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1 sions used to characterize early TCMR can be nonspecific.
2 The majority of criteria used were nonspecific.
3 vated lactate dehydrogenase, are common, but nonspecific.
4 the in-hospital mortality rate were entirely nonspecific.
5 treatment regimens are broad, iterative and nonspecific.
6 ng that a large fraction of DE hit lists are nonspecific.
7 tures of QFT-G-positive patients were mainly nonspecific.
8 a portion of the measured Ab binding can be nonspecific.
9 labeling approach, we showed that excessive, nonspecific actin acetylation did not disrupt characteri
10 quently produced IL-2 and TNF in response to nonspecific activation directly ex vivo and differentiat
11 their long-chain counterparts, may trigger a nonspecific activation of signaling pathways in the inne
13 ro system that spermidine strongly decreases nonspecific activity of Cas1-Cas2 integrase outside the
15 lls are being held closer together (e.g., by nonspecific adhesion), a phenomenon we attribute to the
17 surface with 11-Mercapto-1 -undecanol (MCU), nonspecific adsorption of AuNPs onto the SPR chip surfac
18 ves protein recovery by efficiently reducing nonspecific adsorption of intact proteins on container s
22 : see text]), mercury ([Formula: see text]), nonspecific air pollution ([Formula: see text]), and lea
28 ecificity was demonstrated by the absence of nonspecific amplification using genomic DNA from human o
29 with two loop primers, suffer from undesired nonspecific amplification with strong background signals
30 e the evolution of FSHD clinical trials from nonspecific anabolic or anti-inflammatory/oxidant strate
34 cal history of perinatal hypoxia-ischemia is nonspecific and merits neuroimaging to identify antecede
36 inical signs and symptoms of the disease are nonspecific and often result in misdiagnosis, failure of
37 ughput screen (HTS) that reduced the rate of nonspecific and promiscuous hits and identified leads th
38 bined with simulations demonstrate that both nonspecific and specific cis-interactions contribute to
40 clinical presentation of COVID-19 is fairly nonspecific, and symptoms overlap those of other seasona
43 ins in the humoral immune response and their nonspecific antitumor effects in the B16F10 melanoma mod
44 COVID-19 appearance; 215 (57%) exhibited the nonspecific appearance; and 124 (33%) were considered ne
45 in motions that distinguished cognate versus nonspecific as well as high- versus low-affinity cognate
46 robust differentiation of irrelevant, virus-nonspecific B cells with reactivities against self-antig
47 c analyte) and high-abundance, low-affinity (nonspecific background) binding by measuring the duratio
52 equence specificity as well as low levels of nonspecific binding and recognize a conformational epito
53 ical approach for correction of this assay's nonspecific binding artifact was first described in earl
55 fragment differentiates between specific and nonspecific binding at the single-molecule level, permit
56 To enable this quantification, we reduce nonspecific binding between Qdot-conjugated antibodies a
57 ols to minimize false positives arising from nonspecific binding but at the cost of potentially intro
59 e has indicated that MA-RNA binding prevents nonspecific binding of Gag to non-PI(4,5)P2-containing m
60 ach molecular target could be exaggerated by nonspecific binding of its respective antibody to other
61 ibutes myriad interfering species and causes nonspecific binding of reagents; (ii) hindered delivery
62 is reveals stochastic dynamics emerging from nonspecific binding of TFs and highlights the dual role
65 er from off-target effects and unpredictable nonspecific binding that negatively impact their reliabi
66 cific binding to the protein of interest and nonspecific binding to assay surfaces or matrix componen
69 hermore, the PEG spacer successfully reduces nonspecific binding, enabling high-resolution reconstruc
70 rescence intensities prior to correction for nonspecific binding, even when plates/batches/lots are u
72 ns of the first site result in low-affinity, nonspecific binding; rate-limiting engagement of the sec
77 The "indeterminate" (n = 98) pattern was nonspecific, but vascular enlargement was most frequentl
79 ses had more clinical events than those with nonspecific caused on the basis of imaging classificatio
80 lular infiltrate consists of Ag-specific and nonspecific CD4(+) and CD8(+) T cells, neutrophils, B ce
81 qD-generated cross-linked form of PqqA, with nonspecific cellular proteases completing the release of
82 ive structure differs fundamentally from the nonspecific chain collapse that defines a poor solvent.
83 ening of the permeability transition pore, a nonspecific channel in inner mitochondrial membranes, is
86 lar disorder was a progressive sequence from nonspecific childhood antecedents to adolescent depressi
87 Rs pass multiple kinds of ions, and although nonspecific ChR-mediated conductance is not an issue in
89 such as nonalcoholic fatty liver disease and nonspecific cirrhosis, to intrahepatic cholangiocarcinog
90 pregulation of claudin-1 mRNA and protein, a nonspecific claudin for blood vessels, and downregulatio
91 of the CRISPR-Cas mechanism: (i) collateral, nonspecific, cleavage of host nucleic acids; (ii) second
94 ory of FB ingestion and its wide spectrum of nonspecific clinical presentations makes dietary FB perf
97 und ETS1 and maintained in high-affinity and nonspecific complexes, the low-affinity complex represen
98 een reported but these strategies use either nonspecific conjugation resulting in mixtures, or site-s
99 homa lines and primary targets compared with nonspecific control CAR-ML NK cells or conventional CAR
100 in Pf4-Cre-generated KO mice as a result of nonspecific deletion in other hematopoietic lineages.
102 ection of neuronal cells leads not only to a nonspecific depletion of KIF1A mRNA but also to an accel
104 We suggest that the A-form is due to both a nonspecific desolvation of the DNA by the protein, and a
105 ndered by the sensitivity of such sensors to nonspecific disturbances caused by variations of environ
107 the bacterial nucleoid via an ATP-dependent nonspecific DNA (nsDNA)-binding activity, which is essen
109 ol mu, lacking homologous lysines, displayed nonspecific DNA binding behavior similar to that of pol
110 ults reveal underappreciated consequences of nonspecific DNA binding in shaping gene activity, and su
112 catalyzed AP-DNA destabilization occurs with nonspecific DNA or mitochondrial light-strand promoter s
113 KDelta3A) increased the binding affinity for nonspecific DNA ~11-fold compared with that of the WT.
114 nger DNA containing the 601 motif along with nonspecific DNA, capable of forming dinucleosomes, revea
116 iated with the histone core by more abundant nonspecific DNA-protein contacts, providing a microscopi
124 time into account when studying specific and nonspecific effects of vaccines; early morning should be
125 such as Bacille Calmette-Guerin (BCG), have nonspecific effects, which modulate innate immune respon
126 e conclude that establishment of peripheral, nonspecific electrostatic interactions with the viral me
127 egraded RNA in vitro It is puzzling how such nonspecific endonuclease activity generates primers of a
129 clusters were found: cellulitis on days 1-3, nonspecific erythematous condition on days 2-4, "other c
131 may be a predominant underlying mechanism of nonspecific fear associated with anxiety disorders.
132 disseminated plasma leakage, manifesting as nonspecific fever, headache, and maculopapular rash.
134 phy, are recognized as being insensitive and nonspecific for response monitoring in a clinically rele
135 These increased rates are observed to be nonspecific; for example, children of those with schizop
139 ion in rodents, while chemical inhibition or nonspecific genetic deletion of CXCR2 appears to augment
141 oduces a two-dimensional flow, which reduces nonspecific, geometric capture of normal cells as typica
147 irus reactivation (LTR promoter) relative to nonspecific host cell gene expression (CMV promoter), to
150 physical studies suggest that activators use nonspecific hydrophobic and/or electrostatic interaction
151 Loss of Tfr cells led to greatly increased nonspecific IgE levels, showing that Tfr cells have both
152 nce the clinical and laboratory findings are nonspecific, imaging tests play an important role in the
155 ibody-mediated diseases have been treated by nonspecific immunoglobulin-lowering/modulating therapies
156 is randomized trial aimed to investigate the nonspecific immunological effects of BCG and DTP-contain
157 ever, whether disease amelioration is due to nonspecific immunomodulation or mediated by Ag-specific
158 are widely used as carriers, adjuvants, and nonspecific immunostimulants in cancer because they prom
159 t AMPs can exhibit a range of behaviors from nonspecific incorporation into the nanodisc to formation
160 nnectivity is a prognostic, albeit treatment-nonspecific, indicator of depression improvement, and ea
165 ys has been described in vitro However, this nonspecific integration activity is rare in vivo Here, w
167 neral model to understand the involvement of nonspecific interactions among biomolecules in regulatin
169 proteins become visible in real time, while nonspecific interactions and holistic changes within the
171 trated the importance of specific as well as nonspecific interactions in mediating Ag43-Ag43 recognit
172 n float along the DNA under the influence of nonspecific interactions of bulk crowder molecules.
173 utagenesis experiments, we demonstrated that nonspecific interactions of the linker with membrane alo
174 ducing the contribution of hardly avoidable, nonspecific interactions to their response, to ultimatel
175 ts of this receptor with low background from nonspecific interactions with lipophilic cannabinoid lig
179 ble of effectively mitigating the effects of nonspecific interferences to enable selective water poll
180 les in nanoparticles is challenging, because nonspecific intermolecular interactions are used for enc
183 nodular pulmonary infiltrates and suspected nonspecific interstitial pneumonia or idiopathic pulmona
184 arthritis and an ILD that mimics a cellular nonspecific interstitial pneumonia pattern dominated by
186 ions that are marginally more favorable than nonspecific intrachain interactions are beneficial to pr
187 l outcomes among Medicare-aged patients with nonspecific intraventricular conduction delay (NICD) ver
188 cur through PIP3/PIP2-specific PH domains or nonspecific ionic interactions involving basic-hydrophob
190 MOF is found in two distinct complexes: NSL (nonspecific lethal) in humans and MSL (male-specific let
191 nbinding coaggregates, whereas HSA minimizes nonspecific ligand interactions by functioning as a rese
195 Patients with LD are more likely to report nonspecific long-term sequelae, especially those experie
196 een found to accelerate lipid flip-flop in a nonspecific manner and by various hypothesized mechanism
200 , and the specificity of NT1 for AD versus a nonspecific marker of neurodegeneration (neurofilament l
202 cific localization of Gag via suppression of nonspecific membrane binding.IMPORTANCE The PM-specific
203 of genipin on UCPs is overlaid by increased nonspecific membrane conductance due to the formation of
205 ased potency and reduced in vitro hemolysis, nonspecific membrane toxicity in vivo continues to imped
209 hesis has been supported by the detection of nonspecific mitochondrial DNA mutations in these disorde
213 off-target change or edit is an unintended, nonspecific mutation occurring at a site with sequence s
214 -ischemic cardiomyopathy, coronary spasm, or nonspecific myocardial injury, and the prevalence of COV
215 ical diagnosis alone is difficult due to the nonspecific nature of symptoms; therefore, laboratory di
218 ioneering capabilities of TP53 are driven by nonspecific nucleosome binding with specific binding at
221 negative HCs (n = 90; age range, 21-94 y), 7 nonspecific or off-target binding regions were considere
222 ition of this neural signaling, either using nonspecific or specific inhibitors targeting the TRPV4/a
223 zed each chest radiograph as characteristic, nonspecific, or negative in appearance for COVID-19, uti
224 opsia presented with mild light sensitivity, nonspecific otitis media, and mild developmental delay d
227 rate ratios close to 1.0 for abdominal pain, nonspecific pain, headache, hypotension/syncope, tachyca
228 tion of giant cell arteritis is occasionally nonspecific; patients can have visual symptoms, even bli
229 DNA precipitation removed primers and small, nonspecific PCR products from live-cell PCR products in
230 etable oil production, here we show that the nonspecific phospholipase C6 (NPC6) promotes seed oil pr
231 , pervasive anxiety and worry accompanied by nonspecific physical and psychological symptoms (restles
232 cular, PSs during adolescence appear to be a nonspecific precursor of different psychopathological ou
234 , MAC diagnoses are often delayed due to the nonspecific presentation of MAC-PD and radiological find
235 s the false positive results obtained due to nonspecific priming that can take place with wild-type (
238 obilized Aspergillopepsin I, a highly stable nonspecific protease, was used to cleave reduced antibod
240 veolar spaces, alongside their potential for nonspecific protection, render them an attractive target
241 gnostic (IVD) assays due to the reduction of nonspecific protein adsorption and consequent improvemen
242 on to DUB inhibition, these compounds induce nonspecific protein aggregation, providing molecular exp
243 ia a distinct mechanism wherein unrestricted nonspecific protein-DNA interactions efficiently outcomp
244 with equilibrium dissociation constants for nonspecific protein-protein binding in the Kd ~ 10-mM re
245 While efforts are being made to avoid this nonspecific reaction in MGL, the reaction mechanism rema
246 facilitate retinoid trafficking, to prevent nonspecific reactivity, and to conserve the 11-cis confi
250 mental and computational approach to control nonspecific RNA-DNA interactions that are likely to occu
251 These results suggest essential but sequence nonspecific roles for the PriA pin element and coupling
253 complexes effectively reduces the number of nonspecific salt adducts to biological molecules, theref
254 dies showed that nucleosomes assemble on the nonspecific sequence without any preference for position
256 large conformational entropy associated with nonspecific side-chain interactions, we develop the FuzD
257 nce of cotton wool appearance in retina is a nonspecific sign it needs to be properly evaluated as th
259 As with isolated ileitis the findings of nonspecific small bowel enteritis (NSE) on capsule endos
261 ukemia protein (PML) and thus was not due to nonspecific SUMO conjugation by ubiquitination enzymes.
262 becoming available, but supportive care and nonspecific support for hemostasis with antifibrinolytic
263 ill lacking, and acute disease presents with nonspecific symptomatology and is often misdiagnosed.
264 s of disease in tropical regions, share many nonspecific symptoms and are difficult to diagnose based
266 nfected patients are asymptomatic or display nonspecific symptoms similar to those of other viral inf
267 ypothyroidism may have cognitive impairment, nonspecific symptoms such as fatigue, and altered mood.
268 ress (i.e. 14 months from T1 to a T4 stage), nonspecific symptoms with delay in diagnosis, and the ab
269 gocytophilum The disease often presents with nonspecific symptoms with negative serology during the a
270 , and respiratory for ESRD; and respiratory, nonspecific symptoms, and genitourinary in non-ESRD.
271 xtragenital endometriosis that manifest with nonspecific symptoms, but their detection involves speci
273 Patients with NPSLE typically present with nonspecific symptoms, such as headache and cognitive imp
277 -specific T-cell responses and activation of nonspecific T cells with homing capacity to inflamed tis
280 ction kinetics with SR, thereby reducing the nonspecific targeting of signalless ribosomes and pre-em
282 the clinical features of hypothyroidism are nonspecific, the diagnosis requires laboratory testing.
283 demonstrate that lactam analogues with muted nonspecific thiol reactivities constitute a better elect
284 d inhibitory responses to both immediate and nonspecific threats, collectively referred to as defensi
285 ule transcriptome, this methodology contains nonspecific transcripts that play a confounding role in
286 C) greater than those found in serum for the nonspecific tumor markers carbohydrate antigen 19-9 (CA
289 e days after injection is required to assess nonspecific uptake as a function of time, to optimize st
293 re no CD22(+) cells in the normal liver, but nonspecific uptake of ADCs by liver sinusoidal endotheli
295 ents targeting CXCR4 suffer from either high nonspecific uptake or bind only to the human form of the
297 accommodative disorders); 4 (5%) had both a nonspecific vergence dysfunction and accommodation defic
298 lience to antibiotic treatment duration in a nonspecific way, for example when bacteria transiently a
299 nd, it decondenses the nucleoid through many nonspecific, weak, and transitory interactions with the
300 le tracking, we demonstrate that HU exhibits nonspecific, weak, and transitory interactions with the