ライフサイエンスコーパス: normal human

1 obiota are observed in certain diseases, the normal human adaptive immune response to intestinal micr

2 hondrial disease, and also accumulate during normal human ageing.

3 egulation of the transcriptome, unaltered in normal human aging.

4 Inhibition or deletion of NFAT5 in normal human and murine cells recapitulated several of t

5 We conclude that SMG9 is required for normal human and murine development, most likely through

6 ich is localized to bulge stem cells in both normal human and murine skin.

7 anscriptomics and cytokine data derived from normal human and rat bronchial epithelial cells exposed

8 nificant right-to-left gas exchange shunt in normal humans and canines.

9 human infection and appears adept at evading normal human antiviral responses, yet it remains poorly

10 We found that the normal human appendix harbors populations of Fusobacteri

11 ion in NK cell-mediated cytotoxicity against normal human articular chondrocytes.

12 to be affected in U87 glioblastoma cells or normal human astrocyte (NHA) cells expressing mutant IDH

13 astly, we found that CHD4 is dispensable for normal human astrocyte survival.

14 plication and Zika virus (ZIKV) infection of normal human astrocytes (NHA).

15 In immortalized normal human astrocytes (NHAs) and syngeneic mouse gliom

16 ious cycle of JCPyV were analyzed in primary normal human astrocytes (NHAs).

17 rget all GBM molecular classes while sparing normal human astrocytes.

18 he preimmune ancestor IgG bound intensely to normal human B cells bearing I/i antigen.

19 to detect sufficient numbers of mutations in normal human B cells has precluded the generation of a h

20 us sequence from human band 3, including the normal human band 3 deoxyHb-binding site.

21 ted and myelin-related genes co-expressed in normal human basal ganglia.

22 gen species (ROS) is a fundamental aspect of normal human biology.

23 Here we show that freshly biopsied normal human brain contains abundant alphaS tetramers.

24 biologically relevant model system to study normal human brain development and neurological diseases

25 t characterization of a given dataset across normal human brain development.

26 pressed in glioblastoma tissue compared with normal human brain tissue.

27 Transcriptome profiles of normal human brain tissues showed that the novel candida

28 genomic datasets charting the development of normal human brain with a particular focus on recent sin

29 publicly available expression datasets from normal human brains, one comprised of four brain regions

30 ion of individual genes and co-expression in normal human brains.

31 We analyzed and compared the normal human breast cell line MCF10A in control conditio

32 and PP exposure caused R-loop formation in a normal human breast epithelial cell line when ERalpha wa

33 n breast TMA showed that LASP-1 is absent in normal human breast epithelium but the expression increa

34 atients, and depletion of these factors from normal human breast fibroblasts increased proliferation

35 B) is significantly higher in cancer than in normal human breast tissues and cells.

36 breast cancer, as well as two immortalized ("normal") human breast cell lines.

37 ted, pseudostratified epithelia derived from normal human bronchial basal cells.

38 replicative capacity and relative fitness in normal human bronchial epithelial (NHBE) cells of recomb

39 68 differentially expressed genes in primary normal human bronchial epithelial (NHBE) cells that were

40 Measuring the time evolution of response of Normal Human Bronchial Epithelial (NHBE) cells to aeroso

41 Whereas, normal human bronchial epithelial (NHBE) cells with poor

42 proteomic and transcriptomic measurements of normal human bronchial epithelial (NHBE) primary cells u

43 ) in lung epithelial cells (A549 and primary normal human bronchial epithelial [NHBE]) cells and macr

44 nase inhibitor (ROCKi), and low oxygen (2%), normal human bronchial epithelial basal progenitor cells

45 bronchial epithelial 16HBE cells and primary normal human bronchial epithelial cells (NHBE) at 4-24 h

46 the miRNA content of EV secreted by primary normal human bronchial epithelial cells (NHBE) is altere

47 Primary normal human bronchial epithelial cells (NHBE) represent

48 hBE33 cells and normal human bronchial epithelial cells (NHBE) were pret

49 ulatory mechanisms and clinical relevance in normal human bronchial epithelial cells (NHBEs) and nasa

50 rentiation induced by insulin deprivation in normal human bronchial epithelial cells cultured in orga

51 demonstrate that reduced levels of CARMA3 in normal human bronchial epithelial cells decreases the pr

52 combinant viruses were also characterized in normal human bronchial epithelial cells, and the results

53 In normal human bronchial epithelial cells, IL-8 secretion

54 In normal human bronchial epithelial cells, pH1N1low-1 was

55 We replicated selected findings in normal human bronchial epithelial cells.

56 enescence in mouse embryonic fibroblasts and normal human bronchial epithelial cells.

57 SCs or nonfailing hMSCs were cocultured with normal human cardiac myocytes derived from induced pluri

58 esents a significantly lower AFL compared to normal human cartilage.

59 Compared with age-matched normal human CD cells, CD-derived renal cystic epithelia

60 down of RPS19, RPL5, and RPL11 expression in normal human CD34(+) cells.

61 Initial experiments showed that normal human CD34+ blood cells transduced with a lentivi

62 e demonstrated that in vitro transduction of normal human CD4+ T lymphocytes with NPM-ALK results in

63 eals that Epstein-Barr virus interferes with normal human cell life, such as cholesterol homeostasis,

64 Since cells derived from other normal human cell types are fully supportive of FeLV rep

65 point and ATM signaling promoted recovery of normal human cells after low-dose FA.

66 re, we mapped the locations of RNA Pol II in normal human cells and found that RNA Pol II pauses in a

67 using mutant forms of MAPT in karyotypically normal human cells and found that they cause aneuploidy

68 Normal human cells can either synthesize cholesterol or

69 dings suggest that extending the lifespan of normal human cells due to inactivation of STAG2 could pr

70 p53 populations that accumulate in infected normal human cells in the absence of both mechanisms of

71 ent method to transform fully differentiated normal human cells into high-grade NE tumors (Park et al

72 , small intestine and colon, was analyzed in normal human cells of colon mucosa.

73 ed here indicated that depletion of c-MYC in normal human cells reduced the transforming activity of

74 STAG2 silencing in normal human cells that lack telomerase led to increased

75 These chimeric messenger RNAs are present in normal human cells, and are also detected in various can

76 olated from pancreatic cancer cells, but not normal human cells, can initiate malignant cell transfor

77 In normal human cells, centrosome loss induced by centrinon

78 ption and post-transcriptional regulation in normal human cells.

79 ll lines, and up to 70-fold less toxicity in normal human cells.

80 ntly more toxic to human melanoma cells than normal human cells.

81 tional processes that have been operating in normal human cells.

82 expressing equal amounts of the full-length normal human CFH Y402 (CFH-Y/0) or the AMD-risk associat

83 tivity of the ITPR3 promoter was measured in normal human cholangiocyte (NHC) cells and primary mouse

84 determined by measuring calcium signaling in normal human cholangiocyte cells and secretion in isolat

85 of lipopolysaccharide-induced senescence in normal human cholangiocytes (NHCs), we found increased B

86 cholangiocarcinoma cell lines compared with normal human cholangiocytes.

87 ncogenic proteins compared to EV released by normal human cholangiocytes.

88 cal for survival and sets the foundation for normal human cognitive-emotional behaviour.

89 ound that FOXA1 is robustly expressed in the normal human colon but significantly downregulated in co

90 In the normal human colon, we show that integrin alpha5 localiz

91 Compared with normal human colonic epithelial cells, colon cancer cell

92 a sets using Affymetrix U133 + gene chips on normal human colonic mucosa (NR), adenomas (ADs), and co

93 identified miRNA expression patterns in the normal human colonic SC niche to understand how cancer s

94 ls in human cholangiocarcinoma compared with normal human control liver samples.

95 ored the occurrence of fusion transcripts in normal human cortex along with single neurons and astroc

96 ell type that expands the stem cell niche in normal human cortex.

97 s define PRUNE as a molecule fundamental for normal human cortical development and define cellular an

98 Furthermore, normal human dermal fibroblasts (primary cells) are also

99 concentration, etc.), in primary cultures of normal human dermal fibroblasts exposed to visible and n

100 onstructs engineered with iMyoD-hTERT-NHDFs, normal human dermal fibroblasts transduced with genes en

101 othelial electrical resistance compared with normal human dermal microvascular ECs.

102 angiogenesis and is critically important for normal human development and cancer progression.

103 ignificance of histone lysine methylation in normal human development and the importance of this proc

104 coded protein kinase DYRK1A is essential for normal human development.

105 depletion in U2OS cells or TERT-immortalized normal human diploid fibroblasts results in decreased ex

106 study (GWAS) screen was performed to explore normal human diversity in responses to rapamycin, a micr

107 with macular flat mounts and sections from 1 normal human donor eye and 2 normal primate eyes (Macaca

108 successful hematopoietic engraftment with a normal human donor to model allogeneic stem cell rescue.

109 of acrocentric p-arms in cell lines and from normal human donors have no detectable rDNA.

110 We found that normal human electrophysiology is preserved in slice pre

111 Consequently, HERVK is transcribed during normal human embryogenesis, beginning with embryonic gen

112 In scarce normal human embryos, crypts were sometimes present.

113 using whole-genome sequencing, we show that normal human endometrial glands are clonal cell populati

114 Analysis of cSCC cell lines (n = 8) and normal human epidermal keratinocytes (n = 11) with real-

115 ntiation-specific keratins K1, K10 and K2 in normal human epidermal keratinocytes (NHEK) and two impo

116 Normal human epidermal keratinocytes and 3D raft treatme

117 wn of SCARA3 and MARCO reduced SNA uptake in normal human epidermal keratinocytes and 3D rafts after

118 We explored the mechanism of SNA uptake in normal human epidermal keratinocytes and 3D skin equival

119 f enolase, increased SIRT1 protein levels in normal human epidermal keratinocytes and the immortalize

120 epidermal stem cells in Terc(-/-) mice, and normal human epidermal keratinocytes are also ALT-positi

121 Incubation of normal human epidermal keratinocytes at 4(o)C or with so

122 Furthermore, in normal human epidermal keratinocytes in vitro, treatment

123 ivation of the transcription factor, AHR, in normal human epidermal keratinocytes increased AHR bindi

124 However, direct treatment of normal human epidermal keratinocytes with S1P increased

125 and S. aureus bacterial supernatant-treated normal human epidermal keratinocytes, S1PR1 knockdown re

126 irus 16 (HPV 16) E6 and E7 gene-immortalized normal human epidermal keratinocytes, we demonstrated in

127 was up-regulated in cSCC cells compared with normal human epidermal keratinocytes.

128 studies demonstrated that ELF3 silencing in normal human epithelial cells enhances their motility an

129 In culture, normal human epithelial cells enter senescence after a l

130 Normal human epithelial cells remain unaffected by this

131 s-like chromatin signature when expressed in normal human epithelial cells.

132 L-SNA penetrates 3-dimensional cultures and normal human explants to knock down IL17RA mRNA by 63% a

133 HCMs (and melanins) are important in normal human eye physiology with roles including photopr

134 f abnormal spindle, which did not affect the normal human fibroblast cells NB1, Mrc-5 and IBR3.

135 estigated whether the chronological aging of normal human fibroblasts (NHFs), a previously underappre

136 ls, but instead cGAS is partially nuclear in normal human fibroblasts and keratinocytes, interacts wi

137 ) is a stress response protein that protects normal human fibroblasts from oxidative stress.

138 Using a panel of normal human fibroblasts, we characterized molecular dif

139 levels of nuclear huntingtin in both HD and normal human fibroblasts.

140 , and H1975 NSCLC cells and MRC-9 and CCD-16 normal human fibroblasts.

141 in U2OS and A549 cancer cells as well as in normal human fibroblasts.

142 servable decrease of IFI16 protein levels in normal human foreskin fibroblasts (HFFs), normal oral ke

143 Although they are part of the normal human gastrointestinal and vaginal flora, they ca

144 sional picture of the contribution of TEs to normal human gene regulation is still lacking.

145 ined the distribution of alpha6beta4E within normal human glandular epithelium and its regulation and

146 BM cells and significantly less expressed on normal human glial cells.

147 human lineage and is an integral part of the normal human gut virome.

148 sts an optimum wave condition-occurring near normal human heart rates-that minimizes pulsatile energy

149 ranscriptional and cellular diversity in the normal human heart.

150 SCs in MDS xenograft mouse models, restoring normal human hematopoiesis and eradicating aggressive pa

151 s, MX69, showed minimal inhibitory effect on normal human hematopoiesis in vitro and was very well to

152 To explore the requirement for ARID3a for normal human hematopoiesis, hematopoietic stem cell prog

153 wth and, in HIS mice, had minimal effects on normal human hematopoietic cells.

154 we show that ADAR1-induced hyper-editing in normal human hematopoietic progenitors impairs miR-26a m

155 ared with littermate control mice expressing normal human hemoglobins.

156 MGLL expression was detected in normal human hepatocytes and mouse liver, although it wa

157 ic analysis to date comparing epileptic with normal human hippocampi.

158 estigated global transcriptomic profiling of normal human HSC/hematopoietic progenitor cells [HPCs],

159 entially expressed in primary human LSCs and normal human HSPCs.

160 in vitro (i) Fluorescence microscopy showed normal human IgG and IgM bind C. neoformans (ii) C. neof

161 DE4 inhibitors also blocked TLR signaling in normal human immune cells.

162 phy (PET) were compared among 19 cognitively normal human immunodeficiency virus (HIV)-negative contr

163 amic vestibular stimulation (MVS) by placing normal humans in a 7T MRI for 90 min.

164 the same environment to the bacteria as the normal human intestinal epithelium.

165 Very few LDs were found in normal human juvenile pancreatic acinar and islet cells,

166 PA5 cells had a normal human karyotype (46, XY) and exhibited faster gro

167 In normal human keratinocytes and mouse skin SIRT1 knockdow

168 The addition of recombinant TIP39 to normal human keratinocytes in culture induced an increas

169 Using normal human keratinocytes in vitro and skin explants ex

170 Here, we show that AKR1B10 transfection into normal human keratinocytes reproduced the abnormal retin

171 ecrosis in mice and its cytotoxic effects in normal human keratinocytes, the major cell type in the e

172 hat was reproduced by overexpressing RAC1 in normal human keratinocytes.

173 of compounds in a panel of primary ADPKD and normal human kidney (NHK) epithelial cells.

174 ne, and circulating antibodies reactive with normal human kidney proximal tubular brush border.

175 the patient reacted with the brush border of normal human kidney, in contrast with the negative resul

176 DPKD tissue and cells compared with those of normal human kidneys (NHKs), whereas PDE1 levels are not

177 m injured human kidneys than in samples from normal human kidneys, and in mouse and rat kidneys, ANG

178 Finally, acylcarnitines are detectable in normal human lavage fluid.

179 and sphingosine-1-phosphate phosphatase 1 in normal human liver and cirrhotic liver from patients wit

180 Cholangiocytes were isolated from normal human liver, incubated with LTB receptor agonist,

181 In addition, we found that normal human lung and mammary epithelial cells were less

182 he mechanism employed, we used CD44-negative normal human lung cells (HFL1), A549, and H1299 (p53-nul

183 cells (BR+) as well as L1210 cells and WI38 normal human lung fibroblast cells (biotin-receptor nega

184 We evaluated the response of normal human lung fibroblasts (NHLFs) to stimulation wit

185 PV4 activation in a PI3K-dependent manner in normal human lung fibroblasts in vitro Mechanistically,

186 Asc restoration in human lung H460 cells and normal human lung fibroblasts on the activation and func

187 nced differentiation potential compared with normal human lung fibroblasts.

188 organoid that exhibits characteristics of a normal human lung is developed to study the biology of m

189 nd BAY 60-2770, triggered bronchodilation in normal human lung slices and in mouse airways.

190 Staining of fibrotic and normal human lung tissue localized DSP to airway epithel

191 is lungs but has limited or no expression in normal human lungs.

192 form of the protein, however, has a role in normal human macrophage function has not been determined

193 tic results by karyotyping characteristic of normal human male or female karyotypes.

194 analysis of total cell lysate obtained from normal human mammary epithelial (HME-1) cells treated wi

195 HACE1 downregulation in normal human mammary epithelial cells (HMECs) results in

196 which harbor lower hsa-miR-125b levels than normal human mammary epithelial cells (HMECs).

197 ecture of these cell types was compared with normal human mammary epithelial cells and LNCaP prostate

198 es, whereas it has minimal or less effect on normal human mammary gland epithelial cells (HMECs) and

199 ated cell types via long-term propagation of normal human mammary tissues.

200 , HeLa cervical and CaCo-2 colon, as well as normal human MCF10A mammary epithelial and human periphe

201 d the human vitiligo cell line PIG3V and the normal human melanocyte line HEM-l by RNA sequencing, ta

202 We found that normal human melanocyte lines did not exhibit centrosome

203 d that AC expression is markedly elevated in normal human melanocytes and proliferative melanoma cell

204 MSX1-reprogrammed normal human melanocytes express the neural crest marker

205 Whereas FES is highly expressed in normal human melanocytes, FES expression is strongly dec

206 Compared to normal human melanocytes, miR-211 expression is signific

207 ost human melanoma cell lines, as well as in normal human melanocytes.

208 levated in melanoma cell lines compared with normal human melanocytes.

209 nantly with the HPS-5 component of BLOC-2 in normal human melanocytes.

210 joints, porcine metacarpophalangeal joints, normal human metatarsophalangeal articular tissue and hu

211 s a comprehensive reference data set of the "normal" human microbiome of 242 healthy adults at 5 majo

212 s, but information about the role of miRs in normal human MK and platelet production is limited.

213 CCDC88A is essential for multiple aspects of normal human neurodevelopment.

214 her evidence for the key role of Ca(v)2.2 in normal human neurodevelopment.

215 proteins were also separately purified from normal human neutrophils and used to reconstitute chroma

216 e of debate, it is now largely accepted that normal human neutrophils do not synthetize tissue factor

217 we measured tau and Abeta in 124 cognitively normal human older adults (74 females, 50 males) followe

218 but also determined the efficiency by which normal human oral keratinocytes could be reprogrammed to

219 invasively quantify the tissue parameters of normal human oral mucosa tissues, including labial mucos

220 novative devices could provide insights into normal human organ function and disease pathophysiology,

221 In gene complementation studies, normal human p53 alleles suppressed transposons, but mut

222 a significant effect on the transcriptome of normal human palatal mucosa and seems to target genes im

223 In mixed lymphocyte co-cultures between normal human peripheral blood lymphocytes, (1) frequenci

224 TRPV2 was overexpressed in LBCs compared to normal human peripheral blood mononuclear cells (PBMCs).

225 I PRMT inhibition on arginine methylation in normal human peripheral blood mononuclear cells and util

226 mmunology analysis of daily variation in the normal human peripheral immune system.

227 and protein phosphorylation when compared to normal human plasma.

228 ssay by their ability to neutralize FVIII in normal human plasma.

229 In cultured normal human primary airway epithelial cells, ST2 overex

230 Differences in estrogen signaling between normal human primary breast epithelial cells and primary

231 rSPCs were enriched by spheroid culture from normal human primary or immortalized prostate epithelial

232 nts were shorter in length than those of the normal human productive repertoire.

233 avbeta6 integrin, which is not detectable in normal human prostate but is highly expressed in human p

234 l prostate epithelial cells and immortalized normal human prostate epithelial cells (RWPE1), but the

235 The structure and function of normal human prostate is still not fully understood.

236 We studied how iAs affects normal human prostate stem-progenitor cells (PrSPCs) and

237 We inoculated transgenic mice expressing normal human PrP with amplified urine and brain homogena

238 Controlled stiffening of normal human red blood cells (RBCs) in different shapes

239 tgen sequence 2 colorectal cell lines and 16 normal human samples to illustrate its utility in identi

240 tained with IgHPolyFab and FcMonoIgG against normal human sera, IVIg, and allograft recipients' sera,

241 aumannii strains are resistant to killing by normal human serum (NHS), an observation supported in th

242 of N. meningitidis group B strain H44/76 in normal human serum (NHS).

243 tely resistant to in vitro neutralization by normal human serum (NHS).

244 demonstrate ficolin-2/-3 heterocomplexes in normal human serum and plasma by ELISA using Abs specifi

245 formed on antigen-bearing lipid membranes by normal human serum at 4 degrees C.

246 mutants were less able to compete with FH in normal human serum during complement activation on mGEnC

247 ose dolphins (Tursiops truncatus) and pooled normal human serum led to the discovery of 11 proteins t

248 h of the four DENV serotypes spiked into 50% normal human serum was increased by at least a factor of

249 single protein, C-reactive protein (CRP), in normal human serum, displaying a calcium-dependent, high

250 ganism resistant to killing by complement in normal human serum.

251 varied from 20% to 165% of that expressed in normal human skin and persisted for 3 months.

252 Analyzing digested normal human skin by single-cell RNA sequencing, we expl

253 ific and quantitative approach to monitoring normal human skin cells (keratinocytes and fibroblasts)

254 In an ex vivo human model of BP, normal human skin cryosections were incubated with purif

255 , split-dose and fractionated irradiation in normal human skin fibroblast cells (AGO1522) and human p

256 )PPs] (at 5 and 20 min and 1, 2, and 4 h) in normal human skin fibroblasts.

257 As differ when M. sympodialis is cultured at normal human skin pH versus the elevated pH present on t

258 Psoriatic skin biopsy specimens, as well as normal human skin, blood, and primary cells, were used t

259 expressed in the upper pilosebaceous unit of normal human skin, is down-regulated in acne.

260 Compared with normal human skin, SIRT1 is downregulated in both AD and

261 In normal human skin, the SDR9C7 was abundantly expressed i

262 to overcome this obstacle in the context of normal human skin, thus offering a glimpse into the geno

263 ctivity of the biosensor was tested by using normal human skin-fibroblast.

264 hed malignancy can also occur in PIPs within normal human skin.

265 d induced pluripotent stem cells (iPSC) from normal human small airway epithelial cells (SAEC) to inv

266 array analyses of mRNA isolated from primary normal human small airway epithelial cells indicated tha

267 ow that the rate of particle emission during normal human speech is positively correlated with the lo

268 e X-linked RHOX gene cluster may function in normal human spermatogenesis and we provide evidence tha

269 Normal human stem cells rely on low levels of active tel

270 BAB (R1 and R2) receptor subunits within the normal human STN.

271 -resolved proteome reference map of the near normal, human stomach.

272 two rejectors, compared with those from five normal human subjects and three nonrejectors.

273 Lactate in normal human subjects get cleared very quickly at a rate

274 dcn Clinically, compared with pathologically normal human subjects, patients with IPF presented local

275 ive trait loci (eQTLs) in platelets from 154 normal human subjects.

276 l basis of GABAergic transmission within the normal human subthalamic nucleus and evidence of GABA in

277 tion of cell metabolic pathways that underly normal human T cell responses have taught us that there

278 o determine if histatin-1 (H1) is present in normal human tears and whether tear levels of H1 varied

279 rminal proteoforms nor intact lacritin, from normal human tears promotes loss of stability akin to hu

280 At ages approximately equivalent to normal human term birth, mouse cortex exhibits primarily

281 ding to their initial T2* below or above the normal human threshold of 35 ms (MIC, 0.59 mg/g dry weig

282 fied in the bone marrow, are resident in the normal human thymus.

283 iding a systematic profile of TE activity in normal human tissue.

284 emonstrate that somatic mutational burden in normal human tissues can vary by several orders of magni

285 IHC on normal human tissues found that ALPPL2 is expressed only

286 aster regulators of the Hippo pathway across normal human tissues identified processes of tissue rege

287 g cancer driver mutations, in histologically normal human tissues suggest that mutations alone are no

288 ies have started to map somatic mutations in normal human tissues, and here we discuss their implicat

289 By middle age, normal human tissues, including the esophageal epitheliu

290 ase III drugs across a diverse collection of normal human tissues.

291 tein levels from over 12,000 genes across 32 normal human tissues.

292 P) downstream of PTEN is highly expressed in normal human Treg cells and provides complementary phosp

293 elucidation of early mechanisms that govern normal human trophoblast development and associated path

294 The cancer cell line SK-HEP-1, but not normal human umbilical vein endothelial cells, responded

295 n endogenous straight chain fatty acid, is a normal human urinary metabolite and can be obtained as a

296 vestigated the direct effects of ketamine on normal human urothelium maintained in organ culture or a

297 copic analysis of capillaries located in the normal human utricular stroma showed vascular endothelia

298 the optimal ventricular pacing site to mimic normal human ventricular physiology and best hemodynamic

299 imited NETosis of neutrophils collected from normal human volunteers and naive mice in an exchange pr

300 Our investigation in normal human volunteers revealed the presence of 2 to 4