ライフサイエンスコーパス: normal development

1 sting tumors arise from the dysregulation of normal development.

2 r lymphomagenesis yet partly dispensable for normal development.

3 of its own transcript and are important for normal development.

4 deposition or accelerated implementation of normal development.

5 helial-mesenchymal interactions required for normal development.

6 rn neurons to escape Notch activation during normal development.

7 echanisms to regulate heme metabolism during normal development.

8 is key for cell-cycle control and needed for normal development.

9 st-transcriptional regulators is crucial for normal development.

10 pattern of selection different from that of normal development.

11 tic activities of TET1 that is essential for normal development.

12 te numerous cellular functions essential for normal development.

13 eserve the progenitor state and/or interrupt normal development.

14 any of the experiences that are required for normal development.

15 ility of the tissue and its formation during normal development.

16 ld help to identify critical checkpoints for normal development.

17 ne motility and must be restrained to ensure normal development.

18 fferentiation pathways and are essential for normal development.

19 chromatin opening in early mouse embryos for normal development.

20 apoptosis, all of which are also critical to normal development.

21 g cellular homeostasis and remodeling during normal development.

22 for by other app family members to maintain normal development.

23 r identifying local gene interactions during normal development.

24 ucial in apoptosis and growth control during normal development.

25 rs, drug resistance in fungal infection, and normal development.

26 e importance of this localization pattern in normal development.

27 nt defective in both vacuole trafficking and normal development.

28 occurs when protein production peaks during normal development.

29 nts of GlcCer in excess of that required for normal development.

30 t developmental stages, suggesting a role in normal development.

31 tic physiological functions during and after normal development.

32 retrotransposon expression is essential for normal development.

33 e hypothesis that aggregates are involved in normal development.

34 sympathetic neuroblast proliferation during normal development.

35 of sporadic carcinogenesis and often inform normal development.

36 taining microtubule and genome integrity and normal development.

37 e severe neurodegeneration after a period of normal development.

38 ve SMN knockdown follows variable periods of normal development.

39 ical contexts, and only a small number drive normal development.

40 ic modifications are essential for mammalian normal development.

41 r temporal dynamics) are required to support normal development.

42 sequence in which they are modulated during normal development.

43 vated protein kinase (MAPK) signaling during normal development.

44 to cellular wound repair but is also used in normal development.

45 found that both must be operative to promote normal development.

46 ssive complex 1 (PRC1) that is essential for normal development.

47 ing with exquisite fidelity is essential for normal development.

48 tions under unstressed conditions to support normal development.

49 drocytes are eliminated via apoptosis during normal development.

50 contributions of TGFbeta family signaling to normal development, adult homeostasis and disease, and a

51 ism resembling some of the broad features of normal development, an initial overproduction of functio

52 of Yap in retaining tissue junctions during normal development and after fetal brain injury.

53 ucalopride increases enteric neurogenesis in normal development and after injury.

54 Stem cell regulation during both normal development and aging has become one of the faste

55 d that the trajectory of gyrification during normal development and aging was not linear and could be

56 an increase in sox9b expression during both normal development and AHR2 activation, which suggests r

57 Stiffness increases with age during normal development and approaches adult values during ad

58 e control of gene expression programs during normal development and are disrupted in specific disease

59 ycomb repressive complexes (PRCs) are key to normal development and are frequently deregulated in hum

60 ) superfamily members play critical roles in normal development and become disrupted in human disease

61 notable level of overlap that is crucial for normal development and behavior.

62 Alternative splicing has critical roles in normal development and can promote growth and survival i

63 ignaling and diverse biological processes in normal development and cancer biology.

64 ement membrane barriers is important in both normal development and cancer metastasis.

65 e mechanisms underlying DOT1L's functions in normal development and cancer pathogenesis remain elusiv

66 ulate gene expression play a crucial role in normal development and cancer progression.

67 ficance in cell proliferation control during normal development and cancer.

68 -2alpha (Epas1) have a critical role in both normal development and cancer.

69 ranscriptional switches that are pivotal for normal development and cancer.

70 These results have implications for normal development and carcinogenesis where both nuclear

71 the hedgehog pathway, which is implicated in normal development and carcinogenesis.

72 However, TRADD-deficient mice undergo normal development and contain normal lymphoid populatio

73 ifications control fate determination during normal development and dedifferentiation during disease.

74 s whereby periconceptional folate influences normal development and disease are poorly understood: ep

75 ling and homeostasis of other tissues during normal development and disease.

76 m to further unravel the functions of DCX in normal development and disease.

77 of cell lineage in multicellular systems for normal development and disease.

78 sect the regulation of genomic imprinting in normal development and disease.

79 deciphering how these regions contribute to normal development and disease.

80 the p53 family and has crucial functions in normal development and disease.

81 they play in gene expression control during normal development and disease.

82 nd the functional role of this miR family in normal development and diseases.

83 restimating the microvasculature's impact on normal development and diseases.

84 MYC genes have both essential roles during normal development and exert oncogenic functions during

85 nal mutant Dot1l(mat-/+) offspring displayed normal development and fertility, suggesting that the ex

86 ene regulation and cell behaviour, impacting normal development and fertility.

87 nderstanding of the functions of IMPs during normal development and focuses on a series of recent obs

88 require high levels of SMN protein for their normal development and function in vivo, with reduced le

89 ion of the actin cytoskeleton is crucial for normal development and function of the immune system, as

90 cting the process of cell-cell fusion in the normal development and function of the nervous system.

91 ns in the sensorimotor circuit essential for normal development and function of the neuromuscular sys

92 perties of their apical plasma membranes for normal development and function.

93 n in eIF4E expression, while compatible with normal development and global protein synthesis, signifi

94 in states and genomic stability is vital for normal development and health across a range of organism

95 the actin cytoskeleton, is critical for the normal development and health of podocytes.

96 e correct number of chromosomes is vital for normal development and health.

97 bine to provide a level of HR sufficient for normal development and hematopoiesis.

98 C. trachomatis require mitochondrial ATP for normal development and hence postulate that they preserv

99 de of this, how ADAR1 editing contributes to normal development and homeostasis is uncertain.

100 s encounter and clear apoptotic cells during normal development and homeostasis, including at numerou

101 of histone proteins have essential roles in normal development and human disease.

102 ATX-LPA receptor signaling is essential for normal development and implicated in various (patho)phys

103 maintenance of epigenetic inheritance during normal development and in cancer.

104 NOTCH plays a pivotal role during normal development and in congenital disorders and cance

105 asts, epithelial, cancer, and other cells in normal development and in diseases.

106 mGlu5 receptors play important roles in both normal development and in disorders such as Fragile X sy

107 tor receptor (EGFR) plays a critical role in normal development and in human cancer.

108 molecular basis of tissue homeostasis during normal development and in human disease biology.

109 onents of the Shh transcriptional network in normal development and in oncogenesis.

110 KAT) functions together with MYC both during normal development and in oncogenesis.

111 elastic properties of living tissues during normal development and in pathological processes are oft

112 es to epithelial tissue morphogenesis during normal development and in tumor invasiveness and metasta

113 ocesses, including cellular migration during normal development and invasion in cancer metastasis, ce

114 endent cellular reprogramming is integral to normal development and is central to production of induc

115 Dosage of imprinted genes is crucial for normal development and its dysregulation accounts for se

116 that balanced GDNF signaling plays a role in normal development and maintenance of orthotropia.

117 r transcription factor with crucial roles in normal development and malignancy.

118 a context-specific molecular switch between normal development and malignant transformation.

119 id stimulating hormone (TSH) is critical for normal development and metabolism.

120 imerization partner for MYC, its function in normal development and neoplasia is poorly defined.

121 methylation that regulates genes involved in normal development and neoplastic diseases.

122 lial cells with many important functions for normal development and neural functioning.

123 alternative splicing, a process important in normal development and often dysregulated in disease.

124 endent transcription switches that determine normal development and oncogenesis.

125 orphogenesis and stability are essential for normal development and organ homeostasis.

126 ular localization may impact its function in normal development and pathologic conditions such as NB

127 e multifaceted roles of Wnt signaling in the normal development and pathology of skin, including the

128 Directional cell motility is essential for normal development and physiology, although how motile c

129 expression whose functions are critical for normal development and physiology.

130 cluding HIF1alpha, ATF4, and p53, are key to normal development and play critical roles in disease, i

131 ine RNA editing, and editing is required for normal development and proper neuronal function of anima

132 tissue integrity is a fundamental process in normal development and repair of damaged tissues and org

133 ellent tools for dissecting SFK functions in normal development and signaling and to interfere with a

134 The human cerebral cortex depends for its normal development and size on a precisely controlled ba

135 vastating impact caused by such mutations on normal development and somatic growth.

136 how that dTcf/Pan can limit tissue growth in normal development and suppresses tumorigenesis in the c

137 We conclude that HDAC3 is essential for the normal development and suppressive functions of thymic a

138 sion of CDNF, moreover, is essential for the normal development and survival of enteric dopaminergic

139 m TGCTs may illuminate reprogramming in both normal development and testicular tumorigenesis.

140 itiated axon wrapping were stabilized during normal development and that initiation did not require a

141 s has advanced our understanding of both the normal development and the pathobiology of ocular neovas

142 ial roles for RNA regulatory networks in the normal development and their implications in a variety o

143 by Wnt proteins is finely balanced to ensure normal development and tissue homeostasis while avoiding

144 Primary cilia, which are essential for normal development and tissue homeostasis, are extension

145 ons are robustly regulated in the context of normal development and tissue homeostasis.

146 al transcriptional programs involved in both normal development and tumor differentiation.

147 ontrolling glycolysis in the context of both normal development and tumor growth.

148 The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be deter

149 m is essential for a better understanding of normal development and tumorigenesis.

150 trajectory was followed by PNNs both during normal development and under conditions of critical peri

151 ssociated isoform eIF-5A2 is dispensable for normal development and viability.

152 ession of a subset of genes, is required for normal development, and its disruption leads to human di

153 hology following unexpected cell loss during normal development, and may also be a contributing facto

154 imately 92 microRNA (miRNA) is essential for normal development, and overexpression of certain miRNAs

155 rin ligands control cell interactions during normal development, and reemerge in tumors and the TME,

156 aintaining microtubule and genome integrity, normal development, and tumor suppression.

157 ease complex essential for genome stability, normal development, and viability in mammals.

158 the specific articulations that close during normal development as well as in pathological conditions

159 e expression and are essential components of normal development as well as modulators of disease.

160 developmental trajectory of hemocytes during normal development as well as the emergence of the lamel

161 n transfer RNA (tRNA) are often critical for normal development because they adapt protein synthesis

162 cate that the change in NCoR splicing during normal development both helps drive normal adipocyte dif

163 R-10b is shown to be largely dispensable for normal development but critical to tumorigenesis.

164 omAD database of individuals with presumably normal development, but 12 other SOX4 HMG-domain missens

165 IHCs of Myo7a-DeltaC mice undergo normal development, but exhibit reduced resting open pro

166 CDK2 activity is largely dispensable for normal development, but it is critically associated with

167 Vascular pruning is crucial for normal development, but its underlying mechanisms are po

168 -renewal and differentiation is critical for normal development, but the mechanisms underlying this t

169 ysis of single cells within the framework of normal development can reveal both distinct and shared m

170 ion of adaptive immune responses, regulating normal development, changes the paradigm for studying pl

171 t enzymatic activity of RLIM is required for normal development, cognition and behavior.

172 vidence that specific HARs are essential for normal development, consistent with suggestions that the

173 nonroot tissue and are produced both during normal development (crown roots on cereals and nodal roo

174 acquire such stemness, and to which stage of normal development do PGCCs correspond.

175 Our findings indicate that normal development does not require the C-terminal SH3 d

176 of environmental stressors as part of their normal development, during which they undergo a dramatic

177 eeding, impacting on lipid accumulation, and normal development (e.g., growth, moulting) in an ecolog

178 ding on the cell fate of tumor initiation vs normal development, elevated levels of CD271 can serve a

179 gies was found, and some mutant lines showed normal development followed by deterioration of response

180 RTT is characterized by a period of largely normal development followed by regression in language an

181 ients with Rett syndrome exhibit a period of normal development followed by regression of brain funct

182 termini for 90 min was sufficient to rescue normal development, generating viable larvae and fertile

183 However, the role of this region in normal development has not been addressed.

184 ny organs and cells, with unclear impact for normal development, health, and disease.

185 tebrate trunk neural crest cell fates during normal development, highlight the likely primitive skele

186 e microRNA, expressed at early stages during normal development, improves the differentiation capacit

187 Some cells activated caspase-3 during their normal development in every cell and in every animal wit

188 ylase (NuRD) complex, which is essential for normal development in higher organisms, is one such macr

189 profound influence on stem cell fate during normal development in maintenance of physiologic tissue

190 ned spine morphology at the nanoscale during normal development in mice, and tested the hypothesis th

191 RAD52, a gene dispensable for normal development in mice, was among the top hits.

192 to fully appreciate the remarkable fact that normal development in molluscs, especially snails, can f

193 n syndrome, a genetic disorder that prevents normal development in various parts of the body, is unkn

194 hymal cell crawling is a critical process in normal development, in tissue function, and in many dise

195 Embryos display key landmarks of normal development, including epiblast expansion, lineag

196 s unknown, but it appears to be critical for normal development, including left-right asymmetry and r

197 oproteinases (MMPs) plays important roles in normal development, inflammation, and cancer.

198 Detection of mosaic mutations that arise in normal development is challenging, as such mutations are

199 are an unexpected source of VEGFA and their normal development is required for alveolar angiogenesis

200 Blood vessels are crucial for the normal development, lifelong repair and homeostasis of t

201 L proteins being postulated as essential for normal development, little is known about the specific f

202 Senescence plays roles in normal development, maintains tissue homeostasis, and li

203 data imply that Piccolo is required for the normal development, maturation, and function of neuronal

204 Cell migration is essential for normal development, neural patterning, pathogen eradicat

205 In normal development nodal activity becomes localized to t

206 Here, we review normal development of a placental bed with a safe and ad

207 Apoptotic cell death is important for the normal development of a variety of organisms.

208 primary visual cortex (V1) and disrupts the normal development of acuity.

209 f ghrelin during postnatal life impaired the normal development of ARH projections and caused metabol

210 u receptor with specificity for PE supported normal development of B cells, whereas a VLR:Tmu recepto

211 vity during the critical period prevents the normal development of binocular receptive fields by impa

212 (y442) homozygous mutant zebrafish displayed normal development of blood and lymphatic vasculature.

213 opriate regulation of ARID3a is critical for normal development of both myeloid and B lineage pathway

214 indicate that CRKL is intimately involved in normal development of both the upper and lower GU tracts

215 ion of Rab43 are viable and fertile and have normal development of cDCs but show a defect for in vivo

216 Normal development of cortical circuits, including exper

217 tein response (UPR) has been reported during normal development of cortical neurons and cerebellar wh

218 transcription factors are essential for the normal development of eukaryotes and are the downstream

219 hat early-onset depression adversely affects normal development of functional brain networks.

220 ect biosynthesis of proteins involved in the normal development of gonads and external genitalia.

221 e, we demonstrate that Nfil3 is critical for normal development of gut-associated ILC3s in a cell-int

222 RID3a, in mouse stem cells was important for normal development of hematopoietic lineages; however, p

223 of integrin beta1 in the liver disrupts the normal development of hepatocyte polarity, specification

224 scription factor Runx3 was essential for the normal development of ILC1 and ILC3 cells but not of ILC

225 Mice lacking IL-33 signaling had normal development of ILC2s but retained significantly m

226 d deletion of a peripheral sensor alters the normal development of local and global features of twitc

227 -localized receptor-like kinase required for normal development of maize (Zea mays) leaves, internode

228 major role in iron detoxification and, thus, normal development of malaria parasites in their mammali

229 an essential micronutrient required for the normal development of many organs, including the brain.

230 However, the normal development of many receptive field properties ha

231 r-dependent canonical pathway to orchestrate normal development of many tissues.

232 ruption by homologous recombination leads to normal development of motile ookinetes that exhibit a se

233 xpression of the dev operon is important for normal development of Myxococcus xanthus.

234 ther deficiency of maternal TLR2 affects the normal development of oral tolerance and related immune

235 Although Trim33 is required for the normal development of other tissues, its role in skeleta

236 urrounding somatic cells is critical for the normal development of ovarian follicles, perturbations i

237 ng that Ppal15kDa plays an important role in normal development of P. palmivora infection structures.

238 otein trafficking.SIGNIFICANCE STATEMENT The normal development of photoreceptor cilia is essential t

239 omatin remodeling factor LSH is critical for normal development of plants and mammals.

240 anscription factor that is essential for the normal development of several endoderm-derived organs, i

241 ion of Pou4f1, resulting in a phenotypically normal development of SGN patterning.

242 on of the neural crest, which is crucial for normal development of the aortic arch arteries and crani

243 a requirement for both JNK1 and JNK2 in the normal development of the axial skeleton.

244 ized that the molecular regulators governing normal development of the breast epithelium may double a

245 provide insight into the role of DSPP in the normal development of the calvaria, alveolar bone, and d

246 optosis, which is one of critical events for normal development of the cerebellum.

247 amily zinc finger 2 (Fezf2) is necessary for normal development of the cerebral cortex.

248 membrane proteins that are necessary for the normal development of the CNS.

249 ow that both Mafb and Magi2 are required for normal development of the embryonic zebrafish kidney.

250 nce of thyroid hormones during pregnancy for normal development of the fetal pancreas.

251 ice showed that Gprc5b was not essential for normal development of the glomerular filtration barrier.

252 evidence demonstrates that perturbations to normal development of the gut microbiota in early life m

253 Eighty percent of the patients will have a normal development of the hip after twelve weeks.

254 se data indicate that disc1 is essential for normal development of the hypothalamus and for the corre

255 melanin production and transportation and in normal development of the integumentary system.

256 ern consistent with its proposed role in the normal development of the intrahepatic biliary system.

257 in plays an instrumental role in shaping the normal development of the kidney, skin, neural tube, lun

258 d to several human diseases that disrupt the normal development of the kidney.

259 Several events during the normal development of the mammalian neocortex depend on

260 e kinase receptor ErbB4 is essential for the normal development of the nervous system and has been li

261 Apoptosis is crucial for the normal development of the nervous system, whereas neuron

262 anding molecular mechanisms that control the normal development of the neural crest into cardiomyocyt

263 may cause severe damage to maize, affecting normal development of the plant and decreasing grain yie

264 ptotic activity of Tctp is necessary for the normal development of the retinotectal projection.

265 X-linked gene product that is essential for normal development of the vertebrate embryo.

266 singly, alphavbeta3-deficient mice displayed normal development of the virgin gland with no effect on

267 isually evoked activity is necessary for the normal development of the visual system.

268 Notch is required in type II neuroblasts for normal development of their transit amplifying progeny,

269 ords over a time frame that aligned with the normal development of these cells in humans.

270 As such, the normal development of this region may be disrupted by so

271 racellular matrices (ECMs) is crucial to the normal development of tissues and organs and in disease

272 ions revealed that CD81 was not required for normal development of Treg and MDSC but was essential fo

273 ur data show that CX3CR1 is not required for normal development of V1 responses to visual stimulation

274 me localization block cell proliferation and normal development of zebrafish.

275 Understanding the relationships between the normal development of-and the schizophrenia-associated a

276 emonstrate that p300 is not required for the normal development or functioning of adult skeletal musc

277 al course in affected individuals began with normal development or mild developmental delay, and the

278 response to changes in oxygen tension during normal development or pathologic processes is, in part,

279 nderstanding of the epigenetic regulation of normal development, our work will be useful in decipheri

280 We propose that in normal development, oxygen from nascent retinal vasculat

281 ll fate decisions, identity, and function in normal development, physiology, and disease.

282 During normal development, PMCs alone secrete the embryonic ske

283 nsiderably, but silencers and their roles in normal development remain poorly understood.

284 The importance of these roles during normal development remains untested.

285 tive and asymmetric cell divisions underlies normal development, stem cell maintenance and tissue hom

286 r cytoplasmic mRNA decapping enzyme, impacts normal development, stress survival and ageing.

287 eIF4E is maintained at levels in excess for normal development that are hijacked by cancer cells to

288 Here, we show that during normal development the Drosophila sHsp CryAB [L(2)efl] i

289 Although PTCHD1 is probably critical for normal development, the connection between its deletion

290 in dealing with aneuploidy is fundamental to normal development, the mechanisms responsible for elimi

291 During normal development, the middle muscle precursor stream i

292 In comparison to their defined role in normal development, the miR-183 family is frequently hig

293 oup of genes has been extensively studied in normal development, the second finding suggests importan

294 llular functions and serve distinct roles in normal development throughout life.

295 In contrast, Pcbp2-null embryos undergo normal development until midgestation (12.5 to 13.5 days

296 During normal development, we demonstrate that intracerebrovent

297 ular trafficking genes affected by AS during normal development (when Celf1 is downregulated) show a

298 enotypic spectrum ranged from normal or near-normal development with mild epilepsy and speech delay/a

299 tubule (MT) motor kinesin-1 is essential for normal development, with key roles in the nervous system

300 orm of directed cell migration important for normal development, wound healing, and cancer metastasis