ライフサイエンスコーパス: nonsense-mediated decay

1 rnative exon that targets the transcript for nonsense mediated decay.

2 from the patient shows it does not result in nonsense mediated decay.

3 introduced a cryptic splice site, leading to nonsense mediated decay.

4 enomena such as cis-regulatory variation and nonsense-mediated decay.

5 frameshift mutation in RSPRY1 with resulting nonsense-mediated decay.

6 species that are likely rapidly degraded via nonsense-mediated decay.

7 The 1 bp duplication causes a frameshift and nonsense-mediated decay.

8 pression via alternative splicing coupled to nonsense-mediated decay.

9 ficiencies in known roles of SMG1, including nonsense-mediated decay.

10 The variant F3 transcript is eliminated by nonsense-mediated decay.

11 ng nonfunctional transcripts and/or inducing nonsense-mediated decay.

12 ising from the mutant alleles are subject to nonsense-mediated decay.

13 spectrum of mutant transcripts that survive nonsense-mediated decay.

14 nd the retained intron product is subject to nonsense-mediated decay.

15 upon UPF1, suggesting that it is related to nonsense-mediated decay.

16 nd the transcript was observed to degrade by nonsense-mediated decay.

17 otein mRNAs are predicted to be sensitive to nonsense-mediated decay.

18 oprotein mRNA translation and sensitivity to nonsense-mediated decay.

19 ytoplasmic decapping and 5'-to-3' decay, and nonsense-mediated decay.

20 either by blocking its membrane targeting or nonsense-mediated decay.

21 he latter presumably due to circumvention of nonsense-mediated decay.

22 equence and degradation of the mutant RNA by nonsense-mediated decay.

23 nto how selenoprotein mRNAs might circumvent nonsense-mediated decay.

24 lower expression because of degradation via nonsense-mediated decay.

25 es that are required for translation and for nonsense-mediated decay.

26 selection for fusion transcripts that evade nonsense-mediated decay.

27 are regulated by selenium and are subject to nonsense-mediated decay.

28 odons (PTCs) that are likely targets of mRNA nonsense-mediated decay.

29 ablements, and thus may be more resistant to nonsense-mediated decay.

30 r nuclear export, efficient translation, and nonsense-mediated decay.

31 plicing, and to downstream events, including nonsense-mediated decay.

32 possibly, serving as a downstream 'mark' for nonsense-mediated decay.

33 ly degraded, presumably by the mechanisms of nonsense-mediated decay.

34 ivo such as mRNA transport, translation, and nonsense-mediated decay.

35 tingly these messages are not substrates for nonsense-mediated decay.

36 ons in the smg genes, which are required for nonsense-mediated decay.

37 that co-purifies with cytoplasm is immune to nonsense-mediated decay.

38 ent, the mRNA will no longer be sensitive to nonsense-mediated decay.

39 ifting the EIF4A2 transcript ratio away from nonsense-mediated decay.

40 expression through alternative splicing and nonsense-mediated decay.

41 tic exon, which targets Neurofascin mRNA for nonsense-mediated decay.

42 son exons' (PEs) that target transcripts for nonsense-mediated decay.

43 , including p.R345* transcripts, which evade nonsense-mediated decay.

44 predicted to be sensitive and insensitive to nonsense-mediated decay.

45 edicted effects including protein coding and nonsense-mediated decay.

46 metine, suggesting that the mutation induces nonsense-mediated decay.

47 t the predicted resulting mRNA is subject to nonsense-mediated decay.

48 and demonstrate that SMN6B is a substrate of nonsense-mediated decay.

49 ood and the mutated ASXL2 transcripts escape nonsense-mediated decay.

50 h a premature termination codon that escapes nonsense-mediated decay.

51 ift variant is not a canonical substrate for nonsense-mediated decay.

52 ice-site selection associated with increased nonsense-mediated decay.

53 in domains, or the trigger of or escape from nonsense-mediated decay.

54 n disrupting their translation and promoting nonsense-mediated decay.

55 al sensitivity of the can1-100 transcript to nonsense-mediated decay, a pathway that degrades mRNAs w

56 -gamma is therefore likely to be degraded by nonsense-mediated decay, an important widespread post-tr

57 d that the founder allele results in partial nonsense mediated decay and an absence of detectable pro

58 r the detection of cis-regulatory variation, nonsense mediated decay and imprinting in the personal g

59 iated with the disease, that we show escapes nonsense mediated decay and is expressed in CH patient n

60 4% of W1282X alleles, rescued CFTR mRNA from nonsense mediated decay and restored protein expression.

61 sQTLs influenced isoforms likely impacted by nonsense-mediated decay and 190 that potentially resulte

62 or penultimate exons that are not subject to nonsense-mediated decay and are stably translated into m

63 rame, creating novel transcripts that escape nonsense-mediated decay and are translated to produce hn

64 PAX6 deletions, PAX6 variants subjected to nonsense-mediated decay and C-terminal extension variant

65 Both mutations predict nonsense-mediated decay and complete loss of function.

66 at truncation variants in this region escape nonsense-mediated decay and continue to be incorporated

67 nhibition perturbs exon skipping, leading to nonsense-mediated decay and diminished levels of DNA dam

68 ays related to translation fidelity, such as nonsense-mediated decay and eukaryotic translation elong

69 ects on transcript abundance attributable to nonsense-mediated decay and exonic splicing elements.

70 ein levels were reduced by ~ 50%, suggesting nonsense-mediated decay and haploinsufficiency.

71 on of a cryptic exon in UNC13A, resulting in nonsense-mediated decay and loss of UNC13A protein.

72 transcript stability and translation through nonsense-mediated decay and microRNA-mediated gene regul

73 UPF1 is an RNA helicase that orchestrates nonsense-mediated decay and other RNA surveillance pathw

74 n stop codon (p.R345*), yet the mRNA escapes nonsense-mediated decay and produces sufficient active p

75 HOT RNAs encode components of the nonsense-mediated decay and splicing machinery, as well

76 analysis identified multiple changes in the nonsense-mediated decay and termination machineries that

77 fibroblasts of affected individuals escapes nonsense-mediated decay and thus leads to the expression

78 therapy will sometimes require inhibition of nonsense-mediated decay and translational bypass of the

79 ion of a group II intron in yeast results in nonsense-mediated decay and translational repression of

80 ed in their utility for studying the role of nonsense mediated decay, and as a consequence, in testin

81 POU3F3 is an intronless gene, insensitive to nonsense-mediated decay, and 13 individuals carried prot

82 scripts from the mutated allele are prone to nonsense-mediated decay, and expression of ASXL3 is redu

83 the response to oxidative stress, apoptosis, nonsense-mediated decay, and others.

84 for phenomena such as alternative splicing, nonsense-mediated decay, and regulation through untransl

85 rcentage of isoforms targeted, prediction of nonsense-mediated decay, and restriction enzymes for RFL

86 ties of MPZ-truncating proteins that escaped nonsense-mediated decay, and we found that frameshift mu

87 esults regarding the quantitative effects of nonsense-mediated decay, and we show that predicted loss

88 the hierarchy of selenoprotein synthesis and nonsense-mediated decay are discussed.

89 and intron-retaining transcripts that escape nonsense-mediated decay are not actively translated.

90 og these redistributed proteins and pinpoint nonsense-mediated decay as a therapeutic target for C9-A

91 SMG1 has a well-characterized role in nonsense-mediated decay as well as suggested roles in th

92 sting that alternative splicing coupled with nonsense-mediated decay (AS-NMD) may regulate gene expre

93 ch as those subject to translation-dependent nonsense-mediated decay (AS-NMD), may be completely over

94 selection pressure, and coupling of AS with nonsense-mediated decay (AS-NMD).

95 TEA may be helpful for testing inhibitors of nonsense-mediated decay, as stop codon management therap

96 umors, including Werner helicase inhibition, nonsense-mediated decay blockade, and neoantigen-targete

97 n and we previously demonstrated escape from nonsense-mediated decay by detecting mutant ADNP mRNA in

98 hypothesis that alternative splicing-coupled nonsense-mediated decay contributes to regulation of ery

99 mRNAs with premature termination codons and nonsense-mediated decay, decreased ANAPC1 protein levels

100 splicing by controlling the incorporation of nonsense-mediated decay-determinant exons in genes encod

101 s were retained in the nucleus, and block of nonsense-mediated decay did not affect their accumulatio

102 As are potential targets for degradation via nonsense-mediated decay due to the presence of in-frame

103 some PRRT2 loss-of-function mutations cause nonsense mediated decay, except when in the last exon, w

104 frameshift mutated allele, probably through nonsense-mediated decay, explaining the more severe phen

105 In addition, we unexpectedly find that the nonsense-mediated decay factor DHX34 exhibits widespread

106 rate that hDcp1a and hDcp2 interact with the nonsense-mediated decay factor hUpf1, both in the presen

107 Among the findings, UPF1, a key nonsense-mediated decay factor, and PCNA, the polymerase

108 f ZC3H14, double knockdown of ZC3H14 and the nonsense-mediated decay factor, UPF1, rescues ATP5G1 tra

109 ckdown obtained by forced splicing-dependent nonsense-mediated decay (FSD-NMD).

110 microRNA-mediated translation repression and nonsense mediated decay, further supporting the view tha

111 ssociated chromatin and VEX2, an ortholog of nonsense-mediated-decay helicase, UPF1.

112 XPC-mRNA, which would have been degraded by nonsense-mediated decay; (ii) increased expression of XP

113 , we also demonstrate the reversible role of nonsense-mediated decay in all four mutations, using sma

114 The mutant transcripts do not undergo nonsense-mediated decay in cells from subjects with GPS.

115 this apparent inconsistency is attributed to nonsense mediated decay independent of exon junction com

116 Nonsense-mediated decay is associated with a number of o

117 Previously, we have shown how nonsense-mediated decay is involved in the degradation o

118 In contrast, nonsense-mediated decay is significantly more associated

119 codon in the elongated transcript activates nonsense mediated decay leading to spectrin deficiency.

120 tiation site, resulting in the prevention of nonsense-mediated decay, leading to a consequent stabili

121 e 3' end of mRNAs was observed, suggesting a Nonsense-Mediated Decay-like quality-control mechanism i

122 igured to terminate translation and initiate nonsense-mediated decay, limits the production of cellul

123 For many known AS-NMD targets, the nonsense-mediated decay-linked alternative splicing path

124 the targets for degradation by the cellular nonsense-mediated decay machinery if they contain premat

125 ative target of alternative splicing-coupled nonsense-mediated decay mechanism.

126 The EJC core does not recruit the nonsense-mediated decay mediaters UPF2 and UPF3 until th

127 These data suggest that nonsense mediated decay might itself reduce negative sel

128 Because of nonsense-mediated decay, most hypomorphic alleles are no

129 igenic diversity is potentially regulated by Nonsense Mediated Decay (NMD) and NMD has been shown to

130 ession of a chimera bearing Nos fused to the nonsense mediated decay (NMD) factor Upf1.

131 Inhibition of the nonsense mediated decay (NMD) pathway led to an upregula

132 usually targeted for degradation through the nonsense mediated decay (NMD) pathway.

133 These exons triggered nonsense mediated decay (NMD), as UPF1 and protein synth

134 mpact of PAH mutations on pre-mRNA splicing, nonsense-mediated decay (NMD) and receptor complex inter

135 /401, 11%) were confined to regions escaping nonsense-mediated decay (NMD) and were significantly les

136 XRN4 also contributes to nonsense-mediated decay (NMD) and xrn4 accumulates 3' fr

137 that the cap-binding protein CBP80 promotes nonsense-mediated decay (NMD) at two steps.

138 lear ribonucleoprotein L) protect mRNAs from nonsense-mediated decay (NMD) by preventing the UPF1 RNA

139 his regulatory mechanism is dependent on the nonsense-mediated decay (NMD) component, Upf1, which pro

140 As an intrinsic cellular pathway, nonsense-mediated decay (NMD) conceals neoantigens throu

141 Nonsense-mediated decay (NMD) degrades both normal and a

142 Nonsense-mediated decay (NMD) degrades mRNAs containing

143 Nonsense-mediated decay (NMD) eliminates mRNAs that prem

144 Nonsense-mediated decay (NMD) eliminates transcripts wit

145 he EJC proteins Y14, Magoh, and RNPS1 or the nonsense-mediated decay (NMD) factors Upf1, Upf2, and Up

146 for assessing the ability of PTVs to induce nonsense-mediated decay (NMD) focus primarily on the pos

147 ecialized pathway of mRNA degradation termed nonsense-mediated decay (NMD) functions in mRNA quality

148 In humans, disruption of nonsense-mediated decay (NMD) has been associated with n

149 Nonsense-mediated decay (NMD) has been suggested to be r

150 Nonsense-mediated decay (NMD) is a eukaryotic mRNA surve

151 Nonsense-mediated decay (NMD) is a messenger RNA quality

152 Nonsense-mediated decay (NMD) is a posttranscriptional s

153 Nonsense-mediated decay (NMD) is a translation-dependent

154 Nonsense-mediated decay (NMD) is an important process th

155 Nonsense-mediated decay (NMD) is an RNA surveillance pat

156 radation of UPF1, a central component of the nonsense-mediated decay (NMD) machinery, is associated w

157 mRNA transcript for degradation by the host nonsense-mediated decay (NMD) machinery.

158 Inhibition of the nonsense-mediated decay (NMD) mechanism in cells results

159 d phenotypic patterns are likely mediated by nonsense-mediated decay (NMD) of splicing isoforms, with

160 ng (P < 0.05) and showed that this triggered nonsense-mediated decay (NMD) of the alternatively splic

161 rom a frameshift-inducing INDEL that elicits nonsense-mediated decay (NMD) of the mutant mRNA.

162 the CFTR mRNA and subsequently activate the nonsense-mediated decay (NMD) pathway resulting in rapid

163 ndent RNA helicase DDX3X (DDX3X) through the nonsense-mediated decay (NMD) pathway to promote intron

164 Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise th

165 case subfamily as MOV10 and functions in the nonsense-mediated decay (NMD) pathway.

166 oan mRNA, including its surveillance via the nonsense-mediated decay (NMD) pathway.

167 genes are dramatically downregulated by the nonsense-mediated decay (NMD) pathway.

168 alized only when the mutant mRNAs escape the nonsense-mediated decay (NMD) pathway.

169 sponse were UPF2 and other components of the nonsense-mediated decay (NMD) pathway.

170 ets mRNA transcripts for degradation via the nonsense-mediated decay (NMD) pathway.

171 Nonsense-mediated decay (NMD) provides quality control o

172 UPF1 is a conserved helicase required for nonsense-mediated decay (NMD) regulating mRNA stability

173 Nonsense-mediated decay (NMD) rids eukaryotic cells of a

174 The nonsense-mediated decay (NMD) RNA surveillance pathway d

175 One is rapid mRNA decay triggered by the nonsense-mediated decay (NMD) RNA surveillance pathway.

176 Nonsense-mediated decay (NMD) safeguards against transla

177 The nonsense-mediated decay (NMD) surveillance pathway can r

178 e occupancy, with monosomes predominating on nonsense-mediated decay (NMD) targets, upstream open rea

179 eroxidase 1 (GPx1) is subject to cytoplasmic nonsense-mediated decay (NMD) when the UGA selenocystein

180 ure termination codons (PTCs), which trigger nonsense-mediated decay (NMD), a cytoplasmic RNA degrada

181 Importantly, nonsense-mediated decay (NMD), a major checkpoint for tr

182 ed degradation but are highly susceptible to nonsense-mediated decay (NMD), a regulator of aberrant m

183 ether NAS has characteristics in common with nonsense-mediated decay (NMD), a surveillance mechanism

184 In this study, we identified that cellular nonsense-mediated decay (NMD), an evolutionarily conserv

185 rmination codon within the last exon, escape nonsense-mediated decay (NMD), and most likely generate

186 nts, including RNA subcellular localization, nonsense-mediated decay (NMD), and translation.

187 The EJC has roles in nonsense-mediated decay (NMD), and we found that both th

188 ving upstream frameshift 1 (UPF1), including nonsense-mediated decay (NMD), are inhibited in c9ALS/FT

189 The 3'-extended MAK21 RNA is sensitive to nonsense-mediated decay (NMD), as revealed by its increa

190 ntron-retained mRNAs were not substrates for nonsense-mediated decay (NMD), even though they were det

191 ved mRNA surveillance system, referred to as nonsense-mediated decay (NMD), exists in eukaryotic cell

192 Many transcripts are targeted by nonsense-mediated decay (NMD), leading to their degradat

193 ficient gene editing of early exons elicited nonsense-mediated decay (NMD), overcame neutrophil matur

194 deadenylation-dependent mRNA decay (DDD) and nonsense-mediated decay (NMD), stimulate Ty1 retrotransp

195 chanism allowing UPF1, the central factor in nonsense-mediated decay (NMD), to increasingly attract d

196 nvolved in the mRNA quality control process, nonsense-mediated decay (NMD), were found to genetically

197 In addition, this nonsense mutation induces nonsense-mediated decay (NMD), which degrades the normal

198 lation of fully spliced psiBCH RNA caused by nonsense-mediated decay (NMD), which is an RNA surveilla

199 inclusion of poison exons and production of nonsense-mediated decay (NMD)-sensitive transcripts for

200 cassette exon and transcript degradation via nonsense-mediated decay (NMD).

201 1 is required for mRNA discrimination during nonsense-mediated decay (NMD).

202 05 is within the 5' UTR and cannot result in nonsense-mediated decay (NMD).

203 predicted to predispose mRNA transcripts to nonsense-mediated decay (NMD).

204 on 11 skipping produces an RNA substrate for nonsense-mediated decay (NMD).

205 lternative splicing of nPTB mRNA, leading to nonsense-mediated decay (NMD).

206 undant in dendrites, is a natural target for nonsense-mediated decay (NMD).

207 is exon is skipped, PTBP2 mRNA is subject to nonsense-mediated decay (NMD).

208 significantly associated with high levels of nonsense-mediated decay (NMD).

209 subjected to accelerated turnover, known as nonsense-mediated decay (NMD).

210 of expression from the mutant allele due to nonsense-mediated decay (NMD).

211 APOBEC1 alone induces nonsense-mediated decay (NMD).

212 t mRNAs with premature termination codons to nonsense-mediated decay (NMD).

213 s that are targeted for rapid degradation by nonsense-mediated decay (NMD).

214 h allele-specific regulation of splicing and nonsense-mediated decay (NMD).

215 f a major pathway of RNA surveillance called nonsense-mediated decay (NMD).

216 s (PTVs) near the 3' end of genes may escape nonsense-mediated decay (NMD).

217 that this mutant allele is subjected to the nonsense-mediated decay (NMD).

218 ctively rearranged Igh allele is degraded by nonsense-mediated decay (NMD).

219 which regulates translation termination and nonsense-mediated decay (NMD).

220 te the fact that it is a prime candidate for nonsense-mediated decay (NMD).

221 ng selenoprotein transcripts by antagonizing nonsense-mediated decay (NMD).

222 remain in the nucleus and are not subject to nonsense-mediated decay (NMD).

223 ture termination events target the mRNAs for Nonsense-Mediated-Decay (NMD).

224 that the encoded mRNA should be subject to "nonsense-mediated decay" (NMD).

225 tems monitor mRNAs for translational errors: nonsense-mediated decay, non-stop decay (NSD) and no-go

226 likely to occur in the regions resulting in nonsense mediated decay of both major DSP isoforms, comp

227 ses a moderate hearing impairment likely via nonsense-mediated decay of CABP2-mRNA.

228 s from affected individuals, suggesting that nonsense-mediated decay of COL1A1 RNA is a nuclear pheno

229 n abnormal splicing of ERLIN2 transcript and nonsense-mediated decay of ERLIN2 mRNA.

230 us truncating variant in EXOC2 that leads to nonsense-mediated decay of EXOC2 transcript, a severe re

231 ey could also impact gene expression through nonsense-mediated decay of intron-retained transcripts.

232 CRISPR screens mimicking nonsense-mediated decay of minor intron-containing mRNA

233 a group I RNA helicase that functions in the nonsense-mediated decay of mRNA in yeast.

234 d cells, suggesting that the mutation causes nonsense-mediated decay of mRNA.

235 splicing events including nuclear export and nonsense-mediated decay of mRNA.

236 es in export, translation, localization, and nonsense-mediated decay of mRNAs.

237 Compatible with nonsense-mediated decay of mutant transcripts, CAR8 is v

238 ly result in CTCF haploinsufficiency through nonsense-mediated decay of mutant transcripts, or loss-o

239 We propose that nonsense-mediated decay of nonsense-containing Fed-1 mRN

240 oteins functioning in the nuclear export and nonsense-mediated decay of spliced mRNAs.

241 r domain of the protein and possibly causing nonsense-mediated decay of the corresponding mRNA.

242 lic p.Tyr113(*) stop-gain mutations revealed nonsense-mediated decay of the endogenous mRNA.

243 use premature termination of translation and nonsense-mediated decay of the mRNA and allowing for fle

244 n within an open reading frame (ORF) induces nonsense-mediated decay of the mRNA in vivo.

245 k of FKBP22 protein due to mutations causing nonsense-mediated decay of the mRNA leads to a wide spec

246 n present at the 5' end of intron 2 leads to nonsense-mediated decay of the mRNA.

247 and, hence, would not be expected to lead to nonsense-mediated decay of the mRNA; nonetheless, both m

248 hepatic Fga messenger RNA (mRNA) because of nonsense-mediated decay of the mutant mRNA.

249 asts compared with controls, consistent with nonsense-mediated decay of the mutant transcript and los

250 by the CHADL frameshift mutation results in nonsense-mediated decay of the mutant transcripts.

251 Each mutation triggered nonsense-mediated decay of the respective mRNA transcrip

252 that the c.2737C>T variant does not trigger nonsense-mediated decay of the ZSWIM6 mRNA in affected i

253 tention of a PTBP1-dependent intron triggers nonsense-mediated decay of transcripts encoding DNA meth

254 nsertion of a retrotransposon causing either nonsense-mediated decay of transcripts or alternative sp

255 splicing that can impact mRNA levels through nonsense-mediated decay or by nuclear mRNA detention.

256 n codon, leading to loss of function through nonsense-mediated decay or truncated protein.

257 ere translation termination occurs too soon (nonsense-mediated decay) or fails to occur (non-stop dec

258 Although some ASOs induced nonsense-mediated decay, others reduced mRNA levels thro

259 ants, we uncovered a strong influence of the Nonsense Mediated Decay pathway on CKI levels.

260 Establishing a link between the nonsense-mediated decay pathway and a gene associated wi

261 ng mutations at the 3' end of MPZ escape the nonsense-mediated decay pathway and cause a mild periphe

262 These transcripts are degraded by the nonsense-mediated decay pathway and have a very short ha

263 connection between the chronically activated nonsense-mediated decay pathway and HCM disease developm

264 y of the OLE1 transcript is resistant to the nonsense-mediated decay pathway and that the essential p

265 iated by the HCV IRES was independent of the nonsense-mediated decay pathway and the cap binding prot

266 genes that up-regulate their RNA signal upon nonsense-mediated decay pathway blockade in chronic lymp

267 nally, we demonstrate that components of the nonsense-mediated decay pathway function in at least one

268 Our manipulation of the nonsense-mediated decay pathway in microsatellite unstab

269 Specific inhibition of the nonsense-mediated decay pathway in mutant iPSC-CMs resul

270 The selective degradation of mRNAs by the nonsense-mediated decay pathway is a quality control pro

271 e it constitutes a rate-limiting step in the nonsense-mediated decay pathway that rids cells of mRNAs

272 At the molecular level, the nonsense-mediated decay pathway was activated, and a set

273 d degradation of the rd7 mPNR message by the nonsense-mediated decay pathway, preventing the synthesi

274 strain demonstrated that uAUGs stimulate the nonsense-mediated decay pathway.

275 els by destabilizing the mutant mRNA via the nonsense-mediated decay pathway.

276 the turnover of selenoprotein mRNAs via the nonsense-mediated decay pathway.

277 direct role for DUX4 mRNA in suppression of nonsense-mediated decay pathways has recently been demon

278 icipate in a two-hybrid interaction with the nonsense-mediated decay protein Upf1p.

279 tes that the signaling molecule EIN2 and the nonsense-mediated decay proteins UPFs play a central rol

280 but rather to decreased mRNA translation by nonsense-mediated decay regulation of translation.

281 Additionally, ineffective nonsense-mediated decay resulted in the persistence of t

282 t isoforms targeted for degradation via mRNA nonsense-mediated decay, revealing a common RNA-associat

283 argeted pre-mRNAs leads to the generation of nonsense-mediated decay signatures, indicating that SME1

284 tions such as truncation or frameshift type, nonsense-mediated decay status and Pfam domain interrupt

285 letion mutations predicted to result in mRNA nonsense-mediated decay, suggesting haploinsufficiency a

286 in increased expression of genes involved in nonsense-mediated decay, suggesting that PARP1 might be

287 Analysis using strains lacking nonsense-mediated decay suggests that as many as half of

288 increase in the retained intron isoform and nonsense mediated decay susceptible isoform and a decrea

289 We determined that while a nonsense-mediated, decay-targeted isoform of MDM4 (MDM4-

290 ould allow selenoprotein mRNAs to circumvent nonsense-mediated decay, thus providing new insights int

291 oding variant at the expense of an mRNA with nonsense-mediated decay-triggering features.

292 y decoded UGA which confer the potential for nonsense-mediated decay when factors required for seleno

293 to the 5' untranslated region does not block nonsense-mediated decay when inserted into exon 6 betwee

294 ture protein truncating variants that escape nonsense-mediated decay, which are transcriptionally act

295 -induced phenotypic variation and defects in nonsense-mediated decay, which lead to suppression of pr

296 dicts escape of mutant ZIC1 transcripts from nonsense-mediated decay, which was confirmed in a cell l

297 n-dependent splicing of EZH2, which triggers nonsense-mediated decay, which, in turn, results in impa

298 were informational suppressors that affected nonsense-mediated decay, while the remaining 13 were pha

299 tations identified in these subjects lead to nonsense-mediated decay with subsequent reduction of RNA

300 NC13A messenger RNA, subsequently leading to nonsense mediated decay, with loss of functional protein