ライフサイエンスコーパス: nonhydrolyzable

1 ed phosphodiester backbone with an isosteric nonhydrolyzable 1,2,3-triazole moiety.

2 Clostridium perfringens GH125 enzyme with a nonhydrolyzable 1,6-alpha-thiomannoside substrate mimic

3 In the presence of nonhydrolyzable 5'-adenylyl-beta,gamma-imidodiphosphate,

4 IC(50) approximately 20 mum) as well as by a nonhydrolyzable acyl-CoA thioether analog.

5 ent with high-resolution structural data for nonhydrolyzable acyl-enzyme intermediates from the picro

6 ted by the observation that ATP, but not the nonhydrolyzable adenosine 5'-O-(thiotriphosphate), can i

7 king process has shown that cells in steeper nonhydrolyzable adenosine- 3', 5'- cyclic monophosphorot

8 Treatment of mice with the nonhydrolyzable ADP analog, adenosine-5'-0-(2-thiodiphos

9 ture of ADPRase in complex with Mg(2+) and a nonhydrolyzable ADPR analogue, alpha,beta-methylene ADP-

10 Moreover, the maximal capacity of the nonhydrolyzable agonist ADPbetaS to stimulate inositol p

11 In contrast to dADP, both ADP and its nonhydrolyzable alpha, beta-methylphosphonate analog wer

12 present here the synthesis and evaluation of nonhydrolyzable amide isosteres based on this class, lea

13 n function, is also able to detoxify several nonhydrolyzable aminoacyl adenylates but not processed M

14 level of resistance to McC and various toxic nonhydrolyzable aminoacyl adenylates.

15 cture of Aquifex aeolicus ThiL (AaThiL) with nonhydrolyzable AMP-PCP and TMP, and also with the produ

16 Nonhydrolyzable AMP-PNP and adenosine 5'-(beta,gamma-met

17 In contrast, neither nonhydrolyzable (AMP-PNP, AMP-PCP) nor hydrolyzable ATP

18 for microtubules in the presence of the ATP nonhydrolyzable analog 5'-adenylyl-beta, gamma-imidodiph

19 hio)-cAMP (8CPT-cAMP; 30 microM) but not its nonhydrolyzable analog 8-(4-chlorophenylthio)-cAMP, Sp-i

20 The nonhydrolyzable analog 8-bromo-cyclic GMP (8-Br-cGMP) po

21 First, in the presence of 1 mm ATP or the nonhydrolyzable analog adenosine 5'-(beta,gamma-imino)tr

22 The nonhydrolyzable analog AMP-PNP and ATP-gamma S also stim

23 ed injuries to spinal cord cultures, and the nonhydrolyzable analog beta-NAAG (250-1000 microM) compl

24 f intracellular cAMP, via application of the nonhydrolyzable analog dibutyryl cAMP (dbcAMP), can bloc

25 GTP, GDP, the nonhydrolyzable analog GMP-PNP, and the slowly hydrolyza

26 gnate dCTP, neither the cognate dTTP nor its nonhydrolyzable analog induced fingers closure, as isomo

27 intermediate can be sequestered by ClpA if a nonhydrolyzable analog is added to displace ATP.

28 the labile properties of 2-AG, 2-AG ether, a nonhydrolyzable analog of 2-AG, was also used.

29 ensitive cell, McC is processed, releasing a nonhydrolyzable analog of aspartyl-adenylate, which inhi

30 of bongkrekic acid (BA), an ANT blocker; the nonhydrolyzable analog of ATP (adenosine 5'-beta,gamma-i

31 l muscle Ca2+ release channel activated by a nonhydrolyzable analog of ATP in the presence of Ca2+.

32 ut can readily dimerize in the presence of a nonhydrolyzable analog of ATP, 5'-adenylyl-beta,gamma-im

33 er of the gamma-phosphate from the generally nonhydrolyzable analog of ATP, adenosine-5'-(beta,gamma-

34 interacted with Hsp90 in the presence of the nonhydrolyzable analog of ATP, AMP-PNP.

35 fect, whereas perfusion of ATP or AMP-PNP, a nonhydrolyzable analog of ATP, significantly inhibited T

36 denosine (3-thiotriphosphate) (ATPgammaS), a nonhydrolyzable analog of ATP, to replication factor C w

37 lication and removal of Mg(2+)-free ATP or a nonhydrolyzable analog of ATP, which binds to the cytopl

38 and no effect was observed with ATPgammaS, a nonhydrolyzable analog of ATP.

39 ) potentiates penile erection by acting as a nonhydrolyzable analog of cGMP and competing with this n

40 Both GDP and the nonhydrolyzable analog of GTP, GMP-PCP, inhibit renatura

41 Based on studies involving a nonhydrolyzable analog of GTP, we conclude that nucleoti

42 of endogenous oocyte PIMT with sinefungin, a nonhydrolyzable analog of S-adenosylhomocysteine, increa

43 Thus, MorphGTP behaves as a nonhydrolyzable analog whose binding induces formation o

44 ct required ATP hydrolysis since ADP and the nonhydrolyzable analog, 5'-adenylyl beta, gamma-imidopho

45 yme can introduce negative supercoils with a nonhydrolyzable analog, adenylyl imidodiphosphate.

46 ulated 2- to 4-fold by binding of ATP or the nonhydrolyzable analog, ATPgammaS (but not ADP), to the

47 ed intermediates, in the presence of the ATP nonhydrolyzable analog, beta,gamma-imidoadenosine-5'-tri

48 ble analog of cGMP, 8-bromo-cGMP, but not by nonhydrolyzable analog, dibutyryl cGMP, suggesting that

49 structures of human DNA polymerase beta with nonhydrolyzable analogs containing all atoms in the acti

50 e been overlooked because of the reliance on nonhydrolyzable analogs for studying a single reaction t

51 for optically active (d- and l-enantiomers) nonhydrolyzable analogs of 2-arachidonoyl-lysophosphatid

52 equired for protein import into peroxisomes; nonhydrolyzable analogs of ATP could not substitute for

53 The nonhydrolyzable analogs of ATP, adenosine-5'-O-(3-thiotr

54 In the presence of ATP or nonhydrolyzable analogs of ATP, ClpXP had nearly the sam

55 000) that is stabilized by binding of ATP or nonhydrolyzable analogs of ATP.

56 not block activation of peptide cleavage by nonhydrolyzable analogs of ATP.

57 as tested by dialyzing On bipolar cells with nonhydrolyzable analogs of cGMP.

58 Nonhydrolyzable analogs of GTP did not substitute in thi

59 Two nonhydrolyzable analogs of GTP were fully able to activa

60 cay of rod photoresponses in the presence of nonhydrolyzable analogs of GTP.

61 the channel that is required for ATP and its nonhydrolyzable analogs to reduce open probability.

62 Kinetic experiments performed with the nonhydrolyzable analogue ATPgammaS showed overall change

63 maltose-binding protein, and ADP or another nonhydrolyzable analogue does not substitute for ATP.

64 ful for incorporating useful amounts of this nonhydrolyzable analogue for use as an inhibitor of base

65 substrate indole-3-glycerol phosphate or its nonhydrolyzable analogue indole propanol phosphate (IPP)

66 centrations up to 1 mM, suggesting that this nonhydrolyzable analogue may not be a faithful mimic of

67 A nonhydrolyzable analogue of (GlcNAc)(2,) methyl beta-N,

68 Here, we report the synthesis of a nonhydrolyzable analogue of 29-linked polyubiquitin chai

69 f the selective substrate profile of AsbC, a nonhydrolyzable analogue of 3,4-DHB-AMP was synthesized

70 K complex with the addition of substrates; a nonhydrolyzable analogue of adenosine-triphosphate, AMPP

71 e Escherichia coli enzyme, in complex with a nonhydrolyzable analogue of ATP, 5'-adenylimido-diphosph

72 RecA in complex with MgADP and MnAMP-PNP, a nonhydrolyzable analogue of ATP, at resolutions of 1.9 a

73 (-8) M] only in the presence of ATPgammaS, a nonhydrolyzable analogue of ATP, but not other nucleotid

74 32 or replacement of ATP with ATP-gamma-S, a nonhydrolyzable analogue of ATP, suggesting that ATP is

75 ma-methylene]triphosphate (methylene-ATP), a nonhydrolyzable analogue of ATP.

76 cyclic GMP (CPT-cGMP), a membrane-permeable, nonhydrolyzable analogue of cGMP, resulted in an increas

77 Intracellular elevation of either the nonhydrolyzable analogue of GTP, guanosine-5'-O-(3-thiot

78 uanosine 5'(beta-gamma imino)triphosphate, a nonhydrolyzable analogue of GTP, the binding of AdoCbl t

79 beta-D-cellobioside (MUS-CB), a ground-state nonhydrolyzable analogue of the fluorescent cellulase su

80 This work describes a nonhydrolyzable analogue of the tripolyphosphate (PPP(i)

81 nteractions of DNA containing Fapy.dG or the nonhydrolyzable analogue with Fpg and MutY are described

82 rotein was crystallized in the presence of a nonhydrolyzable analogue, AMPPNP, and its structure dete

83 f fluorescence with ADP, no quenching with a nonhydrolyzable analogue, and slow quenching with ATP.

84 OPII vesicle budding is promoted by GTP or a nonhydrolyzable analogue, guanylimide diphosphate (GMP-P

85 re hydrolysis per se and can be induced by a nonhydrolyzable analogue.

86 critical deficiencies, we designed neutral, nonhydrolyzable analogues of the chicoric acids.

87 of bound oligopeptide inhibitors possessing nonhydrolyzable analogues of the scissile peptide bond.

88 p)-8-BDB-TcAMPSMe reacts in the active site, nonhydrolyzable analogues of the substrate cAMP, or the

89 iation of ClpAP complexes in the presence of nonhydrolyzable analogues was >/=30 min.

90 The interaction of DNA containing Fapy.dA or nonhydrolyzable analogues with Fpg and MutY is described

91 ht be different inhibitory tendencies by the nonhydrolyzable analogues, phosphonothioic acids compare

92 and temperature and a requirement for ATP or nonhydrolyzable analogues.

93 ught about by all the nucleotides, including nonhydrolyzable analogues; this effect of vinblastine wa

94 ies of recombinant 6-MSA synthases with both nonhydrolyzable and hydrolyzable substrate mimics have p

95 of Fhit bound to Ado-p-CH2-p-ps-Ado (IB2), a nonhydrolyzable ApppA analog, was refined to 3.1 A, and

96 roteolyzed with release of a toxic warhead-a nonhydrolyzable aspartamidyl-adenylate, which inhibits a

97 " inhibitor microcin C7 (McC7) consists of a nonhydrolyzable aspartyl-adenylate conjugated to a hexap

98 ssed there, and the product of processing, a nonhydrolyzable aspartyl-adenylate, inhibits translation

99 gets processed to release a toxic warhead-a nonhydrolyzable aspartyl-adenylate, which inhibits aspar

100 rved in response to adenosine, AMP, ADP, and nonhydrolyzable ATP (betagammameATP).

101 NHE1 activity is stable with perfusion of nonhydrolyzable ATP [adenosine 5'-(beta,gamma-imido)trip

102 -ray structures of the open state bound to a nonhydrolyzable ATP analog (AMPPCP) and 1,6-anhydroMurNA

103 Moreover, Top2 bound to the nonhydrolyzable ATP analog 5'-adenylyl-beta,gamma-imidod

104 singly, ADP, guanosine triphosphate, and the nonhydrolyzable ATP analog 5'-adenylyl-beta,gamma-imidod

105 duplexes in the presence and absence of the nonhydrolyzable ATP analog 5'-adenylyl-beta,gamma-imidod

106 1 microM) and eliminated by substituting the nonhydrolyzable ATP analog 5-adenylyl-imidodiphosphate o

107 diphosphate and in ternary complex with the nonhydrolyzable ATP analog adenosine 5'-(beta,gamma-imid

108 ral DEAD-box proteins in the presence of the nonhydrolyzable ATP analog ADP-beryllium fluoride.

109 ATP and a nonhydrolyzable ATP analog also influence the stability

110 sociated within 30 s, whereas those with the nonhydrolyzable ATP analog AMP-PNP had a mean lifetime o

111 is incongruous with the models based on the nonhydrolyzable ATP analog data.

112 the ATPase and CW domains in complex with a nonhydrolyzable ATP analog demonstrates that the two dom

113 The addition of a nonhydrolyzable ATP analog had no effect at early time p

114 Binding of a nonhydrolyzable ATP analog inverts the transporter to an

115 Binding of a nonhydrolyzable ATP analog locks pNS3h in a conformation

116 Second, the binding of a nonhydrolyzable ATP analog to the yeast enzyme appears t

117 ly traps one DNA circle in the presence of a nonhydrolyzable ATP analog under the same conditions tha

118 nthase inhibitor AMP-PNP (gamma-imino ATP, a nonhydrolyzable ATP analog) and Mg(2+)/ADP.

119 Specifically, ATPgammaS (a nonhydrolyzable ATP analog) inhibits secretion of interf

120 s in the presence of magnesium and ATP (or a nonhydrolyzable ATP analog), contains maximal DNA helica

121 One structure, in complex with a nonhydrolyzable ATP analog, adenosine 5'-adenylyl-beta,g

122 ild-type RecF binding in the presence of the nonhydrolyzable ATP analog, adenosine 5'-O-(3-thio)triph

123 er interface mutants, L273A and L108A, and a nonhydrolyzable ATP analog, adenosine 5'-O-(3-thiotripho

124 A nonhydrolyzable ATP analog, ADPCP (beta,gamma-methylene

125 f 46 +/- 1 A in the presence or absence of a nonhydrolyzable ATP analog, AMP-PnP.

126 sence of ATP, 25 microM in the presence of a nonhydrolyzable ATP analog, and 45 microM in the presenc

127 bserved using 5'-adenylylimidodiphosphate, a nonhydrolyzable ATP analog, and was blocked in the prese

128 AMP-PNP, a nonhydrolyzable ATP analog, at a concentration of 1 or 3

129 We demonstrate that the nonhydrolyzable ATP analog, ATP gamma S, supports the fo

130 at the shift in IC50 of inhibitors using the nonhydrolyzable ATP analog, beta, gamma-methyleneadenosi

131 In adenylyl-imidodiphosphate (AMP-PNP), a nonhydrolyzable ATP analog, each kinesin-1 dimer binds t

132 ylyl-beta,gamma-imidodiphosphate (AMPPNP), a nonhydrolyzable ATP analog, promotes stable complex form

133 Hepatocyte treatment with ATPgammaS, a nonhydrolyzable ATP analog, recapitulated early signalin

134 In the presence of a nonhydrolyzable ATP analog, the enzyme is known to promo

135 s open very differently in the presence of a nonhydrolyzable ATP analog, with subconductance openings

136 ease the linking number in the presence of a nonhydrolyzable ATP analog.

137 ranslocation step specifically requires ATP; nonhydrolyzable ATP analogs are ineffective.

138 We have previously shown that nonhydrolyzable ATP analogs block the lytic activity of

139 Nonhydrolyzable ATP analogs did not substitute for ATP t

140 Substitution of nonhydrolyzable ATP analogs for ATP slowed or prevented

141 Effects of two nonhydrolyzable ATP analogs on helicase denaturation wer

142 n, we evaluated the effects of ATP, ADP, and nonhydrolyzable ATP analogs on the lifetime of protein.D

143 mbly system was inhibited by the addition of nonhydrolyzable ATP analogs, suggesting that ATP hydroly

144 TP depletion experiments and inhibition with nonhydrolyzable ATP analogs.

145 rmational changes in the presence of ATP and nonhydrolyzable ATP analogs.

146 of ATP concentration, and by the use of the nonhydrolyzable ATP analogue adenosine 5'-(beta, gamma-i

147 The nonhydrolyzable ATP analogue adenosine 5'-(beta,gamma-im

148 Even though DNA binding is promoted by the nonhydrolyzable ATP analogue adenosine 5'-O-(thiotriphos

149 ctures of MtPPAT in complex with PhP and the nonhydrolyzable ATP analogue adenosine-5'-[(alpha,beta)-

150 nase domain of human Plk1 complexed with the nonhydrolyzable ATP analogue adenylylimidodiphosphate (A

151 proteolysis data indicate that SecB and the nonhydrolyzable ATP analogue AMP-P-C-P induce similar co

152 e, the lysyl-adenylate intermediate, and the nonhydrolyzable ATP analogue AMP-PCP.

153 ransfer was sustained in the presence of the nonhydrolyzable ATP analogue AMP-PNP (adenyl-5'-yl imido

154 The nonhydrolyzable ATP analogue AMP-PNP binds in a unique m

155 The Arp2/3 complex bound to ADP or the nonhydrolyzable ATP analogue AMP-PNP cannot nucleate act

156 In the presence of the nonhydrolyzable ATP analogue AMP-PNP, the drug binding s

157 se from E. coli: one form complexed with the nonhydrolyzable ATP analogue AMPPNP and the second with

158 ct UDP-N-acetylmuramoyl-L-alanine (UMA), the nonhydrolyzable ATP analogue AMPPNP, and Mn(2+) have bee

159 3 degradation in the presence of ATP, or the nonhydrolyzable ATP analogue AMPPNP, indicate a sequenti

160 ase domain in apo form and in complex with a nonhydrolyzable ATP analogue at 2.0 A and 2.5 A resoluti

161 Using the nonhydrolyzable ATP analogue ATP-gamma-S results in form

162 ned with the wild-type protein by use of the nonhydrolyzable ATP analogue ATP-gamma-S.

163 A nonhydrolyzable ATP analogue had the same effects as ATP

164 Simultaneous presence of ADP and a nonhydrolyzable ATP analogue modulates MutSalpha.heterod

165 ted most emphatically in the response to the nonhydrolyzable ATP analogue, 5'-adenylyl-beta,gamma-imi

166 Furthermore, the nonhydrolyzable ATP analogue, 5'-adenylylimidodiphosphat

167 3) Another nonhydrolyzable ATP analogue, adenosine 5'-(beta,gamma-m

168 2) After hexokinase treatment, the nonhydrolyzable ATP analogue, adenyl 5'-(yl iminodiphosp

169 Upon binding the nonhydrolyzable ATP analogue, AMPPNP/Mg(2+), the MutL di

170 imentation rate in the presence of ADP and a nonhydrolyzable ATP analogue, which suggests a change to

171 ce increased upon addition of ATP, ADP, or a nonhydrolyzable ATP analogue.

172 of initial rates obtained in the presence of nonhydrolyzable ATP analogues and the small molecule inh

173 ational/experimental study characterizing 13 nonhydrolyzable ATP analogues as selective human NPP1 in

174 In the presence of DNA and ADP or the nonhydrolyzable ATP analogues ATPgammaS and AMP-PNP, how

175 filter binding assays indicate that ADP and nonhydrolyzable ATP analogues can bind simultaneously to

176 ATP, ADP, and nonhydrolyzable ATP analogues decreased the UIC2 reactiv

177 Nonhydrolyzable ATP analogues partially replicate the ef

178 site for ADP and one high affinity site for nonhydrolyzable ATP analogues per dimer equivalent.

179 e ClpAP complexes requires binding of ATP or nonhydrolyzable ATP analogues to ClpA.

180 s indicate that the nucleotide (ATP, ADP, or nonhydrolyzable ATP analogues) occupancy of the ATPase b

181 l transition was 2 for ATP and ADP but 1 for nonhydrolyzable ATP analogues.

182 the presence of saturating concentrations of nonhydrolyzable ATP analogues.

183 s of wild-type Hsp82 only in the presence of nonhydrolyzable ATP and formed an Hsp82-Cpr6-Cpr7 ternar

184 Nonhydrolyzable ATP, GTP, and guanosine 5'-[gamma-thio]t

185 ATP, but not nonhydrolyzable ATP, is essential for the unwinding acti

186 ATP, but not nonhydrolyzable ATP-gamma S, regulates the SODD binding

187 olution, alone and in the presence of AMP or nonhydrolyzable ATP.

188 Addition of ATP or the nonhydrolyzable ATPgammaS reduces binding of the MSH2-MS

189 Experiments using nonhydrolyzable ATPgammaS show that ATP binding converts

190 , we have demonstrated that a peptide with a nonhydrolyzable beta-amino acid substitution binds DM2 w

191 Nonhydrolyzable branched RNA analogues containing arabin

192 Pretreatment of REF-52 cells with the nonhydrolyzable cAMP analog, 8-(4-chlorophenylthio)-cAMP

193 bited VASP phosphorylation stimulated by the nonhydrolyzable cAMP analog, 8-bromo-cAMP, indicating th

194 by a hydrolyzable cAMP analog, but not by a nonhydrolyzable cAMP analog.

195 /glycosidases and subsequent accumulation of nonhydrolyzable carbohydrate-containing compounds in lys

196 binding of natural glycosides and also of a nonhydrolyzable cellotetraose analogue.

197 purine nucleotides, and membrane-permeable, nonhydrolyzable cyclic nucleotide analogs were all inact

198 he gap (binary complex) and with an incoming nonhydrolyzable dATP analog (ternary complex) were solve

199 mplex structures of polbeta with an incoming nonhydrolyzable dGTP or dCTP analog paired with templati

200 the synthesis of a prodrug that delivers the nonhydrolyzable difluoromethylphosphonate moiety intrace

201 pared to triphosphoric acid is enzymatically nonhydrolyzable due to substitution of two bridging oxyg

202 y at the scissile bond; the other two have a nonhydrolyzable electrophilic group at the P1' position.

203 RNA and K(+) current expression, whereas the nonhydrolyzable Epac activator 8-(4-chlorophenylthio)-2'

204 A nonhydrolyzable ether analog of palmitoyl-carnitine stim

205 , within the nucleus of control L-cells, the nonhydrolyzable fluorescent LCFA-CoA (BODIPY-C16-S-S-CoA

206 Cyclopentyl-adenylylimidodiphosphate, a nonhydrolyzable form of this analog, inhibits the mutant

207 ermore, incubation of Schwann cells with the nonhydrolyzable GDP analog GDP-betaS inhibited TX14(A)-i

208 with 80S complexes formed in the presence of nonhydrolyzable GDPNP, whereas these factors were releas

209 ecause similar results were obtained using a nonhydrolyzable GSL analog.

210 ls, as direct activation of GIRK channels by nonhydrolyzable GTP also potentiated the currents.

211 ermophilus 70S ribosome bound to EF-4 with a nonhydrolyzable GTP analog and A-, P-, and E-site tRNAs.

212 te from ARF1, but only C-1Sec7 displaced the nonhydrolyzable GTP analog bound to mut13F139/L, again i

213 Incubating cells with the nonhydrolyzable GTP analog GTPgammaS (1 microm) or the m

214 of the G protein Gialpha1 complexed with the nonhydrolyzable GTP analog guanosine-5'-(betagamma-imino

215 omponents Sar1p, Sec23/24p, Sec13/31p, and a nonhydrolyzable GTP analog such as GMP-PNP.

216 ard to its internalization, sensitivity to a nonhydrolyzable GTP analog, and anisotropy of a bound fl

217 Ran complexed with the nonhydrolyzable GTP analog, GMPPNP (RanGMPPNP), is used

218 ase binds MeaB 15-fold more tightly when the nonhydrolyzable GTP analog, GMPPNP, is bound versus GDP.

219 The onset of the nonhydrolyzable GTP analog, guanylylimidodiphosphate-med

220 tofilament sheets are assembled in GMPCPP, a nonhydrolyzable GTP analog, or in GTP following chelatio

221 nents and designed to stall with eIF5B and a nonhydrolyzable GTP analog.

222 enin is energy dependent and is inhibited by nonhydrolyzable GTP analogs and by a dominant-negative m

223 10 and 25 degrees C using GTP, GDP, and two nonhydrolyzable GTP analogs, guanosine 5'-O-(gamma-thio)

224 In the presence of GTP or nonhydrolyzable GTP analogs, synapsis happens rapidly, w

225 P and derepressed by Snu114p bound to GTP or nonhydrolyzable GTP analogs.

226 any of the proteins even in the presence of nonhydrolyzable GTP analogs.

227 oluble domain was achieved when bound to the nonhydrolyzable GTP analogue guanosine 5'-[beta,gamma-im

228 ctivated in a Mg2+ complex with GTPgammaS, a nonhydrolyzable GTP analogue that is reported to bind Ga

229 e 70S ribosome with RF3 in the presence of a nonhydrolyzable GTP analogue, guanosine 5'-beta,gamma-me

230 ine 5'-O-(3-thiotriphosphate) (GTPgammaS), a nonhydrolyzable GTP analogue.

231 Given that each of the nonhydrolyzable GTP analogues is able to promote the bin

232 d (signaling-active) state as induced by the nonhydrolyzable GTP analogues, guanosine 5'-(beta,gamma-

233 ndeed, acute desensitization is abolished by nonhydrolyzable GTP analogues.

234 n, driven by the binding of six NTPs (or six nonhydrolyzable GTPgammaS analogues) that are located at

235 quiring acidic phospholipids, Arf1p, and the nonhydrolyzable GTPgammaS.

236 se subunits, one (gp61) primase subunit, and nonhydrolyzable GTPgammaS.

237 e 3 microm and is not supported by Ba(2+) or nonhydrolyzable guanine nucleotides, which do not stimul

238 crystal structures of EF-G complexed with a nonhydrolyzable guanosine 5'-triphosphate (GTP) analog a

239 premutagenic structures were obtained with a nonhydrolyzable incoming nucleotide analog, dAMPCPP, and

240 Other fatty acids, including a nonhydrolyzable inhibitor of both lipooxygenase and cycl

241 it is mimicked by postsynaptic injection of nonhydrolyzable IP(3), and by photolysis of caged IP(3)

242 The fact that nonhydrolyzable L-arginine analogs are not stimulatory i

243 luoromethylene LPA analogues were unique new nonhydrolyzable ligands with surprising enantiospecific

244 ds in rabbit psoas muscle in the presence of nonhydrolyzable ligands.

245 leavage at one site by the introduction of a nonhydrolyzable linkage can lead to the utilization of o

246 A nonhydrolyzable lipoyl-AMP analogue was found to competi

247 xtension was supported by the inability of a nonhydrolyzable malonyl analog to trap products of inter

248 Ub-AMSN (4b) contain a sulfamide group as a nonhydrolyzable mimic of the phosphate group in the cogn

249 to a binary complex composed of Nmt1p and a nonhydrolyzable myristoylCoA analogue (S-(2-oxo)pentadec

250 ion and of a ternary complex of Nmt1p with a nonhydrolyzable myristoylCoA analogue [S-(2-oxo)pentadec

251 ith a bound substrate peptide (GLYASKLA) and nonhydrolyzable myristoylCoA analogue was used as the ba

252 oMet synthetase because of the presence of a nonhydrolyzable NH-link between the beta- and gamma-phos

253 or Pgp is not altered by the presence of the nonhydrolyzable nucleotide 5'-adenylylimididiphosphate a

254 raints due to binding in the presence of the nonhydrolyzable nucleotide adenylylimidodiphosphate.

255 tion activity of Hsp70 can be inhibited by a nonhydrolyzable nucleotide analog and encouraged by phar

256 Addition of ATP or nonhydrolyzable nucleotide analogs stimulated PPR65-cata

257 es, 2-aminopurine nucleotide triphosphate, a nonhydrolyzable nucleotide analogue dAMPCPP, and a rapid

258 Neither phosphatase inhibitors nor nonhydrolyzable nucleotide analogues modified CRAC chann

259 channels were locked open by the addition of nonhydrolyzable nucleotide or when the R334C mutation wa

260 Although the concept of nonhydrolyzable nucleotides has been around for some tim

261 the decrease in UIC2 reactivity produced by nonhydrolyzable nucleotides, but unlike vinblastine, it

262 are reversibly activated (albeit weakly) by nonhydrolyzable nucleotides.

263 alogs-one of the most interesting classes of nonhydrolyzable nucleotides.

264 th adenosine, ATP, and other nucleotides and nonhydrolyzable P2 receptor agonists and antagonists sug

265 rs with methylcarbamyl-PAF (cPAF, 300 nM), a nonhydrolyzable PAF analogue, TNF-alpha (20 ng/mL), and

266 This report examines the effects of the nonhydrolyzable PAF receptor agonist methyl carbamyl PAF

267 ied form was inhibited by S-hexadecyl-CoA, a nonhydrolyzable palmitoyl-CoA analog, demonstrating that

268 turally occurring acyl donor palmitate and a nonhydrolyzable palmitoyl-CoA analog.

269 d novel dipeptides that contain monocharged, nonhydrolyzable phosphate group replacements and bind to

270 Interestingly, the nonhydrolyzable phospholipid dioleoyl ether phosphatidyl

271 Substitution of the phosphate groups with nonhydrolyzable phosphonate groups preserved platelet an

272 ins with unique cysteine residues yielding a nonhydrolyzable phosphonothiolate-linked diubiquitin and

273 nhibited by the cyclic phosphopeptide with a nonhydrolyzable phosphoserine mimetic.

274 tase (PTPase) inhibitors is to incorporate a nonhydrolyzable phosphotyrosine (pTyr) mimic into a pept

275 Results are presented for the binding of a nonhydrolyzable phosphotyrosine analog phosphonodifluoro

276 Using "expressed protein ligation", nonhydrolyzable phosphotyrosine analogs were introduced

277 Protein-tyrosine peptidomimetics containing nonhydrolyzable phosphotyrosine analogues bind to PTPase

278 the greatest stability, ShK-192, contains a nonhydrolyzable phosphotyrosine surrogate, a methionine

279 Nonhydrolyzable phosphotyrosyl (pTyr) mimetics serve as

280 d the potential efficacy of bisphosphonates, nonhydrolyzable PPi analogs, in preventing ectopic miner

281 Free energy profiles demonstrate that the nonhydrolyzable product of the condensation reaction, de

282 T. gondii UPRT bound to uracil and cPRPP, a nonhydrolyzable PRPP analogue, to 2.5-A resolution.

283 report describes the synthesis of three such nonhydrolyzable pTyr mimics that contain alpha-ketoacid,

284 criptase (RT) inhibitors, a new chemotype of nonhydrolyzable purine diphosphate mimic was synthesized

285 We have now synthesized a nonhydrolyzable reactive cAMP analogue, (S(p))-8-[(4-bro

286 We report herein a two-step method to make nonhydrolyzable saccharide-porphyrin conjugates in high

287 ialysis was used to study the binding of two nonhydrolyzable, short chain phospholipid analogues to t

288 d CACNA1H mRNA and Ca(v)3.2 current, whereas nonhydrolyzable Sp-8CPT-cAMP failed to increase either C

289 dCTPase from M. musculus in complex with the nonhydrolyzable substrate analog dCMPNPP and the product

290 2+) to the enzyme in the presence of dUDP, a nonhydrolyzable substrate analog, was specific and compe

291 of the YopH PTPase domain in complex with a nonhydrolyzable substrate analogue, the hexapeptide mime

292 ch and identified shortcomings in the use of nonhydrolyzable substrate analogues for conformational a

293 rate specificity, a series of water-soluble, nonhydrolyzable substrate analogues were needed so their

294 , or leucine attached to adenosine through a nonhydrolyzable sulfamoyl bond.

295 s readily displaceable by S-hexadecyl-CoA, a nonhydrolyzable thioether analogue of LCFA-CoAs.

296 synthetic triketide substrates containing a nonhydrolyzable thioether linkage as well as by site-dir

297 d 14 nucleotides of the CHIKV genome and the nonhydrolyzable transition-state nucleotide analog ADP-A

298 from that observed in the presence of ADP or nonhydrolyzable triphosphate alone, and it is unlikely t

299 Usp15, through affinity purification with a nonhydrolyzable ubH2B mimic.

300 A series of nonhydrolyzable ubiquitin dimer analogues has been synth