthrough hybrid nanomaterial for remote, nongenetic, photothermal stimulation of 2D and 3D neural

244 otoporphyrin accumulation and a reproducible nongenetic porphyria model.

245 reproduction remains a difficult question as nongenetic processes, such as molecular self-organizatio

246 pidly adapt to changing environments through nongenetic processes; however, the metabolic cost of suc

247 of VHL and will serve as a key reference for nongenetics professionals who encounter patients with VH

248 understanding the magnitude and dynamics of nongenetic reprogramming in space and time at single-cel

249 Nongenetic resistance through the activation of AURKA by

250 Overall, 18% of patients with a nongenetic risk factor had a pathogenic gene variant.

251 One in 5 patients with an established nongenetic risk factor or a nonfamilial disease still ca

252 Interest and consideration of nongenetic risk factors (e.g., lead exposure and schizop

253 tions, mutant allele burden, and concomitant nongenetic risk factors (eg, hypertension or cigarette s

254 tic curve increased when we added CAD-PRS to nongenetic risk factors (SMHRP: 0.75 and 0.78, respectiv

255 However, nongenetic risk factors also play an important role and

256 Few data are available on genetic and nongenetic risk factors for CRC among AAs.

257 Our goal was to identify genetic and nongenetic risk factors for osteonecrosis.

258 asis is not yet well understood, but several nongenetic risk factors have been identified as have pos

259 We highlight recent examples of research in nongenetic risk factors in psychiatric disorders that po

260 Nongenetic risk factors include age, sex, and other dise

261 iate controls, but it has the advantage that nongenetic risk factors like exposures can be assessed.

262 al for each pairwise combination of SNPs and nongenetic risk factors using age- and cohort-adjusted l

263 The AUC of a risk model based on known nongenetic risk factors was 0.77 (95% CI, 0.76-0.78).

264 emiologic trends in CRC, data on genetic and nongenetic risk factors, and new approaches for determin

265 One approach is to modify nongenetic risk factors, for instance by lowering elevat

266 btypes and do not appear to be confounded by nongenetic risk factors, suggesting at least some shared

267 l disease influenced by multiple genetic and nongenetic risk factors.

268 Genetic plus nongenetic risk scores provided an area under the receiv

269 cting yet unidentified genetic and, perhaps, nongenetic risks.

270 an of 19 tests and 4 clinical genetics and 4 nongenetics specialist consultations, and 26 (59%) under

271 ic gene MSH1 triggers at least four distinct nongenetic states to impact plant stress response and gr

272 optosis resistance can also be the result of nongenetic stress adaptation, as seen in the cancer-pron

273 her types of genetic association studies and nongenetic studies.

274 As a result, nongenetic systematic environmental effects can be easil

275 warts such as the fly and mouse, but also to nongenetic systems such as primates.

276 (1) whether PTEN knockdown in adult rats by nongenetic techniques enables CST regeneration, (2) whet

277 significant distinctions between genetic and nongenetic tests justify a different approach to testing

278 logical mechanisms potentially accessible to nongenetic therapies.

279 We propose that an additional genetic or nongenetic "third hit" may be required for rapid develop

280 ein transduction domains (PTDs) are powerful nongenetic tools that allow intracellular delivery of co

281 BAG is sensitive to an array of genetic and nongenetic traits and diseases, yet few studies have exa

282 mbination of these properties results in the nongenetic transfer of gene products within transformed

283 y trade-off emerged where greater short-term nongenetic transgenerational effects (low-gamma strategy

284 A nongenetic, transgenerational effect of parental age on

285 logical approaches have found no evidence of nongenetic transmissibility.

286 trains, we serendipitously identified that a nongenetic transmissible factor dramatically increased d

287 type, by a receptor deficit in the mother: a nongenetic transmission of a genetic defect.

288 op therapeutic strategies that capitalize on nongenetic tumor evolution.

289 Thus, rapidly fluctuating, nongenetic variability in bacterial adhesion diversifies

290 Together, genetic and nongenetic variability in ectopic expression of peripher

291 The sources and consequences of nongenetic variability in metastatic progression are lar

292 ransitions that can potentially give rise to nongenetic variability.

293 sion and obtain information about sources of nongenetic variability.

294 te analysis adjusted for HLA mismatching and nongenetic variables associated with each clinical end p

295 onmental or behavioral factors (particularly nongenetic variation in obesity) are important determina

296 Nongenetic variation in phenotypes, or bet-hedging, has

297 Nongenetic variation in protein abundances thus leads to

298 In addition to this nongenetic variation, the process underlying RSVIgmyc me

299 n indirect measures was largely explained by nongenetic variation.

300 OMPSON, and SKOLNICK suggested a simplified, nongenetic version of the model involving only 2n + 1 ge