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1 en recombination occurs without a protruding nonhomologous 3' tail, the mismatch repair protein Msh2
2 Vinculin binding sites (VBSs) from different nonhomologous actin-binding proteins use conserved helic
4 equent sequence comparison showed that these nonhomologous allergens contained several similar surfac
5 of the IgE to these specific homologous and nonhomologous allergens was corroborated in an animal mo
6 ergens such as the walnut Jug r 6 or that of nonhomologous allergens, as shown for the peanut allerge
7 e demonstrate that regulatory "switching" to nonhomologous alternatives is ubiquitous, occurring acro
9 retrotransposon-rich regions that are highly nonhomologous between drug- and hemp-type alleles and ar
11 the clustering and pairwise associations of nonhomologous centromeres that precede stable pairing be
12 Data Bank and identify several sequentially nonhomologous chains that form a Hopf link and a Solomon
13 ere pairing early in meiosis I, even between nonhomologous chromosomes, and clustering of centromeres
15 conservation (e.g., mobile gene clusters and nonhomologous cluster alleles), our approach also implic
16 different alleles corresponded to distinct, nonhomologous clusters; and location polymorphisms, in w
17 4 in regulating homologous recombination and nonhomologous DNA end joining-mediated DSB repair in hum
27 PARP1-, LIG3-, and XPF-dependent alternative nonhomologous end joining (alt-NHEJ), which did not gene
31 end-joining (EJ) repair pathways [canonical nonhomologous end joining (C-NHEJ) or alternative end jo
38 e/phosphatase-like factor (APLF) facilitates nonhomologous end joining (NHEJ) and associates with the
39 posure, which is indicative of activation of nonhomologous end joining (NHEJ) and homologous recombin
40 ables the generation of knockout alleles via nonhomologous end joining (NHEJ) and knock-in alleles vi
42 s used to repair DNA double-strand breaks by nonhomologous end joining (NHEJ) are two related family
43 tection of homologous recombination (HR) and nonhomologous end joining (NHEJ) at the same chromosomal
46 between classical (c)- and alternative (alt)-nonhomologous end joining (NHEJ) during DNA double-stran
47 ter assay, we found that COH29 could inhibit nonhomologous end joining (NHEJ) efficiency and that no
48 joining of noncomplementary DNA ends during nonhomologous end joining (NHEJ) for the repair of doubl
49 BRCA1, and deletion of Rif1 suppresses toxic nonhomologous end joining (NHEJ) induced by PARP inhibit
52 by either homology-directed repair (HDR) or nonhomologous end joining (NHEJ) is tightly regulated.
53 double-strand breaks (DSBs) are repaired by nonhomologous end joining (NHEJ) or homologous recombina
54 f tools for Cas9-mediated genome editing via nonhomologous end joining (NHEJ) or homology-directed re
56 DR) mechanisms: the dominant but error-prone nonhomologous end joining (NHEJ) pathway, and the less-f
57 in mre-11(iow1) mutants are repaired by the nonhomologous end joining (NHEJ) pathway, as removing NH
62 NA-dependent protein kinase (DNA-PK) and the nonhomologous end joining (NHEJ) repair pathway are intr
63 omote KSHV replication, proteins involved in nonhomologous end joining (NHEJ) repair restrict amplifi
64 of the DNA-PK enzyme, which are involved in nonhomologous end joining (NHEJ) repair, enhance amplifi
66 ylation in homologous recombination (HR) and nonhomologous end joining (NHEJ) through the investigati
69 he efficiency of these methods is limited by nonhomologous end joining (NHEJ), an alternative DNA rep
70 pair systems: homologous recombination (HR), nonhomologous end joining (NHEJ), and single-strand anne
71 ntify DNA-PKcs complex proteins that mediate nonhomologous end joining (NHEJ), as TRIP13-binding part
72 knockout cells and organisms via error-prone nonhomologous end joining (NHEJ), but the efficiency of
73 on, which is almost exclusively dependent on nonhomologous end joining (NHEJ), CSR can occur in NHEJ-
74 ocalized sequence changes through inaccurate nonhomologous end joining (NHEJ), often leading to gene
75 subunit (DNA-PKcs) is a central component of nonhomologous end joining (NHEJ), repairing DNA double-s
76 nation (HR) but can inhibit normal repair by nonhomologous end joining (NHEJ), the main DSB repair pa
77 aired both homologous recombination (HR) and nonhomologous end joining (NHEJ), the two major DSB repa
78 early phosphorylations promote initiation of nonhomologous end joining (NHEJ), whereas ABCDE phosphor
79 rohomology-mediated end joining (MMEJ)-, and nonhomologous end joining (NHEJ)-based strategies for th
80 t that TDP-43 is a critical component of the nonhomologous end joining (NHEJ)-mediated DNA double-str
93 d DNA double-stranded break (DSB) repair via nonhomologous end joining and homologous recombination.
94 volved in DNA replication and repair by both nonhomologous end joining and homologous repair is misre
95 s9 to both nuclei, combined with the lack of nonhomologous end joining and markers for positive selec
96 break produced by Ac excision: footprints by nonhomologous end joining and rearrangements by various
97 atures of the fusion fragments indicate that nonhomologous end joining and/or replication-dependent D
100 active cell cycle checkpoints and increased nonhomologous end joining DNA repair, suggesting that pe
102 nase catalytic subunit (DNA-PKcs), a classic nonhomologous end joining factor, antagonizes double str
103 One of the major DSBs repair pathways is nonhomologous end joining for which Ku70/80 is essential
104 es four broken DNA ends that are repaired by nonhomologous end joining forming coding and signal join
105 was an indirect effect of the repression of nonhomologous end joining in Sir(-) mutants and that the
106 ion pattern and a potential microhomology or nonhomologous end joining integration mechanism at the s
107 reaks (DSBs) by homologous recombination and nonhomologous end joining is critical for maintaining ge
108 balance between homology-directed repair and nonhomologous end joining is important for neuronal cell
111 uence analysis suggested fundamental role of nonhomologous end joining mechanism during eccDNA format
112 Cas9 lesions by homologous recombination or nonhomologous end joining mechanisms can lead to the int
113 he integrity of homology-directed repair and nonhomologous end joining of DNA breaks is impaired in K
114 Several of these genes are also involved in nonhomologous end joining of DNA double-strand break rep
115 breaks (DSBs) are generally repaired through nonhomologous end joining or homologous recombination.
116 ble-strand breaks that stimulate error-prone nonhomologous end joining or homology-directed repair at
117 ts must be removed to allow repair by either nonhomologous end joining or homology-directed repair.
118 ecombination but instead form most often via nonhomologous end joining or microhomology-mediated brea
119 Repair of DNA double-strand breaks by the nonhomologous end joining pathway is central for proper
120 genetic disruption strategies relying on the nonhomologous end joining pathway may induce compensator
121 rm of DNA damage, are mainly repaired by the nonhomologous end joining pathway, which relies on DNA-P
123 ltaAID is impaired in its ability to recruit nonhomologous end joining repair factors, resulting in a
124 , increased expression of DSB initiating and nonhomologous end joining repair machinery in newborn ne
125 n inhibitor of the DNA-PK kinase crucial for nonhomologous end joining repair of DNA DSBs, and BRCA2-
130 also find that MMEJ compensates for loss of nonhomologous end joining to repair rereplication DSBs i
131 lar domain, including Tel1 (ATM) activation, nonhomologous end joining, and DNA double-strand break e
132 s switch recombination, two events requiring nonhomologous end joining, at levels comparable to Atm(-
133 uggests that, in addition to its key role in nonhomologous end joining, DNA-PKcs also acts in concert
134 pair, mismatch repair, base excision repair, nonhomologous end joining, homologous recombination, and
135 gD, an ATP-dependent DNA ligase dedicated to nonhomologous end joining, in complexes with ATP that hi
137 d that, distinct from Ku-dependent classical nonhomologous end joining, MMEJ--even with very limited
138 smatch, nucleotide excision, Fanconi anemia, nonhomologous end joining, or translesion synthesis repa
139 sis during DNA double strand break repair by nonhomologous end joining, particularly in nonreplicatin
140 major pathway for Ku-independent alternative nonhomologous end joining, which contributes to chromoso
150 beta (Pol beta) as mediators of alternative nonhomologous end-joining (Alt-NHEJ) events, including c
154 NA polymerase II (RNAP II) and the classical nonhomologous end-joining (C-NHEJ) proteins, including P
155 translocations in wild-type versus classical nonhomologous end-joining (C-NHEJ)-deficient NSPCs revea
159 at are initiated on free DNA ends: classical nonhomologous end-joining (NHEJ) and ATM-dependent DNA d
160 choice between two main DSB repair pathways, nonhomologous end-joining (NHEJ) and homologous recombin
161 lved several DSB repair mechanisms, of which nonhomologous end-joining (NHEJ) and homologous recombin
162 he HPV16 E7 oncoprotein suppresses canonical nonhomologous end-joining (NHEJ) and promotes error-pron
163 esection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as opposed to homologou
164 DNA damage repair by promoting Ku-dependent nonhomologous end-joining (NHEJ) at the expense of homol
165 ing kinases and that it is not suppressed by nonhomologous end-joining (NHEJ) components, arguing tha
167 gase 4 (LIG4), NHEJ1, and NBS1 involving the nonhomologous end-joining (NHEJ) DNA repair pathway resu
168 53BP1 gene silencing induces defects in the nonhomologous end-joining (NHEJ) DNA repair pathway.
170 B cells from mice and ICF2 patients affects nonhomologous end-joining (NHEJ) during immunoglobulin c
171 Such mutant alleles result presumably from nonhomologous end-joining (NHEJ) events before the segre
173 t DNA ligation in vitro and assembly of core nonhomologous end-joining (NHEJ) factors on damaged chro
181 Subsequent repair of this break via the nonhomologous end-joining (NHEJ) or homology-directed re
182 ependent large deletions are products of the nonhomologous end-joining (NHEJ) pathway and require Top
183 triggering end resection and inhibiting the nonhomologous end-joining (NHEJ) pathway in G1 phase.
184 i, suggesting that HR is compromised and the nonhomologous end-joining (NHEJ) pathway is elicited to
187 y demonstrated that HSCs use the error-prone nonhomologous end-joining (NHEJ) pathway of DNA repair t
188 factor (XLF/Cernunnos) is a component of the nonhomologous end-joining (NHEJ) pathway of double-stran
189 u (Polmu) participates in DSB repair via the nonhomologous end-joining (NHEJ) pathway, by filling sma
194 are suppressed by genetically eliminating Ku nonhomologous end-joining (NHEJ) protein, indicating tha
196 -protein kinase (DNA-PK) phosphorylation and nonhomologous end-joining (NHEJ) repair efficiency and f
197 of mice lacking Lig4, a ligase required for nonhomologous end-joining (NHEJ) repair of DNA double-st
198 Here, we show that Ku70, a core protein of nonhomologous end-joining (NHEJ) repair pathway, can dir
199 ization of homologous recombination (HR) and nonhomologous end-joining (NHEJ) repair pathways but exc
200 d impaired homologous recombination (HR) and nonhomologous end-joining (NHEJ) repair pathways, with d
201 and exonuclease activities regulate DSBR by nonhomologous end-joining (NHEJ) versus homologous recom
202 revealed 47 to 58% of reads as repaired via nonhomologous end-joining (NHEJ) with deletions and/or s
204 DSBs, namely homologous recombination (HR), nonhomologous end-joining (NHEJ), and microhomology-medi
205 cle-invasive bladder tumors are defective in nonhomologous end-joining (NHEJ), and this phenotype may
206 tein TRF2 by promoting their mobility, their nonhomologous end-joining (NHEJ), and, as we show here,
207 ence of DNA damage checkpoint components and nonhomologous end-joining (NHEJ), but not homologous rec
208 ir by both homologous recombination (HR) and nonhomologous end-joining (NHEJ), causes accumulation of
209 ment in the second major DSB repair pathway, nonhomologous end-joining (NHEJ), remains controversial.
218 ce between the two major DSB repair pathways-nonhomologous end-joining and homologous recombination r
219 se to DNA damage, which suppresses repair by nonhomologous end-joining and homologous recombination.
220 in the repair of DNA double strand breaks by nonhomologous end-joining and in the signaling of DNA da
221 fore, UbcH7-depleted cells display increased nonhomologous end-joining and reduced homologous recombi
222 y, which prevents end resection and promotes nonhomologous end-joining and therefore directly compete
224 PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cel
228 SPR/SpCas9 system was used to knock out, via nonhomologous end-joining genome repair, the 4'OMT2 in o
229 melphalan sensitivity of the cells, with the nonhomologous end-joining inhibitor SCR7 showing the str
230 but LIG4-dependent manner, establishing that nonhomologous end-joining maintains rDNA integrity durin
231 ons by rejoining broken ends, among them the nonhomologous end-joining mechanism that utilizes a DNA
233 ir of DNA double-strand breaks (DSBs) by the nonhomologous end-joining pathway (NHEJ) is important no
234 d by the DCLRE1C gene, is a component of the nonhomologous end-joining pathway and participates in ha
247 re partially disassembled around DSBs during nonhomologous end-joining repair in G1-arrested mammalia
248 can be efficiently ligated by the classical nonhomologous end-joining repair pathway (c-NHEJ), regen
249 ion and can ultimately become substrates for nonhomologous end-joining repair, leading to large-scale
252 s of chromothripsis in TCC-UB is mediated by nonhomologous end-joining using kilobase, rather than me
253 bination (HR) and repair efficiency, but not nonhomologous end-joining, and decreased the formation o
254 on and DNA-dependent protein kinase-mediated nonhomologous end-joining, and, when combined with olapa
255 ir through both homologous recombination and nonhomologous end-joining, implicating FUS as an upstrea
256 me of these rearrangements appear to involve nonhomologous end-joining, many must have involved mecha
257 h as KU70 and LIG4 (both involved in classic nonhomologous end-joining, NHEJ) and SMC6B (involved in
258 nt protein kinase-mediated (DNA-PK-mediated) nonhomologous end-joining, whereas DNA repair pathways m
259 nucleus" stage embryos led to high-frequency nonhomologous end-joining-mediated, mutagenic lesions in
268 at constrain coexpression within clusters of nonhomologous eukaryotic genes and suggest that gene clu
271 coregulated, and (3) physical clustering of nonhomologous genes that encode components of secondary
275 The three regions were each bordered by two nonhomologous integrase attachment (att) sites, which to
277 enes, the mechanistic logic of clustering of nonhomologous monocistronic genes in eukaryotes is not i
279 eV F TM constructs were coexpressed with the nonhomologous parainfluenza virus 5 (PIV5) fusion protei
280 of previous studies originally based on the nonhomologous partitioning of rodent cingulate cortex.
282 n viruses distinguish between homologous and nonhomologous partners during sexual RNA replication?
286 onal Cu(A) center designed in a structurally nonhomologous protein, cytochrome c peroxidase (CcP), by
287 al sources with structural homology and also nonhomologous proteins arising from the same biological
290 umerous rearrangements due to homologous and nonhomologous recombination, deletions and segmental dup
291 ntrol homologous recombination-dependent and nonhomologous recombination-dependent amplification path
293 odels of CGR genesis and strongly argue that nonhomologous repair of concurrently arising DNA double-
295 ential to distinguish between homologous and nonhomologous RNA templates during sexual RNA replicatio
297 reading frame 1 of the viral genome at five nonhomologous sites, releasing six nonstructural protein
299 Similarly, we also observe that the more nonhomologous subunits that assemble together within a c
300 r, when the DSB end contains a 3' protruding nonhomologous tail, Msh2 promotes the rejection of misma