ライフサイエンスコーパス: nonstructural

1 The nonstructural 1 (NS1) protein of IAV is an important ant

2 the virus, it is kept in check by the viral nonstructural 1 (NS1) protein, which limits RIG-I activa

3 the virus, it is kept in check by the viral nonstructural 1 (NS1) protein; we determined that NS1 li

4 ulation biosensing (MMB) system and the Zika nonstructural 1 protein, we show highly sensitive and sp

5 rotective efficacy of an attenuated WNV, the nonstructural 4B-P38G mutant, which was previously shown

6 The HCV nonstructural 5A (NS5A) protein, in addition to its role

7 The viral nonstructural 5A protein (NS5A) is the target for new an

8 Previously, an HBoV1 nonstructural and capsid protein-expressing plasmid, pHB

9 ng materials are desirable but are typically nonstructural and problematic to control.

10 envelope or core protein and virus-vectored nonstructural antigen vaccines have been tested in healt

11 .12 +/- 0.07%), and all-cause (structural or nonstructural) BVF (0.81 +/- 0.16% vs. 0.27 +/- 0.10%) (

12 as measured, and leaf nitrogen (N) and total nonstructural carbohydrate (TNC) concentrations were det

13 with xylem water tension and positively with nonstructural carbohydrate concentrations.

14 Moreover, we did not find indications for nonstructural carbohydrate reserves limiting hydraulic r

15 erpenes) and biomass C pools (total biomass, nonstructural carbohydrates (NSC) and secondary metaboli

16 tic architecture of rice (Oryza sativa) stem nonstructural carbohydrates (NSC) at two critical develo

17 Despite the importance of nonstructural carbohydrates (NSC) for growth and surviva

18 Parenchyma cells in the xylem store nonstructural carbohydrates (NSC), providing reserves of

19 verage leaf mass per unit area (LMA), water, nonstructural carbohydrates (NSCs) and polyphenols with

20 raulic conductivity (PLC) and the content of nonstructural carbohydrates (NSCs) of distal branches in

21 educed photosynthesis, plants consume stored nonstructural carbohydrates (NSCs).

22 ions in leaf water potential and the role of nonstructural carbohydrates in leaf turgor maintenance.

23 hlorophyll, and carbon allocation (including nonstructural carbohydrates) are most strongly correlate

24 and recovery dynamics of leaf gas exchange, nonstructural carbohydrates, and hydraulic properties in

25 this, diurnal and seasonal patterns of leaf nonstructural carbohydrates, photosynthesis, solute, and

26 otential, loss of hydraulic conductivity and nonstructural carbohydrates.

27 While trees store substantial amounts of nonstructural carbon (NSC) for later use, storage regula

28 ying interactions between the structural and nonstructural components of AAV enhances our fundamental

29 ipah, chikungunya, and influenza viruses and nonstructural genes from Semliki Forest virus.

30 creening each of the six VHSV structural and nonstructural genes, we identified matrix protein (M) as

31 nome, present within both the structural and nonstructural genes.

32 on rates comparable across structural versus nonstructural genes.

33 uctural protein 1 (NS1) is a unique secreted nonstructural glycoprotein.

34 nuclear antigen, HBV-encoded X antigen, and nonstructural HCV protein 5A are all involved in the reg

35 Influenza virus NS1 protein is a nonstructural, multifunctional protein that counteracts

36 West Nile virus (WNV) nonstructural (NS) 4B-P38G mutant has several features f

37 Recent work showed that an attenuated WNV, a nonstructural (NS) 4B-P38G mutant, induced no lethality

38 ed West Nile virus (WNV) vaccine strain, the nonstructural (NS) 4B-P38G mutant.

39 the efficacy and safety of therapy with the nonstructural (NS) 5A inhibitor, ledipasvir, combined wi

40 This backbone comprises the nonstructural (NS) and capsid (C) antigens, which are do

41 T cell receptors (TCRs) recognizing the HCV nonstructural (NS) NS3 or NS5 viral peptide target were

42 eading frame 2 (ORF2) and a second duplicate nonstructural (NS) polyprotein from ORF1.

43 These g4 and g7 strains contain nonstructural (ns) protein 3 and 5A polymorphisms associ

44 RC) formation, where it interacts with viral nonstructural (NS) proteins and inhibits viral RNA repli

45 ral vectors encoding hepatitis C virus (HCV) nonstructural (NS) proteins induce multispecific, high-m

46 shark class II invariant chain) fused to the nonstructural (NS) proteins NS3-NS5B from RHV (ChAd-NS)

47 y, whereas broad responses to structural and nonstructural (NS) proteins were observed after monovale

48 posed donors were mostly CD8(+) and targeted nonstructural (NS) proteins, whereas IFN-gamma responses

49 and Zostavax vaccination dominantly targets nonstructural (NS) proteins, while Shingrix vaccination

50 were focused predominantly on the capsid and nonstructural NS3 and NS5 antigens.

51 ene (green fluorescent protein) or the viral nonstructural NSs protein.

52 motif in the carboxyl terminal region of BTV nonstructural phosphoprotein 2 (NS2).

53 genome encodes a partly conserved 40-residue nonstructural polypeptide, called the delta peptide, tha

54 rovirus replication is the processing of the nonstructural polyprotein by a viral protease into the v

55 Rac1 inhibitor and is regulated by a dynamic nonstructural pool of F-actin.

56 HBoV1 encodes a small nonstructural protein (NP1) that plays an important role

57 DENV nonstructural protein (NS) 1 has been considered to be a

58 cross-reactive Abs, which can recognize DENV nonstructural protein (NS) 1, have been found in dengue

59 Population sequencing of the nonstructural protein (NS) 3, NS5A, and NS5B genes was p

60 were stratified by their cirrhosis and past nonstructural protein (NS) 5A inhibitor exposure.

61 Here, we show that the HCV protein, nonstructural protein (NS) 5B, directly binds to the tum

62 ing plasmid, pHBoV1NSCap, that harbors HBoV1 nonstructural protein (NS) and capsid protein (Cap) gene

63 revealed several prominent mutations in the nonstructural protein (nsP) 3 and nsP4 genes that emerge

64 iruses, it has been well documented that the nonstructural protein (NSs) enables the virus to counter

65 Here we report that a nonstructural protein (NSs) of severe fever with thrombo

66 V (rHB29NSsKO) that cannot express the viral nonstructural protein (NSs) upon infection of cells in c

67 Of note, unlike the large nonstructural protein (Rep78/68 or NS1) of other parvovi

68 The flavivirus nonstructural protein 1 (NS1) alters glycosaminoglycans

69 e of an RDT that detects dengue virus (DENV) nonstructural protein 1 (NS1) and anti-DENV IgM during s

70 rbent assays (ELISAs), for detection of DENV nonstructural protein 1 (NS1) antigen and anti-DENV IgM.

71 ctivity, IgG and IgA antibodies against ZIKV nonstructural protein 1 (NS1) antigen were specific to Z

72 The influenza A virus (IAV) nonstructural protein 1 (NS1) contributes to disease pat

73 DENV nonstructural protein 1 (NS1) has long been considered a

74 e pursuit of subunit vaccine approaches, and nonstructural protein 1 (NS1) has recently emerged as a

75 uated influenza vaccines with truncations in nonstructural protein 1 (NS1) have shown broad protectiv

76 say for the detection of dengue virus (DENV) nonstructural protein 1 (NS1) in serum.

77 (wt) virus-like particles (VLPs) and soluble nonstructural protein 1 (NS1) in the standard immunoglob

78 DENV nonstructural protein 1 (NS1) induces human endothelial

79 Nonstructural protein 1 (NS1) is a membrane-associated a

80 in the replication and pathogenesis of IAV, nonstructural protein 1 (NS1) is a potential target for

81 Flavivirus nonstructural protein 1 (NS1) is a unique secreted nonst

82 Influenza A virus (IAV) nonstructural protein 1 (NS1) is a virulence factor esse

83 The multifunctional nonstructural protein 1 (NS1) is the main viral factor c

84 A critical role of influenza A virus nonstructural protein 1 (NS1) is to antagonize the host

85 d immunosorbent assays (ELISAs) based on the nonstructural protein 1 (NS1) of DENV serotype 1 (DENV1)

86 DDX41-dependent innate immune responses, the nonstructural protein 1 (NS1) of influenza virus associa

87 The nonstructural protein 1 (NS1) of several flaviviruses, i

88 In this study, we demonstrated that the nonstructural protein 1 (NS1) of WNV antagonizes IFN-bet

89 This study demonstrated that the nonstructural protein 1 (NS1) of WNV antagonizes the ind

90 has the ability to track secreted flaviviral nonstructural protein 1 (NS1) over a broad diagnostic an

91 ZIKV nonstructural protein 1 (NS1) plays an essential role in

92 notransferase (AST) level, positivity in the nonstructural protein 1 (NS1) rapid test, and viremia ma

93 rbent assays (ELISAs) based on ZIKV and DENV nonstructural protein 1 (NS1) were established to test a

94 Antibodies to nonstructural protein 1 (NS1) were largely ZIKV-specific

95 of epitopes in the C-terminal region of DENV nonstructural protein 1 (NS1) which are cross-reactive w

96 Influenza A virus (IAV) nonstructural protein 1 (NS1), a potent antagonist of th

97 2), PB1, PB1-F2, Polymerase Acidic-X (PA-X), Nonstructural Protein 1 (NS1), and Nuclear Export Protei

98 We previously generated a ZIKV nonstructural protein 1 (NS1)-specific human monoclonal

99 tudy, we applied a previously developed anti-nonstructural protein 1 (NS1)-specific MAC-ELISA (NS1-MA

100 re directly triggered by dengue virus (DENV) nonstructural protein 1 (NS1).

101 antibodies for rapid detection of the dengue nonstructural protein 1 (NS1).

102 tigens, including membrane, envelope (E) and nonstructural protein 1 (NS1).

103 ied M segment and the open reading frames of nonstructural protein 1 (NS1)/nuclear export protein (NE

104 The nonstructural protein 1 (nsp1) of CoVs is one such prote

105 the COVID-19 pandemic, SARS-CoV-2, uses its nonstructural protein 1 (Nsp1) to suppress cellular, but

106 h inactive versions of interferon antagonist nonstructural protein 1 (nsp1), nsp15, and nsp16 individ

107 (SARS-CoV), establish host shutoff via their nonstructural protein 1 (nsp1).

108 during different stages of infection (viral nonstructural protein 1 and immunoglobulin M) has greatl

109 odes were determined to be VCD by means of a nonstructural protein 1 antigen immunoassay and reverse-

110 st mRNA nuclear export to the cytoplasm, and nonstructural protein 1 beta (nsp1beta) of PRRSV has bee

111 Moreover, rotavirus NSP1 (nonstructural protein 1) employs a pLxIS motif to target

112 dance proteins like the matrix protein 2 and nonstructural protein 1, with a similar impurity level o

113 ring persistent infection requires the viral nonstructural protein 1/2 (NS1/2).

114 In addition, PRRSV nonstructural protein 11 (nsp11) was identified to inter

115 CoV nonstructural protein 14 (nsp14) encodes 3'-to-5' exorib

116 The coronavirus (CoV) nonstructural protein 14 (nsp14) is a multifunctional pr

117 lated at the guanine-N-7 (G-N-7) position by nonstructural protein 14 (nsp14), which facilitates and

118 '-to-5' exoribonuclease in coronavirus (CoV) nonstructural protein 14 (nsp14-ExoN) mediates RNA proof

119 CoVs encode a proofreading exonuclease in nonstructural protein 14 (nsp14-ExoN), which confers a g

120 Here we report that coronavirus nonstructural protein 15 (nsp15), an endoribonuclease, i

121 ein 3 or the endoribonuclease (EndoU) within nonstructural protein 15.

122 are stimulated by the interactions of PRRSV nonstructural protein 1beta (nsp1beta) and host protein

123 ctive and respiratory syndrome virus (PRRSV) nonstructural protein 1beta (nsp1beta) is a multifunctio

124 ne coronavirus (mouse hepatitis virus [MHV]) nonstructural protein 2 (ns2) is a 2',5'-phosphodiestera

125 The RSV nonstructural protein 2 (NS2) is a multifunctional prote

126 Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a multifunctional prote

127 s (BTV) forms VIBs in infected cells through nonstructural protein 2 (NS2), a phosphoprotein.

128 rus with a single phosphomimetic mutation in nonstructural protein 2 (NSP2 S313D) that exhibits delay

129 Nonstructural protein 2 (nsP2) exhibits the protease and

130 athogenic alphavirus representative, and its nonstructural protein 2 (nsP2) plays critical roles in b

131 Here, we show that dengue nonstructural protein 2A (NS2A protein) recruits viral R

132 Flavivirus nonstructural protein 2B (NS2B) is a transmembrane prote

133 M1404I, in the ZIKV polyprotein, located in nonstructural protein 2B (NS2B).

134 n an interaction between capsid proteins and nonstructural protein 2C(ATPase) In particular, residue

135 of capsid proteins with the multifunctional nonstructural protein 2C(ATPase) In this study, we have

136 The conserved nonstructural protein 2C, which is an AAA+ ATPase, is a

137 ranslation of two additional viral proteins, nonstructural protein 2TF (nsp2TF) and nsp2N.

138 ng activity is achieved by the ATP-dependent nonstructural protein 3 (NS3) helicase.

139 The capsid protein followed by nonstructural protein 3 (NS3), NS2A, and NS5 were the mo

140 V replication complex is a helicase known as nonstructural protein 3 (NS3).

141 d by the C-terminal helicase domain of viral nonstructural protein 3 (NS3).

142 was subsequently shown to recognize the HCV nonstructural protein 3 (NS3):1406-1415 epitope with hig

143 1.5-kb segment 7 dsRNA encoding full-length nonstructural protein 3 (NSP3) fused to UnaG, a 139-amin

144 One determinant of alphavirus virulence is nonstructural protein 3 (nsP3) that contains a highly co

145 the papain-like protease 2 (PLP2) domain of nonstructural protein 3 (nsp3), a component of the viral

146 ssential for viral replication and assembly (nonstructural protein 3 [NS3]).

147 enesis and mosquito transmission through the nonstructural protein 3 helicase.

148 antagonists, the deubiquitinase (DUB) within nonstructural protein 3 or the endoribonuclease (EndoU)

149 to strengthen interaction between RCHY1 and nonstructural protein 3, leading to a further increase i

150 -like protease is encoded next to SUD within nonstructural protein 3.

151 5A inhibitor velpatasvir with or without the nonstructural protein 3/4A protease inhibitor voxilaprev

152 The nonstructural protein 3A of poliovirus and related virus

153 Knockdown of nonstructural protein 4 (NSP4) attenuates the [Ca(2+)]cy

154 Rotavirus nonstructural protein 4 (NSP4) is an endoplasmic reticul

155 PgV-2 E2 glycoprotein or bacterium-expressed nonstructural protein 4AB (NS4AB) in detecting past or p

156 Dengue virus nonstructural protein 4B (NS4B) is a membrane protein co

157 n of proline at amino acid 219 (P219) of the nonstructural protein 4B (NS4B) with serine, threonine o

158 The large flavivirus nonstructural protein 5 (NS5) (105 kDa) has RNA methyltr

159 Nonstructural protein 5 (NS5) contains a methyltransfera

160 One RRV construct expressed nonstructural protein 5 (NS5), while a second recombinan

161 Further study showed that nonstructural protein 5 (nsp5) of PRRSV induced the STAT

162 Nonstructural protein 5 is essential for capping and rep

163 riments showed that ZIKV RNA replication and nonstructural protein 5 translation were reduced below t

164 ary structure and long-range interactions in nonstructural protein 5A (NS5A) from hepatitis C virus (

165 The discovery of GSK2818713 (13), a nonstructural protein 5A (NS5A) HCV inhibitor characteri

166 een treated with an HCV regimen containing a nonstructural protein 5A (NS5A) inhibitor; and * genotyp

167 s recommend that patients who have failed on nonstructural protein 5A (NS5A) inhibitors should be ret

168 Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a phosphoprotein that

169 The hepatitis C virus (HCV) nonstructural protein 5A (NS5A) plays a key role in vira

170 Here, we studied the disordered domain 2 of nonstructural protein 5A (NS5A-D2) of hepatitis C virus

171 The nonstructural protein 5A A30K and Y93H substitutions wer

172 ral protein 5B inhibitor sofosbuvir plus the nonstructural protein 5A inhibitor velpatasvir with or w

173 ombination of daclatasvir (DCV; pangenotypic nonstructural protein 5A inhibitor) and sofosbuvir (SOF;

174 may be inherently resistant to all approved nonstructural protein 5A inhibitors for gt3 HCV.

175 ur study reveals high frequencies of RASs to nonstructural protein 5A inhibitors in gt3 HCV; the pair

176 fectiveness and safety of sofosbuvir and the nonstructural protein 5A inhibitors in the treatment of

177 containing regimens, particularly those with nonstructural protein 5A inhibitors, are limited and rem

178 e KT recipient was a nonresponder because of nonstructural protein 5A resistance.

179 rug that targets the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase and inhibits

180 gimens that included the nucleotide analogue nonstructural protein 5B inhibitor sofosbuvir plus the n

181 A inhibitor) and sofosbuvir (SOF; nucleotide nonstructural protein 5B inhibitor) for 12 weeks previou

182 all HCV DAAs and, in particular, not all HCV nonstructural protein 5B inhibitors may exhibit this car

183 tis C viral genome is catalyzed by the NS5B (nonstructural protein 5B) RNA-dependent RNA polymerase,

184 Finally, we found that nonstructural protein 7 (NS7) of MNV co-localizes with G

185 Coronavirus nonstructural protein 8 (nsp8) has been suggested to hav

186 y of interlineage recombination hot spots in nonstructural protein 9 (NSP9) and in the GP2 to GP3 reg

187 y of interlineage recombination hot spots in nonstructural protein 9 (NSP9) and the GP2 to GP3 region

188 Nonstructural protein 9 (Nsp9) is the RNA-dependent RNA

189 ssociated substitutions (RASs) in HCV genes (nonstructural protein [NS]3, NS5A, NS5B) targeted by DAA

190 Using monoclonal antibody fragments against nonstructural protein dengue NS1, an early biomarker for

191 ell populations specific for variants of the nonstructural protein epitope NS3133 that characterize t

192 ovides a unique example of how a small viral nonstructural protein facilitates the multifaceted regul

193 ts into the mechanism by which a viral small nonstructural protein facilitates the multiple regulatio

194 the genetic background of codon-deoptimized nonstructural protein genes and a deleted small hydropho

195 Among them, we proved that one nonstructural protein is critical to the replication of

196 The MRV nonstructural protein muNS comprises the structural matr

197 researchers have focused on visualizing the nonstructural protein muNS, which forms the VF matrix.

198 Further analysis identified that the small nonstructural protein NP1 is required for HBoV1 DNA repl

199 In this study, we demonstrated that the nonstructural protein NP1 is required for the expression

200 nd in vitro Mechanistically, the viral large nonstructural protein NS1 activates p38 MAPK, which lead

201 Here, we characterized IAV nonstructural protein NS1 and the cellular factor CPSF4

202 The large viral nonstructural protein NS1 is sufficient to induce the DD

203 p53 and IAV, in particular through the viral nonstructural protein NS1, has been shown to be supporti

204 inst ZIKV structural E protein compared with nonstructural protein NS1.

205 HCV nonstructural protein NS3/4A interacts with CHK2 and dow

206 In this study, we show that the BTV nonstructural protein NS4 favors viral replication in sh

207 Here, we report that the nonstructural protein NS5 of ZIKV and other flaviviruses

208 otent viral inhibitor of this pathway is the nonstructural protein NS5.

209 ntified a novel cellular target of the viral nonstructural protein NS5A and demonstrated its role in

210 show here that phosphorylation of the viral nonstructural protein NS5A at serine residues is importa

211 helical (AH) domain of the hepatitis C virus nonstructural protein NS5A, anchored at the cytoplasmic

212 host response to HCV infection is the viral nonstructural protein NS5A, which, in addition to its ro

213 plasmic reticulum (ER) because the rotavirus nonstructural protein NSP4, which interacts with the imm

214 The nonstructural protein NSP5, which undergoes a complex hy

215 The nonstructural protein NSs is a major virulence factor kn

216 resulting from deletions or mutations in the nonstructural protein NSs.

217 ese results, for the first time, show that a nonstructural protein of a novel insect reovirus provide

218 In this study, we show that a nonstructural protein of BTV (NS4) is critical to counte

219 P4 position of the cleavage site between the nonstructural protein P1 (nsP1) and nsP2 regions of the

220 ogical analyses showed that the DcRV-encoded nonstructural protein P10 assembled into a virion-packag

221 t the Ebola virus delta peptide, a conserved nonstructural protein produced in large quantities by in

222 a novel mechanism of how a parvoviral small nonstructural protein regulates viral DNA replication by

223 may be facilitated by association of the MRV nonstructural protein sigmaNS with the major SG effector

224 SH3-binding protein 1 (G3BP1), with the MRV nonstructural protein sigmaNS, which localizes to VFs vi

225 l and biophysical characterization of an HEV nonstructural protein using a construct that has partial

226 alysis for the first time of this identified nonstructural protein, expanding the knowledge and under

227 Parvovirus B19 (B19V) nonstructural protein, NS1, a helicase, covalently modif

228 eproducibly detected low levels of the viral nonstructural protein, NS3.

229 l structural glycoproteins, Gn and Gc, and a nonstructural protein, NSm.

230 HBoV1 encodes a small nonstructural protein, nuclear protein 1 (NP1), that pla

231 t reovirus took advantage of a virus-encoded nonstructural protein, P10, for efficient vertical trans

232 A virus-encoded nonstructural protein, termed NSs, is a major virulence

233 Here, we report that flavivirus nonstructural protein-1 (NS1), which is abundantly secre

234 Vs, except for an SF3 helicase domain in its nonstructural protein.

235 addition to NP1, MVC encodes five additional nonstructural proteins (NS) that share an initiation cod

236 By screening MEV nonstructural proteins (NS1 and NS2) and structural prot

237 However, we found that the other four nonstructural proteins (NS1 to -4) are not required for

238 NP1 and other viral nonstructural proteins (NS1 to NS4) colocalized within t

239 During infection, B19V expresses three nonstructural proteins (NS1, 11-kDa, and 7.5-kDa) and tw

240 hampered by gaps in our understanding of how nonstructural proteins (nsPs) function to form the viral

241 ion strategy and identified six mutations in nonstructural proteins (nsPs) of Venezuelan equine encep

242 genome that also serves as the mRNA for four nonstructural proteins (nsPs) representing subunits of t

243 tion enzyme complexes (RCs) containing viral nonstructural proteins (nsPs) that mediate the synthesis

244 Three viral nonstructural proteins (nsps), nsp3, nsp4, and nsp6, are

245 Coronaviruses encode 16 nonstructural proteins (nsps), three of which, nsp3, nsp

246 Our data are consistent with RSV nonstructural proteins 1 and/or 2 perturbing the Jak-STA

247 sions of three viral interferon antagonists, nonstructural proteins 1, 15, and 16, results in a highl

248 First, we confirmed the presence of HCV nonstructural proteins 3, 4b, and 5a besides HCV core an

249 In HCV-infected cells, various HCV nonstructural proteins also interact or colocalize with

250 HCV nonstructural proteins are shown to colocalize with DDX3

251 sk for HCV infection; viral vectors encoding nonstructural proteins are the only vaccine strategy to

252 Nonstructural proteins are translated from genomic RNA a

253 proteomics led to the identification of HCV nonstructural proteins as well as proteins involved in m

254 h genetic vaccines encoding the HCV NS3-NS5b nonstructural proteins during DAA treatment resulted in

255 studies have suggested that multifunctional nonstructural proteins encoded by flaviviruses antagoniz

256 e, little information is available about the nonstructural proteins essential for viral replication,

257 eus and is essential for expression of viral nonstructural proteins independent of RNA-activated prot

258 ZIKV virulence is to limit the action of the nonstructural proteins involved in its viral replication

259 Many of the nonstructural proteins involved in replication possess m

260 mbined the codon deoptimization of genes for nonstructural proteins NS1 and NS2 (dNS), deletion of th

261 SR regulates the expression of HBoV1-encoded nonstructural proteins NS1, NS2, NS3, and NP1 but not NS

262 B (GBV-B) chimeric virus carrying the major nonstructural proteins NS2 to NS4A (HCV NS2 to -4A chime

263 roplasms requires interactions between virus nonstructural proteins NSP2 and NSP5, which are associat

264 Here, we co-expressed the MERS-CoV nonstructural proteins nsp5, nsp7, nsp8, and nsp12 (RdRp

265 ified active SARS-CoV-2 RdRp composed of the nonstructural proteins nsp8 and nsp12.

266 Although it is known that the nonstructural proteins of HEV ORF1 are expressed as a si

267 ne is expressed from a replicon encoding the nonstructural proteins of Semliki Forest virus.

268 ction of antibodies against either the viral nonstructural proteins or the capsid.

269 ning the three structural proteins and seven nonstructural proteins present in ZIKV, we found that tw

270 All nonstructural proteins required for viral replication ar

271 ve attenuated vaccines based on deletions of nonstructural proteins since single mutations in the vir

272 RNA genome, which encodes 3 structural and 7 nonstructural proteins that are expressed as a single po

273 like their enveloped virus counterparts, are nonstructural proteins that evolved specifically to indu

274 lyprotein is required to generate the mature nonstructural proteins that form the viral replicase.

275 Like RSV, PVM also encodes two nonstructural proteins that have been implicated to supp

276 n is restricted by the inability of the EILV nonstructural proteins to form functional replicative co

277 ral replication by generating structural and nonstructural proteins via the cleavage of the viral pol

278 FMDV structural and nonstructural proteins were localized to follicle-associ

279 e peptide epitopes, from both structural and nonstructural proteins, can prevent adenoviral dissemina

280 e compared to the African lineage, mainly in nonstructural proteins, especially protein NS4B.

281 sid proteins (53.7% coverage), but none from nonstructural proteins, indicating capsids are packaged

282 structural proteins, VP1 and VP2, and three nonstructural proteins, NS1, 11-kDa, and 7.5-kDa.

283 entification of interactions among the other nonstructural proteins, offers new avenues for antiviral

284 lication complex formation, the synthesis of nonstructural proteins, or viral RNA synthesis in differ

285 We also detected interactions involving nonstructural proteins, such as the DNA-binding protein

286 to the immunodominance hierarchy of the DENV nonstructural proteins, with NS3, NS5, and NS1 being dom

287 1b region and provide alternative sources of nonstructural proteins.

288 ural DENV infection and were more focused on nonstructural proteins.

289 a, virus shedding or antibodies against FMDV nonstructural proteins.

290 me of rotavirus expresses 6 structural and 6 nonstructural proteins.

291 llular defenses using various structural and nonstructural proteins.

292 DENV T cell epitopes are found primarily in nonstructural proteins.IMPORTANCE The issue of potential

293 is study highlights a compensatory role of a nonstructural regulatory protein, 2A(pro), for an otherw

294 insights into how the phosphoprotein and the nonstructural V and W proteins of NiV perform their mult

295 Nonstructural valve deterioration (NSVD) was defined as

296 ral replication sites and interacts with the nonstructural viral proteins NS2A and NS2B3.

297 Cellular responses to structural and nonstructural viral proteins were observed, indicating d

298 We addressed whether other nonstructural viral proteins, not incorporated into the

299 g the role for the NS3 protein, one of seven nonstructural viral proteins, which remains to be elucid

300 glycoprotein E and all other structural and nonstructural VZV proteins in both BM and blood (periphe